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    NEW PROCESS FOR THE MANUFACTURE OF PHARMACEUTICAL COMPOSITIONS
    1.
    发明申请
    NEW PROCESS FOR THE MANUFACTURE OF PHARMACEUTICAL COMPOSITIONS 有权

    公开(公告)号：US20230020272A1

    公开(公告)日：2023-01-19

    申请号：US17782734

    申请日：2020-12-04

    申请人： NANEXA AB

    发明人： Anders JOHANSSON ,  Marten ROOTH ,  Joel HELLRUP

    IPC分类号： A61K9/50 ,  A61K31/706

    摘要： There is provided a process for the preparation of composition in the form of a plurality of particles having a weight-, number-, and/or volume-based mean diameter that is between amount 10 nm and about 700 μm, which particles comprise: (a) solid cores, preferably comprising a biologically active agent; and (b) two or more sequentially applied, discrete layers, each of which comprises at least one separately applied coating material, and which two or more layers together surround, enclose and/or encapsulate said cores, which process comprises the sequential steps of: (1) applying an initial layer of at least one coating material to said solid cores by way of a gas phase deposition technique; (2) discharging the coated particles from the gas phase deposition reactor and subjecting the coated particles to agitation to disaggregate particle aggregates formed during step (1) by way of mechanical sieving technique; (3) reintroducing the disaggregated, coated particles from step (2) into the gas phase deposition reactor and applying a further layer of at least one coating material to the reintroduced particles; and (1) optionally repeating steps (2) and (3) one or more times to increase the total thickness of the at least one coating material that enclose(s) said solid core. The gas phase deposition technique is preferably atomic layer deposition. When the cores comprise biologically active agent, the compositions may provide for the delayed or sustained release of said active agent without a burst effect.

    NEW PROCESS
    4.
    发明公开
    NEW PROCESS 审中-公开

    公开(公告)号：US20240261228A1

    公开(公告)日：2024-08-08

    申请号：US18567466

    申请日：2022-06-10

    申请人： NANEXA AB

    发明人： Anders JOHANSSON ,  Mårten ROOTH ,  Erik LINDAHL

    IPC分类号： A61K9/50 ,  A61K31/405 ,  A61K31/706

    CPC分类号： A61K9/5089 ,  A61K9/501 ,  A61K31/405 ,  A61K31/706

    摘要： There is provided a process for the preparation of composition in the form of a plurality of particles having a weight-, number-, and/or volume-based mean diameter that is between amount 10 nm and about 700 μm, which particles comprise: (a) solid cores, preferably comprising a biologically active agent; and (b) two or more sequentially applied, discrete layers, each of which comprises at least one separately applied coating material, and which two or more layers together surround, enclose and/or encapsulate said cores, which process comprises the sequential steps of: (1) applying an initial layer of at least one coating material to said solid cores by way of a gas phase deposition technique; (2) subjecting the coated particles to agitation to deagglomerate particle aggregates formed during step (1) by way of a sieving step; (3) applying a further layer of at least one coating material to the deagglomerated particles; and (4) optionally repeating steps (2) and (3) one or more times to increase the total thickness of the at least one coating material that enclose(s) said solid core, wherein at least one of the sieving steps comprises a vibrational sieving technique, in which the vibrational sieving technique comprises supplying electrical power to a vibration motor coupled to a sieve. The gas phase deposition technique is preferably atomic layer deposition. When the cores comprise biologically active agent, the compositions may provide for the delayed or sustained release of said active agent without a burst effect.

    Apparatus for coating particles
    5.
    发明授权
    Apparatus for coating particles 有权

    公开(公告)号：US11214865B2

    公开(公告)日：2022-01-04

    申请号：US16912599

    申请日：2020-06-25

    申请人： Nanexa AB

    发明人： Anders Johansson ,  Mårten Rooth ,  Joel Hellrup

    IPC分类号： C23C16/455 ,  A61J3/00 ,  B01J2/00 ,  B05B7/00 ,  C23C16/54 ,  C23C16/44 ,  B01J13/04 ,  A61K9/50

    摘要： A reactor for forming fully coated particles having a solid core, the reactor comprises a reactor vessel which is configured to receive particles, and a gas phase coating mechanism that is configured to selectively introduce pulses of gas phase materials that form a coating on the particles. The reactor also includes a sieve (16) that is located within the reactor vessel, and a forcing means that is configured to force the particles through the sieve (16) in use. The sieve is configured to deagglomerate any particle aggregates formed in the reactor vessel upon forcing of the particles by the forcing means through the sieve.

    SOLID NANOPARTICLE WITH INORGANIC COATING
    6.
    发明申请
    SOLID NANOPARTICLE WITH INORGANIC COATING 有权

    公开(公告)号：US20210121415A1

    公开(公告)日：2021-04-29

    申请号：US17096511

    申请日：2020-11-12

    申请人： Nanexa AB

    发明人： Jan-Otto Carlsson ,  Anders Johansson ,  Marten Rooth

    IPC分类号： A61K9/51 ,  A61K9/50

    摘要： A nanoparticle having a solid core comprising a biologically active substance, said core being enclosed by an inorganic coating, a method for preparing the nanoparticle, and the use of the nanoparticle in therapy. A kit comprising the nanoparticle and a pharmaceutical composition comprising the nanoparticle.

    INJECTABLE OIL-BASED PHARMACEUTICAL COMPOSITION
    8.
    发明公开
    INJECTABLE OIL-BASED PHARMACEUTICAL COMPOSITION 审中-公开

    公开(公告)号：US20230157968A1

    公开(公告)日：2023-05-25

    申请号：US17919415

    申请日：2021-04-16

    申请人： NANEXA AB

    发明人： Anders JOHANSSON ,  Mårten ROOTH ,  Joel HELLRUP

    IPC分类号： A61K9/51 ,  A61K31/706 ,  A61K9/50

    CPC分类号： A61K9/5115 ,  A61K31/706 ,  A61K9/5192 ,  A61K9/501 ,  A61K9/5089 ,  A61K9/5123 ,  A61K9/0019

    摘要： There is provided a pharmaceutical or veterinary formulation comprising: (a) a plurality of particles having a weight-, number-, or volume-based mean diameter that is between amount 10 nm and about 700 μm, which particles comprise solid cores coated with zinc oxide; suspended in (b) an oleaginous carrier system comprising a pharmaceutically-acceptable or veterinarily-acceptable oil, which zinc oxide coated particles comprise: (1) solid cores comprising a biologically-active agent; (2) one or more discrete layers surrounding said cores, said one or more layers each comprising at least one separate zinc oxide coating. Said zinc oxide coated particles are preferably synthesized via a gas phase coating technique, such as atomic layer deposition. When the cores comprise biologically-active agent, and the particles are suspended in an oleaginous carrier system, the formulation may provide for the delayed or sustained release of said active agent without a burst effect.

    APPARATUS
    9.
    发明申请
    APPARATUS 有权

    公开(公告)号：US20220307132A1

    公开(公告)日：2022-09-29

    申请号：US17545783

    申请日：2021-12-08

    申请人： Nanexa AB

    发明人： Anders JOHANSSON ,  Mårten ROOTH ,  Joel HELLRUP

    IPC分类号： C23C16/455 ,  A61J3/00 ,  B01J2/00 ,  B01J13/04 ,  B05B7/00 ,  C23C16/54 ,  C23C16/44

    摘要： A reactor for forming fully coated particles having a solid core, the reactor comprises a reactor vessel which is configured to receive particles, and a gas phase coating mechanism that is configured to selectively introduce pulses of gas phase materials that form a coating on the particles. The reactor also includes a sieve (16) that is located within the reactor vessel, and a forcing means that is configured to force the particles through the sieve (16) in use. The sieve is configured to deagglomerate any particle aggregates formed in the reactor vessel upon forcing of the particles by the forcing means through the sieve.

    Solid nanoparticle with inorganic coating
    10.
    发明授权
    Solid nanoparticle with inorganic coating 有权

    公开(公告)号：US10166198B2

    公开(公告)日：2019-01-01

    申请号：US15944059

    申请日：2018-04-03

    申请人： Nanexa AB

    发明人： Jan-Otto Carlsson ,  Anders Johansson ,  Marten Rooth

    IPC分类号： A61K9/50 ,  A61K9/51

    摘要： A nanoparticle having a solid core comprising a biologically active substance, said core being enclosed by an inorganic coating, a method for preparing the nanoparticle, and the use of the nanoparticle in therapy. A kit comprising the nanoparticle and a pharmaceutical composition comprising the nanoparticle.