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公开(公告)号:US20140170640A1
公开(公告)日:2014-06-19
申请号:US14107335
申请日:2013-12-16
申请人: NANOMR, INC.
发明人: Colin Dykes
IPC分类号: C12N15/10
CPC分类号: C12N15/1037 , C12Q1/04 , G01N33/54333 , G01N33/6845 , G01N2333/005
摘要: The invention generally relates to methods for universal target capture.
摘要翻译: 本发明一般涉及通用目标捕获的方法。
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公开(公告)号:US20140170021A1
公开(公告)日:2014-06-19
申请号:US14107253
申请日:2013-12-16
申请人: NanoMR, Inc.
发明人: Sergey A. Dryga
IPC分类号: G01N1/34
CPC分类号: G01N1/34 , C12Q1/68 , C12Q1/6802 , C12Q2523/115 , C12Q2565/137
摘要: Methods for degrading contaminant nucleic acid. The methods use combinations of metal ions and peroxide ions to produce a variety of oxidative species that degrade nucleic acid. Methods of the invention are useful for decontaminating laboratory equipment or solutions. After the equipment or solutions have been decontaminated, the metal ion and peroxide ion solution can be deactivated by raising the temperature to dissociate the peroxide or by binding the metal ions, e.g., with a chelating agent.
摘要翻译: 降解污染物核酸的方法。 该方法使用金属离子和过氧化物离子的组合来产生降解核酸的各种氧化物质。 本发明的方法可用于净化实验室设备或溶液。 在设备或溶液已被去污染之后,金属离子和过氧化物离子溶液可以通过升高温度来解离过氧化物或通过例如与螯合剂结合金属离子而失活。
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公开(公告)号:US20110262932A1
公开(公告)日:2011-10-27
申请号:US13091518
申请日:2011-04-21
IPC分类号: G01N33/569 , C01G49/10 , C01G49/08 , C12N1/20 , C07K16/12
CPC分类号: G01N33/54326 , A61B5/055 , B01L3/502761 , B01L2200/0647 , B01L2400/043 , C07K1/22 , C07K16/1267 , C12N13/00 , C12N15/1013 , C12Q1/6806 , C12Q1/689 , C12Q2565/633 , G01N24/08 , G01N33/54333 , G01N33/56911 , G01N2333/195 , G01N2446/20 , G01R33/465 , Y10T428/2982 , C12Q2565/629 , C12Q2563/143
摘要: The invention generally relates to compositions that include magnetic particles bound to pathogens in a body fluid.
摘要翻译: 本发明一般涉及包含与体液中的病原体结合的磁性颗粒的组合物。
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公开(公告)号:US20140170669A1
公开(公告)日:2014-06-19
申请号:US14132770
申请日:2013-12-18
申请人: NanoMR, Inc.
发明人: Jaclyn D. Vandervest
IPC分类号: G01N33/569
CPC分类号: G01N33/56938 , G01N33/54366 , G01N33/56911
摘要: The invention generally relates to devices for target detection and methods of use thereof.
摘要翻译: 本发明一般涉及用于目标检测的装置及其使用方法。
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公开(公告)号:US20140170667A1
公开(公告)日:2014-06-19
申请号:US14133022
申请日:2013-12-18
申请人: NANOMR, INC.
发明人: Colin Dykes , Eddie W. Adams , Alexandra M. Barr , Ravil A. Sitdikov , Magdalena A. Torrance , David K. Aley , Erik J. Smith , Victor C. Esch
IPC分类号: C12N15/10
CPC分类号: C12N15/1013 , C12Q1/6806 , C12Q2531/113 , C12Q2563/143 , C12Q2563/149
摘要: The invention generally relates to methods for amplifying nucleic acid from a target. In certain aspects, methods of the invention involve obtaining a sample including a target, conducting an assay that isolates the target from the sample, lysing the target to release the nucleic acid, and amplifying the released nucleic acid such that the amplifying occurs in the presence of debris from the lysing step.
摘要翻译: 本发明一般涉及用于从靶扩增核酸的方法。 在某些方面,本发明的方法包括获得包含靶的样品,进行将样品从样品中分离出来的试验,裂解靶释放核酸,以及扩增释放的核酸,使得扩增在存在下发生 的碎裂步骤。
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公开(公告)号:US20140170639A1
公开(公告)日:2014-06-19
申请号:US14104164
申请日:2013-12-12
申请人: NanoMR, Inc.
发明人: Meghan Norvell
IPC分类号: G01N33/543
CPC分类号: G01N33/54333 , G01N33/54326 , G01N33/558 , G01N33/569
摘要: The invention generally relates to methods for indicating whether an assay for isolating targets is properly isolating and detecting targets. Methods of the invention involve obtaining a sample suspected of a containing target, introducing a detectable marker into the sample, conducting an assay using magnet particles to isolate the detectable marker and the target if it is present in the sample, determining the presence or absence of the target; and confirming that the assay functioned properly by determining presence or absence of the detectable marker.
摘要翻译: 本发明一般涉及用于指示用于分离靶标的测定是否正确分离和检测靶标的方法。 本发明的方法包括获得怀疑含有靶标的样品,将可检测标记物引入样品中,如果存在于样品中,则使用磁体颗粒进行测定以分离可检测标记物和靶标,确定是否存在 目标; 并通过确定可检测标记的存在或不存在来证实该测定适当地发挥作用。
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公开(公告)号:US20090146658A1
公开(公告)日:2009-06-11
申请号:US12257238
申请日:2008-10-23
CPC分类号: G01N24/088 , G01N24/08 , G01N33/54333 , G01R33/302 , G01R33/307 , G01R33/465 , G01R33/4808
摘要: The present invention provides microcoil magnetic resonance based modules, detection devices, and methods for their use.
摘要翻译: 本发明提供了基于微线圈磁共振的模块,检测装置及其使用方法。
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公开(公告)号:US20140100136A1
公开(公告)日:2014-04-10
申请号:US14102861
申请日:2013-12-11
申请人: NanoMR, Inc.
IPC分类号: G01N33/569 , C12Q1/70 , C12Q1/68
CPC分类号: G01N33/56911 , C07K1/22 , C07K16/1267 , C12N13/00 , C12Q1/689 , C12Q1/6895 , C12Q1/70 , G01N33/54333 , G01N33/569 , G01N33/56961 , G01N33/56983
摘要: Methods of the invention generally involve using magnetic particles to isolate low levels of pathogens from a samples and identifying genes expressed by those pathogen. In one aspect, the method includes obtaining a sample comprising a pathogen, forming magnetic particle/target complexes, separating the magnetic particle/target complexes using magnetic fields, and determining an expression profile of a nucleic acid derived from the target.
摘要翻译: 本发明的方法通常涉及使用磁性颗粒从样品中分离低水平的病原体并鉴定那些病原体表达的基因。 一方面,该方法包括获得包含病原体的样品,形成磁性颗粒/靶复合物,使用磁场分离磁性颗粒/靶复合物,以及确定衍生自靶的核酸的表达谱。
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公开(公告)号:US20110262933A1
公开(公告)日:2011-10-27
申请号:US13091527
申请日:2011-04-21
IPC分类号: G01N33/569 , C12N1/20 , C07K1/107 , C07K16/12
CPC分类号: G01N33/54326 , A61B5/055 , B01L3/502761 , B01L2200/0647 , B01L2400/043 , C07K1/22 , C07K16/1267 , C12N13/00 , C12N15/1013 , C12Q1/6806 , C12Q1/689 , C12Q2565/633 , G01N24/08 , G01N33/54333 , G01N33/56911 , G01N2333/195 , G01N2446/20 , G01R33/465 , Y10T428/2982 , C12Q2565/629 , C12Q2563/143
摘要: The invention generally relates to compositions and methods for isolating mid-log phase bacteria. In certain embodiments, the invention provides a magnetic particle conjugated to an antibody that includes an epitope specific for mid-log phase bacteria.
摘要翻译: 本发明一般涉及用于分离对数中期细菌的组合物和方法。 在某些实施方案中,本发明提供了与抗体缀合的磁性颗粒,其包括对数中期细菌特异性的表位。
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公开(公告)号:US20110262927A1
公开(公告)日:2011-10-27
申请号:US13091548
申请日:2011-04-21
CPC分类号: G01N33/54326 , A61B5/055 , B01L3/502761 , B01L2200/0647 , B01L2400/043 , C07K1/22 , C07K16/1267 , C12N13/00 , C12N15/1013 , C12Q1/6806 , C12Q1/689 , C12Q2565/633 , G01N24/08 , G01N33/54333 , G01N33/56911 , G01N2333/195 , G01N2446/20 , G01R33/465 , Y10T428/2982 , C12Q2565/629 , C12Q2563/143
摘要: The invention generally relates to conducting an assay on a sample that isolates a pathogen from the sample and allows for analysis of the pathogen with minimal (i.e., at most 24 hrs of culturing) or no culturing of the pathogen. In certain embodiments, the invention provides methods for identifying a pathogen from a sample that involve obtaining a sample including a pathogen, conducting an assay that isolates the pathogen from the sample, culturing the isolated pathogen for at most about 24 hrs, and analyzing the pathogen.
摘要翻译: 本发明一般涉及对从样品中分离病原体的样品进行测定,并允许以最小(即培养最多24小时)或不培养病原体来分析病原体。 在某些实施方案中,本发明提供了从样品中鉴定病原体的方法,所述病原体涉及获得包含病原体的样品,进行将病原体与样品分离的培养物,培养分离的病原体至多约24小时,并分析病原体 。
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