公开(公告)号：US20230324221A1

公开(公告)日：2023-10-12

申请号：US18299454

申请日：2023-04-12

申请人： New York Blood Center, Inc.

发明人： Benjamin Matthew Bloomquist

IPC分类号： G01J1/44

CPC分类号： G01J1/44

摘要： A light detection device for alerting an external monitoring system is disclosed herein. In an example, a photosensor apparatus is configured to use one or more photosensors to detect when light is emitted from an indicator lamp of a laboratory instrument. An output from the photosensor(s) is configured to cause a change in a relay switch, which sends a signal to a processor of a system monitor, which may be communicatively coupled to a network. After receiving a signal, the processor is configured to cause the system monitor to generate an alert or alarm indicative that at least one platelet sample within the laboratory instrument has tested positive for bacteria. The system monitor may display the alert or alarm via a user interface and/or may transmit one or more messages to client devices indicative of the light illumination.

公开(公告)号：US20230065376A1

公开(公告)日：2023-03-02

申请号：US17797662

申请日：2021-02-04

申请人： New York Blood Center, Inc. ,  Loyola University of Chicago

发明人： Lanying DU ,  Wanbo TAI ,  Liang QIAO ,  Frank GAMBINO

IPC分类号： A61K39/12 ,  A61P31/14

摘要： Provided herein are immunogenic compositions for the prevention of Zika virus infections. Disclosed herein are immunogenic compositions comprising an expression vector and a nucleotide sequence disposed therein, wherein the nucleotide sequence comprises: a nucleotide sequence encoding a Zika virus NS3 protein. Further disclosed herein are methods for preventing a Zika virus infection in a subject in need thereof, the method comprising administering a therapeutically effective amount of an immunogenic composition of the present disclosure to the subject.

公开(公告)号：US20220313651A1

公开(公告)日：2022-10-06

申请号：US17636775

申请日：2020-08-20

申请人： New York Blood Center, Inc.

发明人： Lanying DU ,  Asim Kumar DEBNATH ,  Shibo JIANG ,  Yaning GAO

IPC分类号： A61K31/343 ,  A61K31/7048 ,  A61K31/58 ,  A61K31/137 ,  A61K31/4184 ,  A61K31/165 ,  A61K31/4196 ,  A61K31/12 ,  A61K31/69 ,  A61P31/14 ,  A61K31/11

摘要： The present specification provides methods of treatment of flavivirus infection, such as Zika or dengue vims infection, by administration of gossypol, a gossypol derivative, digitonin, or conessine. These compounds may be used alone, in combination with each other, or in combination with curcumin or bortezomib.

公开(公告)号：US20210230772A1

公开(公告)日：2021-07-29

申请号：US16769028

申请日：2018-12-05

申请人： New York Blood Center, Inc.

发明人： Pablo Rubinstein

IPC分类号： C40B40/02 ,  C40B40/10

摘要： The present specification provides libraries of HLA homozygous induced pluripotent cell lines.

公开(公告)号：US20210185115A1

公开(公告)日：2021-06-17

申请号：US17188392

申请日：2021-03-01

申请人： New York Blood Center, Inc.

发明人： Sabyasachi Sarkar

IPC分类号： H04L29/08 ,  G06F16/182 ,  G16H10/60 ,  G06F16/16

摘要： A system, method, and apparatus for transferring blood donation files are disclosed. An example system includes a collection device located at a blood donation site and a collection server located in a remote location. The example collection device is configured to store blood donation information from blood donors within a blood donation batch file located at a designated directory of a memory, and store metadata related to the blood donation information to the blood donation batch file. The example collection device also transmits the blood donation batch file to a registered user device. The example collection server is configured to determine the registered user device is available via a network connection. Responsive to determining the user device is connected, the collection server acquires the blood donation batch file from the user device and aggregates the blood donation batch file with blood donation batch files received from other registered user devices.

公开(公告)号：US20210046170A1

公开(公告)日：2021-02-18

申请号：US17076616

申请日：2020-10-21

申请人： New York Blood Center, Inc. ,  The United States of America, as Represented by

发明人： Sara Lustigman ,  Thomas B. Nutman ,  Sasisekhar Bennuru

IPC分类号： A61K39/00 ,  C07K16/18 ,  C07K14/435 ,  A61P33/10 ,  G01N33/53

摘要： Disclosed herein are immunogenic compositions for preventing or treating infection with filarial parasites and biomarkers for diagnosing infection with filarial parasites.

公开(公告)号：US10576059B2

公开(公告)日：2020-03-03

申请号：US16521327

申请日：2019-07-24

申请人： New York Blood Center, Inc. ,  The United States of America, as Represented by the Secretary, Department of Health and Human Services

发明人： Asim Kumar Debnath ,  Francesca Curreli ,  Peter D. Kwong ,  Young Do Kwon

IPC分类号： C07D207/30 ,  A61K31/40 ,  C07D207/34 ,  C07D417/14 ,  C07D417/12 ,  C07D405/14 ,  C07D403/12 ,  A61P31/18 ,  C07D277/20 ,  C07C233/01 ,  C07C25/00

摘要： Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.

公开(公告)号：US09982230B2

公开(公告)日：2018-05-29

申请号：US15181195

申请日：2016-06-13

申请人： New York Blood Center, Inc.

发明人： Beth H. Shaz ,  Christopher D. Hillyer

IPC分类号： A61K35/14 ,  C12N5/078 ,  A61M1/02 ,  A01N1/02 ,  A61K35/16 ,  A61K35/18 ,  A61K35/19 ,  A61M1/34

CPC分类号： C12N5/0641 ,  A01N1/02 ,  A01N1/021 ,  A01N1/0226 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K35/19 ,  A61M1/0272 ,  A61M1/342 ,  A61M1/3496 ,  A61M2202/0429 ,  A61M2202/20 ,  C12N5/0644

摘要： The disclosure provides methods of making a cell-containing product having a uniform amount of cells therein. The method comprises pooling red blood cells from a plurality of blood units, and inactivating any pathogen contained therein. A storage solution added to the cellular component results in a cell-containing product that is essentially pathogen and white blood cell free and has an extended shelf life of about 42 to about 100 days. The cell-containing product is further divided into units which comprise a uniform dose of RBCs per unit.

公开(公告)号：US09943589B2

公开(公告)日：2018-04-17

申请号：US15416968

申请日：2017-01-26

申请人： New York Blood Center, Inc.

发明人： Shibo Jiang ,  Lanying Du

IPC分类号： A61K39/145 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/55516 ,  A61K2039/58 ,  A61K2039/6056 ,  C07K2319/30 ,  C12N7/00 ,  C12N2760/16134 ,  C12Y302/01

摘要： Disclosed herein are immunogenic compositions for preventing infection with influenza viruses wherein the immunogenic compositions comprises an immunogen such as a hemagglutinin of an influenza virus, and an immunopotentiator such as an Fc fragment of human IgG and optionally a stabilization sequence. The immunogen is linked to the stabilization sequence which in turn is linked to the immunopotentiator.

公开(公告)号：US09724383B2

公开(公告)日：2017-08-08

申请号：US14796725

申请日：2015-07-10

申请人： New York Blood Center, Inc.

发明人： Shibo Jiang ,  Zhi Qi ,  Xi Chen ,  Chungen Pan

IPC分类号： C07K14/05 ,  A61K38/16 ,  C07K14/005 ,  C12N7/00 ,  A61K38/00

CPC分类号： A61K38/162 ,  A61K38/00 ,  C07K14/005 ,  C07K2319/735 ,  C12N7/00 ,  C12N2740/16022 ,  C12N2740/16033 ,  C12N2740/16111 ,  C12N2740/16122

摘要： Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.