利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

871 条记录 (耗时 0.034 秒)

    Compositions and methods relating to bone repair and regeneration
    4.
    发明授权
    Compositions and methods relating to bone repair and regeneration 有权

    公开(公告)号：US12036265B2

    公开(公告)日：2024-07-16

    申请号：US17362008

    申请日：2021-06-29

    申请人： Wayne State University

    发明人： Hyeong-Reh C. Kim

    IPC分类号： A61K38/18 ,  A61K35/28 ,  A61K47/64 ,  A61P19/08 ,  C07K14/49

    CPC分类号： A61K38/1858 ,  A61K35/28 ,  A61K47/642 ,  A61P19/08 ,  C07K14/49

    摘要： Methods of treating a subject in need thereof are provided which include: administering a recombinant platelet derived growth factor D (PDGF D) composition to a mesenchymal stem cell of the subject and/or a progenitor derived therefrom, in vivo, or ex vivo, producing a treated mesenchymal stem cell of the subject and/or a progenitor derived therefrom, thereby stimulating the mesenchymal stem cell (MSC) and/or a progenitor derived therefrom. Cells expressing a recombinant PDGF D composition of the present are administered to the subject for in vivo delivery of the recombinant PDGF D composition according to aspects of the present disclosure. Methods and compositions are provided including recombinant PDGF D hemidimer (HD) including a full-length PDGF D polypeptide and a C-terminal growth factor domain of PDGF D, which lacks a CUB domain, promoting regulation of bone marrow MSC differentiation into osteogenic lineage cells.

    ENERGY EFFICIENT DIGITAL TO TIME CONVERTER (DTC) FOR EDGE COMPUTING
    6.
    发明公开
    ENERGY EFFICIENT DIGITAL TO TIME CONVERTER (DTC) FOR EDGE COMPUTING 审中-公开

    公开(公告)号：US20240036525A1

    公开(公告)日：2024-02-01

    申请号：US18227613

    申请日：2023-07-28

    申请人： Wayne State University

    发明人： Hamza Al-Maharmeh ,  Mohammad Alhawari ,  Nabil Sarhan ,  Mohammed Ismail Elnaggar

    IPC分类号： G04F10/00 ,  G06F1/08 ,  G06F9/54

    CPC分类号： G04F10/005 ,  G06F1/08 ,  G06F9/54

    摘要： A spatially unrolled time domain (TD) architecture that includes an input and weight register having i inputs and j weights, where i corresponds with a number of delay lines for i neurons, and j corresponds with a number of processing elements (PEs) for each delay line of the i delay lines. An enable control register sends a global input pulse to i neurons, and each delay line of the i delay lines includes the corresponding j PEs for that delay line. Each PE includes a digital-to-time converter (DTC) that accepts a digital input and weight and generates a relative delay, each time delay within a given delay line contributing to an overall delay for the given delay line. i time-to-digital converters (TDCs). A readout register receives digital outputs from each of the i TDCs, and serially outputs a signal from each of the i delay lines based on the overall time delay for each of the i delay lines.

    COMPOSITIONS AND METHODS FOR INHIBITION OF TISSUE ADHESION
    7.
    发明公开
    COMPOSITIONS AND METHODS FOR INHIBITION OF TISSUE ADHESION 审中-公开

    公开(公告)号：US20230398265A1

    公开(公告)日：2023-12-14

    申请号：US18252416

    申请日：2021-11-09

    申请人： WAYNE STATE UNIVERSITY

    发明人： Zhiqiang CAO ,  Ershuai ZHANG

    IPC分类号： A61L31/06 ,  A61K9/00

    CPC分类号： A61L31/06 ,  A61K9/0024 ,  A61L2400/12

    摘要： The present disclosure provides compositions and methods for inhibition of tissue adhesion. According to specific aspects, implantable anti-adhesion zwitterionic compositions which include: an aqueous liquid; and a zwitterionic polymer are disclosed, wherein the zwitterionic polymer is, consists essentially of, or includes, poly(3-((3-acrylamidopropyl)dimethylammonio)propanoate) (PCBAA). According to specific aspects, implantable anti-adhesion zwitterionic compositions are provided which include nanoparticles and/or microparticles of zwitterionic hydrogel, wherein the zwitterionic hydrogel is, consists essentially of, or includes, PCBAA. Methods of inhibiting tissue adhesion in a subject in need thereof are provided according to aspects of the present disclosure which include administering an implantable anti-adhesion zwitterionic composition to a tissue surface exposed by surgery.

    REVERSE TRANSCRIPTION-FREE QUANTITATIVE-DISCRETE POLYMERASE CHAIN REACTION FOR POST-PROCESS QUALITY CONTROL OF VESICULAR BIOLOGICS
    8.
    发明公开
    REVERSE TRANSCRIPTION-FREE QUANTITATIVE-DISCRETE POLYMERASE CHAIN REACTION FOR POST-PROCESS QUALITY CONTROL OF VESICULAR BIOLOGICS 审中-公开

    公开(公告)号：US20230348959A1

    公开(公告)日：2023-11-02

    申请号：US18308611

    申请日：2023-04-27

    申请人： Wayne State University

    发明人： Thomas H. Linz

    IPC分类号： C12Q1/686 ,  C12Q1/6848

    CPC分类号： C12Q1/6848 ,  C12Q1/686

    摘要： Methods discussed herein are directed to polymerase chain reaction (PCR) techniques, and more specifically quantitative-discrete PCR, wherein individual amplification reactions are performed on a per-payload basis among singly-captured and singly-isolated vesicles, for instance within individually sealed microwell reactors. These techniques enable post-process quality control measurements of per-vesicular manufacture loading efficiency and encapsulation efficiency of nucleic acid active ingredients in vesicular biologics, employing quantitative-discrete PCR techniques. By measuring variability of vesicular encapsulation of nucleic acids at a per-vesicular manufacture level of granularity, such techniques can enable collection of data that may be used to perform post-process formulation upon vesicular biologics, and to yield more homogenous formulations from both synthetic and biogenesis pathways. Furthermore, shortcomings of conventional PCR techniques which can introduce biases, false positives, and false negatives are eliminated.

    ZWITTERIONIC POLYMER PARTICLE COMPOSITIONS AND RELATED METHODS
    10.
    发明公开
    ZWITTERIONIC POLYMER PARTICLE COMPOSITIONS AND RELATED METHODS 审中-公开

    公开(公告)号：US20230225969A1

    公开(公告)日：2023-07-20

    申请号：US17925234

    申请日：2021-05-20

    申请人： WAYNE STATE UNIVERSITY

    发明人： Zhiqiang CAO

    IPC分类号： A61K9/107 ,  A61K38/28 ,  A61K38/26 ,  A61K45/06 ,  A23L33/155

    CPC分类号： A61K9/1075 ,  A61K38/28 ,  A61K38/26 ,  A61K45/06 ,  A23L33/155 ,  A61K9/0053

    摘要： Compositions and methods for oral and/or mucosal administration of a biologically active agent are provided according to aspects of the present disclosure which include: a plurality of particles, wherein each particle has an exterior surface, the exterior surface defining a particle interior, the exterior surface having at least one type of zwitterionic polymer and/or zwitterionic copolymer disposed thereon and/or extending therefrom; and a biologically active agent disposed on the exterior surface and/or in the particle interior, wherein the biologically active agent is or includes a protein, peptide, or dietary supplement. According to particular aspects, compositions and methods for oral and/or mucosal administration of an anti diabetes biological agent, such as insulin and/or an insulin analog.