公开(公告)号：US09489485B2

公开(公告)日：2016-11-08

申请号：US12302309

申请日：2007-06-06

申请人： Carsten Koblischke ,  Markus Hemmer

发明人： Carsten Koblischke ,  Markus Hemmer

IPC分类号： G06F15/16 ,  G06F19/12 ,  G06F9/46 ,  G06F17/50 ,  G06F19/00 ,  G06F19/10

CPC分类号： G06F19/12 ,  G06F9/465 ,  G06F17/509 ,  G06F19/00 ,  G06F19/10 ,  G06F19/70

摘要： A metabolic pathway data management and analysis system in a distributed communication network is provided comprising at least one application server running a metabolic pathway data management server application, at least one client workstation running a metabolic pathway data management client application in communication with the at least one application server via the distributed communication network, and at least one database for storing data in communication with the at least one application server via the distributed communication network, wherein said metabolic pathway data management client application provides a graphical user interface comprising a study editor and a pathway editor.

摘要翻译： 提供了一种分布式通信网络中的代谢途径数据管理和分析系统，其包括运行代谢途径数据管理服务器应用的至少一个应用服务器，运行代谢途径数据管理客户端应用的至少一个客户端工作站与所述至少一个 应用服务器，以及至少一个用于存储经由分布式通信网络与至少一个应用服务器通信的数据的数据库，其中所述代谢途径数据管理客户端应用程序提供图形用户界面，包括研究编辑器和 路径编辑器。

公开(公告)号：US09475601B2

公开(公告)日：2016-10-25

申请号：US14477040

申请日：2014-09-04

申请人： Environmental Resource Associates, Inc.

发明人： Jeffrey C. Lowry

IPC分类号： A61J1/00 ,  B65D1/09 ,  B65D41/04 ,  B65D17/00

CPC分类号： B65D1/09 ,  B65D17/02 ,  B65D41/04

摘要： Embodiments of the present invention feature devices and methods for containing one or more compounds. The inventions feature devices having an ampoule-like closure to preserve the integrity of materials contained therein with vial-{umlaut over (υ)}ke features to allow closure after opening. The devices are sized to be received in a tray or carousal of an autosampler.

摘要翻译： 本发明的实施方案的特征在于含有一种或多种化合物的装置和方法。 本发明的特征在于具有安瓿状封闭件的装置，以保持其中容纳的材料的完整性，其具有小瓶（umlaut over（υ）} ke特征，以允许在打开之后关闭。 这些设备的大小可以被接收在自动进样器的托盘或转盘中。

公开(公告)号：US09176101B2

公开(公告)日：2015-11-03

申请号：US13638984

申请日：2011-04-06

申请人： Mark W. Moeller

发明人： Mark W. Moeller

IPC分类号： G01N30/02 ,  F16K11/074 ,  G01N30/20

CPC分类号： G01N30/02 ,  F16K11/0743 ,  G01N2030/202

摘要： A valve includes a stator that has fluidic ports in a seal surface, and a rotor that has a seal surface contacting the stator's seal surface. The rotor has through-holes that extend from the seal surface to a back surface, providing fluidic communication with a conduit disposed adjacent to the back surface of the rotor. A chromatography apparatus includes a sample source, a solvent source having a higher operating pressure than the sample source, and an injector valve. A method of performing chromatography includes loading a sample with a valve in a load-state configuration that disposes a sample source in fluidic communication with a conduit disposed adjacent to a back surface of the rotor, and injecting the loaded sample with the valve in an inject-state configuration that disposes a solvent source in fluidic communication with a column via at grooves adjacent to a front seal surface of the rotor.

摘要翻译： 阀包括在密封表面中具有流体端口的定子和具有接触定子密封表面的密封表面的转子。 转子具有从密封表面延伸到后表面的通孔，提供与邻近转子背面设置的导管的流体连通。 色谱装置包括样品源，具有比样品源更高的操作压力的溶剂源和喷射器阀。 执行色谱法的方法包括将样品加载在负载状态配置中，该装置状态配置将样品源与与转子的后表面相邻设置的导管流体连通，并且将装载的样品与阀注射到注射器 - 配置溶剂源在与转子的前密封表面相邻的凹槽处与柱通孔流体连通。

公开(公告)号：US08992778B2

公开(公告)日：2015-03-31

申请号：US12278287

申请日：2007-02-05

申请人： Hongji Liu

发明人： Hongji Liu

IPC分类号： G01N30/34

CPC分类号： G01N30/16 ,  G01N30/34 ,  G01N2030/027 ,  G01N2030/347

摘要： Embodiments of the present invention feature methods and apparatus for performing chromatographic separations. The invention feature methods and control means in the form of computer programs and software that control the formation of a concentration gradient at two or more total flow rates, with an elution period occurring in a slow flow rate and at least other portions of the gradient occurring during a fast total flow rate.

摘要翻译： 本发明的实施例的特征在于进行色谱分离的方法和装置。 本发明的特征在于以计算机程序和软件的形式的方法和控制装置，其控制在两个或多个总流速下形成浓度梯度，洗脱时间以缓慢的流速发生，并且至少其它部分的梯度发生 在一个快速的总流速。

公开(公告)号：US08877051B2

公开(公告)日：2014-11-04

申请号：US11490499

申请日：2006-07-21

申请人： Kimber D. Fogelman ,  Edwin E. Wikfors ,  Rui Chen

发明人： Kimber D. Fogelman ,  Edwin E. Wikfors ,  Rui Chen

IPC分类号： G01N30/82

CPC分类号： G01N30/82

摘要： A system and process for chromatography that uses a chromatography column to separate components from a sample received into the column in a mobile phase flowstream and places a second chromatography column between a detector and a collection system that compensates the timing of fraction collection for a delay caused by processing the collection signals generated by the detector. The device and process of the preferred and alternative embodiments add a delay into the flowstream of a chromatographic system, such as LC, HPLC, and SFC. Sample fractions are collected from sample component concentration peaks based upon the chromatographic elution of the sample components.

摘要翻译： 用于色谱柱的系统和方法，其使用色谱柱将来自在流动相流中流入柱的样品中分离组分，并将第二色谱柱置于检测器和收集系统之间，以补偿引起的延迟的馏分收集时间 通过处理由检测器产生的收集信号。 优选和替代实施方案的装置和方法对色谱系统的流动流如LC，HPLC和SFC增加延迟。 基于样品组分的色谱洗脱，从样品组分浓度峰中收集样品级分。

公开(公告)号：US08839970B2

公开(公告)日：2014-09-23

申请号：US13123073

申请日：2009-10-08

申请人： Jeffrey C. Lowry

发明人： Jeffrey C. Lowry

IPC分类号： A61J1/00 ,  B65D1/09 ,  B65D41/04

CPC分类号： B65D1/09 ,  B65D17/02 ,  B65D41/04

摘要： Embodiments of the present invention feature devices and methods for containing one or more compounds. The inventions feature devices having an ampoule-like closure to preserve the integrity of materials contained therein with vial-like features to allow closure after opening. The devices are sized to be received in a tray or carousal of an autosampler.

摘要翻译： 本发明的实施方案的特征在于含有一种或多种化合物的装置和方法。 本发明的特征在于具有安瓿状封闭件的装置，以保持其中容纳的材料的完整性，其具有小瓶状特征，以允许在打开之后关闭。 这些设备的大小可以被接收在自动进样器的托盘或转盘中。

公开(公告)号：US08679333B2

公开(公告)日：2014-03-25

申请号：US12692795

申请日：2010-01-25

申请人： Geoff C. Gerhardt ,  Joseph A. Luongo

发明人： Geoff C. Gerhardt ,  Joseph A. Luongo

IPC分类号： B01D15/08

CPC分类号： B01D15/163 ,  B01L3/50273 ,  B01L2200/143 ,  B01L2400/086 ,  F04B13/02 ,  F04B23/04 ,  F04B2205/09 ,  G01N30/32 ,  G01N2030/324

摘要： A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent composition gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate and precise flow delivery at capillary (

摘要翻译： 用于监测和控制HPLC系统的操作流路中的纳米级流速的方法和装置提供流体流动，而不依赖于复杂的校准程序来补偿通常在HPLC中使用的溶剂组成梯度。 该装置和方法用于校正典型的分析型（0.1-5mL / min）HPLC泵的流量输出，以使毛细管（<0.1mL / min）和纳米级（< 1μL/ min）HPLC流速。

公开(公告)号：US08539819B2

公开(公告)日：2013-09-24

申请号：US13416364

申请日：2012-03-09

申请人： Theodore D. Ciolkosz ,  James E. Usowicz ,  Peyton C. Beals ,  Russell Keene

发明人： Theodore D. Ciolkosz ,  James E. Usowicz ,  Peyton C. Beals ,  Russell Keene

IPC分类号： G01M3/04

CPC分类号： G01M3/02 ,  B01D15/14 ,  B01D15/163 ,  G01N11/00 ,  G01N30/24 ,  G01N30/32

摘要： A device comprising a pressure monitor and a control means that receives a signal representing measured pressure at the pressure monitor and controls the controllable elements of a fluid system is utilized to monitor a fluid system for error conditions, to optimize operations and to diagnose the fluid system. By following a testing protocol that selectively enables parts of the system, the control means narrows the list of possible failing components. Comparing the measured pressure against normal pressures allows the device to identify error conditions. Determining the volume of fluid being transported and controlling the duration of the flow optimizes operation of the fluid system.

摘要翻译： 包括压力监测器和控制装置的装置用于接收表示压力监测器上测量的压力并控制流体系统的可控元件的信号，以监测流体系统的误差状况，优化操作并诊断流体系统 。 通过遵循选择性地启用系统部件的测试协议，控制装置缩小可能出现故障的部件的列表。 将测量的压力与正常压力进行比较允许设备识别错误状况。 确定正在运输的流体的体积并控制流动持续时间优化了流体系统的运行。

公开(公告)号：US08176932B2

公开(公告)日：2012-05-15

申请号：US12652271

申请日：2010-01-05

申请人： John Angelosanto ,  Joseph A. Luongo ,  Frank Rubino

发明人： John Angelosanto ,  Joseph A. Luongo ,  Frank Rubino

IPC分类号： F16L35/00

CPC分类号： F16J15/004 ,  F04B53/04 ,  F04B53/164 ,  Y10T137/0452 ,  Y10T137/5762 ,  Y10T137/9247

摘要： Embodiments of the present invention are directed to methods and devices for conveying or containing fluids under pressure in which seals are provided with a defined path to vent fluid in the event of a seal failure.

摘要翻译： 本发明的实施例涉及用于在压力下输送或容纳流体的方法和装置，其中在密封件发生故障的情况下，密封件具有限定的排放流体路径。

公开(公告)号：US09662595B2

公开(公告)日：2017-05-30

申请号：US13749929

申请日：2013-01-25

申请人： Waters Technologies Corporation

发明人： Christopher C. Benevides ,  Keith Fadgen ,  Michael Lavallee ,  Anthony Jeannotte

IPC分类号： B01D15/10 ,  B01D15/22 ,  G01N30/60 ,  B01D15/14 ,  B01D15/26

CPC分类号： B01D15/14 ,  B01D15/22 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  Y10T29/49826

摘要： A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.