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公开(公告)号：US20220280680A1
公开(公告)日：2022-09-08
申请号：US17714617
申请日：2022-04-06
申请人： AMSILK GMBH
发明人： Gerhard Winter , Elisa Agostini , Julia Engert , Lin Romer , Ute Slotta
摘要： The present invention relates to coated silk films. Further, the present invention relates to pharmaceutical or cosmetic compositions comprising the coaled silk films. Furthermore, the present invention relates to coated silk films or pharmaceutical compositions comprising the coated silk films for use in medicine. In addition, the present invention relates to methods of producing the coated silk films.
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公开(公告)号：US20220257825A1
公开(公告)日：2022-08-18
申请号：US17665947
申请日：2022-02-07
申请人： AMSilk GmbH
发明人： Axel Leimer , Lin Römer , Nathalie Maksimovikj
摘要： The present invention relates to a self-assembling polypeptide for use as tissue adhesive. The present invention also relates to the use of a self-assembling polypeptide as tissue adhesive. Further, the invention is directed to the use of a self-assembling polypeptide to glue one or more cosmetic compounds on skin, mucosa, and/or hair. Furthermore, the invention is directed to a self-assembling polypeptide for use in gluing one or more pharmaceutical compounds on tissue, skin, mucosa, and/or hair.
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公开(公告)号：US20190062557A1
公开(公告)日：2019-02-28
申请号：US16126254
申请日：2018-09-10
申请人： Amsilk GmbH
发明人： Thomas Scheibel , Axel Leimer , Lin Römer , Lukas Eisoldt , Aniela Heidebrecht , Martha Geffers
IPC分类号： C08L89/00 , C08L89/04 , C08L77/06 , C08L75/04 , C08L67/04 , C08L67/00 , C08L33/08 , B29C47/00 , C08L5/02 , C08L1/02 , C07K14/435 , C08L23/12 , B29L31/00
摘要： The present invention provides methods for producing a silk protein spinning dope solution suitable for producing high toughness fibres, the thus produced silk protein spinning dope solution, methods for producing fibres using said silk protein spinning dope solution.
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公开(公告)号：US08729238B2
公开(公告)日：2014-05-20
申请号：US13728762
申请日：2012-12-27
申请人： Amsilk GmbH
CPC分类号： A61K8/11 , A61K8/64 , A61K9/5052 , A61K9/5169 , A61K9/5192 , A61K47/42 , A61K2800/412 , A61K2800/413 , A61Q19/00 , C07K14/43563
摘要： The present invention is directed to a method of producing nano- and microcapsules from spider silk proteins The invention is further directed to nano- or microcapsules obtainable by this method as well as pharmaceutical, cosmetical and food compositions containing same.
摘要翻译： 本发明涉及从蜘蛛丝蛋白制备纳米和微胶囊的方法。本发明还涉及可通过该方法获得的纳米或微胶囊以及含有它们的药物，化妆品和食品组合物。
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公开(公告)号：US20210332092A1
公开(公告)日：2021-10-28
申请号：US17245818
申请日：2021-04-30
发明人： Lin ROMER , Ute SLOTTA , Julia ENGERT , Gerhard WINTER , Matthias LUCKE , Thomas SCHEIBEL
IPC分类号： C07K14/435 , A61K39/385 , A61K47/64 , A61K47/65 , A61P35/00 , A61K47/42 , C12N15/62
摘要： The present invention relates to a polypeptide comprising a silk polypeptide and an antigen. Further, the present invention relates to an article comprising the polypeptide. Furthermore, the present invention relates to a pharmaceutical composition comprising the article. In addition, the present invention relates to the article or pharmaceutical composition for use as a pharmaceutical, for inducing an immune response and/or for use in a prophylactic and/or therapeutic treatment of a disease.
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公开(公告)号：US20200078490A1
公开(公告)日：2020-03-12
申请号：US16600087
申请日：2019-10-11
申请人： AMSilk GmbH
发明人： AXEL LEIMER , Martin Schmidt , Lin Romer , Nathalie Maksimovikj
摘要： The present invention relates to a self-assembling polypeptide for use as tissue adhesive. The present invention also relates to the use of a self-assembling polypeptide as tissue adhesive. Further, the invention is directed to the use of a self-assembling polypeptide to glue one or more cosmetic compounds on skin, mucosa, and/or hair. Furthermore, the invention is directed to a self-assembling polypeptide for use in gluing one or more pharmaceutical compounds on tissue, skin, mucosa, and/or hair.
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公开(公告)号：US20190069541A1
公开(公告)日：2019-03-07
申请号：US15767107
申请日：2016-10-11
申请人： Amsilk GmbH
发明人： Jens Klein , Lin Romer , Thomas Scheibel , Ute Slotta
IPC分类号： A01N25/34 , A01N63/02 , C07K14/435 , A61L27/22
摘要： The present invention relates to the use of a biopolymer for reducing the formation of a biofilm, preferably on a substrate, whereby the biopolymer is preferably a polypeptide, such as recombinant spider silk polypeptide. The present invention further relates to methods for producing a substrate which reduces the formation of a biofilm on a surface of said substrate.
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8.发明申请NOVEL BIOPOLYMER HAVING EXCELLENT TENSILE STRENGTH, EXTENSIBILITY AND TOUGHNESS 有权具有优异的拉伸强度，可伸缩性和韧性的新型生物聚合物公开(公告)号：US20130225476A1
公开(公告)日：2013-08-29
申请号：US13742636
申请日：2013-01-16
申请人： AMSilk GmbH
发明人： Thomas Scheibel , Felix Bauer
IPC分类号： C07K14/00
CPC分类号： C07K14/00 , A61K38/00 , C07K14/43563
摘要： The present invention relates to a biopolymer having excellent tensile strength, extensibility and toughness. The present invention further relates to a nucleic acid molecule encoding the biopolymer of the invention, a vector comprising the nucleic acid molecule of the invention and a non-human host transformed with the vector of the invention. Furthermore, the present invention relates to methods for producing a biopolymer of the invention and to foams, films, gels, coatings, particles, capsules, springs or nonwoven mats as well as fibres comprising or consisting of the biopolymer of the invention. The present invention also relates to a method of producing fibres and the biopolymer of the invention for use in medicine, agriculture, cosmetics as well as surface, paper, leather and/or textile processing.
摘要翻译： 本发明涉及具有优异的拉伸强度，伸长性和韧性的生物聚合物。 本发明还涉及编码本发明的生物聚合物的核酸分子，包含本发明的核酸分子的载体和用本发明的载体转化的非人宿主。 此外，本发明涉及制备本发明的生物聚合物和泡沫，薄膜，凝胶，涂层，颗粒，胶囊，弹簧或非织造垫以及由本发明的生物聚合物组成或由其组成的纤维的方法。 本发明还涉及用于医药，农业，化妆品以及表面，纸，皮革和/或纺织品加工的本发明的纤维和生物聚合物的生产方法。
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公开(公告)号：US11273234B2
公开(公告)日：2022-03-15
申请号：US16600087
申请日：2019-10-11
申请人： AMSilk GmbH
发明人： Axel Leimer , Lin Romer , Nathalie Maksimovikj
摘要： The present invention relates to a self-assembling polypeptide, such as a spider silk polypeptide, for use as a coating material to form a uniform coating around an implant for the purpose of reducing or preventing capsular fibrosis associated with the use of such an implant in the human body.
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公开(公告)号：US11248120B2
公开(公告)日：2022-02-15
申请号：US16126254
申请日：2018-09-10
申请人： Amsilk GmbH
发明人： Thomas Scheibel , Axel Leimer , Lin Römer , Lukas Eisoldt , Aniela Heidebrecht , Martha Geffers
IPC分类号： C08L89/00 , B29C48/00 , C07K14/435 , C08L1/02 , C08L5/02 , C08L23/12 , C08L33/08 , C08L67/00 , C08L67/04 , C08L75/04 , C08L77/06 , C08L89/04 , B29L31/00
摘要： The present invention provides methods for producing a silk protein spinning dope solution suitable for producing high toughness fibres, the thus produced silk protein spinning dope solution, methods for producing fibres using said silk protein spinning dope solution.
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