公开(公告)号：US20220331142A1

公开(公告)日：2022-10-20

申请号：US17639912

申请日：2020-09-09

Applicant: Adrian PAZ

Inventor： Adrian PAZ

IPC: A61F5/41 ,  A61N7/00

Abstract: The current disclosure relates to a system for treating impotence. In some embodiments, the device includes a mount for holding a transducer in intimate contact to a penile tissue. For example, an ultrasound transducer and/or a vibration transducer may be held in vibrational communication with a corpora, a crura, a root of the penis and/or a glans. For example, the mount may include a sheath and/or a tubular body that may be rigid, partially flexible and/or flexible. The sheath may be open on one or both ends and/or may fully surround the penis and/or include a slit on one side. Optionally, the tubular body includes one or more extensions that reach the root of the penis and/or the crura. For example, the extensions may extend proximally from a proximal end of the sheath and/or the extensions may include transducers that face and/or inward (towards one another).

公开(公告)号：US07960507B2

公开(公告)日：2011-06-14

申请号：US12844663

申请日：2010-07-27

Applicant: Lea Eisenbach ,  Boaz Tirosh ,  Erez Bar-Haim ,  Adrian Paz ,  Matityahu Fridkin ,  Cheryl Fitzer-Attas ,  Arthur Machlenkin ,  Esther Tzehoval

Inventor： Lea Eisenbach ,  Boaz Tirosh ,  Erez Bar-Haim ,  Adrian Paz ,  Matityahu Fridkin ,  Cheryl Fitzer-Attas ,  Arthur Machlenkin ,  Esther Tzehoval

IPC: C07K16/00

CPC classification number: C12N9/6445 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/4727 ,  C07K14/705 ,  C12N9/16

Abstract: The present invention relates to tumor associated antigen (TAA) peptides and to use of same, of polynucleotides encoding same and of cells presenting same as anti-tumor vaccines. More particularly, the present invention relates to tumor associated antigen peptides derived from Uroplakin Ia, Ib, II and III, Prostate specific antigen (PSA), Prostate acid phosphatase (PAP) and Prostate specific membrane antigen (PSMA), BA-46 (Lactadherin), Mucin (MUC-1), and Teratocarcinoma-derived growth factor (CRIPTO-1) and the use of same as anti-tumor vaccines to prevent or cure bladder, prostate, breast or other cancers, carcinomas in particular. Most particularly, the present invention relates to tumor associated antigen peptides which are presentable to the immune system by HLA-A2 molecules.

Abstract translation: 本发明涉及肿瘤相关抗原（TAA）肽及其使用方法，其编码相同的多核苷酸和与抗肿瘤疫苗相同的细胞。 更具体地说，本发明涉及衍生自Uroplatinin Ia，Ib，II和III，前列腺特异性抗原（PSA），前列腺酸性磷酸酶（PAP）和前列腺特异性膜抗原（PSMA），BA-46（Lactadherin ），粘蛋白（MUC-1）和细胞因子来源的生长因子（CRIPTO-1），以及其与抗肿瘤疫苗的用途预防或治愈膀胱，前列腺，乳腺癌或其他癌症，特别是癌症。 最特别地，本发明涉及可由HLA-A2分子呈递给免疫系统的肿瘤相关抗原肽。

公开(公告)号：US20080208240A1

公开(公告)日：2008-08-28

申请号：US12063134

申请日：2006-08-13

Applicant: Adrian Paz

Inventor： Adrian Paz

IPC: A61M29/02

CPC classification number: A61F5/003 ,  A61F5/004 ,  A61F5/0043 ,  A61F5/0073

Abstract: A device for controlling the expansion of a hollow internal organ, comprising an inflatable balloon, which is inserted in an uninflated state into the desired position close to the organ using minimally invasive procedures. After insertion, the balloon is inflated to its required size and shape. The invention is useful for restricting the expansion of the stomach during meals, thus inducing a feeling of satiety and preventing over-eating. Inflation may be performed through a catheter connected to a readily accessible inflation port. In the case of the gastric embodiment, the balloon may be positioned pro-peritoneally, such that the procedure is surgically simple. One or more sensors located close to the organ to be controlled, may monitor a physiological effect relating to the organ, and the output of the sensor used to control the level of inflation of the balloon in order to correct the condition being monitored.

Abstract translation: 一种用于控制中空内脏的膨胀的装置，包括可膨胀的气球，其以未充气状态插入到使用微创程序的器官附近的期望位置。 插入后，气球膨胀至所需尺寸和形状。 本发明对于限制饭食期间的胃膨胀是有用的，因此引起饱腹感和防止过度食用。 可以通过连接到容易接近的充气口的导管进行充气。 在胃实施例的情况下，气囊可以被腹膜定位，使得手术简单。 靠近待控制的器官的一个或多个传感器可以监测与器官有关的生理效应，以及用于控制气囊膨胀水平的传感器的输出，以便校正被监测的状况。

公开(公告)号：US20080033471A1

公开(公告)日：2008-02-07

申请号：US11630257

申请日：2005-06-23

Applicant: Adrian Paz ,  Abraham Domb

Inventor： Adrian Paz ,  Abraham Domb

IPC: A61M25/12 ,  A61B17/00

CPC classification number: A61B90/04 ,  A61B17/0218 ,  A61B2017/00004 ,  A61B2017/00526 ,  A61B2017/00557 ,  A61B2017/00831 ,  A61B2017/00867 ,  A61B2017/00902 ,  A61B2017/00907 ,  A61B2017/00929 ,  A61B2017/320048 ,  A61B2090/0427 ,  A61B2090/0463 ,  A61B2090/0472 ,  A61B2090/0481 ,  A61B2090/08021 ,  B29C33/52 ,  B29C41/14

Abstract: A tissue displacement/separation device is provided. The device includes a bladder which is expandable between a first tissue and a second tissue of a body. The bladder has an expanded shape which is selected capable of displacing or separating the first tissue from the second tissue in a manner suitable for protecting the first tissue from an effect of a treatment applied to the second tissue.

Abstract translation: 提供组织置换/分离装置。 该装置包括可在第一组织和身体的第二组织之间扩张的囊。 膀胱具有膨胀形状，其被选择为能够以适于保护第一组织免受施用于第二组织的影响的方式从第二组织移位或分离第一组织。

公开(公告)号：US20230338128A1

公开(公告)日：2023-10-26

申请号：US17922975

申请日：2021-06-14

Applicant: Adrian Paz ,  Yahuda Bachar

Inventor： Adrian Paz ,  Yahuda Bachar

IPC: A61F2/844 ,  A61F2/00

CPC classification number: A61F2/005 ,  A61F2/844 ,  A61F6/12

Abstract: Some embodiments an implant supports female genitlia, for example, to treat and/or prevent prolapse and/or urinary incontinence. The implant may be inserted into a vagina non-surgically. Optionally, the device may be incorporated within the vaginal wall. Optionally, the device includes a hollow elastic frame. For example, the frame may be made of metal and/or wire and/or a cut out and/or a polymer. In some embodiment a cranial portion of the device is designed for supporting the vaginal dome. For example, the cranial end of the device may include an element (e.g., support wires) running in an anterior-posterior direction. Optionally there may be a free space avoiding interference with the uterine cervix. In some embodiments, a caudal portion of the device is configured to hold the device in the vagina. For example, a caudal end of the device may be configured to rest on the pelvic floor

公开(公告)号：US20090264900A1

公开(公告)日：2009-10-22

申请号：US12084317

申请日：2006-11-02

Applicant: Adrian Paz ,  Gilad Heftman ,  Eitan Hod

Inventor： Adrian Paz ,  Gilad Heftman ,  Eitan Hod

IPC: A61B17/10 ,  A61B17/08

CPC classification number: A61B17/076

Abstract: The application provides a device (2) for extracting from a body tissue surgical fasteners (20) having a crown, a baseplate and prongs extending from the crown to the baseplate. The device includes a shaft having a lumen with a cross-sectional shape and dimensions to allow the crown to enter the lumen while preventing the baseplate from entering the lumen.

Abstract translation: 本申请提供了一种用于从身体组织提取外科紧固件（20）的装置（2），所述外科紧固件（20）具有冠部，底板和从冠部延伸到基板的尖头。 该装置包括轴，其具有具有横截面形状和尺寸的内腔，以允许牙冠进入内腔，同时防止基板进入管腔。

公开(公告)号：US20090254075A1

公开(公告)日：2009-10-08

申请号：US11989104

申请日：2006-07-26

Applicant: Adrian Paz ,  Roni Shabat

Inventor： Adrian Paz ,  Roni Shabat

IPC: A61B18/04

CPC classification number: A61B17/3203 ,  A61B2018/046

Abstract: A surgical instrument suitable for endoscopic operations having a gripping handle, tubular body and an operational tip. Jetting outlets laterally disposed at the operational tip provides for jetting pressurized liquid delivered by the tubular body. The jetting outlets are configured as to emit converging jets. Two or more jets converge at a convergence point laterally displaced at a predefined distance from the surface of the operational tip. The operational tip includes a heating member having an active face for contact heating a bleeding tissue. A rotating mechanism provides for independently rotating the jetting outlets and the active surface of the heating member relative to the gripping handle. A method for regulating the operating temperature of the heating member is provided.

Abstract translation: 适于内窥镜操作的手术器械具有握柄，管体和操作尖端。 横向设置在操作尖端处的喷射出口提供喷射由管状体输送的加压液体。 喷射出口配置为发射会聚喷嘴。 两个或更多个射流在与操作尖端的表面预定距离横向移位的会聚点处会聚。 操作尖端包括具有用于接触加热出血组织的主动面的加热构件。 旋转机构提供相对于把手独立地旋转加热构件的喷射出口和活动表面。 提供了一种用于调节加热部件的工作温度的方法。

公开(公告)号：US20090136462A1

公开(公告)日：2009-05-28

申请号：US12326675

申请日：2008-12-02

Applicant: Lea EISENBACH ,  Erez Bar-Haim ,  Adrian Paz ,  Matityahu Fridkin ,  Cheryl Fitzer-Attas

Inventor： Lea EISENBACH ,  Erez Bar-Haim ,  Adrian Paz ,  Matityahu Fridkin ,  Cheryl Fitzer-Attas

IPC: A61K35/12 ,  C07K7/06 ,  A61K38/08

CPC classification number: C12N9/6445 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/4727 ,  C07K14/705 ,  C12N9/16

Abstract: The present invention relates to tumor associated antigen (TAA) peptides and to use of same, of polynucleotides encoding same and of cells presenting same as anti-tumor vaccines. More particularly, the present invention relates to tumor associated antigen peptides derived from Uroplakin Ia, Ib, II and III, Prostate specific antigen (PSA), Prostate acid phosphatase (PAP) and Prostate specific membrane antigen (PSMA), BA-46 (Lactadherin), Mucin (MUC-1), and Teratocarcinoma-derived growth factor (CRIPTO-1) and the use of same as anti-tumor vaccines to prevent or cure bladder, prostate, breast or other cancers, carcinomas in particular. Most particularly, the present invention relates to tumor associated antigen peptides which are presentable to the immune system by HLA-A2 molecules.

Abstract translation: 本发明涉及肿瘤相关抗原（TAA）肽及其使用方法，其编码相同的多核苷酸和与抗肿瘤疫苗相同的细胞。 更具体地说，本发明涉及衍生自Uroplatinin Ia，Ib，II和III，前列腺特异性抗原（PSA），前列腺酸性磷酸酶（PAP）和前列腺特异性膜抗原（PSMA），BA-46（Lactadherin ），粘蛋白（MUC-1）和细胞因子来源的生长因子（CRIPTO-1），以及其与抗肿瘤疫苗的用途预防或治愈膀胱，前列腺，乳腺癌或其他癌症，特别是癌症。 最特别地，本发明涉及可由HLA-A2分子呈递给免疫系统的肿瘤相关抗原肽。

公开(公告)号：US20090069876A1

公开(公告)日：2009-03-12

申请号：US12087469

申请日：2007-01-09

Applicant: Shaul Shohat ,  Roni Shabat ,  Elazar Segal ,  Adrian Paz

Inventor： Shaul Shohat ,  Roni Shabat ,  Elazar Segal ,  Adrian Paz

IPC: A61F7/12

CPC classification number: A61B18/04 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61B2018/046

Abstract: A system and method are provided for thermally treating tissues in percutaneous surgery or endoluminal treatments. The system consists of at least one catheter for thermally treating a tissue, hydraulic unit for circulating fluids through the catheters and a control station by which an operator is displayed with, and inputs and/or modifies, working parameters of the system. The catheters have an operational face, which is optionally expandable and encloses a lumen through which the fluids are circulated. The method disclosed implements cooling of the targeted tissue prior to its heating. For heating and or cooling the tissues, the operational face of a catheter is pressed against a surface of the targeted tissue while heat emitted from or conducted to the tissue is respectively transferred into or from the circulated fluids.

Abstract translation: 提供用于经皮手术或腔内治疗中热处理组织的系统和方法。 该系统包括用于热处理组织的至少一个导管，用于使流体通过导管循环的液压单元和操作者通过该控制站显示并输入和/或修改系统的工作参数。 导管具有可操作的面，其可任选地可膨胀并且包围流体通过其流通的内腔。 所公开的方法在加热之前对目标组织进行冷却。 为了加热和/或冷却组织，将导管的操作面压在目标组织的表面上，同时从组织发出或传导到组织的热量分别转移到循环流体中或从循环流体转移。

公开(公告)号：US20090030434A1

公开(公告)日：2009-01-29

申请号：US11990262

申请日：2006-08-09

Applicant: Adrian Paz ,  Gilad Heftman ,  Eitan Hod

Inventor： Adrian Paz ,  Gilad Heftman ,  Eitan Hod

IPC: A61B17/03

CPC classification number: A61B17/064 ,  A61B17/0401 ,  A61B17/0682 ,  A61B2017/0412 ,  A61B2017/0422 ,  A61B2017/0427 ,  A61B2017/0445 ,  A61B2017/0464 ,  A61B2017/0641 ,  A61F2/0063

Abstract: The invention provides fasteners for surgical fastening. The surgical fastener of the invention has a crown from which extend two or more prongs. The prongs are parallel to the axis of the crown and each prong is provided with one or more barbs. The invention also provides a system for surgical fastening device configured to deploy one or more surgical fasteners of the invention and one or more surgical fasteners of the invention.

Abstract translation: 本发明提供了用于手术紧固的紧固件。 本发明的外科紧固件具有冠部，从其延伸两个或更多个插脚。 尖头平行于表冠的轴线，每个插脚设有一个或多个倒钩。 本发明还提供了一种用于外科紧固装置的系统，其被配置为展开本发明的一个或多个手术紧固件和本发明的一个或多个手术紧固件。