公开(公告)号：US08688220B2

公开(公告)日：2014-04-01

申请号：US12898675

申请日：2010-10-05

Applicant: Christopher DeGiorgio ,  Ian A. Cook ,  Alejandro Covalin

Inventor： Christopher DeGiorgio ,  Ian A. Cook ,  Alejandro Covalin

IPC: A61N1/04

CPC classification number: A61N1/36082 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/0504 ,  A61N1/0529 ,  A61N1/0551 ,  A61N1/36014 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36075 ,  A61N1/36096 ,  A61N1/36157 ,  A61N1/3616 ,  A61N1/36171 ,  A61N1/36175

Abstract: The present disclosure relates to methods, devices, and systems used for the treatment of and/or promoting recovery from various neurological disorders and conditions, including epilepsy and other seizure disorders and movement and other related disorders; for promoting recovery from acute or chronic brain injury (e.g. stroke, hypoxia/ischemia, head trauma, subarachnoid hemorrhage, and other forms of brain injury, for awakening and/or promoting the recovery of patients in various levels of coma, altered mental status or vegetative state); or for promoting recovery from chronic daily headache and migraine and related disorders via external (cutaneous) stimulation of the sensory branches of the trigeminal nerve in the face and forehead. More specifically, devices and electrode assemblies configured for stimulation of the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and infratrochlear nerves are disclosed.

Abstract translation: 本公开涉及用于治疗和/或促进从各种神经障碍和病症恢复的方法，装置和系统，包括癫痫和其他癫痫发作障碍以及运动和其它相关疾病; 用于促进急性或慢性脑损伤（例如中风，缺氧/缺血，头部创伤，蛛网膜下腔出血和其他形式的脑损伤）的恢复，用于唤醒和/或促进各种昏迷水平的患者的恢复，改变的精神状态或 营养状态）; 或通过外部（皮肤）刺激面部和额头中三叉神经的感觉分支来促进慢性日常头痛和偏头痛及相关疾病的恢复。 更具体地，公开了被配置用于刺激眶上，眶上，眶下，z骨，z骨，z骨，z骨，鼻和神经性神经的装置和电极组件。

公开(公告)号：US08257684B2

公开(公告)日：2012-09-04

申请号：US12411710

申请日：2009-03-26

Applicant: Alejandro Covalin ,  Antonio Afonso Ferreira De Salles

Inventor： Alejandro Covalin ,  Antonio Afonso Ferreira De Salles

IPC: A61K51/00 ,  A61M36/14

CPC classification number: A61B5/055 ,  A61B5/4041 ,  A61B6/032 ,  A61B6/037 ,  A61B6/501

Abstract: Disclosed herein are methods for identifying and targeting autonomic and autonomic-related brain regions. In one embodiment, a method of identifying a brain region in a patient comprises administering to the patient a targeting agent that activates or inhibits a brain region and imaging the brain region.

Abstract translation: 本文公开了用于鉴定和靶向自主神经和自主神经相关脑区的方法。 在一个实施方案中，鉴定患者的脑区域的方法包括向患者施用激活或抑制脑区域并使大脑区域成像的靶向剂。

公开(公告)号：US20080046012A1

公开(公告)日：2008-02-21

申请号：US11851821

申请日：2007-09-07

Applicant: Alejandro Covalin ,  Jack Judy ,  Avi Feshali

Inventor： Alejandro Covalin ,  Jack Judy ,  Avi Feshali

IPC: A61N1/00

CPC classification number: A61N1/36025 ,  A61N1/36082

Abstract: A method system for modulating the energy expenditure and/or the expressed brain-derived neurotrophic factor (BDNF) in the brain of an individual is performed by a system that includes a control device that generates a stimulation pattern from a predetermined set of stimulation parameters, and that converts the stimulation pattern into a stimulation signal. A stimulation signal delivery mechanism, configured for implantation into a selected part of the brain, receives the stimulation signal from the control device and delivers the signal to the selected part of the brain. The stimulation signal may be an electrical signal delivered by a brain-implantable electrode, or a chemical signal in the form of a drug dosage regimen delivered by an implantable micropump under the control of the control device. Modulation of the energy expenditure and/or BDNF is achieved by the stimulation of the hypothalamus, either directly or indirectly, by the stimulation signal.

Abstract translation: 用于调节个体脑中能量消耗和/或表达的脑源性神经营养因子（BDNF）的方法系统由包括从预定刺激参数组产生刺激模式的控制装置的系统执行， 并将刺激模式转换为刺激信号。 被配置为植入到脑的选定部分中的刺激信号传递机构接收来自控制装置的刺激信号，并将该信号传送到脑的选定部分。 刺激信号可以是由脑可植入电极传递的电信号，或者是由控制装置的控制下由可植入的微型泵递送的药物剂量形式的化学信号。 通过刺激信号直接或间接地刺激下丘脑来实现能量消耗和/或BDNF的调节。

公开(公告)号：US08560075B2

公开(公告)日：2013-10-15

申请号：US12578369

申请日：2009-10-13

Applicant: Alejandro Covalin

Inventor： Alejandro Covalin

IPC: A61N1/00

CPC classification number: A61B18/00 ,  A61N1/0456 ,  A61N1/36021

Abstract: A battery-operated transcutaneous electrical nerve stimulator (TENS) to treat headache pain in an abortive and/or preventive manner. The TENS unit and its electrodes are built into a unitary device which facilitates a self-administered treatment. In some embodiments, the pulses are monophasic. In other embodiments, pairs of biphasic pulses are provided, wherein each pair of biphasic pulses includes a first pulse having a first polarity separated by a gap in time from a second pulsed having an opposite polarity. In some embodiments, each pulse in each biphasic pair is of a duration equal to that of the other pulse of the pair. In some embodiments, the duration of each pulse is between about 50 microseconds and about 400 microseconds, and the gap in time between pulses of a pair is between about 50 and 100 microseconds.

Abstract translation: 电池操作的经皮电神经刺激器（TENS）以流产和/或预防方式治疗头痛。 TENS单元及其电极内置于一体式设备中，便于进行自我管理。 在一些实施例中，脉冲是单相的。 在其它实施例中，提供成对的双相脉冲，其中每对双相脉冲包括具有第一极性的第一脉冲，第一脉冲具有与具有相反极性的第二脉冲的时间间隔分开的第一极性。 在一些实施例中，每个双相对中的每个脉冲的持续时间等于该对中另一个脉冲的持续时间。 在一些实施例中，每个脉冲的持续时间在约50微秒和约400微秒之间，并且一对脉冲之间的时间间隔在大约50和100微秒之间。

公开(公告)号：US07634314B2

公开(公告)日：2009-12-15

申请号：US11290724

申请日：2005-11-30

Applicant: Robert Applebaum ,  Alejandro Covalin ,  Philip Klein

Inventor： Robert Applebaum ,  Alejandro Covalin ,  Philip Klein

IPC: A61N1/00 ,  A61H1/00 ,  A61H1/02 ,  A61H5/00

CPC classification number: A61H15/0085 ,  A61H39/002 ,  A61H2015/0035 ,  A61H2201/169

Abstract: A device and related method of use are disclosed which employ electrically-conductive wheels to massage and contact the skin to deliver electrical current. The present invention has both cosmetic and drug applications. In a cosmetic application, the rolling action of the wheels provides a light pressure skin massage that is important to reduce the appearance of skin surface irregularities. In a drug application, the device may be used to deliver ingredients of a conductive gel to or into the skin.

Abstract translation: 公开了一种使用的装置和相关方法，其使用导电轮来按摩和接触皮肤以传递电流。 本发明具有化妆品和药物应用。 在化妆品应用中，轮的滚动动作提供了轻压皮肤按摩，其对于减少皮肤表面不规则的外观是重要的。 在药物应用中，该装置可用于将导电凝胶的成分递送至皮肤或进入皮肤。

公开(公告)号：US20090246140A1

公开(公告)日：2009-10-01

申请号：US12411710

申请日：2009-03-26

Applicant: Alejandro Covalin ,  Antonio Afonso Ferreira De Salles

Inventor： Alejandro Covalin ,  Antonio Afonso Ferreira De Salles

IPC: A61K49/00 ,  A61K49/06

CPC classification number: A61B5/055 ,  A61B5/4041 ,  A61B6/032 ,  A61B6/037 ,  A61B6/501

Abstract: Disclosed herein are methods for identifying and targeting autonomic and autonomic-related brain regions. In one embodiment, a method of identifying a brain region in a patient comprises administering to the patient a targeting agent that activates or inhibits a brain region and imaging the brain region.

Abstract translation: 本文公开了用于鉴定和靶向自主神经和自主神经相关脑区的方法。 在一个实施方案中，鉴定患者的脑区域的方法包括向患者施用激活或抑制脑区域并使大脑区域成像的靶向剂。

公开(公告)号：US20140081369A1

公开(公告)日：2014-03-20

申请号：US14117026

申请日：2012-05-11

Applicant: Victor Manuel Valencia Sosa ,  Viridiana Rodríguez Bermudez ,  Juan Manuel González Suárez ,  Omar Mendizabal Riveros ,  Rocío Guzmán ,  Alejandro Covalin

Inventor： Victor Manuel Valencia Sosa ,  Viridiana Rodríguez Bermudez ,  Juan Manuel González Suárez ,  Omar Mendizabal Riveros ,  Rocío Guzmán ,  Alejandro Covalin

IPC: A61N1/04 ,  B65D83/00

CPC classification number: A61N1/0456 ,  A61N1/0484 ,  A61N1/36025 ,  B65D83/0055

Abstract: Electrical-stimulation device with gel-dispensing kit, and a method of making and using the parts of the kit. A convenient and easy-to-use system to provide an electrically conductive path from a transcutaneous electrical nerve stimulation (TENS) device to the skin surface of a patient to supply transcutaneous stimulation, even through hair. The invention provides improved prevention and treatment for headache, depression, alertness, attention deficit hyperactivity disorder (ADHD), epilepsy, anxiety, post-traumatic stress disorder (PTSD), and behavioral and/or other disorders. Some embodiments provide a headache-treatment system that includes an electrode base shaped to conform to a back of a human head; a TENS having projecting spring electrodes each connected to the electrode base; means for holding an electrically conductive gel in a plurality of sealed pockets; and means for unsealing the means for holding the gel and applying the gel substantially simultaneously to the projecting spring electrodes.

Abstract translation: 具有凝胶分配试剂盒的电刺激装置，以及制备和使用试剂盒部分的方法。 一种便利且易于使用的系统，用于提供从经皮电神经刺激（TENS）装置到患者皮肤表面的导电路径，以便甚至通过毛发提供经皮刺激。 本发明提供改善的头痛，抑郁，警觉性，注意力缺陷多动障碍（ADHD），癫痫，焦虑，创伤后应激障碍（PTSD）以及行为和/或其他障碍的预防和治疗。 一些实施例提供一种头痛治疗系统，其包括形状适合人头部背部的电极基座; 具有各自连接到电极基座的突出弹簧电极的TENS; 用于在多个密封袋中保持导电凝胶的装置; 以及用于开封用于保持凝胶并将凝胶基本上同时施加到突出的弹簧电极的装置。

公开(公告)号：US08620422B2

公开(公告)日：2013-12-31

申请号：US11862508

申请日：2007-09-27

Applicant: Robert S. Kieval ,  Martin Rossing ,  Adam Cates ,  Alejandro Covalin

Inventor： Robert S. Kieval ,  Martin Rossing ,  Adam Cates ,  Alejandro Covalin

IPC: A61N1/36

CPC classification number: A61N1/0551 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117

Abstract: A tissue stimulation device includes an electrode array having at least four independently switchable electrodes. In one embodiment, the electrode array comprises a flexible base to which the electrodes are fixed that flexes to encompass at least a portion of an artery or other elongate biological structure. The electrodes are electrically coupled to and energized by a signal generator coupled to a control system. In one embodiment, the array of electrodes are configured such that a suitable signal pattern for stimulation pulses between or among a set of the switchable electrodes may be determined without having to reposition the electrode assembly by using a series of signal patterns activating different combinations of switchable electrodes in response to sub-stimulation test signals to determine a signal pattern that provides suitable patient response. In another embodiment, the array of electrodes includes an array of selectively activatable multi-polar electrodes.

Abstract translation: 组织刺激装置包括具有至少四个可独立切换的电极的电极阵列。 在一个实施例中，电极阵列包括柔性基座，电极被固定到柔性基座上，该电极弯曲以包围动脉或其他细长生物结构的至少一部分。 电极电耦合到耦合到控制系统的信号发生器并由其激励。 在一个实施例中，电极阵列被配置为使得可以确定用于在一组可切换电极之间或之间进行刺激脉冲的合适信号图案，而不必通过使用一系列信号图案来激活电极组件，所述信号图案激活不同的可切换组合 电极响应亚刺激测试信号以确定提供合适的患者反应的信号图案。 在另一个实施例中，电极阵列包括可选择性激活的多极电极的阵列。

公开(公告)号：US08380315B2

公开(公告)日：2013-02-19

申请号：US12898686

申请日：2010-10-05

Applicant: Christopher DeGiorgio ,  Ian A. Cook ,  Alejandro Covalin ,  Patrick R. Miller ,  Lara Schrader

Inventor： Christopher DeGiorgio ,  Ian A. Cook ,  Alejandro Covalin ,  Patrick R. Miller ,  Lara Schrader

IPC: A61N1/00

CPC classification number: A61N1/36082 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/0504 ,  A61N1/0529 ,  A61N1/0551 ,  A61N1/36014 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36075 ,  A61N1/36096 ,  A61N1/36157 ,  A61N1/3616 ,  A61N1/36171 ,  A61N1/36175

Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.

Abstract translation: 本公开涉及通过刺激三叉神经（TNS）的表面元件而用于治疗情绪，焦虑，创伤后应激障碍以及认知和行为障碍（统称为神经精神障碍）的方法，装置和系统。 更具体地说，皮肤刺激面部以外的三叉神经的浅表分支的皮肤刺激方法，即眶上，sup ital，眶下，z atic，z atic，z atic，眶下，鼻和精神神经（也统称为 浅表三叉神经）。

公开(公告)号：US09204828B2

公开(公告)日：2015-12-08

申请号：US13306335

申请日：2011-11-29

Applicant: Daniel Rogers Burnett ,  Alejandro Covalin

Inventor： Daniel Rogers Burnett ,  Alejandro Covalin

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4839

Abstract: A device may be implanted subcutaneously with an attached catheter inserted within, e.g., the peritoneal cavity of a subject. The catheter and/or device may also be inserted into another space, e.g., subcutaneous, vascular, peritoneal, cerebrospinal, pleural spaces, etc. The peritoneal fluid which normally collects and/or flows through the peritoneal cavity may be detected by the catheter and analyzed via the device to detect the concentration of glucose within the fluid.

Abstract translation: 皮下可以将装置植入插入在受试者的例如腹膜腔内的附接的导管。 导管和/或装置也可插入另一空间，例如皮下，血管，腹膜，脑脊液，胸膜腔等。通常通过腹膜腔收集和/或流经的腹膜液可通过导管和 通过装置分析以检测流体内葡萄糖的浓度。