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公开(公告)号：US20120322772A1
公开(公告)日：2012-12-20
申请号：US13594622
申请日：2012-08-24
申请人： Ingo FLAMME , Jens-Kerim ERGÜDEN , Felix OEHME , Kai THEDE , Gunter KARIG , Alexander KUHL , Hanno WILD , Joachim SCHUHMACHER , Peter KOLKHOF , Lars BÄRFACKER , Joachim HÜTTER
发明人： Ingo FLAMME , Jens-Kerim ERGÜDEN , Felix OEHME , Kai THEDE , Gunter KARIG , Alexander KUHL , Hanno WILD , Joachim SCHUHMACHER , Peter KOLKHOF , Lars BÄRFACKER , Joachim HÜTTER
IPC分类号： C07D401/14 , A61K31/444 , A61K31/60 , A61P13/12 , A61P7/06 , A61K31/506 , A61P9/00
CPC分类号： C07D413/14 , C07D401/14
摘要： The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的联吡啶基 - 二氢吡唑酮，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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公开(公告)号：US07989633B2
公开(公告)日：2011-08-02
申请号：US11989277
申请日：2006-07-12
申请人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Figueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
发明人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Figueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
IPC分类号： C07D213/62
CPC分类号： C07D405/04
摘要： The present application relates to novel 4-chromenonyl-1,4-dihydropyridines, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的4-色烯酮基-1,4-二氢吡啶类，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途 ，特别是心血管疾病。
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公开(公告)号：US20090214675A1
公开(公告)日：2009-08-27
申请号：US11989279
申请日：2006-07-14
申请人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Figueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
发明人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Figueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
IPC分类号： A61K33/00 , C07D405/02 , A61K31/4433 , A61K31/60 , A61K31/704 , A61P9/00 , A61P9/12 , A61P13/12 , A61P25/00
CPC分类号： C07D405/04
摘要： The present application relates to novel 4-chromenonyl-1,4-dihydropyridinecarbonitriles, processes for their preparation, pharmaceutical compositions containing them, and their use for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的4-色烯酮基-1,4-二氢吡啶甲腈，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病，特别是心血管疾病的用途。
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4.发明申请Quinoxalinones and their use especially in the treatment of cardiovascular diseases 审中-公开喹喔啉酮及其用途特别用于治疗心血管疾病公开(公告)号：US20060247244A1
公开(公告)日：2006-11-02
申请号：US10503521
申请日：2003-01-27
申请人： Jens-Kerim Ergüden , Peter Kolkhof , Julio Castro-Palomino , Alexander Kuhl , Raimund Kast , Johannes-Peter Stasch , Hanna Tinel , Klaus Münter , Klemens Lustig , Josef Pernerstorfer , Martin Bechem , Jörg Hüser
发明人： Jens-Kerim Ergüden , Peter Kolkhof , Julio Castro-Palomino , Alexander Kuhl , Raimund Kast , Johannes-Peter Stasch , Hanna Tinel , Klaus Münter , Klemens Lustig , Josef Pernerstorfer , Martin Bechem , Jörg Hüser
IPC分类号： A61K31/498 , C07D241/36
CPC分类号： C07D403/12 , C07D241/44 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The invention relates to quinoxalinones and to methods for producing the same as well as the use thereof for preparing drugs for the treatment and/or prophylaxis of diseases, especially of cardiovascular diseases.
摘要翻译： 本发明涉及喹喔啉酮及其制备方法以及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途。
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5.发明授权4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases 有权4-（吡啶-3-基）-2（吡啶-2-基）-1,2-二氢-3H-吡唑-3-酮衍生物作为特异性HIF-裂解-4-羟化酶抑制剂用于治疗心血管和血液病公开(公告)号：US09085572B2
公开(公告)日：2015-07-21
申请号：US13594622
申请日：2012-08-24
申请人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
发明人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
IPC分类号： C07D401/14 , A61K31/4439 , C07D413/14
CPC分类号： C07D413/14 , C07D401/14
摘要： The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的联吡啶基 - 二氢吡唑酮，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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6.发明申请5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS 有权5-ARYL取代的二氢吡啶并嘧啶和二羟基吡啶并将其用作矿物质抗坏血酸公开(公告)号：US20100035902A1
公开(公告)日：2010-02-11
申请号：US12303369
申请日：2007-05-25
申请人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Alexander Kuhl , Rolf Grosser , Klaus Münter , Andreas Knorr
发明人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Alexander Kuhl , Rolf Grosser , Klaus Münter , Andreas Knorr
IPC分类号： A61K31/519 , C07D471/04 , A61P9/10 , A61P9/12
CPC分类号： C07D471/04
摘要： The present application relates to novel aryl-substituted heterobicyclic compounds, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的芳基取代的杂双环化合物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病尤其是心血管疾病的药物的用途 疾病
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公开(公告)号：US08058447B2
公开(公告)日：2011-11-15
申请号：US11989279
申请日：2006-07-14
申请人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Figueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
发明人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Figueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
IPC分类号： C07D213/62
CPC分类号： C07D405/04
摘要： The present application relates to novel 4-chromenonyl-1,4-dihydropyridinecarbonitriles, processes for their preparation, pharmaceutical compositions containing them, and their use for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的4-色烯酮基-1,4-二氢吡啶甲腈，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病，特别是心血管疾病的用途。
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公开(公告)号：US20100022484A1
公开(公告)日：2010-01-28
申请号：US11989277
申请日：2006-07-12
申请人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Gigueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
发明人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Gigueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
IPC分类号： A61K31/60 , C07D405/02 , A61K31/4433 , A61P9/00 , A61P9/12 , A61P13/12 , A61P1/16
CPC分类号： C07D405/04
摘要： The present application relates to novel 4-chromenonyl-1,4-dihydropyridines, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的4-色烯酮基-1,4-二氢吡啶类，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途 ，特别是心血管疾病。
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公开(公告)号：US20060122201A1
公开(公告)日：2006-06-08
申请号：US10506006
申请日：2003-02-14
申请人： Niels Svenstrup , Alexander Kuhl , Dietmar Flubacher , Michael Brands , Kerstin Ehlert , Christoph Ladel , Michael Ottneder , Jorg Keldenich , Marcus Bauser
发明人： Niels Svenstrup , Alexander Kuhl , Dietmar Flubacher , Michael Brands , Kerstin Ehlert , Christoph Ladel , Michael Ottneder , Jorg Keldenich , Marcus Bauser
IPC分类号： A61K31/513 , C07D403/02 , C07D239/46
CPC分类号： C07D239/545 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The invention relates to uracil-thioethers, pharmaceutical compositions containing said compounds and to a method for the production thereof. The invention also relates to the use of said substances in the treatment of diseases in humans and animals.
摘要翻译： 本发明涉及尿嘧啶硫醚，含有所述化合物的药物组合物及其生产方法。 本发明还涉及所述物质用于治疗人和动物疾病的用途。
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公开(公告)号：US09993432B2
公开(公告)日：2018-06-12
申请号：US13130294
申请日：2009-11-19
申请人： Alexander Kuhl , Erich Brendel , Frank Bröcker , Adrian Funke , Andreas Ohm , Dennis Kvesic , Thomas Volkmer
发明人： Alexander Kuhl , Erich Brendel , Frank Bröcker , Adrian Funke , Andreas Ohm , Dennis Kvesic , Thomas Volkmer
IPC分类号： A61K9/20 , A61K9/48 , A61K9/24 , A61K31/4422 , A61K9/00 , A61K9/28 , A61K31/4178 , A61K31/4184 , A61K45/06
CPC分类号： A61K9/2031 , A61K9/0004 , A61K9/2072 , A61K9/2086 , A61K9/209 , A61K9/2853 , A61K9/2866 , A61K31/4178 , A61K31/4184 , A61K31/4422 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a pharmaceutical dosage form comprising an active ingredient combination of nifedipine or nisoldipine and at least one angiotensin II antagonist and/or at least one diuretic, characterized in that nifedipine or nisoldipine is released in the body in a controlled (modified) manner and the angiotensin II antagonist and/or the diuretic is released rapidly (immediate release (IR)), and also to processes for their preparation, to their use as medicaments and to their use for the prophylaxis, secondary prophylaxis or treatment of disorders.
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