公开(公告)号：US08894611B2

公开(公告)日：2014-11-25

申请号：US13061257

申请日：2009-08-31

Applicant: Andre Larsen ,  Ole Christian Nielsen ,  Salim Bouaidat ,  Jan Preuthun

Inventor： Andre Larsen ,  Ole Christian Nielsen ,  Salim Bouaidat ,  Jan Preuthun

IPC: A61M37/00 ,  A61M5/00 ,  A61M5/24 ,  A61M5/315 ,  A61M5/31

CPC classification number: A61M5/24 ,  A61M5/3129 ,  A61M5/31535 ,  A61M5/3157 ,  A61M2005/3143 ,  A61M2205/582 ,  A61M2205/583

Abstract: The present invention relates to an indicating device for use with medical injection devices for administering a drug into the body of a subject user wherein the indicating device is configured for indicating after administration that a dose of the drug actually has been administered and for maintaining this indication until lapse of a pre-defined time interval. The time delay indicator disclosed is based on a mechanical time delay device and includes a visual indicator that is controlled by the mechanical time delay device for signalling the status of the device during lapse of the pre-defined time interval.

Abstract translation: 本发明涉及一种用于医疗注射装置的指示装置，用于将药物施用到受试者体内，其中指示装置被配置用于在给药后指示药物实际已被施用的剂量并用于维持该指示 直到经过预定义的时间间隔。 所公开的延时指示器是基于机械时间延迟装置，并且包括由机械时间延迟装置控制的视觉指示器，用于在经过预定时间间隔期间用于发信号通知装置的状态。

公开(公告)号：US08529518B2

公开(公告)日：2013-09-10

申请号：US13376696

申请日：2010-06-14

Applicant: Andre Larsen ,  Karsten Baker Nielsen ,  Thibaud Hofstatter ,  Omid Reza Hissinian

Inventor： Andre Larsen ,  Karsten Baker Nielsen ,  Thibaud Hofstatter ,  Omid Reza Hissinian

IPC: A61M5/32

CPC classification number: A61M5/3213 ,  A61M5/3129 ,  A61M5/3155 ,  A61M5/3202 ,  A61M5/3204 ,  A61M2005/3206 ,  A61M2005/3208 ,  A61M2005/3215 ,  A61M2205/584 ,  A61M2205/6045 ,  A61M2205/6081

Abstract: Drug delivery system comprising a main portion with a cap as well as a needle assembly with a needle mounted in a hub and a needle cap releasably mountable on the hub to cover the needle. The cap comprises gripping means reversibly operatable between a first condition in which there is no gripping engagement between the mounted cap portion and the needle cap, this allowing the cap portion to be removed from the main portion without removing the needle cap from the hub, and a second condition in which the cap portion grippingly can engage the needle cap of a needle assembly, this allowing the needle cap to be removed from the hub together with the cap. The cap further comprises user actuation means for operating the gripping means between the two conditions.

Abstract translation: 药物递送系统包括具有帽的主要部分以及具有安装在轮毂中的针的针组件和可释放地安装在轮毂上以覆盖针的针帽。 所述盖包括在第一状态之间可逆地操作的夹持装置，在所述第一状态下，在所述安装的盖部和所述针帽之间不存在夹紧接合，这允许所述盖部从所述主体部分移除而不从所述轮毂移除所述针帽， 第二状态，其中盖部分可夹紧地接合针组件的针帽，这允许针帽与盖一起从毂脱离。 盖子还包括用于在两个条件之间操作夹持装置的使用者致动装置。

公开(公告)号：US20110009821A1

公开(公告)日：2011-01-13

申请号：US12811169

申请日：2008-12-31

Applicant: Søren Kragh Jespersen ,  Claus Urup Gjødesen ,  Andre Larsen

Inventor： Søren Kragh Jespersen ,  Claus Urup Gjødesen ,  Andre Larsen

IPC: A61M5/20

CPC classification number: A61M5/172 ,  A61M5/1452 ,  A61M5/1454 ,  A61M5/16804 ,  A61M5/1685 ,  A61M5/20 ,  A61M5/3146 ,  A61M5/31525 ,  A61M5/31533 ,  A61M5/31565 ,  A61M5/3157 ,  A61M2205/3372 ,  A61M2205/3389 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/6018 ,  G06F19/00

Abstract: The present invention relates to a medical injection device (1) for use in combination with a medicament filled cartridge (2), the injection device being provided with a spring-assisted injecting mechanism where energy released from the spring moves a plunger (3) of a held cartridge (2). Sensor circuitry is adapted to detect speed related data during injection so at to detect an abnormal speed condition, such as a needle blocking condition, a priming condition or an air purge condition. The invention also relates to a medical injection device comprising sensor circuitry and user communicating means to provide a recommended needle retraction waiting period which is dependent on the speed of injection.

Abstract translation: 本发明涉及一种与药物填充的药筒（2）组合使用的医疗注射装置（1），该注射装置设置有弹簧辅助的注射机构，其中从弹簧释放的能量将活塞的柱塞（3）移动 （2）。 传感器电路适于在注射期间检测速度相关数据，以便检测异常速度状况，例如针头阻塞状况，起动条件或空气吹扫条件。 本发明还涉及一种医疗注射装置，其包括传感器电路和用户通信装置，用于提供取决于注射速度的推荐的针回缩等待时间段。

公开(公告)号：US20090088701A1

公开(公告)日：2009-04-02

申请号：US12293251

申请日：2007-03-20

Applicant: Andre Larsen

Inventor： Andre Larsen

IPC: G06K19/067

CPC classification number: G06K19/067 ,  A61M5/24 ,  A61M5/3129 ,  A61M2205/6027 ,  A61M2205/6072 ,  G06K7/081

Abstract: The present invention relates to a cartridge adapted to contain a medicament, the cartridge further being adapted to be inserted into an associated medication delivery device. The cartridge according to the present invention comprises a plurality of electrode elements arranged on an exterior surface part of the cartridge, wherein an electrode element of said plurality of electrode elements comprises a receiver zone and a transmitter zone, said receiver and transmitter zones being electrically connected. The receiver and transmitter zones are adapted to electrically couple to one or more transmitters and to one or more receivers, respectively, said one or more transmitters and said one or more receivers being arranged on the associated medication delivery device.

Abstract translation: 本发明涉及一种适于容纳药物的药筒，该药筒还适于插入相关联的药物输送装置中。 根据本发明的盒包括布置在盒的外表面部分上的多个电极元件，其中所述多个电极元件的电极元件包括接收器区域和发射器区域，所述接收器和发射器区域电连接 。 接收器和发射器区域适于分别电耦合到一个或多个发射器和一个或多个接收器，所述一个或多个发射器和所述一个或多个接收器布置在相关联的药物输送装置上。

公开(公告)号：US06277097B1

公开(公告)日：2001-08-21

申请号：US09045314

申请日：1998-03-20

Applicant: Soren Mikkelsen ,  Lars Peter Klitmose ,  Andre Larsen

Inventor： Soren Mikkelsen ,  Lars Peter Klitmose ,  Andre Larsen

IPC: A61M500

CPC classification number: A61M5/31586 ,  A61J1/201 ,  A61J1/2065 ,  A61J1/2096 ,  A61M5/24 ,  A61M5/2448 ,  A61M5/31553 ,  A61M5/3156 ,  A61M5/3202 ,  A61M2005/2411 ,  A61M2205/581 ,  A61M2205/582

Abstract: An injection system for preparing a mixture of a solvent and a medicament and for subsequent dosed injection of the mixture comprises a syringe accommodating an ampoule (7) in which a liquid is stored between a membrane (8) dosing one end of the ampoule (7) and a piston (6) which can by a piston rod (3) be forced into the ampoule (7) to press out a dose of the liquid. The piston rod (3) and the piston (6) has mutual engaging threads (4, 5) by which the piston (6) is coupled to the piston rod (3) to follow this rod in both axial directions. An outer thread (30) engaging an inner thread (29) in a housing is provided on a part (28) of the piston rod (3) so that rotation of the piston rod (3) will screw this rod and the piston (6) into the ampoule (7). A detent (18) ensures that the piston rod (3) is only rotated in a dose administering direction. However, the thread (30) of the piston rod (3) can be disengaged from the thread (29) of the housing to set the piston rod (3) free to be moved in a proximal direction.

Abstract translation: 用于制备溶剂和药物的混合物并用于随后剂量注射混合物的注射系统包括注射器，其容纳安瓿（7），其中液体存储在安装在安瓿（7）的一端的膜（8） ），并且可以通过活塞杆（3）将活塞（6）推入安瓿（7）中以挤压一定剂量的液体。 活塞杆（3）和活塞（6）具有相互啮合的螺纹（4,5），活塞（6）通过该啮合螺纹（4）与活塞杆（3）联接，以沿两个轴向跟随该杆。 在活塞杆（3）的一部分（28）上设有与外壳内的内螺纹（29）接合的外螺纹（30），从而活塞杆（3）的旋转将使该杆和活塞（6） ）放入安瓿（7）。 制动器（18）确保活塞杆（3）仅在剂量施加方向上旋转。 然而，活塞杆（3）的螺纹（30）可以从壳体的螺纹（29）脱离，以使活塞杆（3）沿近端方向自由移动。

公开(公告)号：US06021824A

公开(公告)日：2000-02-08

申请号：US894641

申请日：1997-08-26

Applicant: Andre Larsen ,  Gabriel J.o slashed.rgensen ,  Peter Norland Jensen ,  James M. Flink ,  Peter Christian Klitgaard

Inventor： Andre Larsen ,  Gabriel J.o slashed.rgensen ,  Peter Norland Jensen ,  James M. Flink ,  Peter Christian Klitgaard

IPC: A61J3/00 ,  A61J1/00 ,  A61J1/20 ,  B65B1/04

CPC classification number: A61J1/2089 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2075 ,  A61J1/2082

Abstract: A kit for mixing comprises a housing accommodating an ampoule containing a solid and a container containing a solvent which is either pre-pressurized or which may be pressurized when it is desired to mix to the liquid and solid components. A needle unit comprises a first needle, the opposite ends of which pierce rubber membranes closing the ampoule and the container, to establish a transport channel through which pressurized solvent flows from the container to the ampoule. The ampoule is vented through a second needle inserted through the membrane of the ampoule and provided with a micro-filter. In one embodiment, the needle unit is displaceable to cause the ends of the needles to pierce the respective membranes, and locked in place by a spring biased locking mechanism. A branch passage from the needle is connected to a cylinder containing a piston coupled to the locking mechanism. When the ampoule is full, pressure in the branch passage will rise, actuating the piston and releasing the locking mechanism. In an alternative embodiment, the needle mechanism is stationary, and the ampoule and container are moved into engagement with the respective needle ends.

Abstract translation: PCT No.PCT / DK96 / 00085 Sec。 371日期：1997年8月26日 102（e）日期1997年8月26日PCT提交1996年2月29日PCT公布。 公开号WO96 / 26702 日期1996年9月6日用于混合的试剂盒包括容纳包含固体的容器和容纳含有预加压溶剂的容器的壳体，或者当需要与液体和固体组分混合时可以加压。 针单元包括第一针，其相对端刺穿关闭安瓿和容器的橡胶膜，以建立输送通道，加压溶剂通过该输送通道从容器流到安瓿。 安瓿通过穿过安瓿的膜的第二针排出，并设置有微滤器。 在一个实施例中，针单元可移动以使针的端部刺穿相应的膜，并且通过弹簧偏置的锁定机构锁定就位。 来自针的分支通道连接到包含联接到锁定机构的活塞的气缸。 当安瓿充满时，分支通道中的压力将升高，致动活塞并释放锁定机构。 在替代实施例中，针机构是静止的，并且安瓿和容器被移动成与相应的针端接合。

公开(公告)号：US10166338B2

公开(公告)日：2019-01-01

申请号：US13496671

申请日：2010-09-09

Applicant: Karsten Baker Nielsen ,  Andre Larsen

Inventor： Karsten Baker Nielsen ,  Andre Larsen

IPC: A61M5/31 ,  A61M5/24 ,  A61M5/32 ,  A61M5/315

Abstract: A system comprising first and second drug delivery devices (1) based on the same technology platform, each comprising a main portion (3) with a reservoir holding a type of drug, a drug outlet, and drug expelling means for expelling drug from the reservoir through the drug outlet, as well as a cap (100) releasably mountable to the main portion to enclose the drug outlet, each cap comprising a unique user-identifiable marking indicating the corresponding type of drug. The cap and main portion of each drug delivery device comprise a pair of corresponding key structures preventing the first cap from being mounted on the second main portion, and the second cap from being mounted on the first main portion.

公开(公告)号：US20120271249A1

公开(公告)日：2012-10-25

申请号：US13497472

申请日：2010-09-20

Applicant: Andre Larsen ,  Lasse Wengel Christoffersen ,  Mikael Andersen ,  Jan Harald Preuthun

Inventor： Andre Larsen ,  Lasse Wengel Christoffersen ,  Mikael Andersen ,  Jan Harald Preuthun

IPC: A61M5/00 ,  B21G1/12 ,  C23F1/14

CPC classification number: C23F1/04 ,  A61B17/205 ,  A61B2017/00526 ,  A61M5/32 ,  A61M2207/00 ,  B21G1/006 ,  B21G1/08 ,  C23F1/28

Abstract: A regular metallic, cylindrical tubular needle cannula (1) is subjected to a metal etching liquid (21) in the inside lumen (4) thereby increasing the inside diameter and enhancing the flow properties while maintaining the outside appearance. The inside diameter is only increased over a controlled length (7) of the full length of the needle cannula (1) leaving sufficient length and wall thickness to also taper the outside diameter.

Abstract translation: 常规金属圆柱形管状针插管（1）在内腔（4）中经受金属蚀刻液（21），从而增加内径并增强流动性，同时保持外观。 内径仅在针套管（1）的全长的可控长度（7）处增加，留下足够的长度和壁厚度以使外径逐渐变细。

公开(公告)号：US20120191046A1

公开(公告)日：2012-07-26

申请号：US13376696

申请日：2010-06-14

Applicant: Andre Larsen ,  Karsten Dupont Nielsen ,  Thibaud Hofstatter ,  Omid Reza Hissinian

Inventor： Andre Larsen ,  Karsten Dupont Nielsen ,  Thibaud Hofstatter ,  Omid Reza Hissinian

IPC: A61M5/32

CPC classification number: A61M5/3213 ,  A61M5/3129 ,  A61M5/3155 ,  A61M5/3202 ,  A61M5/3204 ,  A61M2005/3206 ,  A61M2005/3208 ,  A61M2005/3215 ,  A61M2205/584 ,  A61M2205/6045 ,  A61M2205/6081

Abstract: Drug delivery system comprising a main portion with a cap as well as a needle assembly with a needle mounted in a hub and a needle cap releasably mountable on the hub to cover the needle. The cap comprises gripping means reversibly operatable between a first condition in which there is no gripping engagement between the mounted cap portion and the needle cap, this allowing the cap portion to be removed from the main portion without removing the needle cap from the hub, and a second condition in which the cap portion grippingly can engage the needle cap of a needle assembly, this allowing the needle cap to be removed from the hub together with the cap. The cap further comprises user actuation means for operating the gripping means between the two conditions.

Abstract translation: 药物递送系统包括具有帽的主要部分以及具有安装在轮毂中的针的针组件和可释放地安装在轮毂上以覆盖针的针帽。 所述盖包括在第一状态之间可逆地操作的夹持装置，在所述第一状态下，在所述安装的盖部和所述针帽之间不存在夹紧接合，这允许所述盖部从所述主体部分移除而不从所述轮毂移除所述针帽， 第二状态，其中盖部分可夹紧地接合针组件的针帽，这允许针帽与盖一起从毂脱离。 盖子还包括用于在两个条件之间操作夹持装置的使用者致动装置。

公开(公告)号：US08040236B2

公开(公告)日：2011-10-18

申请号：US11722381

申请日：2005-12-27

Applicant: Andre Larsen

Inventor： Andre Larsen

IPC: G08B1/08

CPC classification number: G06F19/3456 ,  G06F19/00 ,  G06F19/3418 ,  G06Q50/22

Abstract: The present invention relates to a medication delivery device comprising a reminder unit for reminding an individual having a medical diseases to take a medicament. The reminder unit comprises means for providing a reminder signal to the individual having the medical disease, the reminder signal being triggered by data associated with a previously occurred event, the associated data being stored in a storage means. Alternatively, the reminder signal may be triggered by a position signal generated by position determining means adapted to determine the position of the medication delivery device.

Abstract translation: 本发明涉及药物输送装置，其包括用于提醒具有医学疾病的个体服用药物的提醒单元。 提醒单元包括用于向具有医学疾病的个体提供提醒信号的装置，该提醒信号由与先前发生的事件相关联的数据触发，相关联的数据被存储在存储装置中。 或者，提醒信号可以由适于确定药物输送装置的位置的位置确定装置产生的位置信号来触发。