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公开(公告)号：US20090211346A1
公开(公告)日：2009-08-27
申请号：US11918078
申请日：2006-03-13
申请人： Doris Damian , Amir Handzel , Aram Adourian
发明人： Doris Damian , Amir Handzel , Aram Adourian
IPC分类号： G01N30/68
CPC分类号： G01N33/6896
摘要： Markers are provided that are predictive of Alzheimer's disease. Levels of these markers, when different from a standard, are indicative of a patient being at risk of having or developing Alzheimer's disease.
摘要翻译： 提供了预测阿尔茨海默病的标记物。 当与标准物不同时，这些标记物的水平指示患有患有或发展阿尔茨海默病的风险的患者。
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公开(公告)号：US20060115429A1
公开(公告)日：2006-06-01
申请号：US10999512
申请日：2004-11-30
申请人： Noubar Afeyan , Aram Adourian , Amir Handzel , Brian Baynes
发明人： Noubar Afeyan , Aram Adourian , Amir Handzel , Brian Baynes
CPC分类号： A61K49/0004 , G06K9/6267
摘要： Disclosed are methods for the practice of systems pharmacology, systems toxicology, and systems pathology using patterns, such as images, reflective of the biological state of subjects such as humans or experimental mammals. The patterns are generated from data obtained from one or more samples from one or more subjects by applying certain data treatment techniques, and are reflective of the biochemistry of the subjects. The patterns are used in drug selection and discovery, assessment of toxicity and drug efficacy, segmentation of populations, discovery of disease subtypes, as surrogate end points, in the assessment of therapeutic options, and for diagnosis and prognosis of disease.
摘要翻译： 公开了使用诸如图像的图案来实现系统药理学，系统毒理学和系统病理学的方法，其反映了诸如人类或实验哺乳动物的受试者的生物学状态。 通过应用某些数据处理技术，从一个或多个受试者的一个或多个样本获得的数据生成图案，并且反映了受试者的生物化学。 这些模式用于药物选择和发现，评估毒性和药物功效，人群分割，发现疾病亚型，作为替代终点，评估治疗选择，以及疾病诊断和预后。
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3.发明申请公开(公告)号：US20060144706A1
公开(公告)日：2006-07-06
申请号：US11300215
申请日：2005-12-13
IPC分类号： C07K1/26
CPC分类号： G01N27/44743 , B01L3/0275 , B01L3/0289 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/0657 , B01L2300/0803 , B01L2300/0816 , B01L2400/0415 , B01L2400/0421 , B01L2400/043 , B01L2400/0442 , G01N27/44782 , G01N35/10 , Y10T436/2575
摘要： A technique processes a sample of biomolecular analyte. The technique uses an apparatus having a support assembly that receives and supports a test module, a load assembly that loads the sample of biomolecular analyte onto the test module, an electrophoresis assembly that applies a current to the test module such that components within the sample separate by electrophoresis, and a controller that controls operations of the load assembly and the electrophoresis assembly. The load assembly and the electrophoresis assembly are coupled to the support assembly. The controller controls the operation of the load assembly in an automated manner. Preferably, the test module includes a dielectric plate member having an upper planar surface and a lower planar surface that is spaced apart from and coplanar with the upper planar surface. The dielectric plate member has at least one set of channels that includes an injection channel and a separation channel. The injection channel extends from the upper planar surface to the lower planar surface. The separation channel extends within the dielectric plate member in a plane parallel with the upper and lower planar surfaces and intersects the injection channel.
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公开(公告)号：US08206986B2
公开(公告)日：2012-06-26
申请号：US11918078
申请日：2006-03-13
申请人： Doris Damian , Amir Handzel , Aram Adourian
发明人： Doris Damian , Amir Handzel , Aram Adourian
CPC分类号： G01N33/6896
摘要： Markers are provided that are predictive of Alzheimer's disease. Levels of these markers, when different from a standard, are indicative of a patient being at risk of having or developing Alzheimer's disease.
摘要翻译： 提供了预测阿尔茨海默病的标记物。 当与标准物不同时，这些标记物的水平指示患有患有或发展阿尔茨海默病的风险的患者。
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公开(公告)号：US20050283320A1
公开(公告)日：2005-12-22
申请号：US11141253
申请日：2005-05-31
申请人： Noubar Afeyan , Jan van der Greef , Frederick Regnier , Aram Adourian , Eric Neumann , Matej Oresic , Elwin Verheij
发明人： Noubar Afeyan , Jan van der Greef , Frederick Regnier , Aram Adourian , Eric Neumann , Matej Oresic , Elwin Verheij
IPC分类号： G01N27/62 , B01J20/283 , C12Q1/02 , C12Q1/68 , G01N30/26 , G01N30/34 , G01N30/72 , G01N30/88 , G01N31/00 , G01N33/48 , G01N33/50 , G01N33/53 , G01R33/465 , G06F19/24
CPC分类号： G16B40/00 , Y10T436/24
摘要： The present invention provides methods and systems for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components, of a single biomolecular component type, of a plurality of biological samples. Preferably, the method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation.
摘要翻译： 本发明提供了用于基于多个生物样品的单个生物分子组分类型的生物分子组分之间的相似性，差异性和/或相关性来识别生物系统的图谱的方法和系统。 优选地，该方法包括在一个或多个相关级别上利用光谱数据的分层多变量分析。
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公开(公告)号：US20050273275A1
公开(公告)日：2005-12-08
申请号：US11141258
申请日：2005-05-31
申请人： Noubar Afeyan , Jan van der Greef , Frederick Regnier , Aram Adourian , Eric Neumann , Matej Oresic , Elwin Verheij
发明人： Noubar Afeyan , Jan van der Greef , Frederick Regnier , Aram Adourian , Eric Neumann , Matej Oresic , Elwin Verheij
IPC分类号： G01N27/62 , B01J20/283 , C12Q1/02 , C12Q1/68 , G01N30/26 , G01N30/34 , G01N30/72 , G01N30/88 , G01N31/00 , G01N33/48 , G01N33/50 , G01N33/53 , G01R33/465 , G06F19/24
CPC分类号： G16B40/00 , Y10T436/24
摘要： The present invention provides methods and systems for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components, of a single biomolecular component type, of a plurality of biological samples. Preferably, the method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation.
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公开(公告)号：US20100173346A1
公开(公告)日：2010-07-08
申请号：US12593149
申请日：2008-03-24
申请人： Aram Adourian , Doris Damian , Amir Handzel
发明人： Aram Adourian , Doris Damian , Amir Handzel
CPC分类号： G01N33/6893 , G01N33/92 , G01N2405/04 , G01N2800/324 , Y10T436/144444 , Y10T436/147777 , Y10T436/173845 , Y10T436/200833 , Y10T436/201666
摘要： Markers are provided for detecting coronary artery disease. Levels of these markers are indicative of a patient being at risk of having or developing coronary artery disease.
摘要翻译： 标记用于检测冠状动脉疾病。 这些标记物的水平表示患有患冠状动脉疾病或发展成冠状动脉疾病的风险的患者。
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公开(公告)号：US20100057368A1
公开(公告)日：2010-03-04
申请号：US11791400
申请日：2005-11-30
申请人： Noubar Afeyan , Aram Adourian , Robert McBurney
发明人： Noubar Afeyan , Aram Adourian , Robert McBurney
CPC分类号： A61K49/0004 , G16B40/00 , G16B45/00 , G16H10/20
摘要： Disclosed are methods for the practice of systems pharmacology, systems toxicology, and systems pathology using patterns, such as images, reflective of the biological state of subjects such as humans or experimental mammals. The patterns are generated from data obtained from one or more samples from one or more subjects by applying certain data treatment techniques, and are reflective of the biochemistry of the subjects. The patterns are used in drug selection and discovery, assessment of toxicity and drug efficacy, segmentation of populations, discovery of disease subtypes, as surrogate end points, in the assessment of therapeutic options, and for diagnosis and prognosis of disease.
摘要翻译： 公开了使用诸如图像的图案来系统药理学，系统毒理学和系统病理学的方法，其反映诸如人类或实验哺乳动物的受试者的生物学状态。 通过应用某些数据处理技术，从一个或多个受试者的一个或多个样本获得的数据生成图案，并且反映了受试者的生物化学。 这些模式用于药物选择和发现，评估毒性和药物功效，人群分割，发现疾病亚型，作为替代终点，评估治疗选择，以及疾病诊断和预后。
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公开(公告)号：US20050170372A1
公开(公告)日：2005-08-04
申请号：US10922820
申请日：2004-08-20
申请人： Noubar Afeyan , Jan van der Greef , Frederick Regnier , Aram Adourian , Eric Neumann , Matej Oresic , Elwin Verheij
发明人： Noubar Afeyan , Jan van der Greef , Frederick Regnier , Aram Adourian , Eric Neumann , Matej Oresic , Elwin Verheij
摘要： Methods and systems are disclosed for developing profiles of a state of a biological system based on the discernment of similarities, differences, and/or correlations between a plurality of data sets that are derived from one or more biomolecular component types, one or more biological sample types, and/or one or more types of measurements.
摘要翻译： 公开了用于基于从一种或多种生物分子组分类型衍生的多个数据集之间的相似性，差异和/或相关性的辨别来发展生物系统的状态的方法和系统，一种或多种生物样品 类型和/或一种或多种类型的测量。
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