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公开(公告)号：US20050074750A1
公开(公告)日：2005-04-07
申请号：US10613018
申请日：2003-07-07
申请人： Ursula-Henrike Wienhues , Cornelia Kruse-Muller , Eva Hoss , Elke Faatz , Beatus Ofenloch-Hahnle , Christoph Seidel , Michael Wiedmann
发明人： Ursula-Henrike Wienhues , Cornelia Kruse-Muller , Eva Hoss , Elke Faatz , Beatus Ofenloch-Hahnle , Christoph Seidel , Michael Wiedmann
IPC分类号： G01N33/53 , C07K7/08 , C07K14/16 , C07K14/18 , G01N33/531 , G01N33/533 , G01N33/543 , G01N33/547 , G01N33/68 , G01N33/92 , C12Q1/70 , G01N33/537
CPC分类号： C07K14/005 , C12N2740/16122 , C12N2770/24222 , G01N33/533 , G01N33/54306 , G01N33/6878 , G01N33/92 , Y10S435/975 , Y10S436/811
摘要： The invention concerns a method for the immunological determination of a specific antibody in a sample liquid in which the sample liquid is incubated in the presence of a solid phase with two antigens directed against the antibody to be determined of which the first antigen carries at least one marker group and the second antigen is (a) bound to the solid phase or (b) is present in a form capable of binding to the solid phase and the antibody to be determined is detected by determining the marker group in the solid phase or/and in the liquid phase characterized in that at least one of the two antigens contains several epitope regions which react with the antibody to be determined.
摘要翻译： 本发明涉及一种用于免疫测定样品液体中的特异性抗体的方法，其中样品液体在固相存在下与针对待测定的抗体的两种抗原一起孵育，所述抗原被确定为第一抗原携带至少一种 标记基团和第二抗原是（a）与固相结合或（b）以能够结合固相的形式存在，并且通过确定固相中的标记基团或/ 并且在液相中，其特征在于，两种抗原中的至少一种包含与要测定的抗体反应的几个表位区域。
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公开(公告)号：US5958783A
公开(公告)日：1999-09-28
申请号：US615278
申请日：1996-06-20
申请人： Hans-Peter Josel , Eva Hoss , Beatus Ofenloch-Hahnle , Christoph Seidel , Barbara Upmeier , Ursula-Henrike Wienhues
发明人： Hans-Peter Josel , Eva Hoss , Beatus Ofenloch-Hahnle , Christoph Seidel , Barbara Upmeier , Ursula-Henrike Wienhues
IPC分类号： G01N33/532 , C07F11/00 , C07F13/00 , C07F15/00 , C07F19/00 , C07K14/00 , C07K14/16 , C07K14/18 , C09K11/06 , C12Q1/68 , G01N33/533 , G01N33/543 , G01N33/58 , G01N33/68 , G01N33/92 , G01N33/20 , G01N21/76
CPC分类号： C07K14/005 , C07F15/0053 , G01N33/533 , G01N33/54306 , G01N33/6878 , G01N33/92 , C12N2740/16122 , C12N2770/24222
摘要： The present invention concerns new metal complexes with a charged linker and their use as luminescent marker groups in an immunoassay.
摘要翻译： PCT No.PCT / EP95 / 02920 Sec。 371日期：1996年6月20日 102（e）1996年6月20日PCT PCT 1995年7月24日PCT公布。 公开号WO96 / 03409 日期1996年2月8日本发明涉及带有电荷接头的新金属配合物及其在免疫测定中作为发光标记基团的用途。
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公开(公告)号：US5804371A
公开(公告)日：1998-09-08
申请号：US615279
申请日：1996-06-13
IPC分类号： G01N33/53 , C07J17/00 , C07K1/00 , C07K1/04 , C07K1/06 , C07K1/107 , C07K1/13 , C07K7/06 , C07K7/08 , C07K14/155 , C07K14/16 , C07K14/18 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/543 , G01N33/68 , G01N33/74 , G01N33/92 , C12Q1/70 , G01N33/569 , G01N33/576
CPC分类号： C07K14/005 , G01N33/532 , G01N33/533 , G01N33/54306 , G01N33/6878 , G01N33/743 , G01N33/92 , C12N2740/16122 , C12N2770/24222 , Y02P20/55 , Y10S435/974 , Y10S436/82 , Y10S530/82
摘要： The invention concerns a process for the production of hapten-labelled peptides which is characterized in that (a) a peptide with the desired amino acid sequence is synthesized on a solid phase from amino acid derivatives whose reactive side groups are blocked by protecting groups wherein the protecting groups on primary amino side groups are selected in such a way that, if desired, they can be selectively cleaved off, (b) protecting groups are cleaved to form at least one free primary amino group, (c) a hapten-active ester derivative is coupled to the at least one free primary amino group of the peptide and (d) if desired protecting groups that still remain are cleaved off, the hapten being selected from the group comprising sterols, bile acids, sexual hormones, corticoids, cardenolides, cardenolide-glycosides, bufadienolides, steroid-sapogenines and steroid alkaloids.
摘要翻译： PCT No.PCT / EP95 / 02921 Sec。 371日期：1996年6月13日 102（e）日期1996年6月13日PCT提交1995年7月24日PCT公布。 公开号WO96 / 03423 日期1996年2月8日本发明涉及半抗原标记肽的制备方法，其特征在于（a）具有所需氨基酸序列的肽在固相上由活性侧基被封闭的氨基酸衍生物合成 通过保护基团，其中选择伯氨基侧基上的保护基团，使得如果需要，它们可以被选择性地切除，（b）保护基团被切割以形成至少一个游离的伯氨基，（c） 半抗原活性酯衍生物与肽的至少一个游离伯氨基偶联，（d）如果需要，仍保留的保护基被切除，该半抗原选自包括甾醇，胆汁酸，性激素 ，皮质激素，心内酯，心内酯苷，蟾蜍烯内苷，类固醇 - 皂苷和类固醇生物碱。
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公开(公告)号：US06613530B1
公开(公告)日：2003-09-02
申请号：US08776188
申请日：1997-01-24
申请人： Ursula-Henrike Wienhues , Cornelia Kruse-Müller , Eva Höss , Elke Faatz , Beatus Ofenloch-Hähnle , Christoph Seidel , Michael Wiedmann
发明人： Ursula-Henrike Wienhues , Cornelia Kruse-Müller , Eva Höss , Elke Faatz , Beatus Ofenloch-Hähnle , Christoph Seidel , Michael Wiedmann
IPC分类号： G01N33576
CPC分类号： C07K14/005 , C12N2740/16122 , C12N2770/24222 , G01N33/533 , G01N33/54306 , G01N33/6878 , G01N33/92 , Y10S435/975 , Y10S436/811
摘要： The invention concerns a method for the immunological determination of a specific antibody in a sample liquid in which the sample liquid is incubated in the presence of a solid phase with two antigens directed against the antibody to be determined of which the first antigen carries at least one marker group and the second antigen is (a) bound to the solid phase or (b) is present in a form capable of binding to the solid phase and the antibody to be determined is detected by determining the marker group in the solid phase or/and in the liquid phase characterized in that at least one of the two antigens contains several epitope regions which react with the antibody to be determined.
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公开(公告)号：US07629295B2
公开(公告)日：2009-12-08
申请号：US10613018
申请日：2003-07-07
申请人： Ursula-Henrike Wienhues , Cornelia Kruse-Müller , Eva Höss , Elke Faatz , Beatus Ofenloch-Hähnle , Christoph Seidel , Michael Wiedmann
发明人： Ursula-Henrike Wienhues , Cornelia Kruse-Müller , Eva Höss , Elke Faatz , Beatus Ofenloch-Hähnle , Christoph Seidel , Michael Wiedmann
CPC分类号： C07K14/005 , C12N2740/16122 , C12N2770/24222 , G01N33/533 , G01N33/54306 , G01N33/6878 , G01N33/92 , Y10S435/975 , Y10S436/811
摘要： The invention concerns a method for the immunological determination of a specific antibody in a sample liquid in which the sample liquid is incubated in the presence of a solid phase with two antigens directed against the antibody to be determined of which the first antigen carries at least one marker group and the second antigen is (a) bound to the solid phase or (b) is present in a form capable of binding to the solid phase and the antibody to be determined is detected by determining the marker group in the solid phase or/and in the liquid phase characterized in that at least one of the two antigens contains several epitope regions which react with the antibody to be determined.
摘要翻译： 本发明涉及一种用于免疫测定样品液体中的特异性抗体的方法，其中样品液体在固相存在下与针对待测定的抗体的两种抗原一起孵育，所述抗原决定于第一抗原携带至少一种 标记基团和第二抗原是（a）与固相结合或（b）以能够结合固相的形式存在，并且通过确定固相中的标记基团或/ 并且在液相中，其特征在于，两种抗原中的至少一种包含与要测定的抗体反应的几个表位区域。
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公开(公告)号：US20100136519A1
公开(公告)日：2010-06-03
申请号：US12606586
申请日：2009-10-27
申请人： Ursula-Henrike Wienhues , Cornelia Kruse-Müller , Eva Höss , Elke Faatz , Beatus Ofenloch-Hähnle , Christoph Seidel , Michael Wiedmann
发明人： Ursula-Henrike Wienhues , Cornelia Kruse-Müller , Eva Höss , Elke Faatz , Beatus Ofenloch-Hähnle , Christoph Seidel , Michael Wiedmann
IPC分类号： C12Q1/70 , G01N33/554 , G01N33/567
CPC分类号： C07K14/005 , C12N2740/16122 , C12N2770/24222 , G01N33/533 , G01N33/54306 , G01N33/6878 , G01N33/92 , Y10S435/975 , Y10S436/811
摘要： The invention concerns a process for the immunological determination of a specific antibody in a fluid sample. The process involves incubating the fluid sample in the presence of a solid phase with two antigens directed against the antibody whose presence is to be determined; the first antigen carries at least one marker group, while the second is either (a) bonded to the solid phase or (b) present in a form in which it can bond with the solid phase, and betrays the presence of the antibody being sought by showing the presence of the marker group in the solid phase and/or in the fluid phase. The proposed process is characterised by the fact that at least one of the two antigens has several epitopic regions which react with the antibody to be determined.
摘要翻译： 本发明涉及流体样品中特异性抗体的免疫学测定方法。 该方法包括在固相存在下孵育流体样品，其中两种抗原针对要测定其存在的抗体; 第一个抗原携带至少一个标记基团，而第二个是（a）与固相结合，或（b）以与固相结合的形式存在，并且表示所寻求的抗体的存在 通过在固相和/或流体相中显示标记基团的存在。 所提出的方法的特征在于，两种抗原中的至少一种具有几个与要测定的抗体反应的表位区域。
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7.发明授权Elimination of interference in diagnostic methods by peptides comprising D-amino acids 失效通过包含D-氨基酸的肽消除对诊断方法的干扰
公开(公告)号：US6153393A
公开(公告)日：2000-11-28
申请号：US210040
申请日：1998-12-11
申请人： Christoph Seidel , Helmut Lenz , Johann Karl , Beatus Ofenloch-Hahnle , Ursula Klause , Elke Faatz
发明人： Christoph Seidel , Helmut Lenz , Johann Karl , Beatus Ofenloch-Hahnle , Ursula Klause , Elke Faatz
IPC分类号： G01N33/531 , C07K7/00 , G01N33/53 , G01N33/543 , A61K38/00 , A61K38/04 , C12N15/09
CPC分类号： G01N33/54393 , G01N33/5306 , Y10S435/962
摘要： The invention concerns the use of peptides which are comprised essentially of D-amino acids to eliminate interference in diagnostic methods, a method for eliminating interference in diagnostic methods by peptides which are comprised essentially of D-amino acids as well as a reagent that eliminates interference containing at least one peptide which is comprised essentially of D-amino acids.
摘要翻译： 本发明涉及使用基本上由D-氨基酸组成的肽以消除诊断方法的干扰，用于消除基本上由D-氨基酸组成的肽的诊断方法的干扰的方法以及消除干扰的试剂 含有至少一种基本上由D-氨基酸组成的肽。
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公开(公告)号：US20080187904A1
公开(公告)日：2008-08-07
申请号：US12026740
申请日：2008-02-06
CPC分类号： C07K14/005 , C07F15/0053 , C12N2740/16122 , C12N2770/24222 , G01N33/532 , G01N33/533 , G01N33/54306 , G01N33/6854 , G01N33/6878 , G01N33/743 , G01N33/92 , Y02P20/55 , Y10S435/974 , Y10S435/975 , Y10S436/811 , Y10S436/82 , Y10S530/82
摘要： The invention concerns a process for the production of metal chelate-labelled peptide antigens, peptides obtainable by this process and their use in an immunological method of detection.
摘要翻译： 本发明涉及一种生产金属螯合物标记的肽抗原的方法，可通过该方法获得的肽及其在免疫学检测方法中的应用。
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公开(公告)号：US20090098528A1
公开(公告)日：2009-04-16
申请号：US11974030
申请日：2007-10-11
申请人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutscheck
发明人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutscheck
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222 , G01N33/56983 , G01N33/5767 , Y10S436/82
摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.
摘要翻译： 本发明涉及由免疫学试验中由丙型肝炎病毒的氨基酸1207±10至1488±10和小于20个外来氨基酸组成的多肽，以及该多肽作为抗原的用途。
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公开(公告)号：US6096319A
公开(公告)日：2000-08-01
申请号：US511759
申请日：1995-08-07
申请人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
发明人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
IPC分类号： G01N33/53 , A61K38/00 , A61K39/29 , A61P1/16 , A61P31/12 , A61P31/14 , C07H21/04 , C07K14/02 , C07K14/10 , C07K14/18 , C07K16/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/40 , C12N15/51 , C12P21/02 , C12P21/04 , C12R1/19 , G01N33/532 , G01N33/537 , G01N33/569 , G01N33/576 , G01N33/68 , C12Q1/70
CPC分类号： C07K14/005 , G01N33/56983 , G01N33/5767 , A61K38/00 , C12N2770/24222 , Y10S436/82
摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207.+-.10 to 1488.+-.10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.
摘要翻译： 本发明涉及由丙型肝炎病毒的氨基酸1207 +/- 10〜1488 +/- 10和少于20种外来氨基酸组成的多肽，以及在免疫学试验中使用该多肽作为抗原 。
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