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1.发明授权Structural phosphoprotein (PP150) of human cytomegalovirus, and the preparation and use thereof 失效人巨细胞病毒的结构磷蛋白（PP150）及其制备及应用
公开(公告)号：US5846733A
公开(公告)日：1998-12-08
申请号：US430274
申请日：1995-04-28
申请人： Gerhard Jahn , Birgit-Christine Scholl , Michael Broker , Michael Mach , Bernhard Fleckenstein , Bernd Traupe
发明人： Gerhard Jahn , Birgit-Christine Scholl , Michael Broker , Michael Mach , Bernhard Fleckenstein , Bernd Traupe
IPC分类号： C07K14/00 , A61K39/00 , A61K39/245 , A61P31/12 , C07H21/04 , C07K14/045 , C07K19/00 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/38 , C12P21/02 , C12R1/19 , C12R1/645 , C12R1/91 , C12R1/92 , G01N33/531 , G01N33/569 , G01N33/577 , G01N33/53
CPC分类号： G01N33/56983 , C07K14/005 , A61K39/00 , C12N2710/16122
摘要： The phosphorylated structural protein of molecular weight about 150 kd (pp 150) of human cytomegalovirus (HCMV) is highly immunogenic and is reliably recognised by human antisera. This protein can, after assignment and sequencing of the gene, be prepared, in whole or in immunogenic sections, by gene manipulation. Proteins of this type are suitable as reagents, for example in an ELISA, and as constituents of vaccines.
摘要翻译： 人巨细胞病毒（HCMV）的分子量约150kd（pp150）的磷酸化结构蛋白是高度免疫原性的，并且被人类抗血清可靠地识别。 通过基因操作，可以在整个或免疫原性切片中制备基因的分配和测序后的该蛋白质。 这种类型的蛋白质适合作为试剂，例如在ELISA中，作为疫苗的组分。
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2.发明授权Peptide of the structural phosphoprotein (pp 150) of human cytomegalovirus, and DNA encoding said peptide 失效人巨细胞病毒的结构磷蛋白（第150页）的肽和编码所述肽的DNA
公开(公告)号：US5728578A
公开(公告)日：1998-03-17
申请号：US159710
申请日：1993-12-01
申请人： Gerhard Jahn , Birgit-Christine Scholl , Michael Broker , Michael Mach , Bernhard Fleckenstein , Bernd Traupe
发明人： Gerhard Jahn , Birgit-Christine Scholl , Michael Broker , Michael Mach , Bernhard Fleckenstein , Bernd Traupe
IPC分类号： C07K14/00 , A61K39/00 , A61K39/245 , A61P31/12 , C07H21/04 , C07K14/045 , C07K19/00 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/38 , C12P21/02 , C12R1/19 , C12R1/645 , C12R1/91 , C12R1/92 , G01N33/531 , G01N33/569 , G01N33/577 , C12N15/70
CPC分类号： G01N33/56983 , C07K14/005 , A61K39/00 , C12N2710/16122
摘要： The phosphorylated structural protein of molecular weight about 150 kd (pp 150) of human cytomegalovirus (HCMV) is highly immunogenic and is reliably recognised by human antisera. This protein can, after assignment and sequencing of the gene, be prepared, in whole or in immunogenic sections, by gene manipulation. Proteins of this type are suitable as reagents, for example in an ELISA, and as constituents of vaccines.
摘要翻译： 人巨细胞病毒（HCMV）的分子量约150kd（pp150）的磷酸化结构蛋白是高度免疫原性的，并且被人类抗血清可靠地识别。 通过基因操作，可以在整个或免疫原性切片中制备基因的分配和测序后的该蛋白质。 这种类型的蛋白质适合作为试剂，例如在ELISA中，作为疫苗的组分。
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公开(公告)号：US06218140B1
公开(公告)日：2001-04-17
申请号：US08338213
申请日：1994-11-09
申请人： Bernhard Fleckenstein , Walter Schaffner , Frank Weber , Karoline Dorsch-Häsler , Gerhard Jahn , Michael Boshart
发明人： Bernhard Fleckenstein , Walter Schaffner , Frank Weber , Karoline Dorsch-Häsler , Gerhard Jahn , Michael Boshart
IPC分类号： C12P2100
CPC分类号： C12N15/85 , C12N2800/60
摘要： An enhancer has been located in the upstream region of the major immediate early gene of human cytomegalovirus and has been isolated, which enhancer is more active than that from SV40 and has a wide host cell spectrum. Hence, it is suitable for eukaryotic expression systems wherein it can be incorporated upstream or downstream of the structural gene or of the regulation region.
摘要翻译： 增强子已经位于人巨细胞病毒的主要即时早期基因的上游区域，并且已被分离，其增强剂比来自SV40的活性更强，并且具有广泛的宿主细胞谱。 因此，它适合于其可以结合到结构基因或调节区的上游或下游的真核表达系统。
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公开(公告)号：US5849522A
公开(公告)日：1998-12-15
申请号：US467143
申请日：1995-06-06
申请人： Bernhard Fleckenstein , Walter Schaffner , Frank Weber , Karoline Dorsch-Hasler , Gerhard Jahn , Michael Boshart
发明人： Bernhard Fleckenstein , Walter Schaffner , Frank Weber , Karoline Dorsch-Hasler , Gerhard Jahn , Michael Boshart
CPC分类号： C12N15/85 , C12N2800/60
摘要： An enhancer has been located in the upstream region of the major immediate early gene of human cytomegalovirus and has been isolated, which enhancer is more active than that from SV40 and has a wide host cell spectrum. Hence, it is suitable for eukaryotic expression systems wherein it can be incorporated upstream or downstream of the structural gene or of the regulation region.
摘要翻译： 增强子已经位于人巨细胞病毒的主要即时早期基因的上游区域，并且已被分离，其增强剂比来自SV40的活性更强，并且具有广泛的宿主细胞谱。 因此，它适合于其可以结合到结构基因或调节区的上游或下游的真核表达系统。
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5.发明授权Use of lymphocytes transformed with herpesvirus saimiri in a process for replicating viruses of the HIV type which cause immune deficiency 失效使用疱疹病毒simiri转化的淋巴细胞在复制HIV型病毒的过程中引起免疫缺陷
公开(公告)号：US5656475A
公开(公告)日：1997-08-12
申请号：US208299
申请日：1994-03-10
申请人： Sigrid Nick , Helmut Fickenscher , Brigitte Biesinger-Zwosta , Gerhard Jahn , Bernhard Fleckenstein
发明人： Sigrid Nick , Helmut Fickenscher , Brigitte Biesinger-Zwosta , Gerhard Jahn , Bernhard Fleckenstein
CPC分类号： C12N7/00 , C12N2710/16611
摘要： A process is disclosed for replicating viruses of the HIV type which cause immune deficiency, in which process lymphocytes are employed which have been transformed with herpesvirus saimiri.
摘要翻译： 公开了一种用于复制引起免疫缺陷的HIV型病毒的方法，其中使用已经用疱疹病毒saimiri转化的淋巴细胞。
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公开(公告)号：US07109002B2
公开(公告)日：2006-09-19
申请号：US10828343
申请日：2004-04-21
申请人： Bernhard Fleckenstein , Jens Christian Albrecht , Frank Neipel , Alvin Friedman-Kien , Yao Qi Huang
发明人： Bernhard Fleckenstein , Jens Christian Albrecht , Frank Neipel , Alvin Friedman-Kien , Yao Qi Huang
CPC分类号： C07K14/005 , A61K38/00 , C07K14/5412 , C07K16/085 , C12N2710/16422 , C12N2710/16622 , G01N33/6869
摘要： The present invention relates to viral interleukin-6 (v-IL-6), which can be obtained by recombinant expression of the DNA of human herpesvirus type 8 (HHV-8), and which may be used in diagnosis and treatment of human diseases such as kaposi sarcoma, Castleman's disease, multiple myeloma, kidney cell carcinoma, mesangial proliferative glomerulonephritis or B cell lymphoma.
摘要翻译： 本发明涉及通过重组表达人疱疹病毒8型（HHV-8）的DNA获得的病毒白细胞介素-6（v-IL-6），其可用于人类疾病的诊断和治疗 如卡波西肉瘤，卡斯尔曼氏病，多发性骨髓瘤，肾细胞癌，肾小球膜增生性肾小球性肾炎或B细胞淋巴瘤。
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公开(公告)号：US5989867A
公开(公告)日：1999-11-23
申请号：US934959
申请日：1997-09-22
CPC分类号： C07K14/5428 , A61K39/00
摘要： Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译： 提供了编码哺乳动物细胞因子的纯化基因，与其相关的试剂，包括纯化蛋白质，特异性抗体和编码该分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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8.发明授权Polypeptides encoded by Kaposi sarcoma-associated herpes virus the use thereof in diagnosis and therapy 失效卡波西肉瘤相关疱疹病毒编码的多肽在诊断和治疗中的应用公开(公告)号：US06177080B1
公开(公告)日：2001-01-23
申请号：US09112248
申请日：1998-07-08
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/085 , C12N2710/16222 , C12N2710/16422
摘要： The invention relates to polypeptides of the Kaposi sarcoma-associated herpes virus which have a part-sequence of at least 10 consecutive amino acids from the sequence Met Ser Ser Thr Gln Ile Arg Thr Glu Ile Pro Val Ala Leu Leu Ile Leu Cys Leu Cys Leu Val Ala Cys His Ala Asn Cys Pro Thr Tyr Arg Ser His Leu Gly Phe Trp Gln Glu Gly Trp Ser Gly Gln Val Tyr Gln Asp Trp Leu Gly Arg Met Asn Cys Ser Tyr Glu Asn Met Thr Ala Leu Glu Ala Val Ser Leu Asn Gly Thr Arg Leu Ala Ala Gly Ser Pro Ser Ser Glu Tyr Pro Asn Val Ser Val Ser Val Glu Asp Thr Ser Ala Ser Gly Ser Gly Glu Asp Ala Ile Asp Glu Ser Gly Ser Gly Glu Glu Glu Arg Pro Val Thr Ser His Val Thr Phe Met Thr Gln Ser Val Gln Ala Thr Thr Glu Leu Thr Asp Ala Leu Ile Ser Ala Phe Ser Gly Val Leu His Val Ser Thr Val Ile Pro Arg Asn Trp Val Asn Arg Arg Cys Val Gly Ile Lys Arg Asn Leu Thr Phe Cys Leu Ile Tyr Arg Ile Ile Phe Ile Trp Gly Thr Ile Gln Asp His Ala Asn Ser Arg Ile Thr Gly Arg Arg Lys Arg Gln Lys and to the use thereof in therapy and diagnosis.
摘要翻译： 本发明涉及卡波西肉瘤相关疱疹病毒的多肽，其在序列中具有至少10个连续氨基酸的部分序列，并且在治疗和诊断中的用途。
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9.发明授权Pharmaceutical compositions containing as active substance sulphur-containing carboxylic acids and their use in combating retroviruses 失效含有活性物质的含硫羧酸的药物组合物及其在抗逆转录病毒药物中的应用
公开(公告)号：US5334612A
公开(公告)日：1994-08-02
申请号：US610560
申请日：1990-11-08
IPC分类号： A61K9/08 , A61K9/107 , A61K31/19 , A61K31/20 , A61K31/385 , A61K38/21 , A61P31/12 , A61P31/14 , A61K37/66 , A61K45/02
CPC分类号： A61K31/385 , A61K31/19
摘要： Pharmaceutical compositions containing at least one compound of Formula I, ##STR1## where X is a hydrogen atom or both X's represent a direct link between the two sulphur atoms; Y is hydrogen or C.sub.1 -C.sub.6 alkyl and n represents a number from 1 to 10, or their pharmaceutically acceptable salts including .alpha.-lipoic acid and dihydrolipoic acid. The pharmaceutical compositions are useful for the treatment of diseases caused by retroviruses.
摘要翻译： 含有至少一种式I化合物的药物组合物，其中X是氢原子，或两者都代表两个硫原子之间的直接连接; Y是氢或C 1 -C 6烷基，n表示1至10的数，或其药学上可接受的盐，包括α-硫辛酸和二氢硫辛酸。 药物组合物可用于治疗由逆转录病毒引起的疾病。
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公开(公告)号：US07968696B1
公开(公告)日：2011-06-28
申请号：US09230048
申请日：1996-07-19
申请人： Bernhard Fleckenstein , Jens-Christian Albrecht , Frank Neipel , Alvin Friedman-Kien , Yao-Qi Huang
发明人： Bernhard Fleckenstein , Jens-Christian Albrecht , Frank Neipel , Alvin Friedman-Kien , Yao-Qi Huang
CPC分类号： C07K14/005 , A61K38/00 , C07K14/5412 , C07K16/085 , C12N2710/16422 , C12N2710/16622 , G01N33/6869
摘要： The present invention relates to viral interleukin-6 (v-IL-6), which can be obtained by recombinant expression of the DNA of human herpesvirus type 8 (HHV-8), and which may be used in diagnosis and treatment of human diseases such as kaposi sarcoma, Castleman's disease, multiple myeloma, kidney cell carcinoma, mesangial proliferative glomerulonephritis or B cell lymphoma.
摘要翻译： 本发明涉及通过重组表达人疱疹病毒8型（HHV-8）的DNA获得的病毒白细胞介素-6（v-IL-6），其可用于人类疾病的诊断和治疗 如卡波西肉瘤，卡斯尔曼氏病，多发性骨髓瘤，肾细胞癌，肾小球膜增生性肾小球性肾炎或B细胞淋巴瘤。
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