公开(公告)号：US20060148771A1

公开(公告)日：2006-07-06

申请号：US10544869

申请日：2004-02-12

Applicant: Keith Biggadike ,  Philip Box ,  Diane Coe ,  Duncan Holmes ,  Brian Looker ,  Panayiotis Procopiou

Inventor： Keith Biggadike ,  Philip Box ,  Diane Coe ,  Duncan Holmes ,  Brian Looker ,  Panayiotis Procopiou

IPC: A61K31/58 ,  A61K31/538 ,  A61K31/4704 ,  A61K31/428 ,  A61K31/549 ,  A61K31/405 ,  A61K31/35 ,  A61K31/325 ,  A61K31/225 ,  A61K31/138

CPC classification number: C07D213/65 ,  C07C217/28

Abstract: A compound of formula (I) or a salt, solvate, or physiologically functional derivative thereof, wherein: m is an integer of from 2 to 8; n is an integer of from 2 to 5; with the proviso that m+n is 4 to 10; R4 and R5 are independently selected from hydrogen and C1-4alkyl with the proviso that the total number of carbon atoms in R4 and R5 is not more than 4; R6 and R7 are independently selected from hydrogen and C1-4alkyl with the proviso that the total number of carbon atoms in R6 and R7 is not more than 4, and Ar1 is a group selected from (a), (b), (c) and (d).

Abstract translation: 式（I）化合物或其盐，溶剂合物或生理功能衍生物，其中：m为2至8的整数; n为2〜5的整数， 条件是m + n为4至10; R 4和R 5独立地选自氢和C 1-4 - 烷基，条件是R 3中的碳原子总数 SUP> 4和R 5不超过4; R 6和R 7独立地选自氢和C 1-4 - 烷基，条件是R 1中的碳原子总数 SUP> 6和R 7不超过4，Ar 1是选自（a），（b），（c）和 （d）。

公开(公告)号：US20080003290A1

公开(公告)日：2008-01-03

申请号：US11566346

申请日：2006-12-04

Applicant: Philip Box ,  Diane Coe ,  Brian Looker ,  Inderjit Mann ,  Panayiotis Procopiou

Inventor： Philip Box ,  Diane Coe ,  Brian Looker ,  Inderjit Mann ,  Panayiotis Procopiou

IPC: A61K31/42 ,  A61K9/14 ,  A61M15/00 ,  A61P11/00 ,  C07D413/00

CPC classification number: C07D213/82 ,  C07C217/08 ,  C07C217/76 ,  C07C233/75 ,  C07C237/42 ,  C07C271/38 ,  C07C275/32 ,  C07C275/40 ,  C07C311/08 ,  C07C311/21 ,  C07C311/29 ,  C07C317/14 ,  C07C317/22 ,  C07C2601/02 ,  C07C2601/08 ,  C07D239/54 ,  C07D333/70 ,  C07D513/04

Abstract: The present invention relates to novel compounds of formula (1), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory disease.

Abstract translation: 本发明涉及式（1）的新化合物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其在预防和治疗呼吸系统疾病中的用途。

公开(公告)号：US20050256201A1

公开(公告)日：2005-11-17

申请号：US10512232

申请日：2003-04-24

Applicant: Philip Box ,  Diane Coe ,  Brian Looker ,  Panayiotis Procopiou

Inventor： Philip Box ,  Diane Coe ,  Brian Looker ,  Panayiotis Procopiou

IPC: C07D307/68 ,  A61K31/137 ,  A61K31/166 ,  A61K31/167 ,  A61K31/17 ,  A61K31/18 ,  A61K31/192 ,  A61K31/341 ,  A61K31/455 ,  A61P1/04 ,  A61P9/00 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08 ,  A61P15/06 ,  A61P17/00 ,  A61P17/06 ,  A61P21/00 ,  A61P25/02 ,  A61P25/24 ,  A61P27/16 ,  A61P43/00 ,  C07C217/56 ,  C07C217/60 ,  C07C219/28 ,  C07C233/25 ,  C07C235/42 ,  C07C255/54 ,  C07C275/32 ,  C07C275/40 ,  C07C279/18 ,  C07C307/06 ,  C07C307/10 ,  C07C311/04 ,  C07C311/08 ,  C07C311/29 ,  C07C313/06 ,  C07C317/22 ,  C07D213/82 ,  C07F7/18 ,  A61K31/16 ,  A61K31/138 ,  C07C217/64

CPC classification number: C07C275/32 ,  C07C217/60 ,  C07C233/25 ,  C07C235/42 ,  C07C255/54 ,  C07C279/18 ,  C07C307/10 ,  C07C311/08 ,  C07C311/29 ,  C07C317/22 ,  C07C2601/08 ,  C07C2601/14

Abstract: The present invention relates to novel compounds of formula (I), or a salt, solvate, or physiologically functional derivative thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

Abstract translation: 本发明涉及新的式（I）化合物或其盐，溶剂合物或生理功能衍生物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其用于 预防和治疗呼吸系统疾病。

公开(公告)号：US20050075394A1

公开(公告)日：2005-04-07

申请号：US10489569

申请日：2002-09-11

Applicant: Philip Box ,  Diane Coe ,  Brian Looker ,  Inderjit Mann ,  Panayiotis Procopiou

Inventor： Philip Box ,  Diane Coe ,  Brian Looker ,  Inderjit Mann ,  Panayiotis Procopiou

IPC: C07D213/56 ,  A61K31/17 ,  A61K31/18 ,  A61K31/222 ,  A61K31/44 ,  A61K31/455 ,  A61K45/00 ,  A61P1/04 ,  A61P9/04 ,  A61P11/00 ,  A61P11/06 ,  A61P15/00 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P21/00 ,  A61P25/24 ,  A61P37/08 ,  A61P43/00 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08 ,  C07C217/76 ,  C07C233/75 ,  C07C237/42 ,  C07C271/38 ,  C07C275/32 ,  C07C275/40 ,  C07C311/08 ,  C07C311/21 ,  C07C311/29 ,  C07C317/14 ,  C07C317/22 ,  C07D213/82 ,  C07D239/54 ,  C07D333/70 ,  C07D413/12 ,  C07D513/04 ,  A61K31/325 ,  A61K31/195

CPC classification number: C07D213/82 ,  C07C217/08 ,  C07C217/76 ,  C07C233/75 ,  C07C237/42 ,  C07C271/38 ,  C07C275/32 ,  C07C275/40 ,  C07C311/08 ,  C07C311/21 ,  C07C311/29 ,  C07C317/14 ,  C07C317/22 ,  C07C2601/02 ,  C07C2601/08 ,  C07D239/54 ,  C07D333/70 ,  C07D513/04

Abstract: The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

公开(公告)号：US5069902A

公开(公告)日：1991-12-03

申请号：US195600

申请日：1988-05-18

Applicant: Jane K. A. Cook ,  Christine A. Dolby ,  Albert P. A. Mockett ,  Matthew M. Binns ,  Judith A. Frazier ,  Philip Box

Inventor： Jane K. A. Cook ,  Christine A. Dolby ,  Albert P. A. Mockett ,  Matthew M. Binns ,  Judith A. Frazier ,  Philip Box

IPC: A61K39/12 ,  A61K39/155 ,  C12N7/04

CPC classification number: A61K39/155 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/543 ,  A61K2039/544 ,  A61K2039/552 ,  C12N2760/18334 ,  Y10S424/816

Abstract: A virus and a vaccine therefrom for use against diseases in fowl caused by turkey rhinotracheitis or serologically related strains. The virus is an attenuated strain of the virus of contagious turkey rhinotracheitis. Turkeys may be vaccinated to stop them getting turkey rhinotracheitis, and chickens may be vaccinated to stop them getting swollen head syndrome.