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公开(公告)号：US08268258B2
公开(公告)日：2012-09-18
申请号：US12362703
申请日：2009-01-30
IPC分类号： G01N33/48
CPC分类号： G01N33/48778 , A61B5/150022 , A61B5/150305 , A61B5/150419 , B01L3/5027 , B01L9/527 , B01L2300/0825 , B01L2300/161 , B01L2400/0406
摘要： A package for an object having a hydrophilic surface includes at least one of a loose cover for the hydrophilic surface and an adsorbing surface, the affinity of which for apolar gases is equal to or greater than that of the hydrophilic surface.
摘要翻译： 用于具有亲水表面的物体的包装包括用于亲水表面的疏松盖和吸附表面中的至少一个，其对非极性气体的亲和力等于或大于亲水表面的亲和力。
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公开(公告)号：US20080199371A1
公开(公告)日：2008-08-21
申请号：US11667204
申请日：2004-11-12
IPC分类号： B01J10/00
CPC分类号： B01L3/502776 , B01J19/0046 , B01J2219/00286 , B01J2219/00432 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/502707 , B01L2200/0636 , B01L2300/0636 , B01L2300/0816 , B01L2400/0487 , B82Y30/00 , Y10T156/10
摘要： A microfluidic device and its use for the production of micro-arrays, in particular for the detection of protein interactions, is described. Said microfluidic device comprises a flow cell part (1) and a chip part (2) together forming at least two crossing, preferably perpendicular, closed channels (3, 4), said flow cell part forming open channels providing the bottom wall and at least part of the side walls, in particular three walls of said closed channels (3, 4), said closed channels (3, 4) being connected to at least three fluid providing means for generating at least three fluid flows (7) and said closed channels (3, 4) being designed and dimensioned such that the flow of at least three aqueous fluids streaming through each of said channels (3, 4) is laminar at least until after said crossing of said channels (6), said chip part (2) forming the top wall and optionally part of said side walls, in particular the fourth wall, of said closed channels (3, 4) and having a surface that is activatable by reaction with an activating molecule.
摘要翻译： 描述了微流体装置及其用于生产微阵列的用途，特别是用于蛋白质相互作用的检测。 所述微流体装置包括流动池部分（1）和芯片部分（2），一起形成至少两个交叉的，优选垂直的封闭通道（3,4），所述流动池部分形成开放通道，提供底壁并且至少 侧壁的一部分，特别是所述封闭通道（3,4）的三个壁，所述封闭通道（3,4）连接至少三个流体供应装置，用于产生至少三个流体流（7）和所述封闭通道 通道（3,4）的设计和尺寸使得流过每个所述通道（3,4）的至少三种含水流体的流动至少在所述通道（6），所述芯片部分 2）形成所述封闭通道（3,4）的顶壁和任选部分所述侧壁，特别是第四壁，并具有可通过与活化分子反应而激活的表面。
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公开(公告)号：US20130004964A1
公开(公告)日：2013-01-03
申请号：US13410336
申请日：2012-03-02
CPC分类号： G01N33/54366 , B01L3/502753 , B01L2200/0631 , B01L2300/0806 , B01L2300/087 , B01L2300/0887 , B01L2400/0409 , G01N35/00069
摘要： Method and system for carrying out heterogeneous chemical or biological reactions are disclosed. The method comprising providing an analytical device having at least one liquid processing unit having at least one reaction chamber and a first inlet channel in fluid communication with the reaction chamber. The method further comprises supplying to the reaction chamber via the first inlet channel or a second inlet channel analyte capturing particles, supplying to the reaction chamber via the first inlet channel or the second inlet channel a liquid sample containing an analyte of interest, and confining by an equilibrium of forces the analyte capturing particles in a particle rearrangement zone within the reaction chamber. The forces comprise a drag force Fd generated by flowing liquids and a counter-oriented force Fg. The method also comprises capturing analytes present in the liquid sample with the particles in the particle rearrangement zone.
摘要翻译： 公开了进行异质化学或生物反应的方法和系统。 该方法包括提供具有至少一个液体处理单元的分析装置，所述液体处理单元具有至少一个反应室和与反应室流体连通的第一入口通道。 该方法还包括经由第一入口通道或第二入口通道分析物捕获颗粒向反应室供应，经由第一入口通道或第二入口通道向反应室供应含有感兴趣分析物的液体样品，并通过 分析物捕获颗粒在反应室内的颗粒重排区中的力的平衡。 力包括通过流动液体产生的牵引力Fd和反向取向力Fg。 该方法还包括用颗粒重排区中的颗粒捕获存在于液体样品中的分析物。
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公开(公告)号：US09151750B2
公开(公告)日：2015-10-06
申请号：US13410336
申请日：2012-03-02
IPC分类号： B01L3/00 , G01N33/543 , G01N35/00
CPC分类号： G01N33/54366 , B01L3/502753 , B01L2200/0631 , B01L2300/0806 , B01L2300/087 , B01L2300/0887 , B01L2400/0409 , G01N35/00069
摘要： Method and system for carrying out heterogeneous chemical or biological reactions are disclosed. The method comprising providing an analytical device having at least one liquid processing unit having at least one reaction chamber and a first inlet channel in fluid communication with the reaction chamber. The method further comprises supplying to the reaction chamber via the first inlet channel or a second inlet channel analyte capturing particles, supplying to the reaction chamber via the first inlet channel or the second inlet channel a liquid sample containing an analyte of interest, and confining by an equilibrium of forces the analyte capturing particles in a particle rearrangement zone within the reaction chamber. The forces comprise a drag force Fd generated by flowing liquids and a counter-oriented force Fg. The method also comprises capturing analytes present in the liquid sample with the particles in the particle rearrangement zone.
摘要翻译： 公开了进行异质化学或生物反应的方法和系统。 该方法包括提供具有至少一个液体处理单元的分析装置，所述液体处理单元具有至少一个反应室和与反应室流体连通的第一入口通道。 该方法还包括通过第一入口通道或第二入口通道分析物捕获颗粒向反应室供应，经由第一入口通道或第二入口通道向反应室供应含有感兴趣分析物的液体样品，并通过 分析物捕获颗粒在反应室内的颗粒重排区中的力的平衡。 力包括通过流动液体产生的牵引力Fd和反向取向力Fg。 该方法还包括用颗粒重排区中的颗粒捕获存在于液体样品中的分析物。
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公开(公告)号：US08567602B2
公开(公告)日：2013-10-29
申请号：US12396932
申请日：2009-03-03
IPC分类号： B65D83/10
CPC分类号： A61M5/002 , A61B5/1411 , A61B5/150022 , A61B5/150305 , A61B50/3001 , B65B55/12
摘要： A plastic package for hydrophilic articles, in particular for hydrophilically coated medical instruments, is intended to ensure the hydrophilic nature of the enclosed instrument over a long period of time. The package comprises at least one receiving compartment with a medical instrument for insertion into body tissue and is characterized in that, after sterilization by radiation, it has a proportion of volatile constituents of ≦0.1 μg/cm2.
摘要翻译： 用于亲水制品的塑料包装，特别是用于亲水涂覆的医疗器械，旨在长期保证封闭器具的亲水性。 该包装包括至少一个具有用于插入身体组织的医疗器械的容纳室，其特征在于，在通过辐射灭菌之后，其具有@ 0.1mug / cm 2的挥发性组分的比例。
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6.发明申请公开(公告)号：US20110124128A1
公开(公告)日：2011-05-26
申请号：US12781473
申请日：2010-05-17
CPC分类号： G01N33/54326 , B01L3/502761 , B01L2200/0668 , B01L2300/0803 , B01L2400/0409 , B01L2400/043
摘要： Centrifugal force based microfluidic systems for the automated analysis of fluids involving the use of magnetically responsive particles and methods thereof are disclosed. A magnet is fixed to a supporting device of the system in correspondence to a retention zone of the system so as to rotate therewith and to generate a magnetic field which magnetically manipulates the magnetically responsive particles contained in a reaction chamber of the system.
摘要翻译： 公开了用于自动分析涉及使用磁响应颗粒的流体的基于离心力的微流体系统及其方法。 磁体被固定到系统的支撑装置上，与系统的保持区相对应，以便与其一起转动，并产生一个磁场，该磁场对包含在该系统的反应室中的磁响应颗粒进行磁操作。
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公开(公告)号：US20100044260A1
公开(公告)日：2010-02-25
申请号：US12396932
申请日：2009-03-03
IPC分类号： A61B19/02
CPC分类号： A61M5/002 , A61B5/1411 , A61B5/150022 , A61B5/150305 , A61B50/3001 , B65B55/12
摘要： The invention relates to a plastic package for hydrophilic articles, in particular for hydrophilically coated medical instruments, which package is intended to ensure the hydrophilic nature of the enclosed instrument over a long period of time. The package comprises at least one receiving compartment with a medical instrument for insertion into body tissue and is characterized in that, after sterilization by radiation, it has a proportion of volatile constituents of ≦0.1 μg/cm2.
摘要翻译： 本发明涉及用于亲水制品的塑料包装，特别是用于亲水涂覆的医疗器械，该包装旨在确保长时间封闭器具的亲水性。 该包装包括至少一个具有用于插入身体组织的医疗器械的容纳室，其特征在于，在通过辐射灭菌之后，其具有一定百分比的挥发性组分＆nlE;0.1μg/ cm 2。
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公开(公告)号：US20090198119A1
公开(公告)日：2009-08-06
申请号：US12362703
申请日：2009-01-30
CPC分类号： G01N33/48778 , A61B5/150022 , A61B5/150305 , A61B5/150419 , B01L3/5027 , B01L9/527 , B01L2300/0825 , B01L2300/161 , B01L2400/0406
摘要： A package for an object having a hydrophilic surface includes at least one of a loose cover for the hydrophilic surface and an adsorbing surface, the affinity of which for apolar gases is equal to or greater than that of the hydrophilic surface.
摘要翻译： 用于具有亲水表面的物体的包装包括用于亲水表面的疏松盖和吸附表面中的至少一个，其对非极性气体的亲和力等于或大于亲水表面的亲和力。
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9.发明授权Centrifugal force based microfluidic system and method for the automated analysis of samples 有权基于离心力的微流体系统和样品自动分析方法公开(公告)号：US09442109B2
公开(公告)日：2016-09-13
申请号：US12781473
申请日：2010-05-17
IPC分类号： C12M1/00 , G01N33/543 , B01L3/00
CPC分类号： G01N33/54326 , B01L3/502761 , B01L2200/0668 , B01L2300/0803 , B01L2400/0409 , B01L2400/043
摘要： Centrifugal force based microfluidic systems for the automated analysis of fluids involving the use of magnetically responsive particles and methods thereof are disclosed. A magnet is fixed to a supporting device of the system in correspondence to a retention zone of the system so as to rotate therewith and to generate a magnetic field which magnetically manipulates the magnetically responsive particles contained in a reaction chamber of the system.
摘要翻译： 公开了用于自动分析涉及使用磁响应颗粒的流体的基于离心力的微流体系统及其方法。 磁体被固定到系统的支撑装置上，与系统的保持区相对应，以便与其一起转动，并产生一个磁场，该磁场对包含在该系统的反应室中的磁响应颗粒进行磁操作。
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公开(公告)号：US20090093735A1
公开(公告)日：2009-04-09
申请号：US12240341
申请日：2008-09-29
CPC分类号： A61B5/14532 , A61B5/150022 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/1519 , A61B5/157 , B01L3/5023 , B01L3/502738 , B01L2200/027 , B01L2300/0825 , B01L2300/0838 , B01L2400/0406 , B01L2400/0633 , Y10T436/2575
摘要： The test unit for analyzing body fluids such as blood comprises a collecting element which has a microfluidic collecting area for the body fluid, and a test element which can be brought into fluidic connection with the collecting area by deflecting a transfer part of the collecting element in order to transfer body fluid. The transfer part is pre-tensioned against a holding-down device and the deflection of the transfer part towards the test element can be triggered by releasing the holding-down device.
摘要翻译： 用于分析体液如血液的测试单元包括具有用于体液的微流体收集区域的收集元件，以及可以通过使收集元件的转移部分偏转而与收集区域流体连接的测试元件 命令转移体液。 转印部件被压靠在压紧装置上，并且转印部件朝向测试元件的偏转可以通过释放压紧装置来触发。
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