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公开(公告)号：US09439935B2
公开(公告)日：2016-09-13
申请号：US14163058
申请日：2014-01-24
Inventor： Brian H. Bird , Cesar G. Albarino , Stuart T. Nichol , Thomas G. Ksiazek
CPC classification number: A61K39/12 , A61K35/76 , A61K39/00 , A61K2039/525 , A61K2039/5254 , C12N7/00 , C12N2760/12211 , C12N2760/12221 , C12N2760/12234 , Y02A50/397
Abstract: Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of RVF virus in livestock and humans. As described herein, the recombinant RVF viruses grow to high titers, provide protective immunity following a single injection and allow for the differentiation between vaccinated animals and animals infected with wild-type RVF virus.
Abstract translation: 本文描述的是重组RVF病毒，其包含一个或多个病毒毒力基因如NS和NSm中的缺失。 使用基于质粒的反向遗传学系统产生的重组RVF病毒可用作疫苗以预防家畜和人类中RVF病毒的感染。 如本文所述，重组RVF病毒生长到高滴度，在单次注射后提供保护性免疫，并允许在接种动物和用野生型RVF病毒感染的动物之间进行分化。
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公开(公告)号：US09115408B2
公开(公告)日：2015-08-25
申请号：US13871098
申请日：2013-04-26
Applicant: Centers for Disease Control and Prevention
Inventor： Patricia Fields , John R. McQuiston , Collette Fitzgerald Leaumont
IPC: C12Q1/68
CPC classification number: C12Q1/689 , C12Q2600/16 , G01N2333/255 , Y02A50/451
Abstract: Processes for the serotype specific detection and identification of one or more Salmonella serotypes are provided. A family of specific primers and probes are provided that allow screening of biological or environmental samples for robust, rapid, and reproducible detection and identification of one or more Salmonella serotypes in the sample.
Abstract translation: 提供了血清型特异性检测和鉴定一种或多种沙门氏菌血清型的方法。 提供了一系列特异性引物和探针，其允许筛选生物或环境样品以在样品中检测和鉴定一种或多种沙门氏菌血清型。
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公开(公告)号：US09091597B2
公开(公告)日：2015-07-28
申请号：US13804512
申请日：2013-03-14
Applicant: Centers for Disease Control and Prevention
Inventor： Pramod Kulkarni , Philip Efthimion
CPC classification number: G01J3/443 , G01N15/0656 , G01N21/67 , G01N21/718
Abstract: Particles of a flow of aerosol are collected and analyzed by passing them through a housing having an inlet area, an outlet area, and a collection and analysis area. A collection electrode has a tip disposed in the flow path in the collection and analysis area. Particles are collected on the tip of the collection electrode. A microwave pulse is applied to the collection and analysis area such that a plasma is created. Atomic emissions produced during at least part of the microwave step are collected for analysis of the ablated particles.
Abstract translation: 通过将它们通过具有入口区域，出口区域和收集和分析区域的壳体来收集和分析气溶胶流的颗粒。 收集电极具有设置在收集和分析区域中的流路中的尖端。 将颗粒收集在收集电极的尖端上。 将微波脉冲施加到收集和分析区域，使得产生等离子体。 收集至少部分微波步骤期间产生的原子辐射用于分析烧蚀颗粒。
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公开(公告)号：US20130321804A1
公开(公告)日：2013-12-05
申请号：US13804512
申请日：2013-03-14
Applicant: CENTERS FOR DISEASE CONTROL AND PREVENTION
Inventor： Pramod Kulkarni , Philip Efthimion
IPC: G01J3/443
CPC classification number: G01J3/443 , G01N15/0656 , G01N21/67 , G01N21/718
Abstract: Particles of a flow of aerosol are collected and analyzed by passing them through a housing having an inlet area, an outlet area, and a collection and analysis area. A collection electrode has a tip disposed in the flow path in the collection and analysis area. Particles are collected on the tip of the collection electrode. A microwave pulse is applied to the collection and analysis area such that a plasma is created. Atomic emissions produced during at least part of the microwave step are collected for analysis of the ablated particles.
Abstract translation: 通过将它们通过具有入口区域，出口区域和收集和分析区域的壳体来收集和分析气溶胶流的颗粒。 收集电极具有设置在收集和分析区域中的流路中的尖端。 将颗粒收集在收集电极的尖端上。 将微波脉冲施加到收集和分析区域，使得产生等离子体。 收集至少部分微波步骤期间产生的原子辐射用于分析烧蚀颗粒。
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公开(公告)号：US20040228208A1
公开(公告)日：2004-11-18
申请号：US10874780
申请日：2004-06-22
Applicant: The Government of the United States of America, , The Department of Health and Human Services, Centers for Disease Control and Prevention
Inventor： Mark James Papania , James J. Barry , Mark C. Bagley
IPC: B01F007/00 , B01F013/00
CPC classification number: B65D51/2885 , B65D51/2814 , B65D51/2878
Abstract: A mixing vial for storing and mixing first and second components includes a mixing container for holding one of the components, and a supplemental container received within the mixing container for holding the other of the components separated from the first component. Manually operable release mechanism is actuatable to produce opening of the supplemental container within the mixing container to permit mixing of the previously segregated components to form a combined mixture in the mixing container.
Abstract translation: 用于存储和混合第一和第二部件的混合小瓶包括用于保持其中一个部件的混合容器和容纳在混合容器内的补充容器，用于保持与第一部件分离的其它部件。 可手动操作的释放机构可致动以在混合容器内产生补充容器的开口，以允许先前分离的部件混合以在混合容器中形成混合的混合物。
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Patent Agency Ranking
公开(公告)号：US10258686B2
公开(公告)日：2019-04-16
申请号：US15888715
申请日：2018-02-05
Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , CORNELL RESEARCH FOUNDATION, INC. , The United States of America as respresented by The Secretary of The Department of Health and Human Services, Centers for Disease Control and Prevention
Inventor： Patti Cynthia Crawford , Paul J. Gibbs , Edward J. Dubovi , Ruben Omar Donis , Jacqueline Katz , Alexander I. Klimov , Nallakannu P. Lakshmanan , Melissa Anne Lum , Daniel Ghislena Emiel Goovaerts , Mark William Mellencamp , Nancy J. Cox , William L. Castleman
IPC: A61K39/145 , C07K14/005 , C12N7/00 , A61K39/12 , C07K16/10 , C12Q1/70 , G01N33/569 , C12N15/86 , A61K39/00
Abstract: The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the present invention. The subject invention also pertains to compositions and methods for identifying a virus of the invention and diagnosing infection of an animal with a virus of the invention.
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公开(公告)号：US09879232B2
公开(公告)日：2018-01-30
申请号：US14883757
申请日：2015-10-15
Inventor： Sang Gu Yeo , Ho Sun Son , June Woo Lee , Seung Bin Cha , Sun Hwa Lee , Kwi Sung Park , Sang Won Lee
CPC classification number: C12N7/00 , A61K39/12 , A61K2039/5254 , C12N2710/24121 , C12N2710/24134 , C12N2710/24164
Abstract: The attenuated vaccinia virus strain KVAC103 was obtained by subculturing a vaccinia virus strain 103 times in VERO cells. The attenuated vaccinia virus strain KVAC103 has significantly low toxicity, shows reduced skin lesions, and, at the same time, induces effectively immune responses to poxvirus. Thus, it can be used as a poxvirus vaccine while causing less side effects.
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8.发明授权Primers and probes for detection and discrimination of types and subtypes of influenza viruses 有权用于检测和鉴别流感病毒类型和亚型的引物和探针公开(公告)号：US09382592B2
公开(公告)日：2016-07-05
申请号：US14056810
申请日：2013-10-17
Inventor： Stephen Lindstrom , Alexander Klimov , Nancy Cox , Lamorris Loftin
CPC classification number: C12Q1/701 , C12Q1/6837
Abstract: Methods of detecting influenza, including differentiating between type and subtype are disclosed, for example to detect, type, and/or subtype an influenza infection. A sample suspected of containing a nucleic acid of an influenza virus, is screened for the presence or absence of that nucleic acid. The presence of the influenza virus nucleic acid indicates the presence of influenza virus. Determining whether the influenza virus nucleic acid is present in the sample can be accomplished by detecting hybridization between an influenza specific probe, influenza type specific probe, and/or subtype specific probe and an influenza nucleic acid. Probes and primers for the detection, typing and/or subtyping of influenza virus are also disclosed. Kits and arrays that contain the disclosed probes and/or primers also are disclosed.
Abstract translation: 公开了检测流感的方法，包括区分类型和亚型，例如检测，分型和/或亚型流感感染。 怀疑含有流感病毒核酸的样品被筛选出存在或不存在该核酸。 流感病毒核酸的存在表明存在流感病毒。 确定流感病毒核酸是否存在于样品中可以通过检测流感特异性探针，流感型特异性探针和/或亚型特异性探针与流感核酸之间的杂交来实现。 还公开了用于流感病毒的检测，分型和/或亚型分析的探针和引物。 还公开了包含公开的探针和/或引物的试剂盒和阵列。
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公开(公告)号：US20150031857A1
公开(公告)日：2015-01-29
申请号：US14450529
申请日：2014-08-04
Applicant: Sanofi Pasteur , Centers for Disease Control and Prevention
Inventor： Richard KINNEY , Claire Y.H. Kinney , Veronique Barban , Jean Lang , Bruno Guy
IPC: C07K14/005 , A61K39/12 , C12N7/00
CPC classification number: C07K14/005 , A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24164 , Y02A50/386
Abstract: The invention relates to live attenuated VDV2 (VERO-Derived Vaccine Dengue serotype 2) strains which have been derived from the wild-type dengue-2 strain 16681 by passaging on PDK and Vero cells and nucleic acids thereof. The invention further relates to a vaccine composition which comprises a VDV2 strain.
Abstract translation: 本发明涉及通过传代PDK和Vero细胞及其核酸而衍生自野生型登革热-2菌株16681的活减毒VDV2（VERO-衍生疫苗登革热血清型2）菌株。 本发明还涉及包含VDV2菌株的疫苗组合物。
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公开(公告)号：US08778619B2
公开(公告)日：2014-07-15
申请号：US14079634
申请日：2013-11-13
Applicant: The United States of America as Represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention , Arlington Scientific, Inc.
Inventor： Arnold R. Castro , Himanshu Champaklal Mody
IPC: G01N33/53 , G01N33/554 , G01N33/567
CPC classification number: G01N33/571 , G01N33/54386 , G01N33/564 , G01N33/56911 , G01N33/92 , G01N2333/20 , G01N2469/20
Abstract: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may be conjugated with a variety of attachment molecules, such as BSA, KLH, biotin, synthetic protein MAPS, IgY, streptavidin, or avidin, are described. Such oxidized cardiolipin, alone or complexed with one or more attachment molecules, are useful to detect anti-lipoidal antibodies (such as IgG and IgM antibodies) in subjects, for example, when used in ELISA plates. ELISA plates are described that permit the detection of anti-lipoidal antibodies and that permit the co-detection of nontreponemal and treponemal antibodies in biological samples.
Abstract translation: 描述了用于检测抗脂质体抗体的组合物，方法和装置以及疾病的诊断，例如梅毒。 特别地，描述了可以与各种附着分子缀合的氧化的心磷脂，例如BSA，KLH，生物素，合成蛋白MAPS，IgY，链霉亲和素或抗生物素蛋白。 这种氧化的心磷脂单独或与一个或多个附着分子复合可用于检测受试者中的抗脂质体抗体（例如IgG和IgM抗体），例如当用于ELISA板时。 描述了允许检测抗脂质体抗体并且允许在生物样品中共同检测非延髓和螺旋体抗体的ELISA板。
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