公开(公告)号：US20240254559A1

公开(公告)日：2024-08-01

申请号：US18396565

申请日：2023-12-26

申请人： Caris MPI, Inc.

发明人： David Spetzler ,  Nianqing Xiao

IPC分类号： C12Q1/6886 ,  C12Q1/6827 ,  G16B20/10 ,  G16B20/20 ,  G16B30/00 ,  G16B30/10 ,  G16H10/40 ,  G16H20/10 ,  G16H50/20

CPC分类号： C12Q1/6886 ,  C12Q1/6827 ,  G16H10/40 ,  G16H20/10 ,  G16H50/20 ,  C12Q2600/156 ,  G16B20/10 ,  G16B20/20 ,  G16B30/00 ,  G16B30/10

摘要： Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for the disease, such as treatments that provide potential benefit or potential lack of benefit for the disease. Molecular profiling can include biomarkers for immune checkpoint therapy, including microsatellite instability, tumor mutational burden, mismatch repair, and expression of checkpoint proteins such as PD-L1.

公开(公告)号：US20230178245A1

公开(公告)日：2023-06-08

申请号：US17922344

申请日：2021-04-30

申请人： Caris MPI, Inc.

发明人： Jim Abraham ,  David Spetzler

IPC分类号： G16H50/30 ,  G16B25/10 ,  G16B40/20

CPC分类号： G16H50/30 ,  G16B25/10 ,  G16B40/20 ,  C12Q1/6886

摘要： Comprehensive molecular profiling provides a wealth of data concerning the molecular status of patient samples. Such data can be compared to patient response to treatments to identify biomarker signatures that predict response or non-response to such treatments. This approach has been applied to identify biomarker signatures that predict cancer patient benefit from immunotherapy such as checkpoint inhibitor therapy.

公开(公告)号：US20200319191A1

公开(公告)日：2020-10-08

申请号：US16675488

申请日：2019-11-06

申请人： Caris MPI, Inc.

发明人： David Spetzler ,  Brian Abbott ,  Philip Ellis ,  Sandeep Reddy

IPC分类号： G01N33/574 ,  G16B20/00 ,  C12Q1/6886 ,  A61K31/335

摘要： Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for the disease, such as treatments that provide likely benefit or likely lack of benefit for the disease.

公开(公告)号：US20200299774A1

公开(公告)日：2020-09-24

申请号：US16597061

申请日：2019-10-09

申请人： Caris MPI, Inc.

发明人： Gargi BASU ,  David ARGUELLO ,  Rebecca FELDMAN ,  Xinan XIU ,  Zoran GATALICA

IPC分类号： C12Q1/6886 ,  G16B25/00 ,  G16B40/00 ,  G01N33/574 ,  C12Q1/6869 ,  G16H50/20

摘要： Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments that have likely benefit for a cancer, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. The molecular profiling can be used to identify likely have lack of benefit for treating the cancer.

公开(公告)号：US20160304972A1

公开(公告)日：2016-10-20

申请号：US15192792

申请日：2016-06-24

申请人： Caris MPI, Inc.

发明人： Daniel D. Von Hoff ,  David M. Loesch ,  Arlet Alarcon ,  Robert J. Penny ,  Alan Wright ,  Matthew J. McGinniss ,  Ryan P. Bender ,  Traci Pawlowski

IPC分类号： C12Q1/68 ,  G06F19/28 ,  G06F19/22

CPC分类号： G01N35/00029 ,  B01L7/52 ,  C12Q1/6841 ,  C12Q1/6874 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  C40B60/12 ,  G01N33/54366 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/5743 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57442 ,  G01N33/57449 ,  G01N33/57484 ,  G01N35/00871 ,  G01N2035/00138 ,  G01N2035/00158 ,  G01N2035/00326 ,  G01N2035/00346 ,  G01N2035/00366 ,  G01N2035/00881 ,  G01N2035/0091 ,  G01N2333/47 ,  G01N2333/9029 ,  G01N2333/91205 ,  G01N2333/99 ,  G01N2500/04 ,  G01N2800/52 ,  G06F19/34 ,  G06F19/3418 ,  G06F19/3456 ,  G16B20/00 ,  G16B25/00 ,  G16B30/00 ,  G16B35/00 ,  G16B40/00 ,  G16B45/00 ,  G16B50/00 ,  G16B99/00 ,  G16C20/60 ,  G16H10/20 ,  G16H15/00 ,  G16H40/63 ,  G16H50/20 ,  Y02A90/26

摘要： Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.

公开(公告)号：US20160232286A1

公开(公告)日：2016-08-11

申请号：US15099466

申请日：2016-04-14

申请人： Caris MPI, Inc.

发明人： Daniel D. Von Hoff ,  David M. Loesch ,  Arlet Alarcon ,  Robert J. Penny ,  Alan Wright ,  Matthew J. McGinniss ,  Ryan P. Bender ,  Traci Pawlowski

IPC分类号： G06F19/20 ,  G01N33/574 ,  C12Q1/68

CPC分类号： G01N35/00029 ,  B01L7/52 ,  C12Q1/6841 ,  C12Q1/6874 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  C40B60/12 ,  G01N33/54366 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/5743 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57442 ,  G01N33/57449 ,  G01N33/57484 ,  G01N35/00871 ,  G01N2035/00138 ,  G01N2035/00158 ,  G01N2035/00326 ,  G01N2035/00346 ,  G01N2035/00366 ,  G01N2035/00881 ,  G01N2035/0091 ,  G01N2333/47 ,  G01N2333/9029 ,  G01N2333/91205 ,  G01N2333/99 ,  G01N2500/04 ,  G01N2800/52 ,  G06F19/34 ,  G06F19/3418 ,  G06F19/3456 ,  G16B20/00 ,  G16B25/00 ,  G16B30/00 ,  G16B35/00 ,  G16B40/00 ,  G16B45/00 ,  G16B50/00 ,  G16B99/00 ,  G16C20/60 ,  G16H10/20 ,  G16H15/00 ,  G16H40/63 ,  G16H50/20 ,  Y02A90/26

摘要： Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.

公开(公告)号：US20160224729A1

公开(公告)日：2016-08-04

申请号：US15094470

申请日：2016-04-08

申请人： Caris MPI, Inc.

发明人： Daniel D. Von Hoff ,  David M. Loesch ,  Arlet Alarcon ,  Robert J. Penny ,  Alan Wright ,  Matthew J. McGinniss ,  Ryan P. Bender ,  Traci Pawlowski

IPC分类号： G06F19/20 ,  C12Q1/68 ,  G06F19/00 ,  G01N33/574

CPC分类号： G01N35/00029 ,  B01L7/52 ,  C12Q1/6841 ,  C12Q1/6874 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  C40B60/12 ,  G01N33/54366 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/5743 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57442 ,  G01N33/57449 ,  G01N33/57484 ,  G01N35/00871 ,  G01N2035/00138 ,  G01N2035/00158 ,  G01N2035/00326 ,  G01N2035/00346 ,  G01N2035/00366 ,  G01N2035/00881 ,  G01N2035/0091 ,  G01N2333/47 ,  G01N2333/9029 ,  G01N2333/91205 ,  G01N2333/99 ,  G01N2500/04 ,  G01N2800/52 ,  G06F19/34 ,  G06F19/3418 ,  G06F19/3456 ,  G16B20/00 ,  G16B25/00 ,  G16B30/00 ,  G16B35/00 ,  G16B40/00 ,  G16B45/00 ,  G16B50/00 ,  G16B99/00 ,  G16C20/60 ,  G16H10/20 ,  G16H15/00 ,  G16H40/63 ,  G16H50/20 ,  Y02A90/26

摘要： Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.

公开(公告)号：US20150080268A1

公开(公告)日：2015-03-19

申请号：US14551345

申请日：2014-11-24

申请人： Caris MPI, Inc.

发明人： Daniel D. Von Hoff ,  David M. Loesch ,  Arlet Alarcon ,  Robert J. Penny ,  Alan Wright ,  Matthew J. McGinniss ,  Ryan P. Bender ,  Traci Pawlowski

IPC分类号： G06F19/18 ,  G01N33/574 ,  G06F19/00 ,  C12Q1/68 ,  C40B30/02 ,  G06F19/24

CPC分类号： G01N35/00029 ,  B01L7/52 ,  C12Q1/6841 ,  C12Q1/6874 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  C40B60/12 ,  G01N33/54366 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/5743 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57442 ,  G01N33/57449 ,  G01N33/57484 ,  G01N35/00871 ,  G01N2035/00138 ,  G01N2035/00158 ,  G01N2035/00326 ,  G01N2035/00346 ,  G01N2035/00366 ,  G01N2035/00881 ,  G01N2035/0091 ,  G01N2333/47 ,  G01N2333/9029 ,  G01N2333/91205 ,  G01N2333/99 ,  G01N2500/04 ,  G01N2800/52 ,  G06F19/34 ,  G06F19/3418 ,  G06F19/3456 ,  G16B20/00 ,  G16B25/00 ,  G16B30/00 ,  G16B35/00 ,  G16B40/00 ,  G16B45/00 ,  G16B50/00 ,  G16B99/00 ,  G16C20/60 ,  G16H10/20 ,  G16H15/00 ,  G16H40/63 ,  G16H50/20 ,  Y02A90/26

摘要： Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.

公开(公告)号：US20140038846A1

公开(公告)日：2014-02-06

申请号：US14052503

申请日：2013-10-11

申请人： Caris MPI, Inc.

发明人： Daniel D. Von Hoff ,  Robert J. Penny

IPC分类号： C12Q1/68

CPC分类号： G01N33/57488 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/6893 ,  G01N2333/71 ,  G01N2333/91205 ,  G01N2333/914 ,  G06F19/00 ,  G06F19/18 ,  G06F19/20 ,  G06F19/28 ,  G06F19/34 ,  G06F19/3481 ,  G16H15/00 ,  G16H50/20

摘要： A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample from the patient, determining whether any molecular findings including one or more genes, one or more gene expressed proteins, one or more molecular mechanisms, and/or combinations of such exhibit a change in expression compared to a reference, and identifying a non-specific disease therapy or agent capable of interacting with the genes, gene expressed proteins, molecular mechanisms, or combinations of such molecular findings that exhibited a change in expression.

公开(公告)号：US20230123908A1

公开(公告)日：2023-04-20

申请号：US17835862

申请日：2022-06-08

申请人： Caris MPI, Inc.

发明人： Daniel D. Von Hoff ,  David M. Loesch ,  Arlet Alarcon ,  Robert J. Penny ,  Alan Wright ,  Matthew J. McGinniss ,  Ryan P. Bender ,  Traci Pawlowski

IPC分类号： G01N35/00 ,  C12Q1/6874 ,  C40B60/12 ,  C12Q1/6841 ,  G01N33/574 ,  G01N33/543 ,  G16B25/10 ,  G16B50/30 ,  G16H70/40 ,  G16B20/10 ,  G16B40/10 ,  G16H50/20 ,  G16H10/20 ,  G16B35/00 ,  G16B40/00 ,  G16B20/40 ,  G16B20/20 ,  G16B99/00 ,  G16B30/00 ,  G16H20/10 ,  G16B30/10 ,  G16B20/00 ,  B01L7/00 ,  G16C20/60 ,  G16H15/00 ,  G16H40/63 ,  C12Q1/6886 ,  G16B50/00 ,  G16B25/00 ,  G16B45/00

摘要： Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.