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公开(公告)号：US11931966B2
公开(公告)日：2024-03-19
申请号：US16964899
申请日：2019-01-25
发明人： Patrick Thayer , Hany Abushall , Hector Martinez , Erik Gatenholm
IPC分类号： B29C67/00 , B29C64/209 , B29C64/393 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y70/00 , B33Y70/10 , G06N3/08 , G06N5/01
CPC分类号： B29C64/393 , B29C64/209 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y70/00 , B33Y70/10 , G06N3/08 , G06N5/01
摘要： Systems and methods for optical assessments of bioink printability are described. The systems and methods include the use of hardware, software and optical targets to aid in the evaluation of bioink printability. The optical targets are developed and fabricated from 3D printable materials determined to be “nozzle fidelic” and/or materials that possess well characterized thermosensitivity. The optical targets make it possible to rapidly compare and evaluate bioink printability and can be easily customized and tailored for specific applications.
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公开(公告)号：US20230166455A1
公开(公告)日：2023-06-01
申请号：US17922095
申请日：2021-05-03
发明人： Anton Andren , Peter FALTPIHL , Erik STERNÅ , Adam MICHA , Ali CAKIR , Hector MARTINEZ , Erik GATENHOLM
IPC分类号： B29C64/393 , B29C64/112 , B29C64/209 , C12M3/00 , C12M1/42
CPC分类号： B29C64/393 , B29C64/112 , B29C64/209 , C12M21/08 , C12M35/04 , B33Y10/00
摘要： A bioprinter (1) comprising at least one printhead (4a, 4b, 4c) with nozzle (5), a printbed (20) onto which the printhead (4a, 4b, 4c) is arranged to print an ink, an ultrasonic sensor arrangement arranged at the printbed (20), a controller (7) arranged to control movement of the printhead/nozzle (4a, 4b, 4c; 5) and to perform calibration of the printhead/nozzle (4a, 4b, 5 4c; 5) based on information from the ultrasonic sensor arrangement.
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公开(公告)号：US11590710B2
公开(公告)日：2023-02-28
申请号：US16477316
申请日：2018-01-10
发明人： Erik Sternå , Jockum Svanberg , Erik Gatenholm , Hector Martinez
IPC分类号： B29C64/393 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y70/00 , B29C64/20 , C12M3/00 , C12N5/00 , C12M1/26 , B33Y40/00 , B29L31/00
摘要： The present disclosure relates to a 3D bioprinter (1) comprising a base unit (2). The base unit (2) has a support (3) adapted for mounting of at least one toolhead (4), a communication interface part (5) for communication of data with the at least one toolhead (4), when mounted, and a base unit processing element (7) adapted to communicate with a toolhead processing element (8) of the at least one toolhead over said communication interface part (5). The present disclosure relates further to a 3D bioprinter toolhead. The present disclosure relates further to a method for bioprinting a construct.
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公开(公告)号：US11548199B2
公开(公告)日：2023-01-10
申请号：US15995562
申请日：2018-06-01
发明人： Erik Sternå , Jockum Svanberg , Erik Gatenholm , Hector Martinez
IPC分类号： B29C64/245 , B29C64/209 , B33Y30/00 , B29C48/92 , B29C64/106 , B29C64/393 , B33Y10/00 , B33Y40/00 , B33Y70/00 , B33Y80/00
摘要： The present disclosure relates to a 3D printer (1) for 3D printing of a construct. The 3D printer (1) has a print bed (2). The 3D printer further comprises at least one actuating tool head (3) with an extrusion element (4), wherein the extrusion element and the print bed are movable in relation to each other. The 3D printer also comprises at least one sensor (5) arranged to sense a force applied to the print bed (2) by the extrusion element (4), or vice versa. The 3D printer additionally comprises a control element (7) arranged to detect when the sensed force exceeds a predetermined value and to record a position of the print bed or extrusion element related to the detection that the predetermined value is exceeded. The present disclosure also relates to corresponding methods and computer programs.
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公开(公告)号：US12092530B2
公开(公告)日：2024-09-17
申请号：US17462615
申请日：2021-08-31
发明人： Erik Gatenholm , Hector Martinez , Ginger Lohman , Mateusz Piotrzkowski , Bryan Jones , Eric Bronnenkant , Kyung Hun Jung
IPC分类号： G01K13/02 , B29C64/255 , B29C64/393 , B33Y40/00 , B33Y50/02
CPC分类号： G01K13/026 , B29C64/255 , B29C64/393 , B33Y40/00 , B33Y50/02
摘要： A material cartridge arrangement (100, 101) for a dispensing system, comprising a material cartridge (2) having a first end (2a), an opposing second end (2b) and an ink material channel (5) extending between the first and second ends in the material cartridge (2), the ink material channel (5) being bounded by an ink material channel wall/walls (9) extending between the first (2a) and second ends (2b). An ink material pressurising device (3) is arranged to cause ink material hold in the ink material channel (5) to flow in a direction from said first end (2a) towards said second end (2b) and through an ink material outlet. At least one temperature sensing element (16) is arranged at a position along the direction of extension of the ink material channel (5) and arranged to measure a temperature at the ink material channel wall (9).
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公开(公告)号：US20240157629A1
公开(公告)日：2024-05-16
申请号：US18550279
申请日：2022-03-14
IPC分类号： B29C64/106 , B29C64/182 , B29C64/209 , B33Y30/00 , B33Y40/20
CPC分类号： B29C64/106 , B29C64/182 , B29C64/209 , B33Y30/00 , B33Y40/20
摘要： Bioprinters use biological inks (i.e. bioinks) to produce biomaterials such as cell cultures (including 3D cell cultures), living tissues, and organs. Bioprinters as described by the present invention include those capable of performing high-throughput industrial scale assays, applications, and development while maintaining precision.
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公开(公告)号：US11648336B2
公开(公告)日：2023-05-16
申请号：US16345363
申请日：2017-10-27
IPC分类号： A61L27/46 , B33Y10/00 , B33Y80/00 , A61L27/38 , A61L27/44 , A61L27/48 , A61L27/52 , C12N5/077 , B29C64/106 , B29C64/165 , B33Y70/10
CPC分类号： A61L27/46 , A61L27/3821 , A61L27/3834 , A61L27/3847 , A61L27/3865 , A61L27/3895 , A61L27/446 , A61L27/48 , A61L27/52 , B29C64/106 , B29C64/165 , B33Y10/00 , B33Y70/10 , B33Y80/00 , C12N5/0654 , A61L2400/12 , A61L2430/02 , A61L2430/12 , C12N2506/1346 , C12N2506/45 , A61L27/46 , C08L1/00
摘要： The present invention relates to preparation of bioink composed of cellulose nanofibril hydrogel with native or synthetic Calcium containing particles. The concentration of the calcium containing particles can be between 1% and 40% w/v. Such bioink can be 3D Bioprinted with or without human or animal cells. Coaxial needle can be used where cellulose nanofibril hydrogel filled with Calcium particles can be used as shell and another hydrogel based bioink mixed with cells can be used as core or opposite. Such 3D Bioprinted constructs exhibit high porosity due to shear thinning properties of cellulose nanofibrils which provides excellent printing fidelity. They also have excellent mechanical properties and are easily handled as large constructs for patient-specific bone cavities which need to be repaired. The porosity promotes vascularization which is crucial for oxygen and nutrient supply. The porosity also makes it possible for further recruitment of cells which accelerate bone healing process. Calcium containing particles can be isolated from autologous bone, allogenic bone or xenogeneic bone but can be also isolated from minerals or be prepared by synthesis. Preferable Calcium containing particles consist of β-tricalcium phosphate which is resorbable or natural bone powder, preferably of human or porcine origin. The particles described in the present invention have particle size smaller than 400 microns, or more preferably smaller than 200 microns, to make it possible to handle in printing nozzle without clogging and to obtain a good resolution. Cellulose nanofibrils can be produced by bacteria orbe isolated from plants. They can be neutral, charged or oxidized to be biodegradable. The bioink can be additionally supplemented by other biopolymers which provide crosslinking. Such biopolymers can be alginates, chitosans, modified hyaluronic acid or modified collagen derived biopolymers.
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