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公开(公告)号：US09216235B2
公开(公告)日：2015-12-22
申请号：US12673400
申请日：2008-08-14
申请人： Alan George Brownlee , Christopher Malcolm Elvin , Jerome Anthony Werkmeister , John Alan Maurice Ramshaw , Charles Mark Lindall
发明人： Alan George Brownlee , Christopher Malcolm Elvin , Jerome Anthony Werkmeister , John Alan Maurice Ramshaw , Charles Mark Lindall
CPC分类号： A61L24/10 , A61L24/001 , A61L24/0026 , A61L24/102 , A61L24/106 , A61L24/108 , A61L26/0028 , A61L26/0061 , A61L26/0076 , A61L27/22 , A61L27/50 , C08H1/00 , C09J189/00
摘要： A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a crosslinking reaction to form a 3-dimensional matrix of the biomaterial.
摘要翻译： 交联用作生物材料的蛋白质或肽的方法，所述方法包括在蛋白质或肽存在下照射可光活化的金属 - 配体复合物和电子受体的步骤，由此引发交联反应以形成3- 生物材料的三维矩阵。
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2.发明授权Joining and/or sealing tissues through photo-activated cross-linking of matrix proteins 有权通过基质蛋白的光激活交联连接和/或密封组织公开(公告)号：US09579415B2
公开(公告)日：2017-02-28
申请号：US12223945
申请日：2007-02-14
CPC分类号： A61L24/106 , A61L24/0015 , A61L24/02 , A61L24/10 , A61L2400/04 , C08J3/24 , C08J2389/00 , C09J189/00
摘要： A method of joining and/or sealing tissues in a surgical procedure or medical treatment, comprising the steps of: (1) applying a matrix protein, a photoactivatable metal-ligand complex and an electron acceptor to a tissue portion; (2) irradiating said tissue portion to photactivate the photoactivatable metal-ligand complex: thereby initiating a cross-linking reaction of the matrix protein to seal said tissue portion or join said tissue portion to an adjacent tissue portion.
摘要翻译： 一种在外科手术或医疗处理中接合和/或密封组织的方法，包括以下步骤：（1）将基质蛋白，可光活化的金属 - 配体复合物和电子受体施用于组织部分; （2）照射所述组织部分以激活可光活化的金属 - 配体络合物：由此引发基质蛋白质的交联反应以密封所述组织部分或将所述组织部分连接到相邻组织部分。
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公开(公告)号：US20110190813A1
公开(公告)日：2011-08-04
申请号：US12673400
申请日：2008-08-14
申请人： Alan George Brownlee , Christopher Malcolm Elvin , Jerome Anthony Werkmeister , John Alan Maurice Ramshaw , Charles Mark Lindall
发明人： Alan George Brownlee , Christopher Malcolm Elvin , Jerome Anthony Werkmeister , John Alan Maurice Ramshaw , Charles Mark Lindall
IPC分类号： A61B17/08 , C07K14/00 , C07K14/75 , C07K14/78 , C07K14/435 , C07K1/00 , C07K14/765
CPC分类号： A61L24/10 , A61L24/001 , A61L24/0026 , A61L24/102 , A61L24/106 , A61L24/108 , A61L26/0028 , A61L26/0061 , A61L26/0076 , A61L27/22 , A61L27/50 , C08H1/00 , C09J189/00
摘要： A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a crosslinking reaction to form a 3-dimensional matrix of the biomaterial.
摘要翻译： 交联用作生物材料的蛋白质或肽的方法，所述方法包括在蛋白质或肽存在下照射可光活化的金属 - 配体复合物和电子受体的步骤，由此引发交联反应以形成3- 生物材料的三维矩阵。
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4.发明申请Joining and/or Sealing Tissues Through Photo-Activated Cross-Linking of Matrix Proteins 有权通过光活化的基质蛋白交联连接和/或密封组织公开(公告)号：US20090306707A1
公开(公告)日：2009-12-10
申请号：US12223945
申请日：2007-02-14
CPC分类号： A61L24/106 , A61L24/0015 , A61L24/02 , A61L24/10 , A61L2400/04 , C08J3/24 , C08J2389/00 , C09J189/00
摘要： A method of joining and/or scaling tissues in a surgical procedure or medical treatment, comprising the steps of: (1) applying a matrix protein, a photoactivatable metal-ligand complex and an electron acceptor to a tissue portion; (2) irradiating said tissue portion to photactivate the photoactivatable metal-ligand complex: thereby initiating a cross-linking reaction of the matrix protein to seal said tissue portion or join said tissue portion to an adjacent tissue portion.
摘要翻译： 一种在外科手术或医学治疗中接合和/或结垢组织的方法，包括以下步骤：（1）将基质蛋白，可光活化的金属 - 配体复合物和电子受体施用于组织部分; （2）照射所述组织部分以激活可光活化的金属 - 配体络合物：由此引发基质蛋白质的交联反应以密封所述组织部分或将所述组织部分连接到相邻组织部分。
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