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    Method of providing particles having biological-binding areas for biological applications
    1.
    发明授权
    Method of providing particles having biological-binding areas for biological applications 有权
    提供具有用于生物应用的生物结合区域的颗粒的方法

    公开(公告)号：US08076162B2

    公开(公告)日：2011-12-13

    申请号：US12419899

    申请日：2009-04-07

    申请人： Jeb H. Flemming ,  Colin T. Buckley ,  Carrie Schmidt

    发明人： Jeb H. Flemming ,  Colin T. Buckley ,  Carrie Schmidt

    IPC分类号： G01N33/552

    CPC分类号： G01N33/54346 ,  G01N33/54313 ,  G01N33/552 ,  G01N33/553

    摘要： The present invention includes micro-sphere composition, methods of making binding assays. The present invention also includes a micro-sphere for binding biological molecules without pretreatment. The micro-sphere includes a spherical glass substrate having one or more metal nanoparticle regions that are exposed from within the glass, wherein the micro-sphere is capable of binding biological molecules without pretreatment.

    摘要翻译： 本发明包括微球组合物，制备结合测定的方法。 本发明还包括用于结合生物分子而不进行预处理的微球。 微球包括具有从玻璃内暴露的一个或多个金属纳米颗粒区域的球形玻璃基底，其中微球能够结合生物分子而不进行预处理。

    Method of providing a pattern of biological-binding areas for biological testing
    3.
    发明授权
    Method of providing a pattern of biological-binding areas for biological testing 有权
    提供用于生物测试的生物结合区域图案的方法

    公开(公告)号：US08492315B2

    公开(公告)日：2013-07-23

    申请号：US12200894

    申请日：2008-08-28

    申请人： Jeb H. Flemming ,  Colin T. Buckley ,  Carrie Schmidt

    发明人： Jeb H. Flemming ,  Colin T. Buckley ,  Carrie Schmidt

    IPC分类号： C40B50/18

    CPC分类号： G01N33/552 ,  G01N33/553

    摘要： The present invention provides a method of forming one or more biological-binding areas on a substrate for biological-testing. The method includes activating at least a portion of a glass-ceramic substrate comprising glass and one or more metal containing compounds. The one or more metal containing compounds have a range of diameters that are less than about 300 nanometers in diameter and are spaced an average distance of at least one-half the midpoint of the diameter range apart. The one or more metals include compounds selected from metal oxides, metal nanoparticles, metal alloys, and atomic metals. The glass-ceramic substrate is heated to a temperature near the glass transformation temperature to form one or more metal nanoparticles in one or more ceramic biological-binding areas. The glass-ceramic substrate is etched to expose one or more metal. One or more biological molecules are contacted with one or more ceramic biological-binding areas to provide one or more biological testing areas with an increased binding area as compared to un-activated areas.

    摘要翻译： 本发明提供了在用于生物测试的底物上形成一个或多个生物结合区域的方法。 该方法包括激活包含玻璃和一种或多种含金属化合物的玻璃 - 陶瓷衬底的至少一部分。 一种或多种含金属化合物的直径范围小于直径约300纳米，并且间隔开至少两分之一直径中点的平均距离。 一种或多种金属包括选自金属氧化物，金属纳米颗粒，金属合金和原子金属的化合物。 将玻璃陶瓷基板加热至接近玻璃化转变温度的温度，以在一个或多个陶瓷生物结合区域中形成一种或多种金属纳米颗粒。 蚀刻玻璃陶瓷衬底以暴露一种或多种金属。 一个或多个生物分子与一个或多个陶瓷生物结合区域接触，以提供与未激活区域相比具有增加的结合面积的一个或多个生物测试区域。

    METHOD OF PROVIDING A PATTERN OF BIOLOGICAL-BINDING AREAS FOR BIOLOGICAL TESTING
    6.
    发明申请
    METHOD OF PROVIDING A PATTERN OF BIOLOGICAL-BINDING AREAS FOR BIOLOGICAL TESTING 有权
    提供生物结合区域生物测试图的方法

    公开(公告)号：US20090069193A1

    公开(公告)日：2009-03-12

    申请号：US12200894

    申请日：2008-08-28

    申请人： Jeb H. Flemming ,  Colin T. Buckley ,  Carrie F. Schmidt

    发明人： Jeb H. Flemming ,  Colin T. Buckley ,  Carrie F. Schmidt

    IPC分类号： C40B30/04 ,  C40B40/00 ,  G03F7/20 ,  B05D3/10 ,  C40B50/18

    CPC分类号： G01N33/552 ,  G01N33/553

    摘要： The present invention provides a method of forming one or more biological-binding areas on a substrate for biological-testing. The method includes activating at least a portion of a glass-ceramic substrate comprising glass and one or more metal containing compounds. The one or more metal containing compounds have a range of diameters that are less than about 300 nanometers in diameter and are spaced an average distance of at least one-half the midpoint of the diameter range apart. The one or more metals include compounds selected from metal oxides, metal nanoparticles, metal alloys, and atomic metals. The glass-ceramic substrate is heated to a temperature near the glass transformation temperature to form one or more metal nanoparticles in one or more ceramic biological-binding areas. The glass-ceramic substrate is etched to expose one or more metal. One or more biological molecules are contacted with one or more ceramic biological-binding areas to provide one or more biological testing areas with an increased binding area as compared to un-activated areas.

    摘要翻译： 本发明提供了在用于生物测试的底物上形成一个或多个生物结合区域的方法。 该方法包括激活包含玻璃和一种或多种含金属化合物的玻璃 - 陶瓷衬底的至少一部分。 一种或多种含金属化合物的直径范围小于直径约300纳米，并且间隔开至少两分之一直径中点的平均距离。 一种或多种金属包括选自金属氧化物，金属纳米颗粒，金属合金和原子金属的化合物。 将玻璃陶瓷基板加热至接近玻璃化转变温度的温度，以在一个或多个陶瓷生物结合区域中形成一种或多种金属纳米颗粒。 蚀刻玻璃陶瓷衬底以暴露一种或多种金属。 一个或多个生物分子与一个或多个陶瓷生物结合区域接触，以提供与未激活区域相比具有增加的结合面积的一个或多个生物测试区域。

    Methods to fabricate a photoactive substrate suitable for microfabrication
    8.
    发明授权
    Methods to fabricate a photoactive substrate suitable for microfabrication 有权
    制造适合微细加工的光敏基材的方法

    公开(公告)号：US08709702B2

    公开(公告)日：2014-04-29

    申请号：US13024952

    申请日：2011-02-10

    申请人： Jeb H. Flemming ,  Colin T. Buckley ,  R. Blake Ridgeway

    发明人： Jeb H. Flemming ,  Colin T. Buckley ,  R. Blake Ridgeway

    IPC分类号： G03F7/20

    CPC分类号： G03F7/0047 ,  C03C4/04 ,  C03C10/00 ,  C03C15/00 ,  C03C23/002 ,  C03C2218/34 ,  G03F7/0043

    摘要： A method of fabrication and device with holes for electrical conduction made by preparing a photosensitive glass substrate comprising at least silica, lithium oxide, aluminum oxide, and cerium oxide, masking a design layout comprising one or more holes to form one or more electrical conduction paths on the photosensitive glass substrate, exposing at least one portion of the photosensitive glass substrate to an activating energy source, exposing the photosensitive glass substrate to a heating phase of at least ten minutes above its glass transition temperature, cooling the photosensitive glass substrate to transform at least part of the exposed glass to a crystalline material to form a glass-crystalline substrate and etching the glass-crystalline substrate with an etchant solution to form the one or more depressions or through holes for electrical conduction in the device.

    摘要翻译： 一种通过制备至少包含二氧化硅，氧化锂，氧化铝和氧化铈的感光玻璃基板制造的具有电导通孔的装置的方法和装置，掩蔽包括一个或多个孔的设计布局以形成一个或多个导电路径 在感光性玻璃基板上，将感光性玻璃基板的至少一部分曝光于活化能源，使感光性玻璃基板暴露于玻璃化转变温度以上至少10分钟的加热相，冷却感光性玻璃基板， 将暴露的玻璃的至少一部分暴露于晶体材料以形成玻璃晶体衬底并用蚀刻剂溶液蚀刻玻璃晶体衬底以形成用于器件中的导电的一个或多个凹陷或通孔。