公开(公告)号：US11016068B2

公开(公告)日：2021-05-25

申请号：US16852769

申请日：2020-04-20

Applicant: THERMO HYPERSIL-KEYSTONE LLC ,  DIONEX CORPORATION

Inventor： Brandon Howard Robson ,  Xuefei Sun ,  Xiaodong Liu

IPC: G01N30/72 ,  H01J49/04 ,  H01J49/16

Abstract: An electrospray emitter assembly for interfacing a separation column to a mass spectrometer is disclosed. An emitter capillary includes an inlet end and an outlet end. A fitting is coupled to the inlet end of the emitter, configured to be removably connected to the separation column A stop with a defined through hole is integrated proximate the inlet end of the emitter to produce a path for liquid to flow from the separation column to the emitter via the through hole where a voltage is applied to the liquid entering the emitter.

公开(公告)号：US20230341357A1

公开(公告)日：2023-10-26

申请号：US18341712

申请日：2023-06-26

Applicant: DIONEX CORPORATION

Inventor： Brandon Howard Robson ,  Xuefei Sun ,  Carla Marie Medlin ,  Shane Bechler

IPC: G01N30/72 ,  G01N30/60 ,  H01J49/04 ,  H01J49/16

CPC classification number: G01N30/7266 ,  G01N30/6004 ,  G01N30/6047 ,  H01J49/0445 ,  H01J49/167

Abstract: An integrated system for liquid separation and electrospray ionization includes an emitter-enabled capillary column including an emitter portion and a column portion; and a retractable protective sleeve for covering and/or supporting the emitter portion along at least a portion of its axis. The protective sleeve is mounted around the emitter-enabled capillary column. The retractable protective sleeve is moveable to an extended position wherein a tip of the emitter portion is covered by the protective sleeve. A resilient member is provided to bias the protective sleeve towards the extended position. The protective sleeve is enclosed and moveable within an outer electrically conductive sheath adapted for insertion within a holder having a high-voltage contact point. The sheath is adapted to contact the high-voltage contact point and provide an electrical connection to enable the emitter-enabled capillary column to receive a high voltage. The sheath has a recess to receive the high-voltage contact point.

公开(公告)号：US11774416B2

公开(公告)日：2023-10-03

申请号：US17328068

申请日：2021-05-24

Applicant: THERMO HYPERSIL-KEYSTONE LLC ,  DIONEX CORPORATION

Inventor： Brandon Howard Robson ,  Xuefei Sun ,  Xiaodong Liu

IPC: H01J49/04 ,  H01J49/16 ,  G01N30/72

CPC classification number: G01N30/7266 ,  H01J49/0431 ,  H01J49/167

Abstract: An electrospray emitter assembly for interfacing a separation column to a mass spectrometer is disclosed. An emitter capillary includes an inlet end and an outlet end. A fitting is coupled to the inlet end of the emitter, configured to be removably connected to the separation column. A stop with a defined through hole is integrated proximate the inlet end of the emitter to produce a path for liquid to flow from the separation column to the emitter via the through hole where a voltage is applied to the liquid entering the emitter.

公开(公告)号：US20230194482A1

公开(公告)日：2023-06-22

申请号：US17557698

申请日：2021-12-21

Applicant: DIONEX CORPORATION

Inventor： Brandon Howard Robson ,  Xuefei Sun ,  Carla Marie Medlin ,  Shane Bechler

IPC: G01N30/72 ,  G01N30/60 ,  H01J49/16 ,  H01J49/04

CPC classification number: G01N30/7266 ,  G01N30/6047 ,  G01N30/6004 ,  H01J49/167 ,  H01J49/0445

Abstract: An integrated system for liquid separation and electrospray ionization includes an emitter-enabled capillary column including an emitter portion and a column portion; and a retractable protective sleeve for covering and/or supporting the emitter portion along at least a portion of its axis. The protective sleeve is mounted around the emitter-enabled capillary column. The retractable protective sleeve is moveable to an extended position wherein a tip of the emitter portion is covered by the protective sleeve. A resilient member is provided to bias the protective sleeve towards the extended position. The protective sleeve is enclosed and moveable within an outer electrically conductive sheath adapted for insertion within a holder having a high-voltage contact point. The sheath is adapted to contact the high-voltage contact point and provide an electrical connection to enable the emitter-enabled capillary column to receive a high voltage. The sheath has a recess to receive the high-voltage contact point.

公开(公告)号：US12130268B2

公开(公告)日：2024-10-29

申请号：US18341712

申请日：2023-06-26

Applicant: DIONEX CORPORATION

Inventor： Brandon Howard Robson ,  Xuefei Sun ,  Carla Marie Medlin ,  Shane Bechler

IPC: G01N30/00 ,  G01N30/60 ,  G01N30/72 ,  H01J49/04 ,  H01J49/16

CPC classification number: G01N30/7266 ,  G01N30/6004 ,  G01N30/6047 ,  H01J49/0445 ,  H01J49/167

Abstract: An integrated system for liquid separation and electrospray ionization includes an emitter-enabled capillary column including an emitter portion and a column portion; and a retractable protective sleeve for covering and/or supporting the emitter portion along at least a portion of its axis. The protective sleeve is mounted around the emitter-enabled capillary column. The retractable protective sleeve is moveable to an extended position wherein a tip of the emitter portion is covered by the protective sleeve. A resilient member is provided to bias the protective sleeve towards the extended position. The protective sleeve is enclosed and moveable within an outer electrically conductive sheath adapted for insertion within a holder having a high-voltage contact point. The sheath is adapted to contact the high-voltage contact point and provide an electrical connection to enable the emitter-enabled capillary column to receive a high voltage. The sheath has a recess to receive the high-voltage contact point.

公开(公告)号：US12181454B2

公开(公告)日：2024-12-31

申请号：US17557698

申请日：2021-12-21

Applicant: DIONEX CORPORATION

Inventor： Brandon Howard Robson ,  Xuefei Sun ,  Carla Marie Medlin ,  Shane Bechler

IPC: G01N30/00 ,  G01N30/60 ,  G01N30/72 ,  H01J49/04 ,  H01J49/16

Abstract: An integrated system for liquid separation and electrospray ionization includes an emitter-enabled capillary column including an emitter portion and a column portion; and a retractable protective sleeve for covering and/or supporting the emitter portion along at least a portion of its axis. The protective sleeve is mounted around the emitter-enabled capillary column. The retractable protective sleeve is moveable to an extended position wherein a tip of the emitter portion is covered by the protective sleeve. A resilient member is provided to bias the protective sleeve towards the extended position. The protective sleeve is enclosed and moveable within an outer electrically conductive sheath adapted for insertion within a holder having a high-voltage contact point. The sheath is adapted to contact the high-voltage contact point and provide an electrical connection to enable the emitter-enabled capillary column to receive a high voltage. The sheath has a recess to receive the high-voltage contact point.

公开(公告)号：US11813588B2

公开(公告)日：2023-11-14

申请号：US17146447

申请日：2021-01-11

Applicant: DIONEX CORPORATION

Inventor： Xiaodong Liu ,  Xiao Cui ,  Xuefei Sun

IPC: B01D15/20 ,  B01D15/32 ,  B01J20/289 ,  B01J20/32 ,  C07H15/23 ,  C07H15/232 ,  C07H15/234 ,  C07H15/238 ,  B01J20/287 ,  B01J20/30 ,  C07D493/04 ,  C07H1/06 ,  C07H15/224 ,  C08G77/392

CPC classification number: B01J20/287 ,  B01D15/20 ,  B01D15/325 ,  B01J20/289 ,  B01J20/3078 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/328 ,  B01J20/3217 ,  B01J20/3272 ,  C07D493/04 ,  C07H1/06 ,  C07H15/224 ,  C07H15/23 ,  C07H15/232 ,  C07H15/234 ,  C07H15/238 ,  C08G77/392 ,  B01J2220/44 ,  B01J2220/52 ,  B01J2220/54 ,  B01J2220/58

Abstract: A chromatographic material including a substrate having a surface and having a polymeric layer covalently bound to the surface; the polymeric layer comprising polymer molecules covalently attached to the surface of the substrate, each polymer molecule being attached to the surface via multiple siloxane bonds and each polymer molecule being connected to one or more functionalizing compounds that each comprise a functional group, wherein the polymeric layer is formed by covalently attaching polymer molecules to the surface of the substrate via multiple siloxane bonds, each polymer molecule containing multiple first reactive groups, and reacting the first reactive groups of the attached polymer molecules with at least one functionalizing compound that comprises a second reactive group that is reactive with the first reactive groups and that further comprises a functional group. Preferred conditions of reacting the polymer with the substrate include elevated temperature and reduced pressure.