公开(公告)号：US08889709B2

公开(公告)日：2014-11-18

申请号：US12554584

申请日：2009-09-04

申请人： Hans-Ulrich Demuth ,  Stephan Schilling ,  Michael Wermann ,  Holger Cynis ,  Astrid Kehlen ,  Daniel Friedrich ,  Torsten Hoffmann ,  Kathrin Gans ,  Jens-Ulrich Rahfeld ,  Ulrich Heiser ,  Michael Almstetter ,  Robert Sommer ,  Ulf-Torsten Gaertner ,  Antje Hamann ,  Michael Thormann ,  Andreas Treml

发明人： Hans-Ulrich Demuth ,  Stephan Schilling ,  Michael Wermann ,  Holger Cynis ,  Astrid Kehlen ,  Daniel Friedrich ,  Torsten Hoffmann ,  Kathrin Gans ,  Jens-Ulrich Rahfeld ,  Ulrich Heiser ,  Michael Almstetter ,  Robert Sommer ,  Ulf-Torsten Gaertner ,  Antje Hamann ,  Michael Thormann ,  Andreas Treml

IPC分类号： A01N43/42 ,  C12N9/00 ,  C12N9/10 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04 ,  C07D417/12 ,  C07D405/12 ,  C07D233/61 ,  C07D409/12 ,  C07D403/12 ,  C07D413/12 ,  C07D403/06 ,  C07D401/12 ,  C07D233/54 ,  C07D235/06

CPC分类号： C07D233/54 ,  C07D233/61 ,  C07D235/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C12N9/104

摘要： The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase-like protein (QPCTL), and the use thereof for the treatment and/or prevention of an inflammatory disease or disorder selected from the group consisting of (a) chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis; (b) other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis, Guillain-Barré syndrome, chronic inflammatory demyelinizing polyradiculoneuropathy and multiple sclerosis; (c) neuroinflammation; and (d) neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, and Familial Danish Dementia, which may result from neuroinflammation.

摘要翻译： 本发明一般涉及谷氨酰胺肽环转移酶样蛋白（QPCTL）的抑制剂及其用于治疗和/或预防炎性疾病或病症的用途，所述炎性疾病或病症选自（a）慢性和急性 炎症，例如 类风湿关节炎，动脉粥样硬化，再狭窄，胰腺炎; （b）其他炎性疾病，例如 艾滋病，睾丸炎，结节性硬化症，吉兰巴利综合征，慢性炎性脱髓鞘性多发性神经系统疾病和多发性硬化; （c）神经炎症; 和（d）神经变性疾病，例如 轻度认知障碍（MCI），阿尔茨海默氏症，唐氏综合征神经变性，家族性英国痴呆和家族性丹麦痴呆，可能由神经炎症引起。

公开(公告)号：US08563752B2

公开(公告)日：2013-10-22

申请号：US13186570

申请日：2011-07-20

申请人： Paul Hanselmann ,  Ellen Klegraf ,  Stephan Elzner ,  Wilhelm Quittmann ,  Daniel Friedrich Fischer

发明人： Paul Hanselmann ,  Ellen Klegraf ,  Stephan Elzner ,  Wilhelm Quittmann ,  Daniel Friedrich Fischer

IPC分类号： C07D305/12

CPC分类号： C07D305/12 ,  C07C227/32 ,  C07C229/22

摘要： The invention relates to a method for the production of L-carnitine, wherein a chiral β-lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X—CH2—CHO, wherein X is selected from Cl, Br, I and trimethylamine, in the presence of a chiral catalyst.

摘要翻译： 本发明涉及L-肉毒碱的生产方法，其中手性β-内酯肉碱前体是通过乙烯酮与醛X-CH 2 -CHO 2 [2 + 2]环加成获得的，其中X选自Cl， Br，I和三甲胺，在手性催化剂存在下进行。

公开(公告)号：US20120022275A1

公开(公告)日：2012-01-26

申请号：US13186570

申请日：2011-07-20

申请人： Paul Hanselmann ,  Ellen Klegraf ,  Stephan Elzner ,  Wilhelm Quittmann ,  Daniel Friedrich Fischer

发明人： Paul Hanselmann ,  Ellen Klegraf ,  Stephan Elzner ,  Wilhelm Quittmann ,  Daniel Friedrich Fischer

IPC分类号： C07C229/06 ,  C07D305/12

CPC分类号： C07D305/12 ,  C07C227/32 ,  C07C229/22

摘要： The invention relates to a method for the production of L-carnitine, wherein a chiral β-lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X—CH2—CHO, wherein X is selected from Cl, Br, I and trimethylamine, in the presence of a chiral catalyst.

摘要翻译： 本发明涉及生产L-肉碱的方法，其中通过乙烯酮与醛X-CH 2 -CHO 2 [2 + 2]环加成获得手性和肉桂内酯肉碱前体，其中X选自Cl ，Br，I和三甲胺，在手性催化剂存在下进行。

公开(公告)号：US20100125086A1

公开(公告)日：2010-05-20

申请号：US12554584

申请日：2009-09-04

申请人： Hans-Ulrich Demuth ,  Stephan Schilling ,  Michael Wermann ,  Holger Cynis ,  Astrid Kehlen ,  Daniel Friedrich ,  Torsten Hoffmann ,  Kathrin Gans ,  Jens-Ulrich Rahfeld ,  Ulrich Heiser ,  Michael Almstetter ,  Robert Sommer ,  Ulf-Torsten Gaertner ,  Antje Hamann ,  Michael Thormann ,  Andreas Tremel

发明人： Hans-Ulrich Demuth ,  Stephan Schilling ,  Michael Wermann ,  Holger Cynis ,  Astrid Kehlen ,  Daniel Friedrich ,  Torsten Hoffmann ,  Kathrin Gans ,  Jens-Ulrich Rahfeld ,  Ulrich Heiser ,  Michael Almstetter ,  Robert Sommer ,  Ulf-Torsten Gaertner ,  Antje Hamann ,  Michael Thormann ,  Andreas Tremel

IPC分类号： A61K31/4178 ,  C12Q1/25 ,  A61K31/437 ,  A61K31/433 ,  A61K31/4184 ,  A61P29/00

CPC分类号： C07D233/54 ,  C07D233/61 ,  C07D235/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C12N9/104

摘要： The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase-like protein (QPCTL), and the use thereof for the treatment and/or prevention of an inflammatory disease or disorder selected from the group consisting of (a) chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis; (b) other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis, Guillain-Barré syndrome, chronic inflammatory demyelinising polyradiculoneuropathy and multiple sclerosis; (c) neuroinflammation; and (d) neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, and Familial Danish Dementia, which may result from neuroinflammation.

摘要翻译： 本发明一般涉及谷氨酰胺肽环转移酶样蛋白（QPCTL）的抑制剂及其用于治疗和/或预防炎性疾病或病症的用途，所述炎性疾病或病症选自（a）慢性和急性 炎症，例如 类风湿关节炎，动脉粥样硬化，再狭窄，胰腺炎; （b）其他炎性疾病，例如 神经性疼痛，移植物排斥/移植物衰竭/移植物血管病变，HIV感染/艾滋病，睾丸炎，结节性硬化症，吉兰巴利综合征，慢性炎症性脱髓鞘性多发性神经病和多发性硬化症; （c）神经炎症; 和（d）神经变性疾病，例如 轻度认知障碍（MCI），阿尔茨海默氏症，唐氏综合征神经变性，家族性英国痴呆和家族性丹麦痴呆，可能由神经炎症引起。

公开(公告)号：US5319917A

公开(公告)日：1994-06-14

申请号：US985677

申请日：1992-12-04

申请人： Jakob Bothner ,  Daniel Friedrich ,  Thomas Peter ,  Rainer Maier ,  Rainer Kurz ,  Bernd Paulisch

发明人： Jakob Bothner ,  Daniel Friedrich ,  Thomas Peter ,  Rainer Maier ,  Rainer Kurz ,  Bernd Paulisch

IPC分类号： D01H1/38 ,  D01H11/00

CPC分类号： D01H1/385 ,  D01H11/006

摘要： A reserve-surface cleaning apparatus is used in combination with a ring-spinning machine having a longitudinally extending row of spindles each adapted to hold a roving sleeve and each formed below the respective sleeve with a respective reserve winding area and a longitudinally extending frame extending along a back side of the row and a service area extending along a front side of the row. The cleaning system has a guide rail extending on the frame longitudinally along the back side of the row of spindles, a cleaner carriage displaceable longitudinally along the rail past the spindles, and a drive for displacing the cleaner carriage longitudinally along the rail past the spindles. A set of tools on the cleaner carriage strips roving from the reserve surfaces as the cleaner carriage passes same. A vacuum carriage displaceable longitudinally along the frame has an attachment with an end projecting from the front side back toward the stations level with the reserve surfaces for aspirating roving stripped therefrom by the tools and a drive engaged between the vacuum carriage and the frame displaces the vacuum carriage longitudinally along the frame and thereby sequentially positions the attachment immediately adjacent the surfaces. A synchronizing unit connected between both of the drives synchronously jointly moves the carriages and maintains the attachment transversely aligned with the tools.

摘要翻译： 备用表面清洁装置与环锭纺纱机组合使用，该纺丝机具有纵向延伸的一排主轴，每个主轴适于保持粗纱套筒，并且每个形成在相应套筒下方，具有相应的备用卷绕区域和沿着 行的后侧和沿着行的前侧延伸的服务区。 所述清洁系统具有沿着所述主轴纵向延伸的所述框架上的导轨，沿着所述轨道经过所述主轴纵向移动的清洁器支架，以及用于沿着所述轨道纵向移动所述清洁器托架通过所述心轴的驱动器。 清洁器车架上的一组工具在清洁器车架通过时从保留表面上粗纱。 沿着框架纵向移动的真空滑架具有附接件，其端部从前侧向后朝向工位水平面突出，备用表面用于通过工具从其中剥离的粗纱，并且在真空托架和框架之间接合的驱动器使真空 沿着框架纵向滑动，从而顺序地将附件紧邻表面定位。 连接在两个驱动装置之间的同步装置同步地共同地移动支架并维持附件与工具横向对准。

公开(公告)号：US5311732A

公开(公告)日：1994-05-17

申请号：US962142

申请日：1992-10-16

申请人： Daniel Friedrich

发明人： Daniel Friedrich

IPC分类号： D01H11/00 ,  D01H1/38 ,  D01H9/16

CPC分类号： D01H1/385

摘要： In a ring-spinning or -twisting machine a longitudinal row of upright and normally rotating spindles mounted on a common support beam each have a lower reserve surface below a sleeve normally carried on the spindle. An apparatus for clearing roving wound on the surface has a guide rail extending longitudinally along a back side of the beam adjacent the spindles, a carriage displaceable along the rail past the spindles, and a drive including a longitudinally extending drive element secured to the carriage for displacing same longitudinally along the rail past the spindles. A roving-cutting element is fixed on the carriage engageable immediately adjacent the spindles between the respective lower reserve surfaces and sleeves and a roving-clearing element is fixed on the carriage below the cutting element and engageable immediately adjacent the lower reserve surfaces of the spindles.

摘要翻译： 在旋转纺丝机中，安装在公共支撑梁上的纵向和正常旋转主轴的纵排每个在通常承载在主轴上的套筒下方具有较低的预留表面。 用于清除表面上的粗纱缠绕的装置具有沿着梁的靠近轴的纵向延伸的导轨，沿着轨道可移动穿过主轴的滑架，以及驱动器，其包括固定到滑架的纵向延伸的驱动元件 沿导轨纵向移动通过主轴。 粗切割元件固定在可在紧邻相应的下备用表面和套筒之间的主轴附近接合的托架上，并且清纱元件固定在切割元件下方的托架上并可紧邻主轴的下保留表面。

公开(公告)号：US2201812A

公开(公告)日：1940-05-21

申请号：US28484439

申请日：1939-07-17

申请人： KONRAD DANIEL FRIEDRICH

发明人： KONRAD DANIEL FRIEDRICH

IPC分类号： D21C11/00

CPC分类号： D21C11/0042 ,  Y10S516/01 ,  Y10S516/03

公开(公告)号：US06604261B2

公开(公告)日：2003-08-12

申请号：US10164277

申请日：2002-06-06

申请人： Angelika Stoll ,  Daniel Friedrich

发明人： Angelika Stoll ,  Daniel Friedrich

IPC分类号： D01H500

CPC分类号： D01H5/26 ,  D01H5/72 ,  D01H5/86

摘要： Downstream of the last roller pair of a drafting frame for a spinning machine, the roving is condensed in a fiber-bundling zone having a belt with perforations to which suction is applied. Another belt converges toward the belt with the perforations and engages the roving at a nip spaced from the nip formed by the last roller pair of the drafting frame so that the wedge-shaped converging of the two belts promotes the compacting or condensing action.