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公开(公告)号：US20100125086A1
公开(公告)日：2010-05-20
申请号：US12554584
申请日：2009-09-04
申请人： Hans-Ulrich Demuth , Stephan Schilling , Michael Wermann , Holger Cynis , Astrid Kehlen , Daniel Friedrich , Torsten Hoffmann , Kathrin Gans , Jens-Ulrich Rahfeld , Ulrich Heiser , Michael Almstetter , Robert Sommer , Ulf-Torsten Gaertner , Antje Hamann , Michael Thormann , Andreas Tremel
发明人： Hans-Ulrich Demuth , Stephan Schilling , Michael Wermann , Holger Cynis , Astrid Kehlen , Daniel Friedrich , Torsten Hoffmann , Kathrin Gans , Jens-Ulrich Rahfeld , Ulrich Heiser , Michael Almstetter , Robert Sommer , Ulf-Torsten Gaertner , Antje Hamann , Michael Thormann , Andreas Tremel
IPC分类号： A61K31/4178 , C12Q1/25 , A61K31/437 , A61K31/433 , A61K31/4184 , A61P29/00
CPC分类号： C07D233/54 , C07D233/61 , C07D235/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C12N9/104
摘要： The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase-like protein (QPCTL), and the use thereof for the treatment and/or prevention of an inflammatory disease or disorder selected from the group consisting of (a) chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis; (b) other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis, Guillain-Barré syndrome, chronic inflammatory demyelinising polyradiculoneuropathy and multiple sclerosis; (c) neuroinflammation; and (d) neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, and Familial Danish Dementia, which may result from neuroinflammation.
摘要翻译： 本发明一般涉及谷氨酰胺肽环转移酶样蛋白（QPCTL）的抑制剂及其用于治疗和/或预防炎性疾病或病症的用途，所述炎性疾病或病症选自（a）慢性和急性 炎症，例如 类风湿关节炎，动脉粥样硬化，再狭窄，胰腺炎; （b）其他炎性疾病，例如 神经性疼痛，移植物排斥/移植物衰竭/移植物血管病变，HIV感染/艾滋病，睾丸炎，结节性硬化症，吉兰巴利综合征，慢性炎症性脱髓鞘性多发性神经病和多发性硬化症; （c）神经炎症; 和（d）神经变性疾病，例如 轻度认知障碍（MCI），阿尔茨海默氏症，唐氏综合征神经变性，家族性英国痴呆和家族性丹麦痴呆，可能由神经炎症引起。
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2.发明授权Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions 有权使用isoQC抑制剂治疗和预防炎性疾病或病症公开(公告)号：US08889709B2
公开(公告)日：2014-11-18
申请号：US12554584
申请日：2009-09-04
申请人： Hans-Ulrich Demuth , Stephan Schilling , Michael Wermann , Holger Cynis , Astrid Kehlen , Daniel Friedrich , Torsten Hoffmann , Kathrin Gans , Jens-Ulrich Rahfeld , Ulrich Heiser , Michael Almstetter , Robert Sommer , Ulf-Torsten Gaertner , Antje Hamann , Michael Thormann , Andreas Treml
发明人： Hans-Ulrich Demuth , Stephan Schilling , Michael Wermann , Holger Cynis , Astrid Kehlen , Daniel Friedrich , Torsten Hoffmann , Kathrin Gans , Jens-Ulrich Rahfeld , Ulrich Heiser , Michael Almstetter , Robert Sommer , Ulf-Torsten Gaertner , Antje Hamann , Michael Thormann , Andreas Treml
IPC分类号： A01N43/42 , C12N9/00 , C12N9/10 , C12N1/20 , C12N15/00 , C07H21/04 , C07D417/12 , C07D405/12 , C07D233/61 , C07D409/12 , C07D403/12 , C07D413/12 , C07D403/06 , C07D401/12 , C07D233/54 , C07D235/06
CPC分类号： C07D233/54 , C07D233/61 , C07D235/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C12N9/104
摘要： The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase-like protein (QPCTL), and the use thereof for the treatment and/or prevention of an inflammatory disease or disorder selected from the group consisting of (a) chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis; (b) other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis, Guillain-Barré syndrome, chronic inflammatory demyelinizing polyradiculoneuropathy and multiple sclerosis; (c) neuroinflammation; and (d) neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, and Familial Danish Dementia, which may result from neuroinflammation.
摘要翻译： 本发明一般涉及谷氨酰胺肽环转移酶样蛋白（QPCTL）的抑制剂及其用于治疗和/或预防炎性疾病或病症的用途，所述炎性疾病或病症选自（a）慢性和急性 炎症，例如 类风湿关节炎，动脉粥样硬化，再狭窄，胰腺炎; （b）其他炎性疾病，例如 艾滋病，睾丸炎，结节性硬化症，吉兰巴利综合征，慢性炎性脱髓鞘性多发性神经系统疾病和多发性硬化; （c）神经炎症; 和（d）神经变性疾病，例如 轻度认知障碍（MCI），阿尔茨海默氏症，唐氏综合征神经变性，家族性英国痴呆和家族性丹麦痴呆，可能由神经炎症引起。
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3.发明授权Antibodies directed against pyroglutamate monocyte chemoattractant protein-1 (MCP-1 N1pE) 有权针对焦谷氨酸单核细胞趋化蛋白-1（MCP-N1PE）的抗体公开(公告)号：US08518406B2
公开(公告)日：2013-08-27
申请号：US12544319
申请日：2009-08-20
申请人： Holger Cynis , Hans-Ulrich Demuth , Jens-Ulrich Rahfeld , Kathrin Gans , Stephan Schilling , Sonja Kampfer
发明人： Holger Cynis , Hans-Ulrich Demuth , Jens-Ulrich Rahfeld , Kathrin Gans , Stephan Schilling , Sonja Kampfer
IPC分类号： A61K39/395 , A61K39/44 , C07K16/24
CPC分类号： C07K16/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92 , G01N33/6854
摘要： Monoclonal antibodies which bind specifically to the proinflammatory cytokine pyroglutamate MCP-1 (MCP-1 N1pE) are described.
摘要翻译： 描述了特异性结合促炎细胞因子焦谷氨酸MCP-1（MCP-1 N1pE）的单克隆抗体。
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4.发明申请IN VIVO SCREENING MODELS FOR TREATMENT OF ALZHEIMER'S DISEASE AND OTHER QPCT-RELATED DISORDERS 审中-公开用于治疗阿尔茨海默病和其他与QPCT有关的疾病的生殖器筛查模型公开(公告)号：US20080200567A1
公开(公告)日：2008-08-21
申请号：US12016266
申请日：2008-01-18
申请人： Stephan Schilling , Holger Cynis , Torsten Hoffmann , Hans-Ulrich Demuth , Michael Wermann , Katrin Schulz
发明人： Stephan Schilling , Holger Cynis , Torsten Hoffmann , Hans-Ulrich Demuth , Michael Wermann , Katrin Schulz
IPC分类号： A61K35/00 , A01K67/027 , G01N33/50 , A61P25/28 , C12N5/10
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/052 , A01K2267/0312 , A01K2267/0318 , C12N9/104
摘要： A transgenic non-human animal, in particular a transgenic mouse, encoding Qpct proteins which have been implicated in Qpct-related diseases. Also disclosed are cells and cell lines comprising transgenes encoding for Qpct. Further disclosed are methods and compositions for evaluating agents that affect Qpct, for use in compositions for the treatment of Qpct-related diseases.
摘要翻译： 编码Qpct蛋白质的转基因非人动物，特别是转基因小鼠，其涉及Qpct相关疾病。 还公开了包含编码Qpct的转基因的细胞和细胞系。 还公开了用于评估影响Qpct的药剂的方法和组合物，用于治疗Qpct相关疾病的组合物。
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公开(公告)号：US20130052203A1
公开(公告)日：2013-02-28
申请号：US13571947
申请日：2012-08-10
申请人： Sigrid Graubner , Wolfgang Jagla , Stephan Schilling , Holger Cynis , Hans-Ulrich Demuth , Torsten Hoffmann , Michael Wermann , Katrin Schulz , Christoph Baeuscher , Stefanie Kohlmann
发明人： Sigrid Graubner , Wolfgang Jagla , Stephan Schilling , Holger Cynis , Hans-Ulrich Demuth , Torsten Hoffmann , Michael Wermann , Katrin Schulz , Christoph Baeuscher , Stefanie Kohlmann
IPC分类号： A01K67/027 , A61K49/00 , C12N5/071 , C07K16/40 , A61K39/395 , A61P11/00 , A61P25/18 , A61P35/00 , A61P19/02 , A61P35/04 , A61P9/10 , A61P1/18 , A01K67/02 , A61P25/28
CPC分类号： A01K67/0278 , A01K2217/052 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/0312 , C07K14/4711 , C12N9/104
摘要： A double transgenic non-human animal, in particular a transgenic mouse encoding Qpct proteins, which have been implicated in Qpct-related diseases, and Amyloid Precursor Protein (APP). Also provided are cells and cell lines comprising transgenes encoding for Qpct and APP. Also provided are methods and compositions for evaluating agents that affect Qpct, for use in compositions for the treatment of Qpct-related diseases.
摘要翻译： 双重转基因非人动物，特别是编码Qpct蛋白的转基因小鼠，其涉及Qpct相关疾病，和淀粉样前体蛋白（APP）。 还提供了包含编码Qpct和APP的转基因的细胞和细胞系。 还提供了用于评估影响Qpct的药剂的方法和组合物，用于治疗Qpct相关疾病的组合物。
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6.发明申请GLUTAMINYL CYCLASE AS A DIAGNOSTIC/PROGNOSTIC INDICATOR FOR NEURODEGENERATIVE DISEASES 审中-公开谷氨酰胺循环作为神经病变疾病的诊断/预防指标公开(公告)号：US20100028918A1
公开(公告)日：2010-02-04
申请号：US12533099
申请日：2009-07-31
申请人： Hans-Ulrich Demuth , Stephan Schilling , Martin Kleinschmidt , Jens-Ulrich Rahfeld , Astrid Kehlen , Monique Haegele
发明人： Hans-Ulrich Demuth , Stephan Schilling , Martin Kleinschmidt , Jens-Ulrich Rahfeld , Astrid Kehlen , Monique Haegele
CPC分类号： G01N33/6896 , C12Q1/48 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , G01N33/573 , G01N2333/4703 , G01N2333/523 , G01N2333/9108 , G01N2800/28 , G01N2800/2814 , G01N2800/2821 , G01N2800/387
摘要： A method for predicting, diagnosing and prognosticating a neurodegenerative disease, such as Alzheimer's disease (AD), Mild Cognitive Impairment (MCI) and neurodegeneration in Down's syndrome (NDS) using glutaminyl cyclase (QC) as a diagnostic/prognostic indicator. The use of antibodies binding to QC and kits for performing said diagnostic method are also provided.
摘要翻译： 作为诊断/预后指标，使用谷氨酰胺环化酶（QC）预测，诊断和预测唐氏综合征（NDS）中的神经变性疾病，如阿尔茨海默病（AD），轻度认知障碍（MCI）和神经变性。 还提供使用结合QC的抗体和用于进行所述诊断方法的试剂盒。
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公开(公告)号：US20100009337A1
公开(公告)日：2010-01-14
申请号：US12497082
申请日：2009-07-02
IPC分类号： C12Q1/00
CPC分类号： C12N9/104 , C07D233/54 , C07D233/61 , C07D235/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Novel glutaminyl-peptide cyclotransferase-like proteins (QPCTLs), which are isoenzymes of glutaminyl cyclase (QC, EC 2.3.2.5), and to isolated nucleic acids coding for these isoenzymes, all of which are useful for the discovery of new therapeutic agents, for measuring cyclase activity, and for determining the inhibitory activity of compounds against these glutaminyl cyclase isoenzymes.
摘要翻译： 作为谷氨酰胺环化酶同功酶（QC，EC 2.3.2.5）的新型谷氨酰胺肽 - 转移酶样蛋白（QPCTL），以及编码这些同工酶的分离的核酸，所有这些都可用于发现新的治疗剂， 用于测定环化酶活性，以及测定化合物对这些谷氨酰胺环化酶同工酶的抑制活性。
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公开(公告)号：US08129160B2
公开(公告)日：2012-03-06
申请号：US12497082
申请日：2009-07-02
CPC分类号： C12N9/104 , C07D233/54 , C07D233/61 , C07D235/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Novel glutaminyl-peptide cyclotransferase-like proteins (QPCTLs), which are isoenzymes of glutaminyl cyclase (QC, EC 2.3.2.5), and to isolated nucleic acids coding for these isoenzymes, all of which are useful for the discovery of new therapeutic agents, for measuring cyclase activity, and for determining the inhibitory activity of compounds against these glutaminyl cyclase isoenzymes.
摘要翻译： 作为谷氨酰胺环化酶同功酶（QC，EC 2.3.2.5）的新型谷氨酰胺肽 - 转移酶样蛋白（QPCTL），以及编码这些同工酶的分离的核酸，所有这些都可用于发现新的治疗剂， 用于测定环化酶活性，以及测定化合物对这些谷氨酰胺环化酶同工酶的抑制活性。
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公开(公告)号：US20120183974A1
公开(公告)日：2012-07-19
申请号：US13325015
申请日：2011-12-13
CPC分类号： C12N9/104 , C07D233/54 , C07D233/61 , C07D235/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Novel glutaminyl-peptide cyclotransferase-like proteins (QPCTLs), which are isoenzymes of glutaminyl cyclase (QC, EC 2.3.2.5), and to isolated nucleic acids coding for these isoenzymes, all of which are useful for the discovery of new therapeutic agents, for measuring cyclase activity, and for determining the inhibitory activity of compounds against these glutaminyl cyclase isoenzymes.
摘要翻译： 作为谷氨酰胺环化酶同功酶（QC，EC 2.3.2.5）的新型谷氨酰胺肽 - 转移酶样蛋白（QPCTL），以及编码这些同工酶的分离的核酸，所有这些都可用于发现新的治疗剂， 用于测定环化酶活性，以及测定化合物对这些谷氨酰胺环化酶同工酶的抑制活性。
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公开(公告)号：US20100021478A1
公开(公告)日：2010-01-28
申请号：US12500940
申请日：2009-07-10
申请人： Hans-Ulrich Demuth , Stephan Schilling , Martin Kleinschmidt , Kathrin Gans , Anita Reisenauer-Schaupp , Jens-Ulrich Rahfeld , Sonja Kampfer
发明人： Hans-Ulrich Demuth , Stephan Schilling , Martin Kleinschmidt , Kathrin Gans , Anita Reisenauer-Schaupp , Jens-Ulrich Rahfeld , Sonja Kampfer
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821 , G01N2800/387
摘要： The present invention pertains to novel diagnostic assays for the diagnosis of amyloidosis, in particular Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided.
摘要翻译： 本发明涉及用于诊断淀粉样变性，特别是阿尔茨海默病的新型诊断测定法和相关方面。 特别地，提供单克隆抗体和抗体测定。
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