公开(公告)号：US5248221A

公开(公告)日：1993-09-28

申请号：US964794

申请日：1992-10-22

Applicant: Donald J. Gerhart ,  Daniel Rittschof ,  Irving R. Hooper

Inventor： Donald J. Gerhart ,  Daniel Rittschof ,  Irving R. Hooper

IPC: C02F1/50

CPC classification number: C02F1/50 ,  Y10S210/931

Abstract: Certain gamma lactones are disclosed as being useful as marine or fresh water antifoulant compounds to be used in protective carrier compositions such as film forming polymer to protect fish nets, boats, pilings, and piers.

Abstract translation: 公开了某些γ内酯可用作海洋或淡水防污化合物，用于保护载体组合物如成膜聚合物中以保护鱼网，船，桩和墩。

公开(公告)号：US4704286A

公开(公告)日：1987-11-03

申请号：US753252

申请日：1985-07-09

Applicant: Daniel Rittschof ,  Gaspard X. Criner ,  Joseph Bonaventura

Inventor： Daniel Rittschof ,  Gaspard X. Criner ,  Joseph Bonaventura

IPC: A01K97/04 ,  A23K1/18

CPC classification number: A01K97/045 ,  A23K50/80 ,  Y10S426/805

Abstract: The gustatory additive of the present invention provides an improved fish bait. The gustatory additive causes a fish to hold a lure treated with the gustatory additive in its mouth for a longer period of time or causes the fish to swallow the lure. Because the fish holds the lure coated with the gustatory additive in its mouth for a relatively longer period of time, the fisherman has more time in which to set the hook in the fish's mouth.The gustatory additive of the present invention is comprised of a mixture of nutrients that are mixed with a water insoluble matrix and then applied to the surface of a lure. The gustatory additive of the present invention can also be distributed throughout the lure.

Abstract translation: 本发明的味觉添加剂提供了改进的鱼饵。 味觉添加剂使鱼类在口中保持用味觉添加剂治疗的诱饵较长时间，或导致鱼吞食诱饵。 因为鱼在口中保持涂有味觉添加剂的诱饵持续相对较长的时间，所以渔夫有更多的时间将钩子放在鱼的嘴里。 本发明的味觉添加剂包括与水不溶性基质混合然后施用于诱饵表面的营养物质的混合物。 本发明的味觉添加剂也可以分布在整个诱饵中。

公开(公告)号：US09169223B2

公开(公告)日：2015-10-27

申请号：US13576808

申请日：2011-02-02

Applicant: Christina Li Lin Chai ,  Brendan Adrian Burkett ,  Serena Lay Ming Teo ,  Daniel Rittschof ,  Serina Siew Chen Lee ,  Gary Howard Dickinson ,  Han Hong

Inventor： Christina Li Lin Chai ,  Brendan Adrian Burkett ,  Serena Lay Ming Teo ,  Daniel Rittschof ,  Serina Siew Chen Lee ,  Gary Howard Dickinson ,  Han Hong

IPC: A61K31/74 ,  C07D295/185 ,  C07C235/34 ,  C09D5/16 ,  A01N25/10 ,  A01N37/18 ,  C09D5/14

CPC classification number: C09D5/1668 ,  A01N25/10 ,  A01N37/18 ,  C07C233/11 ,  C07C235/34 ,  C07D295/185 ,  C07D295/192 ,  C08F120/34 ,  C09D5/14 ,  C09D5/1625 ,  C09D5/165

Abstract: The present invention relates to derivatives of α,α-disubstituted amide compounds which comprise a substituted aryl at the α carbon such that the substituent provides a means for attachment or incorporation of the compound to or in a polymer. The provision of such a substituent on the aryl has surprisingly been found not only to permit attachment to or incorporation in a polymer but also retention of useful antifouling activity. In embodiments, the substituent is selected from hydroxyl, ethers, esters, carboxyls, alkylsilyls and alkenyls. Experiments demonstrate that antifouling activity can be as good or better as the corresponding unsubstituted compound and that polymers functionalized so as to include or be formed from the substituted compound can be used to reduce settlement.

Abstract translation: 本发明涉及α，α-二取代的酰胺化合物的衍生物，其包含在α碳上的取代的芳基，使得取代基提供了将化合物连接或引入到聚合物中的方法。 在芳基上提供这样的取代基已经令人惊奇地发现，不仅允许附着或掺入聚合物中，而且保留有用的防污活性。 在实施方案中，取代基选自羟基，醚，酯，羧基，烷基甲硅烷基和烯基。 实验表明，防污活性可以与相应的未取代的化合物一样好或更好，并且可以使用官能化以包含或由取代的化合物形成的聚合物来减少沉降。

公开(公告)号：US20110092518A1

公开(公告)日：2011-04-21

申请号：US12992044

申请日：2009-05-18

Applicant: Lay Ming Serena Teo ,  Daniel Rittschof ,  Felicity Jameson ,  Christina Chai ,  Chia Lung Chen ,  Siew Chen Serina Lee

Inventor： Lay Ming Serena Teo ,  Daniel Rittschof ,  Felicity Jameson ,  Christina Chai ,  Chia Lung Chen ,  Siew Chen Serina Lee

IPC: A01N43/60 ,  A01N43/40 ,  A01N37/18 ,  C07D213/63 ,  C07D211/70 ,  C07D241/04 ,  C07C233/04 ,  C07C233/11 ,  A01P1/00

CPC classification number: C07D295/185 ,  C07D211/46 ,  C07D211/52 ,  C08K5/3435 ,  C09D5/1625 ,  C09D7/63

Abstract: The present invention relates to the use of compounds which have the following general formula (I), wherein R1 and R2 are independently selected from optionally substituted aryl, optionally substituted C1 to C12 alkyl and H; and R3 and R4 are independently selected from hydroxy, optionally substituted C1 to C6 alkyl, optionally substituted phenyl and H, in a method of preventing or reducing fouling, particularly in the marine environment. The compounds of the present invention have the considerable advantage of providing the antifouling coating market with an organic alternative to the existing technology which relies heavily on the addition of copper to obtain significant antifouling effects. The compounds we have developed may be used as cheap, easy to prepare additives that do not contain metals and therefore have reduced toxicity in marine environment.

Abstract translation: 本发明涉及具有以下通式（I）的化合物的用途，其中R 1和R 2独立地选自任选取代的芳基，任选取代的C 1至C 12烷基和H; 并且特别是在海洋环境中，R3和R4独立地选自羟基，任意取代的C1至C6烷基，任选取代的苯基和H，以防止或减少结垢。 本发明的化合物具有相当大的优点，即为防污涂料市场提供有选择的替代现有技术，其主要依赖于添加铜以获得显着的防污效果。 我们开发的化合物可以用作廉价，易于制备不含金属的添加剂，因此在海洋环境中具有降低的毒性。

公开(公告)号：US4788302A

公开(公告)日：1988-11-29

申请号：US824959

申请日：1986-01-31

Applicant: John D. Costlow ,  Irving R. Hooper ,  Daniel Rittschof

Inventor： John D. Costlow ,  Irving R. Hooper ,  Daniel Rittschof

IPC: C07D307/93 ,  C09D5/16 ,  C07D307/92 ,  A61K31/34 ,  C09D5/14

CPC classification number: C09D5/1625 ,  C07D307/93

Abstract: A tissue extract containing a low molecular weight, non-proteinaceous compound selected from the group consisting of (A) methanol-soluble compounds obtainable from Leptogorgia virgulata with R.sub.f values in reverse-phase, thin layer, silica gel chromatography of (1) 0.42, 0.54, and 0.62; (2) 0.35, 0.50, and 0.58; (3) 0.37, 0.47, and 0.58; or (4) 0.31, 0.43, and 0.54, respectively, in 1:1:1 methanol:ethyl acetate:water, 2:1:1 methanol:ethyl acetate:water, and 1:2:1 methanol:ethyl acetate:water, or (B) methanol-soluble compounds obtainable from Renilla reinformis with R.sub.f values in thin layer, silica gel chromatography of (1) 0:44, 0.37, and 0.53; (2) 0.52, 0.42, and 0.60; (3) 0.56, 0.43, and 0.63; or (4) 0.32, 0.26, and 0.37, respectively, in 9:1 chloroform:acetonitrile, 9:1 methylene chloride:acetonitrile, and 4:1 methylene chloride:acetonitrile and compositions containing the same, which is useful as antifouling compositions, is disclosed.

Abstract translation: 一种含有低分子量非蛋白质化合物的组织提取物，所述组合物选自（A）可从反相中得到的具有Rf值的Leptogorgia virgulata的甲醇可溶性化合物，（1）0.42的薄层，硅胶色谱， 0.54和0.62; （2）0.35,0.50和0.58; （3）0.37,0.47和0.58; 或分别在1:1:1甲醇：乙酸乙酯：水，2:1:1甲醇：乙酸乙酯：水和1:2:1甲醇：乙酸乙酯：水中的（4）0.31,0.43和0.54 ，或（B）可从Renilla reinformis获得的甲醇可溶性化合物，薄层中的Rf值，（1）0:44,0.33和0.53的硅胶色谱法; （2）0.52,0.42和0.60; （3）0.56,0.33和0.63; 或分别在9:1氯仿：乙腈，9:1二氯甲烷：乙腈和4:1二氯甲烷：乙腈中的（4）0.32,0.26和0.37和含有该组合物的组合物，其可用作防污组合物， 被披露。

公开(公告)号：US20120301423A1

公开(公告)日：2012-11-29

申请号：US13576808

申请日：2011-02-02

Applicant: Christina Li Lin Chai ,  Brendan Adrian Burkett ,  Serena Lay Ming Teo ,  Daniel Rittschof ,  Serina Siew Chen Lee ,  Gary Howard Dickinson ,  Han Hong

Inventor： Christina Li Lin Chai ,  Brendan Adrian Burkett ,  Serena Lay Ming Teo ,  Daniel Rittschof ,  Serina Siew Chen Lee ,  Gary Howard Dickinson ,  Han Hong

IPC: A01N43/40 ,  C07F7/10 ,  A01N55/10 ,  C08F226/10 ,  A01N37/38 ,  C07F7/18 ,  A01P7/00 ,  C08F226/06 ,  C07D295/192 ,  C07C235/34

CPC classification number: C09D5/1668 ,  A01N25/10 ,  A01N37/18 ,  C07C233/11 ,  C07C235/34 ,  C07D295/185 ,  C07D295/192 ,  C08F120/34 ,  C09D5/14 ,  C09D5/1625 ,  C09D5/165

Abstract: The present invention relates to derivatives of α,α-disubstituted amide compounds which comprise a substituted aryl at the α carbon such that the substituent provides a means for attachment or incorporation of the compound to or in a polymer. The provision of such a substituent on the aryl has surprisingly been found not only to permit attachment to or incorporation in a polymer but also retention of useful antifouling activity. In embodiments, the substituent is selected from hydroxyl, ethers, es ters, carboxyls, alkylsilyls and alkenyls. Experiments demonstrate that antifouling activity can be as good or better as the corresponding unsubstituted compound and that polymers functionalised so as to include or be formed from the substituted compound can be used to reduce settlement.

Abstract translation: 本发明涉及α，α-二取代的酰胺化合物的衍生物，其包含在α碳上的取代的芳基，使得取代基提供了将化合物连接或引入到聚合物中的方法。 在芳基上提供这样的取代基已经令人惊奇地发现，不仅允许附着或掺入聚合物中，而且保留有用的防污活性。 在实施方案中，取代基选自羟基，醚，酯，羧基，烷基甲硅烷基和烯基。 实验证明防污活性可以与相应的未取代的化合物一样好或更好，并且可以使用官能化以包含或由取代的化合物形成的聚合物来减少沉降。

公开(公告)号：US20110041725A1

公开(公告)日：2011-02-24

申请号：US12665505

申请日：2008-06-13

Applicant: Daniel Rittschof ,  Gary H. Dickinson ,  Beatriz Orihuela de Diaz ,  Eric R. Holm

Inventor： Daniel Rittschof ,  Gary H. Dickinson ,  Beatriz Orihuela de Diaz ,  Eric R. Holm

IPC: C09D5/16 ,  C12Q1/56 ,  C12Q1/37 ,  C12Q1/48 ,  C08B37/00 ,  C07D311/06 ,  C08B37/10 ,  C08B37/02 ,  C07C55/22 ,  C07C229/04 ,  C07C65/10

CPC classification number: C09D5/1606

Abstract: Methods and compositions are provided for the reduction of fouling of objects present in marine environments. The methods and compositions include anticoagulants, such as, for example, glycosaminoglycans, coumarin-type molecules, metal chelators, plasminogen activators and platelet inhibitors. The methods include reducing marine fouling, comprising incorporating an anticoagulant compound into a marine coating. In addition, the methods include identifying compounds useful for reducing marine fouling, comprising measuring either blood coagulation or barnacle cement polymerization in the presence and absence of the compound, wherein a reduction in the blood coagulation or the barnacle cement polymerization in the presence of the compound identifies the compound as useful for reducing marine fouling. The coagulation or the polymerization can be measured by a serine protease activity or a transglutaminase activity.

Abstract translation: 提供了减少海洋环境中存在的物体污染的方法和组合物。 所述方法和组合物包括抗凝血剂，例如糖胺聚糖，香豆素型分子，金属螯合剂，纤溶酶原激活剂和血小板抑制剂。 所述方法包括减少海洋结垢，其包括将抗凝血剂化合物掺入海洋涂料中。 此外，所述方法包括鉴定可用于减少海洋结垢的化合物，包括在化合物存在和不存在下测量血液凝固或藤壶水泥聚合，其中在化合物存在下凝血或藤壶水泥聚合的减少 鉴定该化合物可用于减少海洋污染。 凝血或聚合可以通过丝氨酸蛋白酶活性或转谷氨酰胺酶活性测量。

公开(公告)号：US20060110456A1

公开(公告)日：2006-05-25

申请号：US11265833

申请日：2005-11-03

Applicant: Serena Lay Ming Teo ,  Amy Mei Fun Choong ,  Tsai Min Sin ,  Daniel Rittschof ,  James Maki

Inventor： Serena Lay Ming Teo ,  Amy Mei Fun Choong ,  Tsai Min Sin ,  Daniel Rittschof ,  James Maki

IPC: A61K9/24

CPC classification number: A01N33/04 ,  A01N33/10 ,  A01N43/40 ,  A01N43/50 ,  A01N43/60 ,  A01N43/84 ,  A01N43/90 ,  A01N2300/00

Abstract: There is provided a method of biocidal and/or biostatic treatment and compounds and compositions thereof. In particular, there is provided a composition comprising at least one compound having the formula R1R2NR3, wherein R1, R2 and R3, are selected from the group consisting of hydrido, alkyl, aryl, heteroaryl, cycloalkyl, cycloaryl, cycloheteroaryl, alkenyl and alkynyl. In particular, the compounds and compositions of the invention are suitable for preventing, reducing and/or eliminating biofilms and/or fouling.

Abstract translation: 提供了一种杀生物和/或生物处理的方法及其化合物及其组合物。 特别地，提供了一种组合物，其包含至少一种具有式R 1，R 2，R 3，R 3，R 3，R 3， R 2，R 3和R 3选自氢，烷基，芳基，杂芳基，环烷基，环芳基，环杂芳基，烯基和炔基。 特别地，本发明的化合物和组合物适用于预防，减少和/或消除生物膜和/或结垢。

公开(公告)号：US5259701A

公开(公告)日：1993-11-09

申请号：US964795

申请日：1992-10-22

Applicant: Donald L. Gerhart ,  Daniel Rittschof ,  Irving R. Hooper ,  Anthony Clare

Inventor： Donald L. Gerhart ,  Daniel Rittschof ,  Irving R. Hooper ,  Anthony Clare

IPC: A01N43/08 ,  A01N43/90 ,  B63B59/04 ,  C04B24/00 ,  C09D5/16 ,  C02F1/50

CPC classification number: C09D5/1625 ,  A01N43/08 ,  A01N43/90 ,  B63B59/04 ,  C04B24/00 ,  Y10S210/931

Abstract: Certain furan compounds are disclosed as being useful as marine or fresh water antifoulant compounds to be used in protective carrier compositions such as film forming polymer to protect fish nets, boats, pilings, and piers.

Abstract translation: 公开了某些呋喃化合物可用作海洋或淡水防污化合物，用于保护载体组合物如成膜聚合物以保护鱼网，船只，桩和墩。