公开(公告)号：US20070207148A1

公开(公告)日：2007-09-06

申请号：US11625085

申请日：2007-01-19

Applicant: David Lewin ,  Timothy Stewart

Inventor： David Lewin ,  Timothy Stewart

IPC: A61K38/00 ,  A61K31/7052 ,  A61K39/395 ,  C07H21/04 ,  C07K14/00 ,  C07K16/18 ,  C12N15/00 ,  C12N5/06 ,  C12Q1/68

CPC classification number: C07K14/665 ,  A61K38/00 ,  A61K2123/00 ,  C07K14/57554 ,  C07K14/5759 ,  C07K14/805 ,  C12N9/6424 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y304/21094

Abstract: The instant invention is concerned with genes associated with obesity. Additionally, the invention provides methods of using the differential expression of these genes associated with obesity to diagnose and treat obesity, as well as to screen for compounds useful for treating obesity.

Abstract translation: 本发明涉及与肥胖相关的基因。 另外，本发明提供了使用与肥胖相关的这些基因的差异表达来诊断和治疗肥胖症以及筛选可用于治疗肥胖症的化合物的方法。

公开(公告)号：US20050228171A1

公开(公告)日：2005-10-13

申请号：US11146835

申请日：2005-06-07

Applicant: John More ,  Jacqueline Rott ,  David Lewin

Inventor： John More ,  Jacqueline Rott ,  David Lewin

IPC: A61K38/00 ,  A61P39/00 ,  C07K1/18 ,  C07K1/20 ,  C07K14/195 ,  C07K14/47

CPC classification number: C07K14/473 ,  A61K38/00 ,  Y10S530/829 ,  Y10S530/831

Abstract: The invention relates to a method of removing endotoxin from preparation of alpha-1-acid glycoprotein (orosomucoid) by contact with a finely divided non-toxic resin such as fumed silica. The invention also relates to a purification process for alpha-1-acid glycoprotein which includes this depyrogenation step, and to the depyrogenated product and its clinical uses.

Abstract translation: 本发明涉及通过与细碎的无毒树脂如热解法二氧化硅接触来除去内毒素从制备α-1-酸糖蛋白（orosomucoid）的方法。 本发明还涉及包括该去除热解步骤的α-1-酸糖蛋白的纯化方法，以及该脱氢产物及其临床用途。

公开(公告)号：US20050042655A1

公开(公告)日：2005-02-24

申请号：US10886160

申请日：2004-07-06

Applicant: David Lewin ,  Richard Shimkets ,  Lawrence Lasky ,  Bruce Taillon ,  Steven Gold

Inventor： David Lewin ,  Richard Shimkets ,  Lawrence Lasky ,  Bruce Taillon ,  Steven Gold

IPC: G01N33/50 ,  A61K31/711 ,  A61K38/00 ,  A61K45/00 ,  A61P7/06 ,  A61P35/00 ,  A61P35/02 ,  C07K14/47 ,  C07K14/52 ,  C07K16/18 ,  C07K19/00 ,  C12M1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566

CPC classification number: C07K14/521

Abstract: Disclosed are novel hematopioetic modulating nucleic acid sequences and polypeptides. Also disclosed are methods in which the nucleic acids and polypeptides are utilized in the detection and treatment of hematopoietic disorders.

Abstract translation: 公开了新的造血调节核酸序列和多肽。 还公开了将核酸和多肽用于造血障碍的检测和治疗中的方法。

公开(公告)号：US4645090A

公开(公告)日：1987-02-24

申请号：US779219

申请日：1985-09-23

Applicant: David Lewin

Inventor： David Lewin

IPC: A21B3/13 ,  B65D21/02

CPC classification number: A21B3/133

Abstract: A baking utensil which is designed for use in commercial baking operations has a rigid frame for supporting baking pans. The pans themselves have non-stick baking surfaces and are attached to the frame in a manner which permit ready detachment and replacement. Typically, the pans' baking surfaces are coated with PTFE (polytetrafluororethylene).

Abstract translation: 设计用于商业烘烤操作的烘烤用具具有用于支撑烤盘的刚性框架。 平底锅本身具有不粘的烘烤表面，并以允许准备拆卸和更换的方式附接到框架。 通常，锅的烘烤表面涂覆有PTFE（聚四氟乙烯）。

公开(公告)号：USD685831S1

公开(公告)日：2013-07-09

申请号：US29438684

申请日：2012-11-30

Applicant: Michael Wunnicke ,  David Lewin

Designer： Michael Wunnicke ,  David Lewin

公开(公告)号：US08051703B2

公开(公告)日：2011-11-08

申请号：US12394129

申请日：2009-02-27

Applicant: David Lewin Poff ,  Darin Wayne Felty ,  John W Mikels ,  Robert A Smith

Inventor： David Lewin Poff ,  Darin Wayne Felty ,  John W Mikels ,  Robert A Smith

IPC: G01M3/02 ,  G01N19/04

CPC classification number: B01D46/2418 ,  B01D46/0086 ,  B01D46/2425 ,  B01D46/42

Abstract: Methods are provided for testing a honeycomb body comprised of a core portion comprising honeycomb cell walls and a circumferential skin portion overlying at least some outer honeycomb cell walls. The circumferential skin portion includes a cement mixture layer. The method comprises the step of directing a fluid stream from a pressurized fluid source at the honeycomb body. The fluid stream is capable of separating at least part of the skin portion from the outer honeycomb cell walls when the adherence between at least part of the skin portion and the outer honeycomb cell walls is below a minimum threshold. In one example, the method further comprises the step of inspecting at least part of the interface between the honeycomb body and the skin portion during or after directing the fluid stream at the honeycomb body. In further examples, an apparatus is provided for testing the honeycomb body.

Abstract translation: 提供了用于测试蜂窝体的方法，所述蜂窝体由包括蜂窝状细胞壁和覆盖至少一些外部蜂窝状细胞壁的周边皮肤部分的核心部分组成。 周向皮肤部分包括水泥混合物层。 该方法包括将来自加压流体源的流体流引导到蜂窝体的步骤。 当至少部分皮肤部分和外部蜂窝状细胞壁之间的粘附力低于最小阈值时，流体流能够将至少部分皮肤部分与外部蜂窝状细胞壁分离。 在一个示例中，该方法还包括在将流体流引导到蜂窝体期间或之后检查蜂窝体和皮肤部分之间的界面的至少一部分的步骤。 在另外的实施例中，提供了用于测试蜂窝体的装置。

公开(公告)号：US20100218596A1

公开(公告)日：2010-09-02

申请号：US12394129

申请日：2009-02-27

Applicant: David Lewin Poff ,  Darin Wayne Felty ,  John W. Mikels ,  Robert A. Smith

Inventor： David Lewin Poff ,  Darin Wayne Felty ,  John W. Mikels ,  Robert A. Smith

IPC: G01M3/02 ,  G01N33/38

CPC classification number: B01D46/2418 ,  B01D46/0086 ,  B01D46/2425 ,  B01D46/42

Abstract: Methods are provided for testing a honeycomb body comprised of a core portion comprising honeycomb cell walls and a circumferential skin portion overlying at least some outer honeycomb cell walls. The circumferential skin portion includes a cement mixture layer. The method comprises the step of directing a fluid stream from a pressurized fluid source at the honeycomb body. The fluid stream is capable of separating at least part of the skin portion from the outer honeycomb cell walls when the adherence between at least part of the skin portion and the outer honeycomb cell walls is below a minimum threshold. In one example, the method further comprises the step of inspecting at least part of the interface between the honeycomb body and the skin portion during or after directing the fluid stream at the honeycomb body. In further examples, an apparatus is provided for testing the honeycomb body.

Abstract translation: 提供了用于测试蜂窝体的方法，所述蜂窝体由包括蜂窝状细胞壁和覆盖至少一些外部蜂窝状细胞壁的周边皮肤部分的核心部分组成。 周向皮肤部分包括水泥混合物层。 该方法包括将来自加压流体源的流体流引导到蜂窝体的步骤。 当至少部分皮肤部分和外部蜂窝状细胞壁之间的粘附力低于最小阈值时，流体流能够将至少部分皮肤部分与外部蜂窝状细胞壁分离。 在一个示例中，该方法还包括在将流体流引导到蜂窝体期间或之后检查蜂窝体和皮肤部分之间的界面的至少一部分的步骤。 在另外的实施例中，提供了用于测试蜂窝体的装置。

公开(公告)号：US07914724B2

公开(公告)日：2011-03-29

申请号：US11494914

申请日：2006-07-28

Applicant: Dana Craig Bookbinder ,  Thomas William Brew ,  Frank Fabian ,  Darin Wayne Felty ,  Robert Bernard Lubberts ,  David Lewin Poff ,  Kenneth Charles Sariego ,  Andrew Joseph Sullivan ,  David Robertson Treacy, Jr.

Inventor： Dana Craig Bookbinder ,  Thomas William Brew ,  Frank Fabian ,  Darin Wayne Felty ,  Robert Bernard Lubberts ,  David Lewin Poff ,  Kenneth Charles Sariego ,  Andrew Joseph Sullivan ,  David Robertson Treacy, Jr.

IPC: B29C47/00 ,  B29C47/12 ,  B29C47/88 ,  A01J21/00 ,  A21C3/00 ,  B32B3/00

CPC classification number: B29C47/12 ,  B28B3/269 ,  B29C47/0028 ,  B29C47/04 ,  B29L2031/60 ,  B29L2031/608 ,  Y10T428/236

Abstract: Disclosed is a method and apparatus for forming a circumferential skin surrounding a central cellular structure of an extruded honeycomb article. The method and apparatus may be used to produce defect-free skins and/or skins having large thickness and a high degree of particle alignment thereby preferably exhibiting CTE comparable to the extruded webs. These benefits are achieved by providing a die and method wherein a flow, Q, exiting any two active ones of a plurality of peripheral slots forming the skin is substantially equal. Also disclosed is a thick-skinned ceramic article having a thick extruded skin (ts′>5 tw′) with an I-value comparable to the webs.

Abstract translation: 公开了一种用于形成围绕挤压蜂窝制品的中心细胞结构的周向皮肤的方法和装置。 该方法和设备可以用于生产具有大厚度和高度粒子对准的无缺陷表皮和/或表皮，因此优选地表现出与挤出纤维网相当的CTE。 这些益处通过提供一种模具和方法来实现，其中从形成皮肤的多个外围槽中的任何两个活动的流出口Q基本相等。 还公开了一种厚皮陶瓷制品，其具有与网状物相当的I值的厚的挤压皮肤（ts'> 5 tw'）。

公开(公告)号：US20050100554A1

公开(公告)日：2005-05-12

申请号：US10367057

申请日：2003-02-14

Applicant: Amanda Jackson ,  Chean Ooi ,  David Lewin ,  Scott Cuthill

Inventor： Amanda Jackson ,  Chean Ooi ,  David Lewin ,  Scott Cuthill

IPC: A61K38/00 ,  A61K39/00 ,  C07H21/04 ,  C07K14/025 ,  C07K14/47 ,  C07K16/18 ,  C12P21/04 ,  G01N33/532 ,  G01N33/569 ,  G01N33/574

CPC classification number: C07K14/005 ,  A61K38/00 ,  C07K2319/00 ,  C12N2710/20022 ,  G01N33/532 ,  G01N33/56983 ,  G01N33/57442 ,  G01N2333/025 ,  G01N2500/00 ,  G01N2500/02

Abstract: The invention provides complexes of at least two polypeptides, and methods of using the same. Purified complexes of two polypeptides are provided, including chimeric complexes, and chimeric polypeptides and complexes thereof are also provided, as are nucleic acids encoding chimeric polypeptides and vectors and cells containing the same. Also provided are methods of identifying agents that disrupt polypeptide complexes, methods of identifying complex or polypeptide in a sample, and for removing the same, methods of determining altered expression of a polypeptide in a subject, and methods of treating/preventing disorders involving altered levels of complex or polypeptide.

Abstract translation: 本发明提供至少两种多肽的复合物及其使用方法。 还提供了两种多肽的纯化复合物，包括嵌合复合物，以及嵌合多肽及其复合物，编码嵌合多肽的核酸和含有该多肽的载体和细胞也是如此。 还提供了鉴定破坏多肽复合物的试剂的方法，鉴定样品中复合物或多肽的方法，以及用于除去它们的方法，确定受试者中多肽表达改变的方法，以及治疗/预防涉及改变水平的病症的方法 的复合物或多肽。

公开(公告)号：US20110080725A1

公开(公告)日：2011-04-07

申请号：US12572910

申请日：2009-10-02

Applicant: David C. BRANDS ,  R. Stephen MULDER ,  David LEWIN

Inventor： David C. BRANDS ,  R. Stephen MULDER ,  David LEWIN

IPC: F21L4/00 ,  G02B7/02

CPC classification number: F21L4/027 ,  F21V5/006 ,  F21V5/04 ,  F21V7/0091 ,  F21V14/06 ,  F21V14/065 ,  F21Y2115/10 ,  G02B19/0028 ,  G02B19/0061 ,  Y10S362/80

Abstract: A lens for a flashlight or other lighting unit provides for focusing light from a source, such as an LED, to provide a light beam adjustable between a spot beam and a wide beam. The lens includes a lens body with a front face, a rear LED-receiving well, and a side surface extending between the front face and the rear well. The front face includes a central surface surrounded by an annular concave surface. The rear well includes a space for the LED to be adjusted in position. The rear well space is defined by a concavely-curved sidewall and a concavely-curved base. The concave curvature of the sidewall and base may be Bezier curves.