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公开(公告)号：US08936926B2
公开(公告)日：2015-01-20
申请号：US11645125
申请日：2006-12-21
Applicant: David Hanzel , Jonas Korlach , Paul Peluso , Geoffrey Otto , Thang Pham , David Rank , Stephen Turner
Inventor： David Hanzel , Jonas Korlach , Paul Peluso , Geoffrey Otto , Thang Pham , David Rank , Stephen Turner
CPC classification number: C12Q1/6837 , C07K2319/23 , C12N9/1252 , C12Q1/6844 , C12Q2521/101 , C12Q2565/531
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
Abstract translation: 提供活性表面偶联的聚合酶，包括这种聚合酶的表面，以及制备和使用表面连接的聚合酶的方法。
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公开(公告)号：US20100261247A1
公开(公告)日：2010-10-14
申请号：US11645125
申请日：2006-12-21
Applicant: David Hanzel , Jonas Korlach , Paul Peluso , Geoffrey Otto , Thang Pham , David Rank , Stephen Turner
Inventor： David Hanzel , Jonas Korlach , Paul Peluso , Geoffrey Otto , Thang Pham , David Rank , Stephen Turner
IPC: C12N9/96
CPC classification number: C12Q1/6837 , C07K2319/23 , C12N9/1252 , C12Q1/6844 , C12Q2521/101 , C12Q2565/531
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
Abstract translation: 提供活性表面偶联的聚合酶，包括这种聚合酶的表面，以及制备和使用表面连接的聚合酶的方法。
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3.发明申请Protein engineering strategies to optimize activity of surface attached proteins 审中-公开蛋白质工程策略来优化表面附着蛋白质的活性公开(公告)号：US20100260465A1
公开(公告)日：2010-10-14
申请号：US11645135
申请日：2006-12-21
Applicant: David Hanzel , Jonas Korlach , Paul Peluso , Geoff Otto , Thang Pham , David Rank , Stephen Turner
Inventor： David Hanzel , Jonas Korlach , Paul Peluso , Geoff Otto , Thang Pham , David Rank , Stephen Turner
IPC: G02B6/00 , C12N9/00 , C12N9/10 , C12N9/48 , C12N9/16 , C12N9/02 , C12N9/84 , C12N9/38 , C07K14/00 , B32B1/00 , B32B17/06 , B32B18/00 , B32B9/00
CPC classification number: C12N9/22 , C07K2319/21 , Y10T428/2991 , Y10T428/2993 , Y10T428/2996 , Y10T428/31663 , Y10T428/31768
Abstract: Isolated and/or recombinant enzymes that include surface binding domains, surfaces with active enzymes bound to them and methods of coupling enzymes to surfaces are provided. Enzymes can include large and/or multiple surface coupling domains for surface coupling.
Abstract translation: 提供了包括表面结合结构域，与其结合的活性酶的表面和将酶与表面偶联的方法的分离和/或重组酶。 酶可以包括用于表面偶联的大的和/或多个表面耦合域。
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Patent Agency Ranking
公开(公告)号：US20080108082A1
公开(公告)日：2008-05-08
申请号：US11977160
申请日：2007-10-22
Applicant: David Rank , Arek Bibillo , David Hanzel , Paul Peluso , Jeff Wegener
Inventor： David Rank , Arek Bibillo , David Hanzel , Paul Peluso , Jeff Wegener
CPC classification number: C12N9/1252 , C12P19/34
Abstract: Compositions that include DNA polymerases having increased residence times for nucleotide analogues, particularly modified recombinant Φ29-type DNA polymerases with such increased residence times, are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA amplification are also provided. Compositions including α-thiophosphate nucleotide analogues with four or more phosphate groups are described, as are methods for determining the sequence of nucleic acid molecules using such analogues.
Abstract translation: 提供包含具有增加的核苷酸类似物的停留时间的DNA聚合酶的组合物，特别是具有这种增加的停留时间的经修饰的重组Phi29型DNA聚合酶。 还提供了在测序和DNA扩增中制备聚合酶和使用聚合酶的方法。 描述了包括具有四个或更多个磷酸基团的α-硫代磷酸核苷酸类似物的组合物，以及使用这种类似物确定核酸分子的序列的方法。
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5.发明授权Surface comprising DNA polymerase having mutations bound through an affinity tag 有权表面包含具有通过亲和标签结合的突变的DNA聚合酶公开(公告)号：US08323939B2
公开(公告)日：2012-12-04
申请号：US11978139
申请日：2007-10-26
Applicant: David Hanzel , Jonas Korlach , Paul Peluso , Geoffrey Otto , Thang Pham , David Rank , Stephen Turner
Inventor： David Hanzel , Jonas Korlach , Paul Peluso , Geoffrey Otto , Thang Pham , David Rank , Stephen Turner
CPC classification number: C12Q1/6837 , C07K2319/23 , C12N9/1252 , C12Q1/6844 , C12Q2521/101 , C12Q2565/531
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
Abstract translation: 提供活性表面偶联的聚合酶，包括这种聚合酶的表面，以及制备和使用表面连接的聚合酶的方法。
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公开(公告)号：US20080199932A1
公开(公告)日：2008-08-21
申请号：US11978139
申请日：2007-10-26
Applicant: David Hanzel , Jonas Korlach , Paul Peluso , Geoffrey Otto , Thang Pham , David Rank , Stephen Turner
Inventor： David Hanzel , Jonas Korlach , Paul Peluso , Geoffrey Otto , Thang Pham , David Rank , Stephen Turner
IPC: C12N11/14
CPC classification number: C12Q1/6837 , C07K2319/23 , C12N9/1252 , C12Q1/6844 , C12Q2521/101 , C12Q2565/531
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
Abstract translation: 提供活性表面偶联的聚合酶，包括这种聚合酶的表面，以及制备和使用表面连接的聚合酶的方法。
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公开(公告)号：US20070196846A1
公开(公告)日：2007-08-23
申请号：US11645223
申请日：2006-12-21
Applicant: David Hanzel , Geoff Otto , Devon Murphy , Paul Peluso , Thang Pham , David Rank , Paul Mitsis
Inventor： David Hanzel , Geoff Otto , Devon Murphy , Paul Peluso , Thang Pham , David Rank , Paul Mitsis
CPC classification number: C12N9/1252 , C07K2319/20 , C12P19/34 , C12Q1/6827 , C12Q1/6869 , C12Y207/07007 , Y02P20/52
Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
Abstract translation: 提供了包含具有改善核苷酸类似物进入活性位点区域并与活性位点区域中的核苷酸类似物配位的特征的聚合酶的组合物。 还提供了制备聚合酶和在测序和DNA复制和扩增中使用聚合酶的方法以及聚合酶活性的动力学模型和使用该模型的计算机实现的方法。
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公开(公告)号：US20060051763A1
公开(公告)日：2006-03-09
申请号：US10529193
申请日：2003-09-25
Applicant: Anu-Maria Loukola , Sharron Penn , David Rank , David Hanzel , Graham Casey , John Witte
Inventor： Anu-Maria Loukola , Sharron Penn , David Rank , David Hanzel , Graham Casey , John Witte
CPC classification number: G01N33/57434 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/172 , G01N33/57415 , G01N2500/00 , G01N2800/52
Abstract: The present invention relates to the prognosis, diagnosis and treatment of cancer, particularly prostate cancer. Polynucleotides having single nucleotide polymorphisms (SNPs) and haplotypes are provided which are of utility in the prognosis, diagnosis, prophylaxis and treatment of prostate and breast cancer.
Abstract translation: 本发明涉及癌症，特别是前列腺癌的预后，诊断和治疗。 提供了具有单核苷酸多态性（SNPs）和单体型的多核苷酸，其可用于前列腺和乳腺癌的预后，诊断，预防和治疗。
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