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公开(公告)号：US08518643B2
公开(公告)日：2013-08-27
申请号：US13018617
申请日：2011-02-01
Applicant: David Rank , Paul Peluso
Inventor： David Rank , Paul Peluso
Abstract: The quality of information from single molecule analyses is improved by employing a method in which a single molecule reaction carried out within an optical confinement is monitored, the single molecule reaction is halted, and data from the optical confinement is obtained while the reaction is not occurring. Characteristic optical behavior observed while the reaction is halted is used to improve the quality of information obtained during the single molecule reaction, for example, by correcting the reaction data, excluding the reaction data, or providing a confidence level to the reaction data.
Abstract translation: 单分子分析的信息质量通过采用一种方法来改善，其中监测在光限制内进行的单分子反应，停止单分子反应，并且在不发生反应的同时获得光限制的数据 。 在反应停止时观察到的特征光学行为用于改善在单分子反应期间获得的信息的质量，例如通过校正反应数据，排除反应数据，或为反应数据提供置信水平。
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公开(公告)号：US20110217698A1
公开(公告)日：2011-09-08
申请号：US13018617
申请日：2011-02-01
Applicant: David Rank , Paul Peluso
Inventor： David Rank , Paul Peluso
Abstract: The quality of information from single molecule analyses is improved by employing a method in which a single molecule reaction carried out within an optical confinement is monitored, the single molecule reaction is halted, and data from the optical confinement is obtained while the reaction is not occurring. Characteristic optical behavior observed while the reaction is halted is used to improve the quality of information obtained during the single molecule reaction, for example, by correcting the reaction data, excluding the reaction data, or providing a confidence level to the reaction data.
Abstract translation: 单分子分析的信息质量通过采用一种方法来改善，其中监测在光限制内进行的单分子反应，停止单分子反应，并且在不发生反应的同时获得光限制的数据 。 在反应停止时观察到的特征光学行为用于改善在单分子反应期间获得的信息的质量，例如通过校正反应数据，排除反应数据，或为反应数据提供置信水平。
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公开(公告)号：US20100068723A1
公开(公告)日：2010-03-18
申请号：US12605217
申请日：2009-10-23
Applicant: Stevan Bogdan Jovanovich , Iuliu Ioan Blaga , David Rank
Inventor： Stevan Bogdan Jovanovich , Iuliu Ioan Blaga , David Rank
IPC: C12Q1/68 , G01N33/543 , G01N1/14
CPC classification number: B01L3/50273 , B01F11/0071 , B01F13/0059 , B01J2219/005 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/0654 , B01L2300/0803 , B01L2300/0806 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1844 , B01L2400/0409 , B01L2400/0421 , B01L2400/043 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , C12Q2565/629 , G01N1/34 , G01N27/44721 , G01N27/44743 , G01N27/44791 , G01N35/0098
Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such asDNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
Abstract translation: 公开了用于将微芯片连接到各种类型的模块的方法和装置。 所公开的技术可用作各种应用的样品制备和分析系统，如DNA测序和基因分型，蛋白质组学，病原体检测，诊断和生物防治。
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公开(公告)号：US20080014576A1
公开(公告)日：2008-01-17
申请号：US11670866
申请日：2007-02-02
Applicant: Stevan Jovanovich , Iuliu Blaga , David Rank
Inventor： Stevan Jovanovich , Iuliu Blaga , David Rank
CPC classification number: C12Q1/6869 , B01F11/0071 , B01F13/0059 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0668 , B01L2200/10 , B01L2300/0627 , B01L2300/0636 , B01L2300/0654 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0415 , B01L2400/0421 , B01L2400/0481 , B01L2400/0655 , C12N15/1003 , C12N15/1013 , C12Q1/24 , C12Q1/6806 , C12Q1/6844 , C12Q1/686 , C12Q1/70 , G01N2035/00514 , Y10T436/163333 , Y10T436/25875
Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
Abstract translation: 公开了用于将微芯片连接到各种类型的模块的方法和装置。 所公开的技术可用作各种应用的样品制备和分析系统，如DNA测序和基因分型，蛋白质组学，病原体检测，诊断和生物防治。
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公开(公告)号：US20070248958A1
公开(公告)日：2007-10-25
申请号：US11229065
申请日：2005-09-15
Applicant: Stevan Jovanovich , Iuliu Blaga , David Rank
Inventor： Stevan Jovanovich , Iuliu Blaga , David Rank
CPC classification number: B01L3/50273 , B01F11/0071 , B01F13/0059 , B01J2219/005 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/0654 , B01L2300/0803 , B01L2300/0806 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1844 , B01L2400/0409 , B01L2400/0421 , B01L2400/043 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , C12Q2565/629 , G01N1/34 , G01N27/44721 , G01N27/44743 , G01N27/44791 , G01N35/0098
Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
Abstract translation: 公开了用于将微芯片连接到各种类型的模块的方法和装置。 所公开的技术可用作各种应用的样品制备和分析系统，如DNA测序和基因分型，蛋白质组学，病原体检测，诊断和生物防治。
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Patent Agency Ranking
6.发明申请Articles having localized molecules disposed thereon and methods of producing same 有权具有位于其上的局部分子的制品及其制备方法公开(公告)号：US20070238679A1
公开(公告)日：2007-10-11
申请号：US11394352
申请日：2006-03-30
Applicant: David Rank , Jonas Korlach , Yue Xu , Stephen Turner , Jeffrey Wegener , Daniel Roitman , John Lyle
Inventor： David Rank , Jonas Korlach , Yue Xu , Stephen Turner , Jeffrey Wegener , Daniel Roitman , John Lyle
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , B01J19/0046 , B01J2219/00427 , B01J2219/0045 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y20/00 , B82Y30/00 , C12Q1/6837 , Y10T29/49002 , C12Q2565/629 , C12Q2527/127
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
Abstract translation: 通过使用底物的元素来辅助活性化学基团在基底的所需区域中的定位来制备具有选定的活性化学区域的基底的方法。 所述方法可以包括用于沉积，去除，激活和/或去活衬底的选定区域中的化学基团的光学，化学和/或机械方法，以提供衬底的选择性活性区域。
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公开(公告)号：US08993230B2
公开(公告)日：2015-03-31
申请号：US12328715
申请日：2008-12-04
Applicant: Paul S. Peluso , John S. Eid , David Rank
Inventor： Paul S. Peluso , John S. Eid , David Rank
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , C12Q2535/101 , C12Q2527/113
Abstract: The present invention provides methods, reagents and apparatus for conducting single molecule sequencing in an asynchronous manner. The subject methods and compositions are particularly useful for high throughput and multiplexed sequencing.
Abstract translation: 本发明提供了以异步方式进行单分子测序的方法，试剂和装置。 本发明方法和组合物对于高通量和多重测序特别有用。
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8.发明授权Surface comprising DNA polymerase having mutations bound through an affinity tag 有权表面包含具有通过亲和标签结合的突变的DNA聚合酶公开(公告)号：US08323939B2
公开(公告)日：2012-12-04
申请号：US11978139
申请日：2007-10-26
Applicant: David Hanzel , Jonas Korlach , Paul Peluso , Geoffrey Otto , Thang Pham , David Rank , Stephen Turner
Inventor： David Hanzel , Jonas Korlach , Paul Peluso , Geoffrey Otto , Thang Pham , David Rank , Stephen Turner
CPC classification number: C12Q1/6837 , C07K2319/23 , C12N9/1252 , C12Q1/6844 , C12Q2521/101 , C12Q2565/531
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
Abstract translation: 提供活性表面偶联的聚合酶，包括这种聚合酶的表面，以及制备和使用表面连接的聚合酶的方法。
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公开(公告)号：US20100143900A1
公开(公告)日：2010-06-10
申请号：US12328715
申请日：2008-12-04
Applicant: Paul S. Peluso , John S. Eid , David Rank
Inventor： Paul S. Peluso , John S. Eid , David Rank
CPC classification number: C12Q1/6874 , C12Q2535/101 , C12Q2527/113
Abstract: The present invention provides methods, reagents and apparatus for conducting single molecule sequencing in an asynchronous manner. The subject methods and compositions are particularly useful for high throughput and multiplexed sequencing.
Abstract translation: 本发明提供了以异步方式进行单分子测序的方法，试剂和装置。 本发明方法和组合物对于高通量和多重测序特别有用。
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公开(公告)号：US20080199932A1
公开(公告)日：2008-08-21
申请号：US11978139
申请日：2007-10-26
Applicant: David Hanzel , Jonas Korlach , Paul Peluso , Geoffrey Otto , Thang Pham , David Rank , Stephen Turner
Inventor： David Hanzel , Jonas Korlach , Paul Peluso , Geoffrey Otto , Thang Pham , David Rank , Stephen Turner
IPC: C12N11/14
CPC classification number: C12Q1/6837 , C07K2319/23 , C12N9/1252 , C12Q1/6844 , C12Q2521/101 , C12Q2565/531
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
Abstract translation: 提供活性表面偶联的聚合酶，包括这种聚合酶的表面，以及制备和使用表面连接的聚合酶的方法。
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