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1.发明授权公开(公告)号：US07067276B2
公开(公告)日：2006-06-27
申请号：US10836453
申请日：2004-04-30
申请人： Edwin L. Adair
发明人： Edwin L. Adair
CPC分类号： A61K49/0021 , A61K49/0036 , A61K51/0485
摘要： A method for treating arteriosclerotic lesions is provided wherein the method is characterized by administering a chemical compound to the patient, the compound being a porphyrin complexed with a radioactive metal. Cells which exhibit an affinity for the porphyrin element indicate sites of plaque buildup. The radioactive metal within the compound is cytotoxic to cells in and surrounding the plaque and may allow tomographic scanning of the plaque as well. The complexed compound can be introduced to the patient a desired number of times to provide the necessary radiation treatment and ongoing monitoring of plaque removal.
摘要翻译： 提供了治疗动脉硬化病变的方法，其中该方法的特征在于向患者施用化合物，该化合物是与放射性金属络合的卟啉。 对卟啉元素显示亲和力的细胞表明斑块积聚的位点。 化合物内的放射性金属对斑块中和周围的细胞具有细胞毒性，并且还可允许斑块的层析扫描。 可以将复合化合物引入患者所需的次数以提供必要的放射治疗和持续监测斑块去除。
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2.发明授权公开(公告)号：US06982740B2
公开(公告)日：2006-01-03
申请号：US09971749
申请日：2001-10-04
IPC分类号： H04N7/18
CPC分类号： A61B1/0607 , A61B1/00096 , A61B1/00135 , A61B1/0051 , A61B1/043 , A61B1/05 , A61B1/07 , H01L25/167 , H01L2924/0002 , H01L2924/3011 , H04N5/2253 , H04N5/353 , H04N5/374 , H04N2005/2255 , H01L2924/00
摘要： A reduced area imaging device is provided which utilizes selected charge integration periods. Various configurations of the imaging device are provided which locate the elements of the imagine device at desired locations. Regardless of the particular arrangement or configuration of the imaging device, selected charge integration periods are incorporated. The imaging device can be defined as a CMOS-CID device wherein a user may select an appropriate integration period in order to enhance the viewed image to a desired level of brightness. Particularly in fluorescence guided endoscopy and fluorescence assisted surgery, the ability to vary and select particular charge integration periods improves these processes.
摘要翻译： 提供了利用所选择的电荷积分周期的缩小面积成像装置。 提供了成像装置的各种配置，其将想象装置的元件定位在期望的位置。 不管成像装置的具体布置或配置如何，并入所选择的电荷积分期。 成像装置可以被定义为CMOS-CID装置，其中用户可以选择适当的积分周期，以将观看图像增强到期望的亮度水平。 特别是在荧光引导内窥镜检查和荧光辅助手术中，改变和选择特定电荷积分期的能力改善了这些过程。
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公开(公告)号：US06452626B1
公开(公告)日：2002-09-17
申请号：US09613027
申请日：2000-07-10
IPC分类号： H04N718
CPC分类号： H04N5/3765 , A61B1/00009 , A61B1/00016 , A61B1/00032 , A61B1/00034 , A61B1/00045 , A61B1/00048 , A61B1/00135 , A61B1/00163 , A61B1/005 , A61B1/0051 , A61B1/045 , A61B1/05 , G06F1/1616 , G06F1/1626 , G06F1/1647 , G06F1/1649 , G06F1/1671 , G06F1/1686 , G06F1/1698 , H01L25/167 , H01L2924/0002 , H01L2924/3011 , H04N5/2252 , H04N5/2253 , H04N5/2254 , H04N5/2257 , H04N5/3745 , H04N7/142 , H04N2005/2255 , H01L2924/00
摘要： A reduced area imaging device is provided for use with a communication device, such as a wireless/cellular phone. In one configuration of the imaging device, the image sensor is placed remote from the remaining image processing circuitry. In a second configuration, all of the image processing circuitry to include the image sensor is placed in a stacked fashion near the same location. In the first configuration, the entire imaging device can be placed at the distal end of a camera module. In a second configuration, the image sensor is remote from the remaining image processing circuitry wherein available space within the phone is used to house the remaining circuitry. In any of the embodiments, the image sensor may be placed alone on a first circuit board, or timing and control circuits may be included on the first circuit board containing the image sensor. One or more video processing boards can be stacked in a longitudinal fashion with respect to the first board, or the video processing boards may be placed within the housing of the communication device. The communication device includes a miniature LCD-type monitor which is capable of viewing not only the images taken by the camera module, but also can show incoming video images. The camera module is of such small size that it can be easily stored within the housing of the communication device, and may be attached thereto as by a small retractable cable. Having a tethered camera module allows it to be pointed at any desired object within sight of the user, and without having to actually point or move the phone housing in order to take an image.
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4.发明授权Method of cancer screening primarily utilizing non-invasive cell collection and fluorescence detection techniques 失效主要利用非侵入性细胞收集和荧光检测技术进行癌症筛查的方法公开(公告)号：US06190877B1
公开(公告)日：2001-02-20
申请号：US09472945
申请日：1999-12-27
申请人： Edwin L. Adair
发明人： Edwin L. Adair
IPC分类号： C12Q102
CPC分类号： H04N5/2253 , G01N33/5091 , G01N33/574 , H04N2005/2255 , Y10S435/968
摘要： The method of cancer screening allows for a safe, reliable, inexpensive and minimally invasive diagnosis. Cells are first collected through non-invasive or minimally invasive means. The collected cells are stored in a cell culture media to keep them viable. A chemical compound such as 5-ALA is introduced to the cultured cells. The cells are incubated a period of time in order for the interaction to occur between the introduced chemical compound and the collected cells. The cells are then studied under a fluorescence microscope which emits a specific frequency of light which matches the excitation frequency of light which would be required to induce flourescence of abnormal cells. Pre-malignant and malignant cells will fluoresce in response to the interaction with the introduced compound and the specific frequency of light, while normal healthy cells generally will not fluoresce. If necessary, the collected cells may be passed through a flow cytometer to more easily identify the fluorescing cells. A presumptive diagnosis as to cancer may be made based upon the presence or absence of fluorescing cells. If a cell sample is adequately concentrated, a cell sorter does not need to be used and the cell sample may simply viewed under the fluorescence microscope. Specific techniques are disclosed for non-invasive cell collection and minimally invasive collection. Each of these techniques minimize patient trauma and do not call for any type of incision for forced tissue removal as occurs in traditional biopsy procedures.
摘要翻译： 癌症筛查的方法允许安全，可靠，廉价和微创的诊断。 首先通过非侵入性或微创手段收集细胞。 将收集的细胞储存在细胞培养基中以保持其活性。 将诸如5-ALA的化合物引入培养的细胞中。 将细胞孵育一段时间，以便引入的化合物和收集的细胞之间发生相互作用。 然后在荧光显微镜下研究细胞，其发射与引发异常细胞荧光所需的光的激发频率相匹配的光的特定频率。 前恶性和恶性细胞将响应于与引入的化合物的相互作用和光的特定频率而发荧光，而正常的健康细胞通常不会发荧光。 如果需要，可以将收集的细胞通过流式细胞仪，以更容易地识别荧光细胞。 可以基于荧光细胞的存在或不存在对癌症的推定性诊断。 如果细胞样品充分浓缩，则不需要使用细胞分选器，并且可以在荧光显微镜下简单地观察细胞样品。 公开了用于非侵入性细胞收集和微创收集的具体技术。 这些技术中的每一种最小化患者的创伤，并且不要求在传统活检程序中发生的用于强制组织去除的任何类型的切口。
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公开(公告)号：US5986693A
公开(公告)日：1999-11-16
申请号：US976976
申请日：1997-11-24
IPC分类号： A61B1/04 , A61B1/005 , A61B1/05 , A61B19/00 , H01L25/16 , H01L27/146 , H04N3/15 , H04N5/225 , H04N5/335 , H04N7/18 , G01N23/04
CPC分类号： H04N5/2253 , A61B1/00135 , A61B1/05 , A61B1/0607 , H01L25/167 , H01L27/14643 , A61B1/0051 , A61B1/07 , H01L2924/0002 , H01L2924/3011 , H04N2005/2255
摘要： A reduced area imaging device is provided for use in medical or dental instruments such as an endoscope. In one configuration of the imaging device, the image sensor is placed remote from the remaining circuitry. In another configuration, all of the circuitry to include the image sensor is placed in a stacked fashion at the same location. In a first embodiment of the invention, the entire imaging device can be placed at the distal tip of an endoscope. In a second embodiment, the image sensor is remote from the remaining circuitry according to the first configuration, and wherein a control box can be provided which communicates with the image sensor and is placed remotely from the endoscope. In yet another embodiment, the imaging device can be incorporated in the housing of a standard medical camera which is adapted for use with traditional rod lens endoscopes. In any of the embodiments, the image sensor may be placed alone on a first circuit board, or timing and control circuits may be included on the first circuit board containing the image sensor. One or more video processing boards can be stacked in a longitudinal fashion with respect to the first board, or the video processing boards may be placed in the control box.
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公开(公告)号：US5873814A
公开(公告)日：1999-02-23
申请号：US867343
申请日：1997-06-02
申请人： Edwin L. Adair
发明人： Edwin L. Adair
CPC分类号： A61B1/00048 , A61B1/00039 , A61B1/00052 , A61B1/00142 , A61B1/05 , A61B46/10 , A61B2090/372
摘要： A sterile enclosure is provided having a body portion for encapsulating one or more monitor modules used for viewing one or more surgical areas in a sterile operating field. The video monitor can be very thin and lightweight monitor modules. The sterile enclosure may be flexible or rigid and have one or more cable drapes extending from the body to cover one or more cables associated with the video monitor. In some embodiments, the body is flexible. In another embodiment, the body is rigid. The body is transparent in at least an area for viewing the screen of the video monitor and is substantially impervious to liquid and gas. A vacuum line may be connected to the body portion to evacuate air therefrom. The video monitor may be controlled by controls located on the monitor, or may be controlled by voice activation or by a remote video control system. During use, the monitor module may be placed on or adjacent to the patient. Alternatively, a miniaturized sterile monitor module or LCD display unit may be provided which is directly mountable to a surgical instrument such as an endoscope.
摘要翻译： 提供了一种无菌外壳，其具有用于封装用于在无菌操作区域中观察一个或多个外科手术区域的一个或多个监测模块的主体部分。 视频监视器可以是非常薄和轻便的监视器模块。 无菌外壳可以是柔性的或刚性的，并且具有从主体延伸以覆盖与视频监视器相关联的一个或多个电缆的一个或多个电缆盖。 在一些实施例中，身体是柔性的。 在另一个实施例中，主体是刚性的。 身体在至少一个用于观看视频监视器的屏幕的区域中是透明的，并且基本上不透液体和气体。 真空管线可以连接到主体部分以从其中排出空气。 视频监视器可以由位于监视器上的控制器控制，或者可以通过语音激活或远程视频控制系统来控制。 在使用期间，监视器模块可以放置在患者身上或与患者相邻。 或者，可以提供可直接安装到诸如内窥镜的外科器械的小型化无菌监视器模块或LCD显示单元。
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公开(公告)号：US5812188A
公开(公告)日：1998-09-22
申请号：US678811
申请日：1996-07-12
申请人： Edwin L. Adair
发明人： Edwin L. Adair
CPC分类号： A61B1/00048 , A61B1/00039 , A61B1/00052 , A61B1/00142 , A61B1/05 , A61B46/10 , A61B2090/372
摘要： A sterile enclosure is provided having a body portion for encapsulating one or more video monitors used for viewing one or more surgical areas in a sterile operating field. The enclosure may be flexible or rigid and have one or more cable drapes extending from the body to cover one or more cables associated with the video monitor. In some embodiments, the body is flexible. In another embodiment, the body is rigid. The body is transparent in at least an area for viewing the screen of the video monitor and is substantially impervious to liquid and gas. A vacuum line may be connected to the body portion to evacuate air therefrom.
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公开(公告)号：US5495286A
公开(公告)日：1996-02-27
申请号：US261331
申请日：1994-06-16
申请人： Edwin L. Adair
发明人： Edwin L. Adair
CPC分类号： A61B1/00135 , A61B1/00142 , A61B1/042 , A61B1/0607 , A61B1/07
摘要： A sterilizable video microscope holder for supporting and positioning a video microscope unit in an operating room is provided which has a sterilizable flexible tubular arm, a bundle of optical fibers running through the arm, a support attached to one end of the arm for supporting it in the operating room and a connector at the same end of the arm for holding an end of the fiber optic bundle in aligned positioned for connection to a light source. The arm includes an inner articulated member which is bendable in all directions and will remain in any position to which it is bent and an outer covering over the inner articulated member to protect it from moisture, body oils and chemicals. The connector includes a tubular member for receiving and supporting the first end of the bundle of optical fibers in aligned position and an adaptor at a distal end of the tubular member connected to the first end of the bundle and being connectable to a light source.
摘要翻译： 提供一种用于在手术室中支撑和定位视频显微镜单元的可灭菌视频显微镜支架，其具有可消毒的柔性管状臂，穿过臂的一束光纤，支撑在臂的一端以支撑其的支撑件 手术室和在臂的同一端的连接器，用于将光纤束的一端保持对齐的位置以连接到光源。 臂包括内部铰接构件，其可以在所有方向上弯曲并且将保持在其弯曲的任何位置，并且在内部铰接构件上保持外部覆盖物，以防止其被水分，身体油和化学物质保护。 连接器包括用于接收和支撑处于对准位置的光纤束的第一端的管状构件和连接到束的第一端并且可连接到光源的管状构件的远端处的适配器。
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公开(公告)号：US5433221A
公开(公告)日：1995-07-18
申请号：US318271
申请日：1994-10-05
申请人： Edwin L. Adair
发明人： Edwin L. Adair
CPC分类号： A61B46/10
摘要： In accordance with this invention, a windowed self-centering drape for a surgical camera is provided. The drape includes a generally cylindrical body portion and a flexible and elastic distal end. The body portion is flexible and substantially non-elastic. The proximal end of the body portion may include either a roll fold or an accordion fold in order to reduce the size of the drape for storage prior to use. An optically clear window is formed integrally with the elastic distal end. The window may be coated with substances which filter out certain wavelengths of light.
摘要翻译： 根据本发明，提供了一种用于外科手术相机的窗口自定心罩。 悬垂状包括大致圆柱形主体部分和柔性且弹性的远端。 主体部分是柔性的并且基本上是非弹性的。 主体部分的近端可以包括卷折或折叠折叠，以便在使用之前减小用于存放的盖布的尺寸。 光学透明的窗口与弹性远端一体地形成。 窗口可以涂覆有过滤掉某些波长的光的物质。
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公开(公告)号：US5284474A
公开(公告)日：1994-02-08
申请号：US954655
申请日：1992-09-30
申请人： Edwin L. Adair
发明人： Edwin L. Adair
CPC分类号： A61B17/3496 , A61B17/3474
摘要： In accordance with this invention a disposable trochar for use as a gas insufflation needle is provided for insertion through the abdominal wall of a patient and into a body cavity. It has an outer sheath with a tubular body, a distal open end and a proximate open end. The distal end may have means which is expandable after the trochar has been inserted into the body cavity to minimize dislocation of the outer sheath during use. A cannula is removably received within in the sheath which has a sharp distal end extendable beyond the distal end of the sheath and an enlarged head at the proximate end of the cannula. The head has a flat land which is engageable with the proximate end of the sheath to limit the extension of the distal end of the cannula beyond the distal end of the sheath. A rod is mounted within the cannula for longitudinal movement between a retracted position and an extended position. A blunt member is provided at the distal end of the rod extending beyond the sharp distal end of the cannula when in extended position. A spring, in a cavity in the head, is attached to the proximate end of the rod urging it toward the extended position. The method of using the trochar is also disclosed.
摘要翻译： 根据本发明，提供用作气体吹入针的一次性药液穿过患者的腹壁插入体腔内。 它具有外壳，其具有管状体，远端开口端和近端开口端。 远端可以具有在套管已经插入体腔中之后可扩张的装置，以使外护套在使用过程中的脱位最小化。 套管可移除地容纳在护套内，其具有可伸出鞘的远端的尖锐远端，并且在插管的近端处具有扩大的头部。 头部具有平坦的平台，其能够与护套的近端接合，以限制插管的远端延伸超过护套的远端。 杆被安装在套管内以在缩回位置和延伸位置之间纵向运动。 当处于延伸位置时，钝器构件设置在杆的远端处，延伸超过套管的尖锐远端。 在头部中的空腔中的弹簧被附接到杆的近端，将其推向伸出位置。 还公开了使用该路线车辆的方法。
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