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公开(公告)号：US20230202973A1
公开(公告)日：2023-06-29
申请号：US16978447
申请日：2019-03-06
申请人： Leibniz-Institut Für Naturstoff-Forschung Und Infektionsbiologie E.V. (HKI) , Friedrich-Schiller-Universität Jena
发明人： Christine Beemelmanns , Huijuan Guo , Sandra Höfgen , Maja Rischer , Luka Raguz , Francois Keiff , Tobias Goris
IPC分类号： C07C279/14 , C12N15/52 , C12P13/02 , C12N9/00 , C12N9/10 , C07C237/52 , C07C279/12 , A61P33/02
CPC分类号： C07C279/14 , C12N15/52 , C12P13/02 , C12N9/93 , C12N9/1029 , C07C237/52 , C07C279/12 , A61P33/02
摘要： This invention relates to a compound according to general formula (IA), which acts as a selective cysteine protease inhibitor; to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament.
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公开(公告)号：US11579512B2
公开(公告)日：2023-02-14
申请号：US16074240
申请日：2017-02-01
申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. , FRIEDRICH-SCHILLER-UNIVERSITÄT JENA
IPC分类号： G02F1/39 , H01S3/067 , H01S3/00 , H01S3/1118 , H01S3/13
摘要： A device for generating laser pulses is provided, the device having an optical parametric oscillator converts the laser pulses of a pump laser to laser pulses at a signal wavelength and at an idler wavelength. The optical parametric oscillator has an optical resonator with a non-linear wavelength converter. It is an object of the invention to provide a device that makes efficient generation of synchronous laser pulse trains with two different central wavelengths possible. To this end, the invention proposes that the pump laser is tunable with respect to the pump wavelength and the repetition frequency, wherein the resonator has an optical fibre with a dispersion in the range of 10-100 ps/nm and a length of 10-1000 m. The invention furthermore relates to a method for generating laser pulses using such a device.
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公开(公告)号：US20210402512A1
公开(公告)日：2021-12-30
申请号：US17270470
申请日：2019-08-23
申请人： Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung E.V. , Friedrich-Schiller-Universität Jena
发明人： Malte Per SIEMS , Stefan NOLTE , Daniel RICHTER , Ria KRÄMER , Thorsten Albert GOEBEL , Maximilian HECK
IPC分类号： B23K26/0622 , B23K26/00
摘要： The invention relates to a method for producing an optical component (1) by means of laser radiation. The object of the invention is that of providing a method that is improved compared with the prior art, which method allows for the correction of deviations of the optical functionality of the component from specified target parameters. For this purpose, the method according to the invention comprises the following method steps: generating a structure in the material of the component (1) which gives the component (1) an optical functionality, and modifying the refractive index in the material of the component (1) by means of laser beams in a pre- and/or post-processing step, i.e. before or after the generation of the structure, in order to correct deviations of the optical functionality of the component (1) from specified target parameters.
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公开(公告)号：US20200206841A1
公开(公告)日：2020-07-02
申请号：US16643641
申请日：2018-09-03
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. , Friedrich-Schiller-Universität Jena
发明人： Klaus Bergner , Stefan Nolte
IPC分类号： B23K26/00 , B23K26/03 , B23K26/062 , B23K26/50 , B23K26/0622 , B23K26/53 , B23K26/064 , B23K26/06 , G01N21/39 , C03C15/00
摘要： The invention relates to a method for machining a transparent workpiece (4) by generating non-linear absorption of laser radiation in a laser beam focus located in a volume of the workpiece (4). The object of the invention is that of providing a method of improved precision and quality, and a corresponding device, for laser machining of workpieces. In particular, it is also intended for it to be possible for workpieces made of composite materials or of other special materials, such as filter glass, to be machined at an improved level of quality. For this purpose, the method according to the invention comprises the following steps: spectroscopic measurement of the linear absorption of the laser radiation in the workpiece (4), selecting a working wavelength at which the linear absorption is low, and machining the workpiece (4) by means of application of laser radiation at the working wavelength. The invention furthermore relates to a corresponding device for machining a transparent workpiece (4).
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公开(公告)号：US20190385762A1
公开(公告)日：2019-12-19
申请号：US16489813
申请日：2018-03-02
IPC分类号： H01B1/12 , C08F220/18 , C08F212/08 , C08J5/18 , G02F1/1523 , E06B9/24
摘要： The present invention relates to a composition for producing a polymer, comprising: a) from 20 to 60% by weight, based on the entire composition, of at least one monomer; and b) from 30 to 60% by weight, based on the entire composition, of at least one branched pre-polymer, wherein the composition is liquid at room temperature and under normal pressure; use of the composition, a method for producing a polymer using the composition, as well as an electrically dimmable glazing that encloses the polymer.
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公开(公告)号：US10429549B2
公开(公告)日：2019-10-01
申请号：US15320721
申请日：2015-06-12
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. , Friedrich-Schiller-Universität Jena
发明人： Mark Schürmann , Stefan Schwinde , Norbert Kaiser
摘要： An optical element including a reflective coating is disclosed. In an embodiment the reflective coating includes an adhesion-promoting layer, an at least partially reflective silver layer disposed on the adhesion-promoting layer and a protective layer system disposed on the silver layer, wherein the protective layer system includes a plurality of dielectric layers, wherein the dielectric layers include at least one first layer and at least one second layer, wherein the first layer and the second layer have a different resistance to at least two different contamination substances, wherein the dielectric layers have a thickness of not more than 30 nm, and wherein a number of the dielectric layers amounts to at least five.
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公开(公告)号：US10378888B2
公开(公告)日：2019-08-13
申请号：US15571803
申请日：2016-05-04
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. , Friedrich-Schiller-Universität Jena
发明人： Stefan Heist , Gunther Notni , Kevin Srokos , Peter Lutzke , Ingo Schmidt , Peter Kühmstedt
摘要： A device, for spatially measuring surfaces, includes a projector for projecting patterns into an object space, two cameras for recording pictures of a surface in the object space, and a control and evaluation unit for activating the cameras and evaluating the pictures. The projector includes a light source, a projection lens, at least one rotatably arranged pattern structure, and a drive for rotating the at least one pattern structure. The control and evaluation unit to: activate the cameras for simultaneously recording a picture at each of a plurality of successive points in time; identify corresponding points in the picture planes of the cameras, by way of evaluating a correlation function between the sequences of brightness values acquired for potentially corresponding points and maximizing a value of the correlation; and determine spatial coordinates of surface points by way of triangulation on the basis of the identified corresponding points.
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公开(公告)号：US20180331363A1
公开(公告)日：2018-11-15
申请号：US15777076
申请日：2016-11-14
CPC分类号： H01M4/60 , H01M4/38 , H01M4/42 , H01M8/188 , H01M2250/20 , H01M2300/0005 , Y02E60/528
摘要： Disclosed is a redox flow battery which is of simple construction, inexpensive and long-lasting.The redox flow battery for storing electrical energy comprises a reaction cell having two electrode chambers for catholyte and anolyte, which are each connected to at least one store for liquid and are separated by a semipermeable membrane that is impermeable for the redox pair in the catholyte, and which are equipped with electrodes, wherein the electrode chambers are each filled with electrolyte solutions comprising redox-active components in liquid state, dissolved or dispersed in an aqueous electrolyte solvent, and optionally conducting salts dissolved therein and optionally further additives.The redox flow battery is characterized in that the anolyte comprises a zinc salt as redox-active component and that the catholyte comprises as a redox-active component a compound comprising at least one residue of formula I in the molecule wherein the line going off the 4-position in the structure of formula I represents a covalent bond connecting the structure of formula I with the remainder of the molecule, and R1, R2, R3 and R4 independently of one another represent alkyl, cycloalkyl, aryl or aralkyl.
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公开(公告)号：US20160320687A1
公开(公告)日：2016-11-03
申请号：US15032525
申请日：2014-10-28
申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWAND TEN FORSCHUNG E.V. , FRIEDRICH-SCHILLER-UNIVERSITÄT JENA
CPC分类号： G02F1/39 , G02F1/3536 , G02F1/395 , G02F2201/02 , G02F2203/15
摘要： The invention relates to an apparatus (1) for producing short synchronous radiation pulses at different wavelengths, particularly to an optically parametric oscillator, comprising at least one pump radiation source (2), preferably a pump laser, for outputting radiation at a pump wavelength, and a resonator (3) having a wavelength-dependent effective resonator length, wherein the resonator (3) has a non-linear wavelength converter (4) for producing radiation at a first and a second wavelength; a dispersive element (5) having a strong wavelength-dependent delay characteristic; and a coupling-out element (6) for at least partially coupling-out the radiation from the resonator (3). In addition, the invention relates to a method for producing short radiation pulses by means of an apparatus (1), particularly an optically parametric oscillator.
摘要翻译： 本发明涉及一种用于产生不同波长的短同步辐射脉冲的装置（1），特别是涉及一种光学参量振荡器，包括用于输出泵浦波长的辐射的至少一个泵浦辐射源（2），优选为泵浦激光器， 以及具有波长相关的有效谐振器长度的谐振器（3），其中所述谐振器（3）具有用于产生第一和第二波长的辐射的非线性波长转换器（4） 具有强烈的波长相关延迟特性的色散元件（5）; 以及用于至少部分地耦合来自谐振器（3）的辐射的耦合输出元件（6）。 此外，本发明涉及一种借助于装置（1）产生短辐射脉冲的方法，特别是光学参数振荡器。
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