公开(公告)号：US07625382B2

公开(公告)日：2009-12-01

申请号：US10288231

申请日：2002-11-05

Applicant: Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Rogers C. Ritter

Inventor： Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Rogers C. Ritter

IPC: A61F11/00

CPC classification number: A61M25/0127 ,  A61B6/12 ,  A61B34/73 ,  A61B90/10 ,  A61B2034/732 ,  A61B2090/374 ,  A61M25/01

Abstract: The movement of a catheter through a medium, which may be living tissue such as a human brain, is controlled by mechanically pushing a flexible catheter having a magnetic tip through the medium and applying a magnetic field having a magnitude and a direction that guides the mechanically-pushed catheter tip stepwise along a desired path. The magnetic field is controlled in a Magnetic Stereotaxis System by a processor using an adaptation of a PID (proportional, integral, and derivative) feedback method. The magnetic fields are applied by superconducting coils, and the currents applied through the coils are selected to minimize a current metric.

公开(公告)号：US07137976B2

公开(公告)日：2006-11-21

申请号：US10881825

申请日：2004-06-28

Applicant: Rogers C. Ritter ,  Bevil J. Hogg ,  Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Roger N. Hastings

Inventor： Rogers C. Ritter ,  Bevil J. Hogg ,  Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Roger N. Hastings

IPC: A61B17/00

CPC classification number: A61B1/00158 ,  A61B1/01 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12131 ,  A61B34/70 ,  A61B34/73 ,  A61B2017/00876 ,  A61B2017/1205 ,  A61B2034/733 ,  A61M25/0105 ,  A61M25/0127

Abstract: A method of turning a medical device, having a magnetically responsive element associated with its distal end, at an operating point within an operating region inside a patient's body from an initial direction to a desired final direction, through the movement of at least one external source magnet. The at least one external source magnet is moved in such a way as to change the direction of the distal end of the magnetic medical device from the initial direction to the desired final direction without substantial deviation from the plane containing the initial direction and the desired final direction.

公开(公告)号：US06975197B2

公开(公告)日：2005-12-13

申请号：US10056227

申请日：2002-01-23

Applicant: Francis M. Creighton, IV

Inventor： Francis M. Creighton, IV

IPC: A61B6/12 ,  A61B19/00 ,  H01F7/02

CPC classification number: H01F7/0278 ,  A61B6/12 ,  A61B34/70 ,  A61B34/73 ,  A61B2034/733

Abstract: A magnet assembly comprising a magnet mounted for pivoting about a first axis spaced from the magnet, and rotating about a second axis that is perpendicular to and intersects with the first axis. The magnet comprising a plurality of segments each with a magnetization direction such that through a combination of pivoting and rotating the magnet projects a magnetic field in any direction at an operating point spaced from the front of the assembly. The segmented construction with segments of different magnetization directions allows small changes in the orientation of the magnet to substantially change the magnet field direction at a system operating point.

Abstract translation: 一种磁体组件，包括安装用于围绕与磁体间隔开的第一轴线枢转并围绕垂直于第一轴线并与其相交的第二轴线旋转的磁体。 磁体包括多个段，每个段具有磁化方向，使得通过枢转和旋转磁体的组合在与组件的前部间隔开的操作点处以任何方向突出磁场。 具有不同磁化方向的段的分段结构允许磁体的取向的小的变化，以在系统工作点基本上改变磁场方向。

公开(公告)号：US06755816B2

公开(公告)日：2004-06-29

申请号：US10460710

申请日：2003-06-12

Applicant: Rogers C. Ritter ,  Bevil J. Hogg ,  Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Roger N. Hastings

Inventor： Rogers C. Ritter ,  Bevil J. Hogg ,  Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Roger N. Hastings

IPC: A61B1700

CPC classification number: A61B1/00158 ,  A61B1/01 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12131 ,  A61B34/70 ,  A61B34/73 ,  A61B2017/00876 ,  A61B2017/1205 ,  A61B2034/733 ,  A61M25/0105 ,  A61M25/0127

Abstract: A method of turning a medical device, having a magnetically responsive element associated with its distal end, at an operating point within an operating region inside a patient's body from an initial direction to a desired final direction, through the movement of at least one external source magnet. The at least one external source magnet is moved in such a way as to change the direction of the distal end of the magnetic medical device from the initial direction to the desired final direction without substantial deviation from the plane containing the initial direction and the desired final direction.

Abstract translation: 一种通过至少一个外部源的移动来将具有与其远端相关联的具有磁响应元件的医疗装置转动到患者身体内部的操作区域内的操作区域的方法，所述操作区域从初始方向到期望的最终方向 磁铁。 至少一个外部源磁体以使得磁性医疗装置的远端的方向从初始方向改变到期望的最终方向的方式移动，而不会从包含初始方向的平面和期望的最终方向显着偏离 方向。

公开(公告)号：US06537196B1

公开(公告)日：2003-03-25

申请号：US09695119

申请日：2000-10-24

Applicant: Francis M. Creighton, IV ,  Roger N. Hastings ,  Andrew F. Hall

Inventor： Francis M. Creighton, IV ,  Roger N. Hastings ,  Andrew F. Hall

IPC: A61N200

CPC classification number: A61B1/00158 ,  A61B17/00234 ,  A61B34/70 ,  A61B34/73 ,  A61B2034/732

Abstract: An adjustable field magnet assembly comprising at least two magnets rotatably mounted so that the rotation of at least one of the at least two rotatably mounted magnets changes the magnetic field projected by magnet assembly. The magnet is particularly useful in providing a magnet field of variable direction for use in magnetically navigating medical objects in the body by rotating the magnets comprising the assembly and/or rotating the entire assembly.

Abstract translation: 一种可调磁场组件，包括至少两个可旋转地安装的磁体，使得至少两个可旋转地安装的磁体中的至少一个的旋转改变由磁体组件投射的磁场。 磁体特别可用于通过旋转包括组件的磁体和/或旋转整个组件来提供可变方向的磁场，用于磁体导航身体中的医疗物体。

公开(公告)号：US06311082B1

公开(公告)日：2001-10-30

申请号：US09251164

申请日：1999-02-17

Applicant: Francis M. Creighton, IV ,  Bevil J. Hogg ,  Rogers C. Ritter

Inventor： Francis M. Creighton, IV ,  Bevil J. Hogg ,  Rogers C. Ritter

IPC: A61B505

CPC classification number: A61B1/00158 ,  A61B34/20 ,  A61B34/73 ,  A61B90/10 ,  A61B2034/733 ,  A61B2090/376 ,  H02K41/00

Abstract: A device and a method for guiding or applying force to a magnetic implant within the body of a patient. The device includes a bed for support of the patient, a set of separately energizable electromagnets or separately controllable permanent magnets so arranged to produce magnetic fields of varying orientations in a treatment region of the patient, and a processor that controls the currents in the electromagnets, or shutters on the permanent magnets to produce a selected magnetic field and/or gradient for guiding or moving the implant. The magnets are configured to allow a medical imaging device to be used to provide a real-time display of an operating procedure in which magnetic guidance is used. The method for guiding the implant includes the placing of the body on the bed, which may be servo-controlled, inserting a magnetically-guided implant into the treatment region, arranging the magnets around the body so that they can supply the necessary magnetic fields and/or gradients through appropriate energization of subsets of the magnets, and applying current or shutter control to subsets of the magnets to provide a guiding magnetic field for the implant, which may occur while real-time medical imaging of the procedure is occurring. The bed may be moved under servo control to provide further control of the direction and magnitude of the magnetic field affecting the implant.

Abstract translation: 用于引导或施加力到患者体内的磁性植入物的装置和方法。 该装置包括用于支撑患者的床，一组单独可激励的电磁体或单独控制的永磁体，其被布置成产生患者治疗区域中具有不同取向的磁场，以及控制电磁体中的电流的处理器， 或快门以产生用于引导或移动植入物的选定的磁场和/或梯度。 磁体被配置为允许医疗成像装置用于提供其中使用磁性引导的操作过程的实时显示。 用于引导植入物的方法包括将身体放置在可以被伺服控制的床上，将磁引导植入物插入治疗区域中，将磁体布置在身体周围，使得它们可以提供必要的磁场和 /或通过磁体的子集的适当激励梯度，以及将电流或快门控制施加到磁体的子集，以为在该过程的实时医学成像发生时可能发生的植入物提供引导磁场。 床可以在伺服控制下移动，以进一步控制影响植入物的磁场的方向和幅度。

公开(公告)号：US20120330089A1

公开(公告)日：2012-12-27

申请号：US13441366

申请日：2012-04-06

Applicant: Rogers C. Ritter ,  Jeffrey M. Garibaldi ,  Charles Wolfersberger ,  Francis M. Creighton ,  Peter R. Werp ,  Bevil J. Hogg ,  Walter M. Blume

Inventor： Rogers C. Ritter ,  Jeffrey M. Garibaldi ,  Charles Wolfersberger ,  Francis M. Creighton ,  Peter R. Werp ,  Bevil J. Hogg ,  Walter M. Blume

IPC: A61N2/02 ,  A61N2/10

CPC classification number: A61B34/73 ,  A61B6/0457 ,  A61B6/4441 ,  A61B34/70 ,  A61B2034/733

Abstract: A system of navigating a magnetic medical device within that part of a patient located within an operating region of the system, the system comprising magnets, and preferably electromagnets, arranged to provide a magnetic field sufficient to navigate the magnetic medical device within the operating region. There are preferably three magnetic coils arranged in mutually perpendicular planes such that their axes intersect in the operating region. The magnetic coils are sized and arranged so that a patient can easily access the operating region to allow virtually any portion of the patient to be positioned within the operating region. The openness of the magnetic system allows access to the operating region by a bi-planer imaging system.

Abstract translation: 一种在位于系统的操作区域内的患者的该部分内导航磁性医疗装置的系统，所述系统包括磁体，优选地电磁体，其被设置成提供足以在操作区域内导航磁性医疗装置的磁场。 优选地，在相互垂直的平面中布置有三个磁性线圈，使得它们的轴线在操作区域相交。 磁性线圈的尺寸和布置使得患者可以容易地进入操作区域，以允许患者的几乎任何部分位于操作区域内。 磁性系统的开放性允许通过双平面成像系统进入操作区域。

公开(公告)号：US20120310034A1

公开(公告)日：2012-12-06

申请号：US13505447

申请日：2010-11-02

Applicant: Francis M. Creighton ,  Rogers C. Ritter

Inventor： Francis M. Creighton ,  Rogers C. Ritter

IPC: A61N2/10 ,  B82Y5/00

CPC classification number: A61K41/00 ,  A61B17/22 ,  A61B17/22012 ,  A61B34/73 ,  A61B2017/00876 ,  A61B2017/22084 ,  A61B2017/22094 ,  A61B2034/733 ,  A61K9/0019 ,  A61K38/482 ,  A61K38/484 ,  A61K47/6941 ,  A61N2/004 ,  A61N2/02 ,  A61N2/06 ,  B82Y5/00 ,  C12Y304/21007 ,  C12Y304/21068 ,  H01F7/0273 ,  Y10S977/811 ,  Y10S977/905 ,  Y10S977/909

Abstract: The present invention relates to a system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator. In one aspect, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Examples of vascular occlusions targeted by the system include, but are not limited to, atherosclerotic plaques, including fibrous caps, fatty buildup, coronary occlusions, arterial stenosis, restenosis, vein thrombi, arterial thrombi, cerebral thrombi, embolisms, hemorrhages, other blood clots, and very small vessels.

Abstract translation: 本发明涉及一种用于使用远程放置的产生磁场的定子在循环系统中物理地操纵自由磁转子的系统。 一方面，本发明涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体培养基中的扩散，其可导致循环系统中的流体障碍（例如血管闭塞）的实质性清除，导致血流量增加。 系统靶向的血管闭塞的实例包括但不限于动脉粥样硬化斑块，包括纤维帽，脂肪积聚，冠状动脉闭塞，动脉狭窄，再狭窄，静脉血栓，动脉血栓，脑血栓，栓塞，出血，其他血块 ，和非常小的船只。

公开(公告)号：US08088129B2

公开(公告)日：2012-01-03

申请号：US12628711

申请日：2009-12-01

Applicant: Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Rogers C. Ritter

Inventor： Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Rogers C. Ritter

IPC: A61B19/00

CPC classification number: A61M25/0127 ,  A61B6/12 ,  A61B34/73 ,  A61B90/10 ,  A61B2034/732 ,  A61B2090/374 ,  A61M25/01

Abstract: The movement of a catheter through a medium, which may be living tissue such as a human brain, is controlled by mechanically pushing a flexible catheter having a magnetic tip through the medium and applying a magnetic field having a magnitude and a direction that guides the mechanically-pushed catheter tip stepwise along a desired path. The magnetic field is controlled in a Magnetic Stereotaxis System by a processor using an adaptation of a PID (proportional, integral, and derivative) feedback method. The magnetic fields are applied by superconducting coils, and the currents applied through the coils are selected to minimize a current metric.

Abstract translation: 通过机械地将具有磁性尖端的柔性导管机械地推动通过介质并且施加具有引导机械的大小和方向的磁场来控制导管通过可能是诸如人脑的活体组织的介质的移动 沿着所需的路径逐步引导导管末端。 通过使用PID（比例，积分和微分）反馈方法的调整的处理器在磁立体定位系统中控制磁场。 磁场由超导线圈施加，并且通过线圈施加的电流被选择以使电流量度最小化。

公开(公告)号：US07966059B2

公开(公告)日：2011-06-21

申请号：US11699003

申请日：2007-01-26

Applicant: Francis M. Creighton, IV ,  Seth Burgett

Inventor： Francis M. Creighton, IV ,  Seth Burgett

IPC: A61B6/00

CPC classification number: H01F7/0278 ,  A61B6/12 ,  A61B34/70 ,  A61B34/73 ,  A61B2034/732

Abstract: A system for magnetically navigating a medical device in an operating region within the body of a patient. The system includes a magnet having a front field projecting from the front of the magnet sufficient to project a magnetic field into the operating region in the patient. The magnet is mounted for movement between a navigation position in which the magnet is located adjacent to the patient with the front of the magnetic generally facing the operating region, and an imaging position in which the magnet is spaced from the patient and the front generally faces away from the operating region.

Abstract translation: 一种用于在患者体内的操作区域中磁性导航医疗装置的系统。 该系统包括具有从磁体的前部突出的前场的磁体，其足以将磁场投射到患者的操作区域中。 磁体被安装成在磁体位于与病人相邻的导航位置之间移动，磁体的大致面向操作区域的磁体的前部，以及磁体与患者间隔开的成像位置， 远离经营区域。