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    DEVICES FOR CONTROLLING MAGNETIC NANOPARTICLES TO TREAT FLUID OBSTRUCTIONS
    2.
    发明申请
    DEVICES FOR CONTROLLING MAGNETIC NANOPARTICLES TO TREAT FLUID OBSTRUCTIONS 有权
    用于控制磁性纳米颗粒以治疗流体阻塞的装置

    公开(公告)号：US20120310034A1

    公开(公告)日：2012-12-06

    申请号：US13505447

    申请日：2010-11-02

    申请人： Francis M. Creighton ,  Rogers C. Ritter

    发明人： Francis M. Creighton ,  Rogers C. Ritter

    IPC分类号： A61N2/10 ,  B82Y5/00

    CPC分类号： A61K41/00 ,  A61B17/22 ,  A61B17/22012 ,  A61B34/73 ,  A61B2017/00876 ,  A61B2017/22084 ,  A61B2017/22094 ,  A61B2034/733 ,  A61K9/0019 ,  A61K38/482 ,  A61K38/484 ,  A61K47/6941 ,  A61N2/004 ,  A61N2/02 ,  A61N2/06 ,  B82Y5/00 ,  C12Y304/21007 ,  C12Y304/21068 ,  H01F7/0273 ,  Y10S977/811 ,  Y10S977/905 ,  Y10S977/909

    摘要： The present invention relates to a system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator. In one aspect, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Examples of vascular occlusions targeted by the system include, but are not limited to, atherosclerotic plaques, including fibrous caps, fatty buildup, coronary occlusions, arterial stenosis, restenosis, vein thrombi, arterial thrombi, cerebral thrombi, embolisms, hemorrhages, other blood clots, and very small vessels.

    摘要翻译： 本发明涉及一种用于使用远程放置的产生磁场的定子在循环系统中物理地操纵自由磁转子的系统。 一方面，本发明涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体培养基中的扩散，其可导致循环系统中的流体障碍（例如血管闭塞）的实质性清除，导致血流量增加。 系统靶向的血管闭塞的实例包括但不限于动脉粥样硬化斑块，包括纤维帽，脂肪积聚，冠状动脉闭塞，动脉狭窄，再狭窄，静脉血栓，动脉血栓，脑血栓，栓塞，出血，其他血块 ，和非常小的船只。

    CONTROL OF MAGNETIC ROTORS TO TREAT THERAPEUTIC TARGETS
    8.
    发明申请
    CONTROL OF MAGNETIC ROTORS TO TREAT THERAPEUTIC TARGETS 有权
    磁控转子控制治疗目标

    公开(公告)号：US20150099919A1

    公开(公告)日：2015-04-09

    申请号：US14268244

    申请日：2014-05-02

    申请人： Pulse Therapeutics, Inc.

    发明人： Francis M. Creighton

    IPC分类号： A61N2/00 ,  A61N2/06 ,  A61B17/22 ,  A61N2/02

    CPC分类号： A61K41/00 ,  A61B17/22 ,  A61B17/22012 ,  A61B34/73 ,  A61B2017/00876 ,  A61B2017/22084 ,  A61B2017/22094 ,  A61B2034/733 ,  A61K9/0019 ,  A61K38/482 ,  A61K38/484 ,  A61K47/6941 ,  A61N2/004 ,  A61N2/02 ,  A61N2/06 ,  B82Y5/00 ,  C12Y304/21007 ,  C12Y304/21068 ,  H01F7/0273 ,  Y10S977/811 ,  Y10S977/905 ,  Y10S977/909

    摘要： A system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator is provided. In one embodiment, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Examples of vascular occlusions targeted by the system include, but are not limited to, atherosclerotic plaques, including fibrous caps, fatty buildup, coronary occlusions, arterial stenosis, restenosis, vein thrombi, arterial thrombi, cerebral thrombi, embolisms, hemorrhages, other blood clots, and very small vessels.

    摘要翻译： 提供了一种用于使用远程放置的磁场产生定子在循环系统中物理地操纵自由磁转子的系统。 在一个实施例中，本发明涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体培养基中的扩散，其可导致循环系统中的流体障碍（例如血管闭塞）的实质性清除，导致血流量增加。 系统靶向的血管闭塞的实例包括但不限于动脉粥样硬化斑块，包括纤维帽，脂肪积聚，冠状动脉闭塞，动脉狭窄，再狭窄，静脉血栓，动脉血栓，脑血栓，栓塞，出血，其他血块 ，和非常小的船只。

    MAGNETIC-BASED SYSTEMS AND METHODS FOR MANIPULATION OF MAGNETIC PARTICLES
    10.
    发明申请
    MAGNETIC-BASED SYSTEMS AND METHODS FOR MANIPULATION OF MAGNETIC PARTICLES 有权
    基于磁体的系统和用于操纵磁性颗粒的方法

    公开(公告)号：US20150230810A1

    公开(公告)日：2015-08-20

    申请号：US14400999

    申请日：2013-05-13

    申请人： PULSE THERAPEUTICS, INC.

    发明人： Francis M. Creighton ,  Michael Sabo ,  Christopher Null ,  Gerard Epplin ,  James Christopher Wachtman

    IPC分类号： A61B17/22 ,  H01F7/02 ,  A61M37/00

    CPC分类号： A61B17/22 ,  A61B17/22004 ,  A61B17/22012 ,  A61B17/32002 ,  A61B17/3207 ,  A61B2017/00345 ,  A61B2017/00876 ,  A61B2017/22084 ,  A61B2017/320004 ,  A61K41/0028 ,  A61M37/00 ,  A61M2037/0007 ,  B82Y5/00 ,  H01F7/0226 ,  H01F7/0273 ,  Y10S977/811 ,  Y10S977/905 ,  Y10S977/909

    摘要： Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one embodiment, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Magnetic nanoparticles are provided having a non-specialized chemical coating facilitating association with a chemical composition by a user before infusion. Systems are provided for delivering a consistent infusion mass of magnetic nanoparticles to a patient.

    摘要翻译： 一些实施例提供了一种用于使用远程放置的产生磁场的定子在脉管系统中外部操纵磁性纳米颗粒的系统。 在一个实施例中，系统和方法涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性纳米颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体培养基中的扩散，其可导致循环系统中的流体障碍（例如血管闭塞）的实质性清除，导致血流量增加。 提供了具有非专门化学涂层的磁性纳米颗粒，其在输注之前促使使用者与化学成分相关联。 提供系统用于将一致的输注质量的磁性纳米颗粒递送给患者。