公开(公告)号：US07757694B2

公开(公告)日：2010-07-20

申请号：US11849906

申请日：2007-09-04

申请人： Rogers C. Ritter ,  Bevil J. Hogg ,  Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Roger N. Hastings

发明人： Rogers C. Ritter ,  Bevil J. Hogg ,  Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Roger N. Hastings

IPC分类号： A61B19/00 ,  A61B17/00

CPC分类号： A61B1/00158 ,  A61B1/01 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12131 ,  A61B34/70 ,  A61B34/73 ,  A61B2017/00876 ,  A61B2017/1205 ,  A61B2034/733 ,  A61M25/0105 ,  A61M25/0127

摘要： A method of turning a medical device, having a magnetically responsive element associated with its distal end, at an operating point within an operating region inside a patient's body from an initial direction to a desired final direction, through the movement of at least one external source magnet. The at least one external source magnet is moved in such a way as to change the direction of the distal end of the magnetic medical device from the initial direction to the desired final direction without substantial deviation from the plane containing the initial direction and the desired final direction.

摘要翻译： 一种通过至少一个外部源的移动来将具有与其远端相关联的具有磁响应元件的医疗装置转动到患者身体内部的操作区域内的操作区域的方法，所述操作区域从初始方向到期望的最终方向 磁铁。 至少一个外部源磁体以使得磁性医疗装置的远端的方向从初始方向改变到期望的最终方向的方式移动，而不会从包含初始方向的平面和期望的最终方向显着偏离 方向。

公开(公告)号：US20100174234A1

公开(公告)日：2010-07-08

申请号：US12628711

申请日：2009-12-01

申请人： Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Rogers C. Ritter

发明人： Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Rogers C. Ritter

IPC分类号： A61M25/08

CPC分类号： A61M25/0127 ,  A61B6/12 ,  A61B34/73 ,  A61B90/10 ,  A61B2034/732 ,  A61B2090/374 ,  A61M25/01

摘要： The movement of a catheter through a medium, which may be living tissue such as a human brain, is controlled by mechanically pushing a flexible catheter having a magnetic tip through the medium and applying a magnetic field having a magnitude and a direction that guides the mechanically-pushed catheter tip stepwise along a desired path. The magnetic field is controlled in a Magnetic Stereotaxis System by a processor using an adaptation of a PID (proportional, integral, and derivative) feedback method. The magnetic fields are applied by superconducting coils, and the currents applied through the coils are selected to minimize a current metric.

摘要翻译： 通过机械地将具有磁性尖端的柔性导管机械地推动通过介质并且施加具有引导机械的大小和方向的磁场来控制导管通过可能是诸如人脑的活体组织的介质的移动 沿着所需的路径逐步引导导管末端。 通过使用PID（比例，积分和微分）反馈方法的调整的处理器在磁立体定位系统中控制磁场。 磁场由超导线圈施加，并且通过线圈施加的电流被选择以使电流量度最小化。

公开(公告)号：US06241671B1

公开(公告)日：2001-06-05

申请号：US09211723

申请日：1998-12-14

申请人： Rogers C. Ritter ,  Jeffrey M. Garibaldi ,  Charles Wolfersberger ,  Francis M. Creighton ,  Peter R. Werp ,  Bevil J. Hogg ,  Walter M. Blume

发明人： Rogers C. Ritter ,  Jeffrey M. Garibaldi ,  Charles Wolfersberger ,  Francis M. Creighton ,  Peter R. Werp ,  Bevil J. Hogg ,  Walter M. Blume

IPC分类号： A61B600

CPC分类号： A61B34/73 ,  A61B6/0457 ,  A61B6/4441 ,  A61B34/70 ,  A61B2034/733

摘要： A system of navigating a magnetic medical device within that part of a patient located within an operating region of the system, the system comprising magnets, and preferably electromagnets, arranged to provide a magnetic field sufficient to navigate the magnetic medical device within the operating region. There are preferably three magnetic coils arranged in mutually perpendicular planes such that their axes intersect in the operating region. The magnetic coils are sized and arranged so that a patient can easily access the operating region to allow virtually any portion of the patient to be positioned within the operating region. The openness of the magnetic system allows access to the operating region by a bi-planer imaging system.

摘要翻译： 一种在位于系统的操作区域内的患者的该部分内导航磁性医疗装置的系统，所述系统包括磁体，优选地电磁体，其被设置为提供足以导航所述操作区域内的所述磁性医疗装置的磁场。 优选地，在相互垂直的平面中布置有三个磁性线圈，使得它们的轴线在操作区域相交。 磁性线圈的尺寸和布置使得患者可以容易地进入操作区域，以允许患者的几乎任何部分位于操作区域内。 磁性系统的开放性允许通过双平面成像系统进入操作区域。

公开(公告)号：US20120330089A1

公开(公告)日：2012-12-27

申请号：US13441366

申请日：2012-04-06

申请人： Rogers C. Ritter ,  Jeffrey M. Garibaldi ,  Charles Wolfersberger ,  Francis M. Creighton ,  Peter R. Werp ,  Bevil J. Hogg ,  Walter M. Blume

发明人： Rogers C. Ritter ,  Jeffrey M. Garibaldi ,  Charles Wolfersberger ,  Francis M. Creighton ,  Peter R. Werp ,  Bevil J. Hogg ,  Walter M. Blume

IPC分类号： A61N2/02 ,  A61N2/10

CPC分类号： A61B34/73 ,  A61B6/0457 ,  A61B6/4441 ,  A61B34/70 ,  A61B2034/733

摘要： A system of navigating a magnetic medical device within that part of a patient located within an operating region of the system, the system comprising magnets, and preferably electromagnets, arranged to provide a magnetic field sufficient to navigate the magnetic medical device within the operating region. There are preferably three magnetic coils arranged in mutually perpendicular planes such that their axes intersect in the operating region. The magnetic coils are sized and arranged so that a patient can easily access the operating region to allow virtually any portion of the patient to be positioned within the operating region. The openness of the magnetic system allows access to the operating region by a bi-planer imaging system.

摘要翻译： 一种在位于系统的操作区域内的患者的该部分内导航磁性医疗装置的系统，所述系统包括磁体，优选地电磁体，其被设置成提供足以在操作区域内导航磁性医疗装置的磁场。 优选地，在相互垂直的平面中布置有三个磁性线圈，使得它们的轴线在操作区域相交。 磁性线圈的尺寸和布置使得患者可以容易地进入操作区域，以允许患者的几乎任何部分位于操作区域内。 磁性系统的开放性允许通过双平面成像系统进入操作区域。

公开(公告)号：US20120310034A1

公开(公告)日：2012-12-06

申请号：US13505447

申请日：2010-11-02

申请人： Francis M. Creighton ,  Rogers C. Ritter

发明人： Francis M. Creighton ,  Rogers C. Ritter

IPC分类号： A61N2/10 ,  B82Y5/00

CPC分类号： A61K41/00 ,  A61B17/22 ,  A61B17/22012 ,  A61B34/73 ,  A61B2017/00876 ,  A61B2017/22084 ,  A61B2017/22094 ,  A61B2034/733 ,  A61K9/0019 ,  A61K38/482 ,  A61K38/484 ,  A61K47/6941 ,  A61N2/004 ,  A61N2/02 ,  A61N2/06 ,  B82Y5/00 ,  C12Y304/21007 ,  C12Y304/21068 ,  H01F7/0273 ,  Y10S977/811 ,  Y10S977/905 ,  Y10S977/909

摘要： The present invention relates to a system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator. In one aspect, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Examples of vascular occlusions targeted by the system include, but are not limited to, atherosclerotic plaques, including fibrous caps, fatty buildup, coronary occlusions, arterial stenosis, restenosis, vein thrombi, arterial thrombi, cerebral thrombi, embolisms, hemorrhages, other blood clots, and very small vessels.

摘要翻译： 本发明涉及一种用于使用远程放置的产生磁场的定子在循环系统中物理地操纵自由磁转子的系统。 一方面，本发明涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体培养基中的扩散，其可导致循环系统中的流体障碍（例如血管闭塞）的实质性清除，导致血流量增加。 系统靶向的血管闭塞的实例包括但不限于动脉粥样硬化斑块，包括纤维帽，脂肪积聚，冠状动脉闭塞，动脉狭窄，再狭窄，静脉血栓，动脉血栓，脑血栓，栓塞，出血，其他血块 ，和非常小的船只。

公开(公告)号：US08088129B2

公开(公告)日：2012-01-03

申请号：US12628711

申请日：2009-12-01

申请人： Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Rogers C. Ritter

发明人： Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Rogers C. Ritter

IPC分类号： A61B19/00

CPC分类号： A61M25/0127 ,  A61B6/12 ,  A61B34/73 ,  A61B90/10 ,  A61B2034/732 ,  A61B2090/374 ,  A61M25/01

摘要： The movement of a catheter through a medium, which may be living tissue such as a human brain, is controlled by mechanically pushing a flexible catheter having a magnetic tip through the medium and applying a magnetic field having a magnitude and a direction that guides the mechanically-pushed catheter tip stepwise along a desired path. The magnetic field is controlled in a Magnetic Stereotaxis System by a processor using an adaptation of a PID (proportional, integral, and derivative) feedback method. The magnetic fields are applied by superconducting coils, and the currents applied through the coils are selected to minimize a current metric.

摘要翻译： 通过机械地将具有磁性尖端的柔性导管机械地推动通过介质并且施加具有引导机械的大小和方向的磁场来控制导管通过可能是诸如人脑的活体组织的介质的移动 沿着所需的路径逐步引导导管末端。 通过使用PID（比例，积分和微分）反馈方法的调整的处理器在磁立体定位系统中控制磁场。 磁场由超导线圈施加，并且通过线圈施加的电流被选择以使电流量度最小化。

公开(公告)号：US06505062B1

公开(公告)日：2003-01-07

申请号：US09020942

申请日：1998-02-09

申请人： Rogers C. Ritter ,  Bevil J. Hogg ,  Peter R. Werp ,  Francis M. Creighton, IV

发明人： Rogers C. Ritter ,  Bevil J. Hogg ,  Peter R. Werp ,  Francis M. Creighton, IV

IPC分类号： A61B500

CPC分类号： A61B5/066 ,  A61B5/06 ,  A61B5/743

摘要： An apparatus and method for locating a magnetic implant in a surgical application using the field of a source magnet for the implant guiding field. The source magnet is an electromagnet having a separate calibrated magnetic field component in addition to the guiding field, so that both the magnitude and orientation of the magnetic field as a function of position around the magnet are known. A magnetic implant is provided with a sensor, such as a three-axis Hall effect sensor, to provide an indication of the magnitude and orientation of an applied magnetic field when the implant is surgically implanted in a patient. After implantation, the source magnet is energized with a current having a modulated component. The modulated component is received and filtered from the signal received from the Hall effect sensor in the implant, and provided to a processor that computes the location of the implant relative to the electromagnet based upon the detected magnitude and orientation of the modulated component of the magnetic field, and the location and orientation of the electromagnet. Localizers may be used to supply the relative locations of the patient and the electromagnet to the processor. A display may be provided to display a representation of the location of the implant in the patient, which may also be superimposed over a preoperative image of the patient.

摘要翻译： 一种用于在外科应用中使用用于植入物引导区的源磁体的场来定位磁性植入物的装置和方法。 源极磁体除了引导场之外还具有单独的校准磁场分量的电磁体，使得作为磁体周围位置的函数的磁场的大小和取向都是已知的。 磁性植入物设置有诸如三轴霍尔效应传感器的传感器，以在植入物被手术植入患者体内时提供所施加的磁场的大小和取向的指示。 在植入之后，源磁体用具有调制分量的电流通电。 调制分量从在植入物中从霍尔效应传感器接收的信号接收和滤波，并提供给处理器，该处理器基于检测到的磁性调制分量的大小和取向来计算植入物相对于电磁体的位置 场，以及电磁铁的位置和方向。 定位器可用于将患者和电磁体的相对位置提供给处理器。 可以提供显示器来显示植入物在患者中的位置的表示，其也可以叠加在患者的术前图像上。

公开(公告)号：US07625382B2

公开(公告)日：2009-12-01

申请号：US10288231

申请日：2002-11-05

申请人： Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Rogers C. Ritter

发明人： Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Rogers C. Ritter

IPC分类号： A61F11/00

CPC分类号： A61M25/0127 ,  A61B6/12 ,  A61B34/73 ,  A61B90/10 ,  A61B2034/732 ,  A61B2090/374 ,  A61M25/01

摘要： The movement of a catheter through a medium, which may be living tissue such as a human brain, is controlled by mechanically pushing a flexible catheter having a magnetic tip through the medium and applying a magnetic field having a magnitude and a direction that guides the mechanically-pushed catheter tip stepwise along a desired path. The magnetic field is controlled in a Magnetic Stereotaxis System by a processor using an adaptation of a PID (proportional, integral, and derivative) feedback method. The magnetic fields are applied by superconducting coils, and the currents applied through the coils are selected to minimize a current metric.

公开(公告)号：US07137976B2

公开(公告)日：2006-11-21

申请号：US10881825

申请日：2004-06-28

申请人： Rogers C. Ritter ,  Bevil J. Hogg ,  Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Roger N. Hastings

发明人： Rogers C. Ritter ,  Bevil J. Hogg ,  Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Roger N. Hastings

IPC分类号： A61B17/00

CPC分类号： A61B1/00158 ,  A61B1/01 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12131 ,  A61B34/70 ,  A61B34/73 ,  A61B2017/00876 ,  A61B2017/1205 ,  A61B2034/733 ,  A61M25/0105 ,  A61M25/0127

摘要： A method of turning a medical device, having a magnetically responsive element associated with its distal end, at an operating point within an operating region inside a patient's body from an initial direction to a desired final direction, through the movement of at least one external source magnet. The at least one external source magnet is moved in such a way as to change the direction of the distal end of the magnetic medical device from the initial direction to the desired final direction without substantial deviation from the plane containing the initial direction and the desired final direction.

公开(公告)号：US06755816B2

公开(公告)日：2004-06-29

申请号：US10460710

申请日：2003-06-12

申请人： Rogers C. Ritter ,  Bevil J. Hogg ,  Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Roger N. Hastings

发明人： Rogers C. Ritter ,  Bevil J. Hogg ,  Peter R. Werp ,  Walter M. Blume ,  Francis M. Creighton, IV ,  Roger N. Hastings

IPC分类号： A61B1700

CPC分类号： A61B1/00158 ,  A61B1/01 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12131 ,  A61B34/70 ,  A61B34/73 ,  A61B2017/00876 ,  A61B2017/1205 ,  A61B2034/733 ,  A61M25/0105 ,  A61M25/0127

摘要： A method of turning a medical device, having a magnetically responsive element associated with its distal end, at an operating point within an operating region inside a patient's body from an initial direction to a desired final direction, through the movement of at least one external source magnet. The at least one external source magnet is moved in such a way as to change the direction of the distal end of the magnetic medical device from the initial direction to the desired final direction without substantial deviation from the plane containing the initial direction and the desired final direction.

摘要翻译： 一种通过至少一个外部源的移动来将具有与其远端相关联的具有磁响应元件的医疗装置转动到患者身体内部的操作区域内的操作区域的方法，所述操作区域从初始方向到期望的最终方向 磁铁。 至少一个外部源磁体以使得磁性医疗装置的远端的方向从初始方向改变到期望的最终方向的方式移动，而不会从包含初始方向的平面和期望的最终方向显着偏离 方向。