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公开(公告)号：US5320966A
公开(公告)日：1994-06-14
申请号：US752200
申请日：1991-08-21
申请人： Hiroshi Mitsumaki , Fujiya Takahata
发明人： Hiroshi Mitsumaki , Fujiya Takahata
CPC分类号： G01N35/0092 , G01N35/025 , G01N2035/0093 , G01N2035/0097 , Y10T436/113332 , Y10T436/115831 , Y10T436/12
摘要： An automatic processor for analyzing reaction solutions has a large number of reaction vessels arranged in a circle on a disk, a disk driver for circulating the reaction vessels successively to pass through a sample pouring position, a reagent adding position and an analyzing position in order, sample pouring pipet nozzle for pouring a sample into each of the reaction chambers at the sample pouring position, reagent adding pipet nozzle for adding a reagent into each of the reaction chambers at the reagent adding position, and analyzer for analyzing a reaction solution in each of the reaction vessels at the analyzing position. A large number of reaction vessels are divided into a plurality of reaction vessel groups each of which has a plurality of reaction vessels. The disk driver circulates each of the reaction vessel groups in a predetermined time in accordance with the reaction times of the reaction solutions in the reaction vessels of the same reaction vessel group.
摘要翻译： 用于分析反应溶液的自动处理器具有大量圆盘上设置的反应容器，用于使反应容器连续循环的盘驱动器依次通过样品倾倒位置，试剂添加位置和分析位置， 用于在样品倾倒位置将样品倾倒到每个反应室中的试样注入吸管，用于在试剂添加位置向每个反应室中添加试剂的试剂添加移液管喷嘴，以及用于分析每个反应溶液 在分析位置的反应容器。 将大量的反应容器分成多个反应容器组，每个反应容器组具有多个反应容器。 磁盘驱动器根据同一反应容器组的反应容器中的反应溶液的反应时间，在预定时间内循环每个反应容器组。
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公开(公告)号：US4429230A
公开(公告)日：1984-01-31
申请号：US333413
申请日：1981-12-22
申请人： Tadashi Honkawa , Fujiya Takahata , Koichi Yagai , Yoshio Maeda , Tetuya Shinden
发明人： Tadashi Honkawa , Fujiya Takahata , Koichi Yagai , Yoshio Maeda , Tetuya Shinden
CPC分类号： G01N21/272 , G01N21/21 , G01N21/6445
摘要： Fluorescent dye is added to a sample including lymphatic cells stimulated by antic bodies to measure fluorescence polarization. The fluorescence polarization varies with time. The measurement is stopped after a predetermined measurement time, and the lymphatic cells are separated from the sample by filtering. In order to determine the fluorescence polarization in a filtering process, approximate equations of the reaction are determined based on the fluorescence polarization measured during the reaction process. Based on the approximate equations, the fluorescence polarization in the filtering process is calculated. The reaction process is approximated by both an approximate linear line and an approximate curve. A reaction data at a predetermined future time is calculated based on the two approximate functions so that a reliability of the resulting data is improved.
摘要翻译： 将荧光染料添加到包含由抗体刺激的淋巴细胞的样品中以测量荧光偏振。 荧光偏振随时间变化。 在预定的测量时间之后停止测量，并且通过过滤将淋巴细胞与样品分离。 为了在滤波过程中确定荧光偏振，基于在反应过程中测量的荧光偏振来确定反应的近似方程。 基于近似等式，计算滤波过程中的荧光偏振。 反应过程由近似线性线和近似曲线近似。 基于两个近似函数计算预定未来时间的反应数据，从而提高所得数据的可靠性。
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3.发明授权
公开(公告)号：US5104807A
公开(公告)日：1992-04-14
申请号：US311272
申请日：1989-02-16
申请人： Hiroshi Mitsumaki , Fujiya Takahata
发明人： Hiroshi Mitsumaki , Fujiya Takahata
CPC分类号： G01N35/02 , B01F9/0001 , B01F2009/0079 , B01F2009/0085 , G01N2035/00524 , G01N35/025 , G01N35/026 , Y10T436/113332
摘要： An analyzing apparatus includes a turntable, and a plurality of reaction containers which are arranged on the turntable. This turntable is intermittently rotated so that the train of reaction containers is alternately in a conveyed state and a stopped state. The outer walls of part of the reaction containers in the train of reaction containers are in contact with a fixedly provided friction flange, while the remaining reaction containers in the train of reaction containers is not in contact with the friction flange. Since the reaction containers located in an area where they make contact with the friction flange are conveyed while they are contacting with the friction flange as the turntable is rotated, the motion of the turntable is transmitted to the reaction containers, and the reaction containers are thereby rotated on their own axes so as to allow the reaction liquid in the containers to be stirred. The rotation of the reaction containers on their own axes is stopped when they reach an area where they do not make contact with the friction flange. After the rotation of the reaction liquid in the reaction containers has been substantially stopped, the light measurement of the reaction liquid is performed using a photometer.
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公开(公告)号：US5242371A
公开(公告)日：1993-09-07
申请号：US662104
申请日：1991-02-28
申请人： Takeshi Sato , Fujiya Takahata
发明人： Takeshi Sato , Fujiya Takahata
CPC分类号： B04B5/0414 , G01N35/021 , B04B2005/0435 , B04B2011/046 , G01N2035/00495 , G01N2035/0406 , G01N2035/041 , G01N35/025 , Y10T436/111666
摘要： A shaft for centrifugally separating a sample includes a first shaft element having a first end taper portion and a middle straight portion, and a second shaft element having a second end taper portion. The first shaft element and the second shaft element are coupled and rotate in opposite directions. An adapter having a ring is mounted on the rotating first taper portion of the shaft by the ring. The adapter receives a sample tube and the adapter and the sample tube are transported forward on the first end taper portion of the shaft. The adapter and the sample tube are sent to the middle straight portion of the shaft and the sample is centrifugally separated in the middle straight portion of the shaft. The adapter and the sample tube are sent to the second taper portion of the shaft and disengaged from the second end taper portion of the shaft. The adapter and the sample tube are automatically mounted on the shaft, and the sample is centrifugally separated on the shaft, after which the adapter and the sample tube are automatically disengaged from the shaft.
摘要翻译： 用于离心分离样品的轴包括具有第一端锥形部分和中间直线部分的第一轴元件和具有第二端部锥形部分的第二轴元件。 第一轴元件和第二轴元件联接并沿相反方向旋转。 具有环的适配器通过环安装在轴的旋转的第一锥形部分上。 适配器接收样品管，并且适配器和样品管在轴的第一端锥形部分上向前输送。 适配器和样品管被送到轴的中间直线部分，样品在轴的中间直线部分离心分离。 适配器和样品管被送到轴的第二锥形部分并与轴的第二端部锥形部分分离。 适配器和样品管自动安装在轴上，样品在轴上离心分离，然后适配器和样品管自动脱离轴。
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公开(公告)号：US4983038A
公开(公告)日：1991-01-08
申请号：US178651
申请日：1988-04-07
申请人： Hiroshi Ohki , Ryo Miyake , Isao Yamazaki , Fujiya Takahata
发明人： Hiroshi Ohki , Ryo Miyake , Isao Yamazaki , Fujiya Takahata
CPC分类号： G01N15/1404 , B01F13/0062
摘要： A sheath flow type flow-cell device for photo-particle-analyzer comprises a substantially flat top surface, at least one first inlet for sheath fluid, at least one first flow passage communicated with the at least one first inlet and contracted toward downstream to be a straight capillary flow passage, a discharge port provided at a terminal end of the straight capillary flow passage, a second inlet for sample fluid, a second flow passage for sample fluid communicated with the second inlet and contracted toward downstream, and coupling portions for sealingly coupling with the particle photo-analyzer. The second flow passage is opened within the at least one first flow passage so as to keep a part of the at least one first flow passage above and below an opening of the second flow passage. The opening is faced in the same direction as the straight capillary flow passage. A wall portion on which the opening locates is rounded. The wall portion is further chamfered and a pair of projections are extended from the wall portion.
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公开(公告)号：US3966323A
公开(公告)日：1976-06-29
申请号：US524868
申请日：1974-11-18
CPC分类号： G01N21/253 , G01J3/42
摘要： Apparatus for producing timing signals for photometric measurement by utilizing light transmitted through samples to be analyzed. The apparatus comprises a light source, a group of sample containing cells, a driving mechanism for moving the sample cells relative to the light source, a concave diffraction grating for dispersing light transmitted through the sample cell, a first photo-detector for receiving a light beam of a predetermined wave length from the concave diffraction grating, a second photo-detector to receive light beams of the zero spectral order subjected to the total refrection at the concave diffraction grating, a signal hold circuit for holding an electric signal available from the first photo-detector, and a command circuitry which responds to the signal held by the hold circuit to produce signals which resets the hold circuit to release the held signal on one hand and on the other hand allows a read-out and/or record apparatus to read out and/or record the peak value of the signal held by the signal hold circuit. A delay circuit may be provided to delay the operation of the command circuit in order that an analog-to-digital conversion of the peak value signal be effected before the read-out thereof.
摘要翻译： 用于通过利用透过待分析样品的光产生测光测量的定时信号的装置。 该装置包括光源，一组含有细胞的样品，用于使样品池相对于光源移动的驱动机构，用于分散透过样品池的光的凹形衍射光栅，用于接收光的第一光检测器 来自凹衍射光栅的预定波长的光束，第二光检测器，用于接收经受在凹衍射光栅处的总体校正的零光谱级的光束;信号保持电路，用于保持从第一 光检测器和指令电路，其响应由保持电路保持的信号，以产生复位保持电路以一方面释放保持信号的信号，另一方面允许读出和/或记录设备 读出和/或记录由信号保持电路保持的信号的峰值。 可以提供延迟电路来延迟命令电路的操作，以便在其读出之前进行峰值信号的模数转换。
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