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公开(公告)号：US09469876B2
公开(公告)日：2016-10-18
申请号：US13639756
申请日：2011-04-06
申请人： George Poste , Michael Klass , David Spetzler , Traci Pawlowski
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , G01N33/57419 , G01N33/57434 , G01N2800/52
摘要： Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.
摘要翻译： 可以评估生物标志物的诊断，治疗相关或预后的方法来鉴定表型，如病情或疾病，或疾病的阶段或进展。 来自体液的循环生物标志物可用于生理状态的分析或确定表型。 这些包括核酸，蛋白质和循环结构如囊泡。 生物标志物可以用于选择用于疾病，病症，疾病阶段和病症阶段的候选治疗方案，并且还可以用于确定治疗功效。 生物标志物可以是循环生物标志物，包括囊泡和微小RNA。
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公开(公告)号：US20130184169A1
公开(公告)日：2013-07-18
申请号：US13459016
申请日：2012-04-27
申请人： Michael KLASS , George POSTE
发明人： Michael KLASS , Christine KUSLICH , George POSTE
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G01N33/57434 , C12Q2525/207
摘要： Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.
摘要翻译： 本文提供了通过评估RNA水平来表征癌症的方法和组合物，例如确定RNA模式。 可通过检测一种或多种RNA（例如微小RNA）来确定诊断，预后，监测和治疗或癌症。
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3.发明申请公开(公告)号：US20110237450A1
公开(公告)日：2011-09-29
申请号：US13009393
申请日：2011-01-19
IPC分类号： C40B30/04 , G01N33/574 , C12Q1/68 , B82Y15/00
CPC分类号： G01N33/57484 , C12Q1/6811 , C12Q1/6886 , C12Q2600/112 , C12Q2600/16 , C12Q2600/178 , G01N33/5023 , G01N33/54326 , G01N33/574 , G01N33/57419 , G01N33/57434 , G01N33/6848 , C12Q2525/205
摘要： Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
摘要翻译： 外来体可用于检测用于诊断，治疗相关或预后方法的生物标志物，以鉴定表型，例如病症或疾病，例如疾病的阶段或进展。 原核细胞外源体可用于生理状态的分析或确定表型。 可以使用来自细胞来源特异性外来体的生物标志物或标记来确定疾病，病症，疾病阶段和病症阶段的治疗方案，并且还可以用于确定治疗功效。 来自细胞来源的特异性外来体的标记物也可用于鉴定未知来源的疾病状况。
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公开(公告)号：US07888035B2
公开(公告)日：2011-02-15
申请号：US12609847
申请日：2009-10-30
申请人： Michael Klass , Christine Kuslich , George Poste
发明人： Michael Klass , Christine Kuslich , George Poste
CPC分类号： G01N33/57484 , C12Q1/6809 , C12Q1/6886 , C12Q2600/112 , C12Q2600/178 , G01N33/57434 , C12Q2525/207
摘要： Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.
摘要翻译： 本文提供了通过评估RNA水平来表征癌症的方法和组合物，例如确定RNA模式。 可通过检测一种或多种RNA（例如微小RNA）来确定诊断，预后，监测和治疗或癌症。
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公开(公告)号：US20130178383A1
公开(公告)日：2013-07-11
申请号：US13598408
申请日：2012-08-29
申请人： David SPETZLER , Traci PAWLOWSKI , Michael KLASS , George POSTE
IPC分类号： G01N1/40
CPC分类号： G01N1/4077 , C12Q1/6806 , C12Q1/6886 , C12Q2600/118 , C12Q2600/178 , G01N33/5023 , G01N33/5432 , G01N33/54326 , G01N33/574 , G01N33/57419 , G01N33/57434 , G01N33/57484 , G01N33/6848 , G01N2800/50 , G01N2800/52
摘要： Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.
摘要翻译： 可以评估生物标志物的诊断，治疗相关或预后的方法来鉴定表型，如病情或疾病，或疾病的阶段或进展。 来自体液的循环生物标志物可用于生理状态的分析或确定表型。 这些包括核酸，蛋白质和循环结构如囊泡。 生物标志物可以用于选择用于疾病，病症，疾病阶段和病症阶段的候选治疗方案，并且还可以用于确定治疗功效。 生物标志物可以是循环生物标志物，包括囊泡和微小RNA。
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公开(公告)号：US08211653B2
公开(公告)日：2012-07-03
申请号：US13009285
申请日：2011-01-19
申请人： Michael Klass , Christine Kuslich , George Poste
发明人： Michael Klass , Christine Kuslich , George Poste
IPC分类号： G01N33/53
CPC分类号： G01N33/57484 , C12Q1/6811 , C12Q1/6886 , C12Q2600/112 , C12Q2600/16 , C12Q2600/178 , G01N33/5023 , G01N33/54326 , G01N33/574 , G01N33/57419 , G01N33/57434 , G01N33/6848 , C12Q2525/205
摘要： Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
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公开(公告)号：US20110159506A1
公开(公告)日：2011-06-30
申请号：US12963468
申请日：2010-12-08
申请人： MICHAEL KLASS , CHRISTINE KUSTILICH , GEORGE POSTE
发明人： MICHAEL KLASS , CHRISTINE KUSTILICH , GEORGE POSTE
IPC分类号： C12Q1/68
CPC分类号： G01N33/57484 , C12Q1/6809 , C12Q1/6886 , C12Q2600/112 , C12Q2600/178 , G01N33/57434 , C12Q2525/207
摘要： Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.
摘要翻译： 本文提供了通过评估RNA水平来表征癌症的方法和组合物，例如确定RNA模式。 可通过检测一种或多种RNA（例如微小RNA）来确定诊断，预后，监测和治疗或癌症。
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公开(公告)号：US08278059B2
公开(公告)日：2012-10-02
申请号：US13009393
申请日：2011-01-19
申请人： Michael Klass , Christine Kuslich , George Poste
发明人： Michael Klass , Christine Kuslich , George Poste
CPC分类号： G01N33/57484 , C12Q1/6811 , C12Q1/6886 , C12Q2600/112 , C12Q2600/16 , C12Q2600/178 , G01N33/5023 , G01N33/54326 , G01N33/574 , G01N33/57419 , G01N33/57434 , G01N33/6848 , C12Q2525/205
摘要： Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
摘要翻译： 外来体可用于检测用于诊断，治疗相关或预后方法的生物标志物，以鉴定表型，例如病症或疾病，例如疾病的阶段或进展。 原核细胞外源体可用于生理状态的分析或确定表型。 可以使用来自细胞来源特异性外来体的生物标志物或标记来确定疾病，病症，疾病阶段和病症阶段的治疗方案，并且还可以用于确定治疗功效。 来自细胞来源的特异性外来体的标记物也可用于鉴定未知来源的疾病状况。
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公开(公告)号：US20100113290A1
公开(公告)日：2010-05-06
申请号：US12609847
申请日：2009-10-30
申请人： Michael KLASS , Christine Kuslich , George Poste
发明人： Michael KLASS , Christine Kuslich , George Poste
CPC分类号： G01N33/57484 , C12Q1/6809 , C12Q1/6886 , C12Q2600/112 , C12Q2600/178 , G01N33/57434 , C12Q2525/207
摘要： Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.
摘要翻译： 本文提供了通过评估RNA水平来表征癌症的方法和组合物，例如确定RNA模式。 可通过检测一种或多种RNA（例如微小RNA）来确定诊断，预后，监测和治疗或癌症。
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公开(公告)号：US09128101B2
公开(公告)日：2015-09-08
申请号：US13581795
申请日：2011-03-01
申请人： David D. Halbert , George Poste , Michael Klass , David Spetzler , Traci Pawlowski , Daniel Holterman
发明人： David D. Halbert , Christine Kuslich , George Poste , Michael Klass , David Spetzler , Traci Pawlowski , Andrea Tasinato , Daniel Holterman
IPC分类号： G01N33/53 , G01N33/68 , C12Q1/68 , G01N33/574
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N33/57484 , G01N33/6872 , G01N2333/705 , G01N2800/52 , G01N2800/60
摘要： Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.
摘要翻译： 可以评估生物标志物的诊断，治疗相关或预后的方法来鉴定表型，如病情或疾病，或疾病的阶段或进展。 来自体液的循环生物标志物可用于生理状态的分析或确定表型。 这些包括核酸，蛋白质和循环结构如囊泡。 生物标志物可以用于选择用于疾病，病症，疾病阶段和病症阶段的候选治疗方案，并且还可以用于确定治疗功效。 生物标志物可以是循环生物标志物，包括囊泡和微小RNA。
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