公开(公告)号：US09469876B2

公开(公告)日：2016-10-18

申请号：US13639756

申请日：2011-04-06

Applicant: George Poste ,  Michael Klass ,  David Spetzler ,  Traci Pawlowski

Inventor： Christine Kuslich ,  George Poste ,  Michael Klass ,  David Spetzler ,  Traci Pawlowski

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  G01N33/57419 ,  G01N33/57434 ,  G01N2800/52

Abstract: Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.

Abstract translation: 可以评估生物标志物的诊断，治疗相关或预后的方法来鉴定表型，如病情或疾病，或疾病的阶段或进展。 来自体液的循环生物标志物可用于生理状态的分析或确定表型。 这些包括核酸，蛋白质和循环结构如囊泡。 生物标志物可以用于选择用于疾病，病症，疾病阶段和病症阶段的候选治疗方案，并且还可以用于确定治疗功效。 生物标志物可以是循环生物标志物，包括囊泡和微小RNA。

公开(公告)号：US20130203061A1

公开(公告)日：2013-08-08

申请号：US13512017

申请日：2010-11-30

Applicant: Michael Klass ,  David Spetzler ,  Traci Pawlowski

Inventor： Christine Kuslich ,  Michael Klass ,  David Spetzler ,  Traci Pawlowski

IPC: G01N33/574 ,  C12Q1/68

CPC classification number: G01N33/57484 ,  C12Q1/6886 ,  G01N33/5076

Abstract: Provided herein are methods and systems for isolating, storing, and analyzing a vesicle from a sample The vesicle can be isolated using one or more lectins that bind to a vesicle One or more additional binding agents, such as a non lectin binding agent can also be used to isolate or analyze a vesicle

Abstract translation: 本文提供了用于从样品中分离，储存和分析囊泡的方法和系统。可以使用结合囊泡的一种或多种凝集素分离囊泡。一种或多种另外的结合剂，例如非凝集素结合剂也可以是 用于分离或分析囊泡

公开(公告)号：US20130184169A1

公开(公告)日：2013-07-18

申请号：US13459016

申请日：2012-04-27

Applicant: Michael KLASS ,  George POSTE

Inventor： Michael KLASS ,  Christine KUSLICH ,  George POSTE

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q1/6809 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/57434 ,  C12Q2525/207

Abstract: Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.

Abstract translation: 本文提供了通过评估RNA水平来表征癌症的方法和组合物，例如确定RNA模式。 可通过检测一种或多种RNA（例如微小RNA）来确定诊断，预后，监测和治疗或癌症。

公开(公告)号：US07888035B2

公开(公告)日：2011-02-15

申请号：US12609847

申请日：2009-10-30

Applicant: Michael Klass ,  Christine Kuslich ,  George Poste

Inventor： Michael Klass ,  Christine Kuslich ,  George Poste

IPC: C12Q1/68 ,  C12P19/34 ,  C07H21/04

CPC classification number: G01N33/57484 ,  C12Q1/6809 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/178 ,  G01N33/57434 ,  C12Q2525/207

Abstract: Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.

Abstract translation: 本文提供了通过评估RNA水平来表征癌症的方法和组合物，例如确定RNA模式。 可通过检测一种或多种RNA（例如微小RNA）来确定诊断，预后，监测和治疗或癌症。

公开(公告)号：US20050170414A1

公开(公告)日：2005-08-04

申请号：US11055308

申请日：2005-02-10

Applicant: Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Mark Hayden ,  Michael Klass ,  Lisa Roberts-Rapp ,  John Russell ,  Stephen Stroupe

Inventor： Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Mark Hayden ,  Michael Klass ,  Lisa Roberts-Rapp ,  John Russell ,  Stephen Stroupe

IPC: C07K16/30 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/47

CPC classification number: C07K16/3046 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS193 and transcribed from GI tract tissue, are described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS193-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS193 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

Abstract translation: 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为CS193并从胃肠道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。 还提供了特异性结合CS193编码的多肽或蛋白质的抗体，以及预防组织特异性CS193多肽作用的激动剂或抑制剂，该分子可用于胃肠道疾病，肿瘤或转移瘤的治疗性治疗。

公开(公告)号：US20130178383A1

公开(公告)日：2013-07-11

申请号：US13598408

申请日：2012-08-29

Applicant: David SPETZLER ,  Traci PAWLOWSKI ,  Michael KLASS ,  George POSTE

Inventor： David SPETZLER ,  Traci PAWLOWSKI ,  Michael KLASS ,  Christine KUSLICH ,  George POSTE

IPC: G01N1/40

CPC classification number: G01N1/4077 ,  C12Q1/6806 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/178 ,  G01N33/5023 ,  G01N33/5432 ,  G01N33/54326 ,  G01N33/574 ,  G01N33/57419 ,  G01N33/57434 ,  G01N33/57484 ,  G01N33/6848 ,  G01N2800/50 ,  G01N2800/52

Abstract: Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.

Abstract translation: 可以评估生物标志物的诊断，治疗相关或预后的方法来鉴定表型，如病情或疾病，或疾病的阶段或进展。 来自体液的循环生物标志物可用于生理状态的分析或确定表型。 这些包括核酸，蛋白质和循环结构如囊泡。 生物标志物可以用于选择用于疾病，病症，疾病阶段和病症阶段的候选治疗方案，并且还可以用于确定治疗功效。 生物标志物可以是循环生物标志物，包括囊泡和微小RNA。

公开(公告)号：US08211653B2

公开(公告)日：2012-07-03

申请号：US13009285

申请日：2011-01-19

Applicant: Michael Klass ,  Christine Kuslich ,  George Poste

Inventor： Michael Klass ,  Christine Kuslich ,  George Poste

IPC: G01N33/53

CPC classification number: G01N33/57484 ,  C12Q1/6811 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/16 ,  C12Q2600/178 ,  G01N33/5023 ,  G01N33/54326 ,  G01N33/574 ,  G01N33/57419 ,  G01N33/57434 ,  G01N33/6848 ,  C12Q2525/205

Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.

公开(公告)号：US20110159506A1

公开(公告)日：2011-06-30

申请号：US12963468

申请日：2010-12-08

Applicant: MICHAEL KLASS ,  CHRISTINE KUSTILICH ,  GEORGE POSTE

Inventor： MICHAEL KLASS ,  CHRISTINE KUSTILICH ,  GEORGE POSTE

IPC: C12Q1/68

CPC classification number: G01N33/57484 ,  C12Q1/6809 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/178 ,  G01N33/57434 ,  C12Q2525/207

Abstract: Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.

Abstract translation: 本文提供了通过评估RNA水平来表征癌症的方法和组合物，例如确定RNA模式。 可通过检测一种或多种RNA（例如微小RNA）来确定诊断，预后，监测和治疗或癌症。

公开(公告)号：US20060029963A1

公开(公告)日：2006-02-09

申请号：US11201347

申请日：2005-08-10

Applicant: Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Julian Gordon ,  Edward Granados ,  Steven Hodges ,  Michael Klass ,  Jon Kratochvil ,  John Russell ,  Stephen Stroupe

Inventor： Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Julian Gordon ,  Edward Granados ,  Steven Hodges ,  Michael Klass ,  Jon Kratochvil ,  John Russell ,  Stephen Stroupe

IPC: C12Q1/68 ,  C07H21/04

CPC classification number: C12Q1/6886 ,  C07K14/47 ,  C07K16/3015 ,  C12Q2600/136 ,  C12Q2600/156

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS325 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to SB325-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS325 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

Abstract translation: 描述了一组连续且部分重叠的cDNA序列和由此编码的多肽，命名为BS325并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。 还提供了特异性结合SB325编码的多肽或蛋白质的抗体，以及预防组织特异性BS325多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。

公开(公告)号：US20050266477A1

公开(公告)日：2005-12-01

申请号：US11148108

申请日：2005-06-08

Applicant: Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Michael Klass ,  Lisa Roberts-Rapp ,  John Russell ,  Stephen Stroupe

Inventor： Patricia Billing-Medel ,  Maurice Cohen ,  Tracey Colpitts ,  Paula Friedman ,  Michael Klass ,  Lisa Roberts-Rapp ,  John Russell ,  Stephen Stroupe

IPC: C07H21/04 ,  C07K14/47 ,  C07K16/00 ,  C07K16/22 ,  C07K16/32 ,  C12N9/24 ,  C12N9/64 ,  C12P21/06 ,  C12Q1/68 ,  G01N33/574

CPC classification number: C07K14/47 ,  C07K16/005 ,  C07K16/22 ,  C07K16/32 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/57419 ,  G01N33/57438 ,  G01N33/57446

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS194 and transcribed from GI tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS194-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS194 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

Abstract translation: 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为CS194并从胃肠道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。 还提供了特异性结合CS194编码的多肽或蛋白质的抗体，以及预防组织特异性CS194多肽的作用的激动剂或抑制剂，该分子可用于治疗GI道疾病，肿瘤或转移瘤。