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公开(公告)号：US08779189B2
公开(公告)日：2014-07-15
申请号：US13719678
申请日：2012-12-19
申请人： George Scheele
发明人： George Scheele
IPC分类号： C07C205/00 , C07C207/00 , C07C229/00 , A23K1/18 , A61K31/198 , A61K31/4192 , A61K45/06 , A23L1/29
CPC分类号： A23L1/305 , A23L33/17 , A23L33/175 , A23L33/30 , A61K31/197 , A61K31/198 , A61K31/4172 , A61K31/4192 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to high protein dietary supplements for treating various symptoms and diseases associated with protein deficiency including weight gain, obesity, catabolic diseases, fibromyalgia, anxiety reactions, posttraumatic stress and chronic fatigue syndrome. Embodiments of dietary supplements comprise combinations of proteins, essential and semi-essential amino acids including L-Lysine, L-Arginine, and/or L-Histidine.
摘要翻译： 本公开涉及用于治疗与蛋白质缺乏相关的各种症状和疾病的高蛋白质膳食补充剂，包括体重增加，肥胖症，分解代谢疾病，纤维肌痛，焦虑反应，创伤后应激和慢性疲劳综合征。 膳食补充剂的实施方案包括蛋白质，包括L-赖氨酸，L-精氨酸和/或L-组氨酸的必需和半必需氨基酸的组合。
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公开(公告)号：US08362297B2
公开(公告)日：2013-01-29
申请号：US13164536
申请日：2011-06-20
申请人： George Scheele
发明人： George Scheele
IPC分类号： C07C205/00 , C07C207/00 , C07C229/00 , A61K38/00 , A61P3/04
CPC分类号： A23L1/305 , A23L33/17 , A23L33/175 , A23L33/30 , A61K31/197 , A61K31/198 , A61K31/4172 , A61K31/4192 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to high protein dietary supplements for treating various symptoms and diseases associated with protein deficiency including weight gain, obesity, catabolic diseases, fibromyalgia, anxiety reactions, posttraumatic stress and chronic fatigue syndrome. Embodiments of dietary supplements comprise combinations of proteins, essential and semi-essential amino acids including L-Lysine, L-Arginine, and/or L-Histidine.
摘要翻译： 本公开涉及用于治疗与蛋白质缺乏相关的各种症状和疾病的高蛋白质膳食补充剂，包括体重增加，肥胖症，分解代谢疾病，纤维肌痛，焦虑反应，创伤后应激和慢性疲劳综合征。 膳食补充剂的实施方案包括蛋白质，包括L-赖氨酸，L-精氨酸和/或L-组氨酸的必需和半必需氨基酸的组合。
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公开(公告)号：US20090018072A1
公开(公告)日：2009-01-15
申请号：US12135933
申请日：2008-06-09
申请人： George Scheele
发明人： George Scheele
CPC分类号： A23L1/305 , A23L33/17 , A23L33/175 , A23L33/30 , A61K31/197 , A61K31/198 , A61K31/4172 , A61K31/4192 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to high protein dietary supplements for treating various symptoms and diseases associated with protein deficiency including weight gain, obesity, catabolic diseases, fibromyalgia, anxiety reactions, posttraumatic stress and chronic fatigue syndrome. Embodiments of dietary supplements comprise combinations of proteins, essential and semi-essential amino acids including L-Lysine, L-Arginine, and/or L-Histidine.
摘要翻译： 本公开涉及用于治疗与蛋白质缺乏相关的各种症状和疾病的高蛋白质膳食补充剂，包括体重增加，肥胖症，分解代谢疾病，纤维肌痛，焦虑反应，创伤后应激和慢性疲劳综合征。 膳食补充剂的实施方案包括蛋白质，包括L-赖氨酸，L-精氨酸和/或L-组氨酸的必需和半必需氨基酸的组合。
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公开(公告)号：US20050015847A1
公开(公告)日：2005-01-27
申请号：US10637793
申请日：2003-08-08
申请人： George Scheele , James Hildreth
发明人： George Scheele , James Hildreth
IPC分类号： A41D19/00 , A61K20060101
CPC分类号： A61L31/16 , A61B42/00 , A61B42/10 , A61B2017/00889 , A61B2017/00893 , A61F13/104 , A61F2013/00302 , A61F2013/00306 , A61F2013/0031 , A61F2013/15065 , A61F2013/15081 , A61L2300/404
摘要： This invention relates to cholesterol-sequestering agents and methods of using cholesterol-sequestering agents to prevent infection. The compositions of the invention can be used to decontaminate skin and environmental surfaces that are contacted with microorganisms such as envelope viruses.
摘要翻译： 本发明涉及胆固醇螯合剂和使用胆固醇螯合剂来预防感染的方法。 本发明的组合物可用于去除与诸如包膜病毒的微生物接触的皮肤和环境表面。
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5.发明授权Treatment of pulmonary conditions associated with insufficient secretion of surfactant 失效治疗与表面活性剂分泌不足有关的肺部疾病
公开(公告)号：US5863563A
公开(公告)日：1999-01-26
申请号：US326692
申请日：1994-10-20
申请人： George Scheele
发明人： George Scheele
IPC分类号： A61K9/12 , A61K9/14 , A61K9/72 , A61K31/13 , A61K31/495 , A61K33/00 , A61K33/10 , A61K33/42 , A61K45/00 , A61M15/00 , A61P11/00
CPC分类号： A61K33/42 , A61K33/00 , A61K9/0073 , A61M15/0086 , A61M15/009 , A61M2202/064 , Y10S514/826 , Y10S514/851 , Y10S514/951
摘要： Methods and compositions for the treatment of the symptoms of a patient who has a pulmonary condition associated with an inhibition of surfactant secretion by type II alveolar cells are described. The method of treatment involves causing a patient to inhale an amount of a pH-raising buffer effective to raise the pH of the aqueous fluid in the microenvironment of the type II alveolar cell lumenal surface, thereby inducing an increase in the rate of surfactant secretion by type II alveolar cells.
摘要翻译： 描述了治疗患有与通过II型肺泡细胞表面活性剂分泌的抑制相关的肺部病症的患者的症状的方法和组合物。 治疗方法包括使患者吸入一定量的pH升高缓冲液，其有效地提高II型肺泡细胞腔表面的微环境中的水性液体的pH值，从而通过以下方式诱导表面活性剂分泌的速率增加 II型肺泡细胞。
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公开(公告)号：US5663315A
公开(公告)日：1997-09-02
申请号：US350435
申请日：1994-12-06
申请人： George Scheele , Shin-Ichi Fukuoka
发明人： George Scheele , Shin-Ichi Fukuoka
CPC分类号： C07K16/18 , C07K14/47 , C07K14/4733 , G01N33/68
摘要： The invention features a method for diagnosis of pancreatitis by detecting an elevation in the amount of GP2 pancreatic glycoprotein in a sample of bodily fluid such as human blood, serum, or urine. The invention also features isolated DNA encoding human GP2, a method for producing recombinant human GP2, antibodies which specifically bind to human GP2, a method for producing anti-human GP2 antibodies, and a kit for use in the diagnosis of pancreatitis.
摘要翻译： 本发明特征在于通过检测人体血液，血清或尿液等样品中GP2胰腺糖蛋白量的升高来诊断胰腺炎的方法。 本发明还具有编码人GP2的分离的DNA，生产重组人GP2的方法，特异性结合人GP2的抗体，抗人GP2抗体的制备方法和用于诊断胰腺炎的试剂盒。
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公开(公告)号：US20130108731A1
公开(公告)日：2013-05-02
申请号：US13719678
申请日：2012-12-19
申请人： George Scheele
发明人： George Scheele
CPC分类号： A23L1/305 , A23L33/17 , A23L33/175 , A23L33/30 , A61K31/197 , A61K31/198 , A61K31/4172 , A61K31/4192 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to high protein dietary supplements for treating various symptoms and diseases associated with protein deficiency including weight gain, obesity, catabolic diseases, fibromyalgia, anxiety reactions, posttraumatic stress and chronic fatigue syndrome. Embodiments of dietary supplements comprise combinations of proteins, essential and semi-essential amino acids including L-Lysine, L-Arginine, and/or L-Histidine.
摘要翻译： 本公开涉及用于治疗与蛋白质缺乏相关的各种症状和疾病的高蛋白质膳食补充剂，包括体重增加，肥胖症，分解代谢疾病，纤维肌痛，焦虑反应，创伤后应激和慢性疲劳综合征。 膳食补充剂的实施方案包括蛋白质，包括L-赖氨酸，L-精氨酸和/或L-组氨酸的必需和半必需氨基酸的组合。
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8.发明授权Synthesis of full-length, double-stranded DNA from a single-stranded linear DNA template 失效从单条线性DNA模板合成全长，双链DNA
公开(公告)号：US5162209A
公开(公告)日：1992-11-10
申请号：US643438
申请日：1991-01-18
申请人： George Scheele
发明人： George Scheele
CPC分类号： C12N15/1096 , C12Q1/6855
摘要： A method for preparing a ds DNA from a ss DNA template, which method includes:(a) providing a first DNA strand;(b) adding a homopolymeric oligonucleotide tail to the 3' end of the first DNA strand, to yield a tailed first DNA strand;(c) providing a ss homopolymeric oligonucleotide primer complementary to a portion of the tail;(d) contacting the primer with the tailed first DNA strand;(e) synthesizing, in the presence of the primer and the tailed first DNA strand, a second DNA strand complementary to the first DNA strand; and(f) removing the tail and the primer from the first and second DNA strands, respectively; provided that one or both of the tail and the primer contain(s) RNA.
摘要翻译： 一种从ssDNA模板制备ds DNA的方法，该方法包括：（a）提供第一条DNA链; （b）向第一DNA链的3'末端添加均聚寡核苷酸尾，产生尾部的第一DNA链; （c）提供与尾部的一部分互补的ss均聚寡核苷酸引物; （d）将引物与尾部的第一DNA链接触; （e）在引物和尾部的第一DNA链的存在下合成与第一DNA链互补的第二DNA链; 和（f）分别从第一和第二DNA链中除去尾巴和引物; 条件是尾和引物中的一个或两个含有RNA。
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公开(公告)号：US07982066B2
公开(公告)日：2011-07-19
申请号：US12135933
申请日：2008-06-09
申请人： George Scheele
发明人： George Scheele
IPC分类号： C07C205/00 , C07C207/00 , C07C229/00 , A61K38/00 , A61P3/04
CPC分类号： A23L1/305 , A23L33/17 , A23L33/175 , A23L33/30 , A61K31/197 , A61K31/198 , A61K31/4172 , A61K31/4192 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to high protein dietary supplements for treating various symptoms and diseases associated with protein deficiency including weight gain, obesity, catabolic diseases, fibromyalgia, anxiety reactions, posttraumatic stress and chronic fatigue syndrome. Embodiments of dietary supplements comprise combinations of proteins, essential and semi-essential amino acids including L-Lysine, L-Arginine, and/or L-Histidine.
摘要翻译： 本公开涉及用于治疗与蛋白质缺乏相关的各种症状和疾病的高蛋白质膳食补充剂，包括体重增加，肥胖症，分解代谢疾病，纤维肌痛，焦虑反应，创伤后应激和慢性疲劳综合征。 膳食补充剂的实施方案包括蛋白质，包括L-赖氨酸，L-精氨酸和/或L-组氨酸的必需和半必需氨基酸的组合。
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公开(公告)号：US20110245158A1
公开(公告)日：2011-10-06
申请号：US13164536
申请日：2011-06-20
申请人： George Scheele
发明人： George Scheele
IPC分类号： A61K38/00 , A61K31/4172 , A61K8/64 , A61K31/198 , A61K31/405 , A61P1/00 , A61P3/04 , A61P37/00 , A61P43/00 , A61P25/22 , A61Q19/00
CPC分类号： A23L1/305 , A23L33/17 , A23L33/175 , A23L33/30 , A61K31/197 , A61K31/198 , A61K31/4172 , A61K31/4192 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to high protein dietary supplements for treating various symptoms and diseases associated with protein deficiency including weight gain, obesity, catabolic diseases, fibromyalgia, anxiety reactions, posttraumatic stress and chronic fatigue syndrome. Embodiments of dietary supplements comprise combinations of proteins, essential and semi-essential amino acids including L-Lysine, L-Arginine, and/or L-Histidine.
摘要翻译： 本公开涉及用于治疗与蛋白质缺乏相关的各种症状和疾病的高蛋白质膳食补充剂，包括体重增加，肥胖症，分解代谢疾病，纤维肌痛，焦虑反应，创伤后应激和慢性疲劳综合征。 膳食补充剂的实施方案包括蛋白质，包括L-赖氨酸，L-精氨酸和/或L-组氨酸的必需和半必需氨基酸的组合。
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