Magnetic Manipulation of Biological Samples
    1.
    发明申请
    Magnetic Manipulation of Biological Samples 有权
    生物样品的磁操作

    公开(公告)号:US20080038806A1

    公开(公告)日:2008-02-14

    申请号:US10591068

    申请日:2005-02-25

    申请人: Gunter Fuhr

    发明人: Gunter Fuhr

    IPC分类号: C12N13/00 C12M1/00

    CPC分类号: C12M25/16

    摘要: The invention relates to a cell carrier (10) for receiving a biological sample. Said carrier comprises a magnetic element (20) and a floor element (30) that forms a stable support (31) that can be displaced on a solid base surface in at least one direction. The invention also relates to a manipulation device for biological samples and to a method for manipulating biological samples.

    摘要翻译: 本发明涉及用于接收生物样品的细胞载体(10)。 所述载体包括形成可在至少一个方向上在固体基底表面上移位的稳定支撑体(31)的磁性元件(20)和地板元件(30)。 本发明还涉及用于生物样品的操作装置和用于操纵生物样品的方法。

    Low-temperature storage of suspension samples in suspended sample chambers
    3.
    发明申请
    Low-temperature storage of suspension samples in suspended sample chambers 失效
    悬浮样品在悬浮样品室中的低温储存

    公开(公告)号:US20060014134A1

    公开(公告)日:2006-01-19

    申请号:US10532017

    申请日:2003-11-05

    IPC分类号: A01N1/02 F25C1/00

    摘要: A cryostorage device (100) is described that includes at least one data storage device (200) and at least one sample receptacle device (300) with at least one sample chamber (301, 302, etc.) for the uptake of a suspension sample, the at least one sample chamber (301, 302, etc.) being connected to the data storage device (200) and having a elongated, hollow shape that extends from an inlet end (320) over a predetermined length to an outlet end (330) and being attached to the at least one data storage device (200) in a flexible and movably hanging manner.

    摘要翻译: 描述了一种包括至少一个数据存储装置(200)和至少一个具有用于吸收悬浮液样品的至少一个样品室(301,302等)的样品容器装置(300)的冷冻装置(100) ,所述至少一个样品室(301,302等)连接到所述数据存储装置(200)并且具有从入口端(320)延伸超过预定长度的细长的中空形状到出口端( 330)并且以柔性和可移动的悬挂方式附接到所述至少一个数据存储设备(200)。

    Process for manipulating microscopic, dielectric particles and a device
therefor
    4.
    发明授权
    Process for manipulating microscopic, dielectric particles and a device therefor 失效
    用于操作微观电介质颗粒的方法及其装置

    公开(公告)号:US6149789A

    公开(公告)日:2000-11-21

    申请号:US508079

    申请日:1995-07-27

    摘要: Disclosed is a process for manipulating microscopic dielectric particles in which particles are exposed to an electric field. In disadvantaged processes the particles are exposed to inhomogeneous electric field and are polarized by them. The polarized particles are moved in the direction of higher field strength. These processes permit no reversal of the traveling direction of the particles. The particles are enriched at the electrode so that they cannot be retained in free space. In the invented process the particles are exposed to high-frequency field traveling in one or more prescribed direction, by which the particles are subject to a force which sets them in a motion that is strongly synchronous to the field. With the aid of a device for carrying out the invented process, the particles can be manipulated very flexibly. By means of linearly or circularly disposed electrodes, the particles can be moved on linear paths in any direction including through branched microstructures, they can be separated according to their dielectric properties and retained without contact. Applications are in the fields of biotechnology and molecular separation, focussing and microtransport technology.

    摘要翻译: 公开了一种操作微粒介质颗粒的方法,其中颗粒暴露于电场。 在不利的过程中,颗粒暴露于不均匀的电场,并被它们极化。 极化粒子沿高场强的方向移动。 这些处理不允许反转颗粒的行进方向。 颗粒在电极处富集,使得它们不能保留在自由空间中。 在本发明的方法中,颗粒暴露于在一个或多个规定方向上行进的高频场,通过该方法,颗粒受到将其设置成与场强同步的运动的力。 借助于用于实施本发明方法的装置,可以非常灵活地操纵颗粒。 通过线性或圆形设置的电极,颗粒可以在包括通过分支微结构的任何方向上在线性路径上移动,它们可以根据其介电性质分离并保持而不接触。 应用领域包括生物技术和分子分离,聚焦和微传输技术。

    Dielectric micromechanical element
    5.
    发明授权
    Dielectric micromechanical element 失效
    电介质微机械元件

    公开(公告)号:US5572076A

    公开(公告)日:1996-11-05

    申请号:US730914

    申请日:1991-10-21

    CPC分类号: H02N1/004

    摘要: A dielectric micromechanical element the moveable component of which (hereinafter referred to as rotor) is an electrically homogeneous or inhomogeneous dielectric. The rotor is driven via one or more electric field vectors which are generated via electrode arrangements by switched voltages and/or by triggering the electrodes with phase-shifted voltages. On at least one side of the rotor and/or inside the rotor the electrodes form a linear or curved row of electrodes.

    摘要翻译: PCT No.PCT / DE90 / 00069 Sec。 371日期1991年10月21日 102(e)日期1991年10月21日PCT提交1990年2月2日PCT公布。 第WO90 / 09059号公报 日期1990年8月9日介电微机电元件其可动部件(以下称为转子)是电均匀或不均匀的电介质。 转子通过一个或多个通过电极装置通过开关电压产生的电场矢量和/或通过用相移电压触发电极来驱动。 在转子的至少一侧和/或转子内部,电极形成线性或弯曲的电极行。

    Method for the production of a cell composition containing epithelial cells
    6.
    发明授权
    Method for the production of a cell composition containing epithelial cells 有权
    用于生产含有上皮细胞的细胞组合物的方法

    公开(公告)号:US08298822B2

    公开(公告)日:2012-10-30

    申请号:US11547678

    申请日:2005-04-01

    摘要: Disclosed is a method for forming epithelial cells. Said method comprises the steps of aggregating stem cells from differentiated exocrine gland tissue to obtain an organoid body and differentiating at least one portion of the organoid body or a tissue body grown therefrom to obtain epithelial cells. Also disclosed is a cultivation device, particularly for forming differential epithelial cells.

    摘要翻译: 公开了形成上皮细胞的方法。 所述方法包括以下步骤:从分化的外分泌腺组织聚集干细胞以获得有机体,并分化至少一部分有机体或由其生长的组织体以获得上皮细胞。 还公开了一种培养装置,特别是用于形成差异上皮细胞的培养装置。

    Microsystem for the dielectric and optical manipulation of particles
    7.
    发明授权
    Microsystem for the dielectric and optical manipulation of particles 失效
    微系统用于电介质和光学操纵的粒子

    公开(公告)号:US07276207B2

    公开(公告)日:2007-10-02

    申请号:US10432793

    申请日:2001-11-28

    摘要: Described is a fluidic microsystem with at least one compartment for the receiving and/or the through-flow of a liquid and having an electrode arrangement with a multiplicity of electrodes, between which a coaction zone is established, whereby the compartment possesses at least one wall, through which electromagnetic radiation can be linked into the said coaction zone in accord with a predetermined incident direction, and on at least one electrode a cooling apparatus is provided, and on which at least one respective electrode at least one reflector layer is provided, and wherein the respective electrode is at least partially shielded in reference to the incident beam direction, and having at least one heat conducting layer by means of which the respective electrode stands in thermal communication with a wall of the compartment, and/or includes an active cooling element, which is placed in thermal contact with the respective electrode.

    摘要翻译: 描述了一种流体微系统,其具有至少一个用于液体的接收和/或通过流动的隔室,并且具有多个电极的电极装置,在其间建立了一个共同作用区域,从而隔室具有至少一个壁 ,电磁辐射可以根据预定的入射方向连接到所述配位区中,并且在至少一个电极上设置有冷却装置,并且在其上设置至少一个相应的电极至少一个反射器层,以及 其中相应的电极相对于入射光束方向被至少部分地屏蔽,并且具有至少一个导热层,通过该导热层,相应的电极与隔室的壁热连通,和/或包括主动冷却 元件,其被放置成与相应的电极热接触。

    Carrier for a sample chamber, especially for the cryopreservation of biological samples
    10.
    发明申请
    Carrier for a sample chamber, especially for the cryopreservation of biological samples 审中-公开
    用于样品室的载体,特别是用于生物样品的冷冻保存

    公开(公告)号:US20060131196A1

    公开(公告)日:2006-06-22

    申请号:US10532281

    申请日:2003-11-05

    摘要: A carrier (10) for at least one specimen chamber (11), in particular for cryoconservation of biological specimens is described, comprising a mounting frame (20) which is set up for positioning the specimen chamber (11) and has a first frame part (30) and a second frame part (40) which can be detachably assembled with connecting elements (50) and are in contact on the side faces (31, 41) in the assembled state, wherein the specimen chamber (11) can be secured between the side faces (31, 41).

    摘要翻译: 描述了用于至少一个标本室(11)的载体(10),特别是用于生物试样的低温保存,其包括安装框架(20),其安装用于定位试样室(11),并具有第一框架部分 (30)和第二框架部分(40),其可以与连接元件(50)可拆卸地组装并且在组装状态下在侧面(31,41)上接触,其中,样本室(11)可以被固定 在所述侧面(31,41)之间。