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    Cloning sequencing and characterization of two cell death genes and uses therefor
    1.
    发明授权
    Cloning sequencing and characterization of two cell death genes and uses therefor 失效
    克隆两个细胞死亡基因的测序和表征及其用途

    公开(公告)号：US07138510B1

    公开(公告)日：2006-11-21

    申请号：US08984178

    申请日：1997-12-03

    Applicant: H. Robert Horvitz ,  Junying Yuan ,  Shai Shaham

    Inventor： H. Robert Horvitz ,  Junying Yuan ,  Shai Shaham

    IPC: C07H21/02

    CPC classification number: C12N9/6475 ,  A61K38/00 ,  C07K14/43581 ,  C07K14/4747

    Abstract: Described herein are genes shown to be essential for programmed cell death in C. elegans, their encoded products (RNA and polypeptides), antibodies directed against the encoded polypeptides; probes for identifying structurally related genes and bioassays for identifying functionally related cell death genes from various organisms; methods and agents for altering (increasing or decreasing) the activity of the cell death-genes and, thus, of altering cell death; and uses therefor. Specifically, two genes shown to be essential for almost all of the cell deaths which occur in the development of C. elegans, referred to as ced-3 and ced-4, have been cloned, sequenced and characterized.

    Abstract translation: 本文描述的是显示为秀丽隐杆线虫程序性细胞死亡，其编码产物（RNA和多肽），针对编码多肽的抗体所必需的基因; 用于识别结构相关基因的探针和用于鉴定来自各种生物体的功能相关的细胞死亡基因的生物测定; 改变（增加或减少）细胞死亡基因的活性，从而改变细胞死亡的方法和试剂; 并用于此。 具体来说，已经克隆，测序和表征了对秀丽隐杆线虫发生中几乎所有的细胞死亡（被称为ced-3和ced-4）所必需的两个基因。

    Relatedness of human interleukin-1.beta. convertase gene to a C. elegans cell death gene, inhibitory portions of these genes and uses therefor
    3.
    发明授权
    Relatedness of human interleukin-1.beta. convertase gene to a C. elegans cell death gene, inhibitory portions of these genes and uses therefor 失效
    人白细胞介素-1β转化酶基因与线虫细胞死亡基因的相关性，这些基因的抑制部分及其用途

    公开(公告)号：US5962301A

    公开(公告)日：1999-10-05

    申请号：US394189

    申请日：1995-02-24

    Applicant: H. Robert Horvitz ,  Junying Yuan ,  Shai Shaham

    Inventor： H. Robert Horvitz ,  Junying Yuan ,  Shai Shaham

    IPC: A61K38/00 ,  A61K38/55 ,  C07K14/435 ,  C07K14/47 ,  C12N9/64 ,  C12Q1/68 ,  C12N9/50

    CPC classification number: C12N9/641 ,  A61K38/55 ,  C07K14/43581 ,  C07K14/4747 ,  C12N9/6475 ,  C12Q1/6876 ,  C07K2319/00 ,  C12Q2600/156 ,  C12Q2600/158

    Abstract: Described herein is the discovery that human interleukin-1.beta. convertase (ICE) is structurally similar to the protein encoded by the C. elegans cell death gene, ced-3. Comparative and mutational analyses of the two proteins, together with previous observations, suggest that the Ced-3 protein may be a cysteine protease like ICE and that ICE may be a human equivalent of the nematode cell death gene. Another mammalian protein, the murine NEDD-2 protein, was also found to be similar to Ced-3. The NEDD-2 gene is implicated in the development of the murine central nervous system. On the basis of these findings, novel drugs for enhancing or inhibiting the activity of ICE, ced-3, or related genes are provided. Such drugs may be useful for treating inflammatory diseases and/or diseases characterized by cell deaths, as well as cancers, autoimmune disorders, infections, and hair growth and hair loss. Furthermore, such drugs may be useful for controlling pests, parasites and genetically engineered organisms. Furthermore, novel inhibitors of the activity of ced-3, ICE and related genes are described which comprise portions of the genes or their encoded products.

    Abstract translation: 这里描述的发现是人白介素-1β转化酶（ICE）在结构上类似于由线虫类细胞死亡基因ced-3编码的蛋白质。 两种蛋白质的比较和突变分析结合以前的观察结果表明，Ced-3蛋白可能是像ICE这样的半胱氨酸蛋白酶，并且ICE可能是人类等效于线虫细胞死亡基因。 还发现另一种哺乳动物蛋白，鼠类NEDD-2蛋白质与Ced-3相似。 NEDD-2基因涉及鼠中枢神经系统的发展。 在这些发现的基础上，提供了用于增强或抑制ICE，ced-3或相关基因活性的新型药物。 这些药物可用于治疗以细胞死亡为特征的炎性疾病和/或疾病，以及癌症，自身免疫性疾病，感染和毛发生长和脱发。 此外，这些药物可用于控制害虫，寄生虫和遗传工程生物体。 此外，描述了包含部分基因或其编码产物的ced-3，ICE和相关基因的活性的新型抑制剂。

    Tumor suppressor pathway in C. elegans
    5.
    发明授权
    Tumor suppressor pathway in C. elegans 有权
    秀丽隐杆线虫的肿瘤抑制途径

    公开(公告)号：US07670778B2

    公开(公告)日：2010-03-02

    申请号：US11973006

    申请日：2007-10-04

    Applicant: H. Robert Horvitz ,  Ewa M. Davison ,  Xiaowei Lu

    Inventor： H. Robert Horvitz ,  Ewa M. Davison ,  Xiaowei Lu

    IPC: C12Q1/68

    CPC classification number: C07K14/43545 ,  A61K38/00

    Abstract: The invention provides novel lin-8, lin-56, and lin-61 genes and polypeptides involved in cell fate determination and in cell proliferation. In addition, the invention includes mutants of these three genes, as well as methods for utilizing these genes, and their encoded polypeptides, in diagnosing and treating abnormal cell proliferation.

    Abstract translation: 本发明提供了涉及细胞命运测定和细胞增殖的新颖的lin-8，lin-56和lin-61基因和多肽。 此外，本发明包括这三种基因的突变体，以及利用这些基因及其编码的多肽来诊断和治疗异常细胞增殖的方法。

    Tumor suppressor pathway in C. elegans
    7.
    发明申请
    Tumor suppressor pathway in C. elegans 有权
    秀丽隐杆线虫的肿瘤抑制途径

    公开(公告)号：US20080213777A1

    公开(公告)日：2008-09-04

    申请号：US11973006

    申请日：2007-10-04

    Applicant: H. Robert Horvitz ,  Ewa M. Davison ,  Xiaowei Lu

    Inventor： H. Robert Horvitz ,  Ewa M. Davison ,  Xiaowei Lu

    IPC: C12Q1/68

    CPC classification number: C07K14/43545 ,  A61K38/00

    Abstract: The invention provides novel lin-8, lin-56, and lin-61 genes and polypeptides involved in cell fate determination and in cell proliferation. In addition, the invention includes mutants of these three genes, as well as methods for utilizing these genes, and their encoded polypeptides, in diagnosing and treating abnormal cell proliferation.

    Abstract translation: 本发明提供了涉及细胞命运测定和细胞增殖的新颖的lin-8，lin-56和lin-61基因和多肽。 此外，本发明包括这三种基因的突变体，以及利用这些基因及其编码的多肽来诊断和治疗异常细胞增殖的方法。

    Altered human interleukin-1β convertase (ICE), NEDD-2, and C. elegans ced-3 polypeptides and uses therefor
    9.
    发明授权
    Altered human interleukin-1β convertase (ICE), NEDD-2, and C. elegans ced-3 polypeptides and uses therefor 失效
    改变人白细胞介素-1β转换酶（ICE），NEDD-2和秀丽隐杆线虫ced-3多肽，并用于其

    公开(公告)号：US06939850B2

    公开(公告)日：2005-09-06

    申请号：US09888243

    申请日：2001-06-22

    Applicant: H. Robert Horvitz ,  Junying Yuan ,  Shai Shaham

    Inventor： H. Robert Horvitz ,  Junying Yuan ,  Shai Shaham

    IPC: A61K38/00 ,  A61K38/55 ,  C07K14/435 ,  C07K14/47 ,  C12N9/64 ,  C12Q1/68 ,  A61K38/43

    CPC classification number: C12N9/641 ,  A61K38/00 ,  C07K14/43581 ,  C07K14/4747 ,  C07K2319/00 ,  C12N9/6475 ,  C12Q1/6876 ,  C12Q2600/156 ,  C12Y304/22036 ,  C12Y304/22055

    Abstract: Described herein is the discovery that human interleukin-1β convertase (ICE) is structurally similar to the protein encoded by the C. elegans cell death gene, ced-3. Comparative and mutational analyses of the two proteins, together with previous observations, suggest that the Ced-3 protein may be a cysteine protease like ICE and that ICE may be a human equivalent of the nematode cell death gene. Another mammalian protein, the murine NEDD-2 protein, was also found to be similar to Ced-3. The NEDD-2 gene is implicated in the development of the murine central nervous system. On the basis of these findings, novel drugs for enhancing or inhibiting the activity of ICE, ced-3, or related genes are provided. Such drugs may be useful for treating inflammatory diseases and/or diseases characterized by cell deaths, as well as cancers, autoimmune disorders, infections, and hair growth and hair loss. Furthermore, such drugs may be useful for controlling pests, parasites and genetically engineered organisms. Furthermore, novel inhibitors of the activity of ced-3, ICE and related genes are described which comprise portions of the genes or their encoded products.

    Abstract translation: 本文描述了人白细胞介素-1β转化酶（ICE）在结构上类似于由线虫类细胞死亡基因ced-3编码的蛋白质的发现。 两种蛋白质的比较和突变分析结合以前的观察结果表明，Ced-3蛋白可能是像ICE这样的半胱氨酸蛋白酶，并且ICE可能是人类等效于线虫细胞死亡基因。 还发现另一种哺乳动物蛋白，鼠类NEDD-2蛋白质与Ced-3相似。 NEDD-2基因涉及鼠中枢神经系统的发展。 在这些发现的基础上，提供了用于增强或抑制ICE，ced-3或相关基因活性的新型药物。 这些药物可用于治疗以细胞死亡为特征的炎性疾病和/或疾病，以及癌症，自身免疫性疾病，感染和毛发生长和脱发。 此外，这些药物可用于控制害虫，寄生虫和遗传工程生物体。 此外，描述了包含部分基因或其编码产物的ced-3，ICE和相关基因的活性的新型抑制剂。

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