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公开(公告)号：US20130062515A1
公开(公告)日：2013-03-14
申请号：US13229296
申请日：2011-09-09
IPC分类号： H01J49/26
CPC分类号： H01J49/0027 , G01N30/7206 , G01N30/7213 , G01N30/78 , G01N2030/8435 , H01J49/0422
摘要： In a mass spectrometer or gas chromatograph/mass spectrometer system, a conditioning gas such as, for example, hydrogen is added to condition or clean one or more components or regions of the mass spectrometer such as the ion source. The conditioning gas may be added upstream of the mass spectrometer such as, for example, into a sample inlet or a chromatographic column, or may be added directly into the mass spectrometer. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample, or on-line during sample analysis. When added on-line, the conditioning gas may be mixed with a carrier gas such as, for example, helium. In another embodiment, the conditioning gas also serves as the carrier gas through the column; another gas such as, for example, helium may be added to the carrier gas stream.
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2.发明授权Photoactivated collision induced dissociation (PACID) (apparatus and method) 有权光活化碰撞诱导解离（PACID）（仪器和方法）公开(公告)号：US07816644B2
公开(公告)日：2010-10-19
申请号：US11506933
申请日：2006-08-18
IPC分类号： H01J49/26
CPC分类号： H01J49/0059 , G01N33/6848 , G01N33/6851 , H01J49/0068
摘要： The invention provides a system apparatus and methods for fragmenting various molecules. In particular, the invention may be employed for fragmenting biomolecules like peptides to determine sequence information. The invention provides a mass spectrometry system for photo-activated collision induced dissociation. The mass spectrometry system or device includes an ion source for producing ions, a photon source adjacent to the ion source for photo-activating ions produced by the ion source, an electrical element adjacent to the photon source for creating an electric field for accelerating ions produced by the ion source and photo-activated by the photon source; wherein ions are produced by the ion source, photo-activated by the photon source and accelerated into a surface to cause dissociation of the activated ions; and a detector downstream from the ion source for detecting the collision induced and dissociated ions.
摘要翻译： 本发明提供了一种分散各种分子的系统装置和方法。 特别地，本发明可用于片段生物分子如肽以确定序列信息。 本发明提供了一种用于光激活碰撞诱导解离的质谱系统。 质谱系统或装置包括用于产生离子的离子源，邻近于离子源的光子源，用于由离子源产生的光激活离子;邻近光子源的电元件，用于产生用于加速产生的离子的电场 由离子源和光子源激活; 其中离子由离子源产生，由光子源光激活并加速到表面以引起活化离子的解离; 以及用于检测碰撞诱导和离解离子的离子源下游的检测器。
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公开(公告)号：US20090206293A1
公开(公告)日：2009-08-20
申请号：US12032419
申请日：2008-02-15
申请人： Timothy Beerling , Harry F. Prest
发明人： Timothy Beerling , Harry F. Prest
IPC分类号： F16K7/12
CPC分类号： F16K99/0001 , F16K99/0026 , F16K99/0059 , G05D7/0694
摘要： An apparatus and method for controlling the flow of fluid though a channel. A first substrate defines features comprising a first channel. At least a portion of the first channel is bounded a deformable material having a first contour in which the first channel has a first cross-sectional area and a second contour in which the first channel has a second cross-sectional area.
摘要翻译： 用于控制通过通道的流体流动的装置和方法。 第一衬底限定包括第一通道的特征。 第一通道的至少一部分被界定为具有第一轮廓的可变形材料，其中第一通道具有第一横截面积和第二轮廓，其中第一通道具有第二横截面积。
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4.发明申请APPARATUSES, METHODS AND COMPOSITIONS FOR IONIZATION OF SAMPLES AND MASS CALIBRANTS 有权用于离子化和大量校准的装置，方法和组合物公开(公告)号：US20080067336A1
公开(公告)日：2008-03-20
申请号：US11757369
申请日：2007-06-02
CPC分类号： H01J49/168 , H01J49/0009
摘要： The present invention provides, inter alia, apparatuses and methods for ionizing samples that are in gaseous phase or can be vaporized/sublimated. The samples include samples to be analyzed and mass calibrants that serve as standards. In addition, the present invention also provides calibrant formulations that release mass calibrants in a slow, controlled manner.
摘要翻译： 本发明尤其提供了用于电离处于气相或可蒸发/升华的样品的装置和方法。 样品包括要分析的样品和用作标准品的质量标准。 此外，本发明还提供了以缓慢且受控的方式释放大量校准物的校准剂制剂。
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5.发明授权Apparatuses, methods and compositions for ionization of samples and mass calibrants 有权用于电离样品和质量卡尺的装置，方法和组合物公开(公告)号：US07737395B2
公开(公告)日：2010-06-15
申请号：US11757369
申请日：2007-06-02
IPC分类号： B01D59/44
CPC分类号： H01J49/168 , H01J49/0009
摘要： The present invention provides, inter alia, apparatuses and methods for ionizing samples that are in gaseous phase or can be vaporized/sublimated. The samples include samples to be analyzed and mass calibrants that serve as standards. In addition, the present invention also provides calibrant formulations that release mass calibrants in a slow, controlled manner.
摘要翻译： 本发明尤其提供了用于电离处于气相或可蒸发/升华的样品的装置和方法。 样品包括要分析的样品和用作标准品的质量标准。 此外，本发明还提供了以缓慢且受控的方式释放大量校准物的校准剂制剂。
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公开(公告)号：US20080083874A1
公开(公告)日：2008-04-10
申请号：US11546197
申请日：2006-10-10
IPC分类号： H01J49/04
CPC分类号： H01J49/10 , H01J49/0031
摘要： A system includes a vacuum manifold for a mass spectrometer. The vacuum manifold defines an orifice. A vacuum valve is joined to the manifold at the orifice. A load-lock adapter is joined to the vacuum valve. A transfer line may be introduced to the mass spectrometer and withdrawn therefrom via the vacuum valve and load-lock adapter without substantially disturbing the operating environment of the mass spectrometer.
摘要翻译： 系统包括用于质谱仪的真空歧管。 真空歧管限定孔。 真空阀在孔口处连接到歧管。 加载锁定适配器连接到真空阀。 传输线可以被引入质谱仪，并通过真空阀和加载锁定适配器从中抽出，而基本上不干扰质谱仪的操作环境。
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公开(公告)号：US20080142701A1
公开(公告)日：2008-06-19
申请号：US11551806
申请日：2006-10-23
申请人： Harry F. Prest
发明人： Harry F. Prest
IPC分类号： H01J49/00
CPC分类号： H01J49/10 , G01N30/7206
摘要： The invention provides a GC mass spectrometry system, including a column for introducing a sample into the GC mass spectrometry system, a heating source for providing heat to the sample to be separated by the column, an ion source downstream from the heating source for ionizing the sample separated by the column, the ion source having a sensor for determining the temperature of the ion source, an interface coupled to the ion source sensor and the heating source wherein the interface provides a feedback loop between the ion source sensor and the heating source and the temperature of the ion source or the heating source can be tracked and altered during data acquisition.The invention also provides an apparatus for GC mass spectrometry, including a heating source for providing heat to a column for volatizing molecules to be separated by the column; an ion source downstream from the heating source for ionizing the sample separated by the column, the ion source having a sensor for determining the temperature of the ion source; and an interface for coupling the ion source sensor to the heating source wherein the interface provides a feedback loop between the sensor of the ion source and the heating source and the temperature of the ion source and the heating source can be altered during data acquisition.Methods of heating and volatilizing samples using the GC mass spectrometry system and apparatus are also disclosed.
摘要翻译： 本发明提供了一种GC质谱系统，其包括用于将样品引入GC质谱系统的塔，用于向待分离柱的样品提供热量的加热源，加热源下游的离子源，用于离子化 样品由柱分离，离子源具有用于确定离子源的温度的传感器，耦合到离子源传感器和加热源的界面，其中界面在离子源传感器和加热源之间提供反馈回路，以及 在数据采集期间可以跟踪和改变离子源或加热源的温度。 本发明还提供了一种用于气相色谱质谱的装置，其包括用于向柱提供热量的加热源，用于挥发待被柱分离的分子; 离子源，其从所述加热源的下游离子化由所述柱分离的样品，所述离子源具有用于确定所述离子源的温度的传感器; 以及用于将离子源传感器耦合到加热源的接口，其中界面在离子源的传感器和加热源之间提供反馈回路，并且可以在数据采集期间改变离子源和加热源的温度。 还公开了使用GC质谱系统和装置加热和挥发样品的方法。
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公开(公告)号：US20080067356A1
公开(公告)日：2008-03-20
申请号：US11523963
申请日：2006-09-20
IPC分类号： H01J49/04
CPC分类号： H01J49/02 , H01J49/0009
摘要： An apparatus for ionizing an analyte sample with a mass calibrant is provided. The apparatus includes an ionization chamber defining an ionization region, a first passageway coupled to the ionization region for delivering the analyte sample to the ionization region, a second passageway leading to a mass analyzer having an orifice arranged adjacent to the ionization region to receive ions from the ionization region, a third passageway coupled to the ionization chamber at a first end and having a second end with an orifice arranged to receive gaseous neutral mass calibrant molecules, and an ionization device arranged within the ionization chamber. The ionization device generates primary ions from the analyte sample, and the primary ions ionize a portion of the gaseous neutral mass calibrant molecules received into the ionization region via the third passageway.
摘要翻译： 提供了一种用质量校准物离子化分析物样品的装置。 该装置包括限定电离区域的电离室，耦合到离子化区域的用于将分析物样品输送到电离区域的第一通道，通向质量分析器的第二通道，该质量分析器具有邻近离子化区域布置的孔口， 电离区域，第三通道，其在第一端处耦合到电离室，并且具有布置成接收气态中性质量校准物分子的孔的第二端，以及布置在电离室内的电离装置。 离子化装置从分析物样品产生初级离子，并且初级离子通过第三通道将接收到电离区的气态中性质量校准物分子的一部分电离。
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9.发明申请Photoactivated collision induced dissociation (PACID) (apparatus and method) 有权光活化碰撞诱导解离（PACID）（仪器和方法）公开(公告)号：US20080042056A1
公开(公告)日：2008-02-21
申请号：US11506933
申请日：2006-08-18
申请人： Steven M. Fischer , Harry F. Prest , Robert Lee
发明人： Steven M. Fischer , Harry F. Prest , Robert Lee
IPC分类号： H01J49/10
CPC分类号： H01J49/0059 , G01N33/6848 , G01N33/6851 , H01J49/0068
摘要： The invention provides a system apparatus and methods for fragmenting various molecules. In particular, the invention may be employed for fragmenting biomolecules like peptides to determine sequence information. The invention provides a mass spectrometry system for photo-activated collision induced dissociation. The mass spectrometry system or device includes an ion source for producing ions, a photon source adjacent to the ion source for photo-activating ions produced by the ion source, an electrical element adjacent to the photon source for creating an electric field for accelerating ions produced by the ion source and photo-activated by the photon source; wherein ions are produced by the ion source, photo-activated by the photon source and accelerated into a surface to cause dissociation of the activated ions; and a detector downstream from the ion source for detecting the collision induced and dissociated ions.Methods for molecule and/or peptide fragmentation are also disclosed.
摘要翻译： 本发明提供了一种分散各种分子的系统装置和方法。 特别地，本发明可用于片段生物分子如肽以确定序列信息。 本发明提供了一种用于光激活碰撞诱导解离的质谱系统。 质谱系统或装置包括用于产生离子的离子源，邻近于离子源的光子源，用于由离子源产生的光激活离子;邻近光子源的电元件，用于产生用于加速产生的离子的电场 由离子源和光子源激活; 其中离子由离子源产生，由光子源光激活并加速到表面以引起活化离子的解离; 以及用于检测碰撞诱导和离解离子的离子源下游的检测器。 还公开了分子和/或肽断裂的方法。
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公开(公告)号：US06484560B1
公开(公告)日：2002-11-26
申请号：US09708794
申请日：2000-11-07
申请人： Harry F. Prest
发明人： Harry F. Prest
IPC分类号： G01N100
CPC分类号： G01N30/12 , G01N1/40 , G01N30/18 , G01N2001/4027 , G01N2030/127
摘要： An apparatus and method for selectively concentrating an analyte on an apparatus by evaporating solvent from the analyte. Concentration is performed by heating or by flowing a gas stream over the analyte to evaporate solvent from the analyte. The invention also provides a method to be used in conjunction with the apparatus.
摘要翻译： 通过从分析物蒸发溶剂来选择性地将分析物浓缩在装置上的装置和方法。 通过加热或使气流在分析物上流动从蒸馏分析物中蒸发溶剂来进行浓缩。 本发明还提供了一种与该装置结合使用的方法。
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