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    Ionization of neutral gas-phase molecules and mass calibrants
    3.
    发明申请
    Ionization of neutral gas-phase molecules and mass calibrants 审中-公开
    中性气相分子和质量卡尺的电离

    公开(公告)号：US20080067356A1

    公开(公告)日：2008-03-20

    申请号：US11523963

    申请日：2006-09-20

    申请人： Paul C. Goodley ,  Harry F. Prest ,  Christine A. Miller

    发明人： Paul C. Goodley ,  Harry F. Prest ,  Christine A. Miller

    IPC分类号： H01J49/04

    CPC分类号： H01J49/02 ,  H01J49/0009

    摘要： An apparatus for ionizing an analyte sample with a mass calibrant is provided. The apparatus includes an ionization chamber defining an ionization region, a first passageway coupled to the ionization region for delivering the analyte sample to the ionization region, a second passageway leading to a mass analyzer having an orifice arranged adjacent to the ionization region to receive ions from the ionization region, a third passageway coupled to the ionization chamber at a first end and having a second end with an orifice arranged to receive gaseous neutral mass calibrant molecules, and an ionization device arranged within the ionization chamber. The ionization device generates primary ions from the analyte sample, and the primary ions ionize a portion of the gaseous neutral mass calibrant molecules received into the ionization region via the third passageway.

    摘要翻译： 提供了一种用质量校准物离子化分析物样品的装置。 该装置包括限定电离区域的电离室，耦合到离子化区域的用于将分析物样品输送到电离区域的第一通道，通向质量分析器的第二通道，该质量分析器具有邻近离子化区域布置的孔口， 电离区域，第三通道，其在第一端处耦合到电离室，并且具有布置成接收气态中性质量校准物分子的孔的第二端，以及布置在电离室内的电离装置。 离子化装置从分析物样品产生初级离子，并且初级离子通过第三通道将接收到电离区的气态中性质量校准物分子的一部分电离。

    Vacuum interface for mass spectrometer
    5.
    发明申请
    Vacuum interface for mass spectrometer 审中-公开
    真空接口用于质谱仪

    公开(公告)号：US20080083874A1

    公开(公告)日：2008-04-10

    申请号：US11546197

    申请日：2006-10-10

    申请人： Harry F. Prest ,  James D. Foote ,  Jeffrey T. Kernan

    发明人： Harry F. Prest ,  James D. Foote ,  Jeffrey T. Kernan

    IPC分类号： H01J49/04

    CPC分类号： H01J49/10 ,  H01J49/0031

    摘要： A system includes a vacuum manifold for a mass spectrometer. The vacuum manifold defines an orifice. A vacuum valve is joined to the manifold at the orifice. A load-lock adapter is joined to the vacuum valve. A transfer line may be introduced to the mass spectrometer and withdrawn therefrom via the vacuum valve and load-lock adapter without substantially disturbing the operating environment of the mass spectrometer.

    摘要翻译： 系统包括用于质谱仪的真空歧管。 真空歧管限定孔。 真空阀在孔口处连接到歧管。 加载锁定适配器连接到真空阀。 传输线可以被引入质谱仪，并通过真空阀和加载锁定适配器从中抽出，而基本上不干扰质谱仪的操作环境。

    Photoactivated collision induced dissociation (PACID) (apparatus and method)
    6.
    发明授权
    Photoactivated collision induced dissociation (PACID) (apparatus and method) 有权
    光活化碰撞诱导解离（PACID）（仪器和方法）

    公开(公告)号：US07816644B2

    公开(公告)日：2010-10-19

    申请号：US11506933

    申请日：2006-08-18

    申请人： Steven M. Fischer ,  Harry F. Prest ,  Robert Lee, Jr.

    发明人： Steven M. Fischer ,  Harry F. Prest ,  Robert Lee, Jr.

    IPC分类号： H01J49/26

    CPC分类号： H01J49/0059 ,  G01N33/6848 ,  G01N33/6851 ,  H01J49/0068

    摘要： The invention provides a system apparatus and methods for fragmenting various molecules. In particular, the invention may be employed for fragmenting biomolecules like peptides to determine sequence information. The invention provides a mass spectrometry system for photo-activated collision induced dissociation. The mass spectrometry system or device includes an ion source for producing ions, a photon source adjacent to the ion source for photo-activating ions produced by the ion source, an electrical element adjacent to the photon source for creating an electric field for accelerating ions produced by the ion source and photo-activated by the photon source; wherein ions are produced by the ion source, photo-activated by the photon source and accelerated into a surface to cause dissociation of the activated ions; and a detector downstream from the ion source for detecting the collision induced and dissociated ions.

    摘要翻译： 本发明提供了一种分散各种分子的系统装置和方法。 特别地，本发明可用于片段生物分子如肽以确定序列信息。 本发明提供了一种用于光激活碰撞诱导解离的质谱系统。 质谱系统或装置包括用于产生离子的离子源，邻近于离子源的光子源，用于由离子源产生的光激活离子;邻近光子源的电元件，用于产生用于加速产生的离子的电场 由离子源和光子源激活; 其中离子由离子源产生，由光子源光激活并加速到表面以引起活化离子的解离; 以及用于检测碰撞诱导和离解离子的离子源下游的检测器。

    Flow Controller with Channel Having Deformable Wall
    7.
    发明申请
    Flow Controller with Channel Having Deformable Wall 审中-公开
    具有可变形壁的通道的流量控制器

    公开(公告)号：US20090206293A1

    公开(公告)日：2009-08-20

    申请号：US12032419

    申请日：2008-02-15

    申请人： Timothy Beerling ,  Harry F. Prest

    发明人： Timothy Beerling ,  Harry F. Prest

    IPC分类号： F16K7/12

    CPC分类号： F16K99/0001 ,  F16K99/0026 ,  F16K99/0059 ,  G05D7/0694

    摘要： An apparatus and method for controlling the flow of fluid though a channel. A first substrate defines features comprising a first channel. At least a portion of the first channel is bounded a deformable material having a first contour in which the first channel has a first cross-sectional area and a second contour in which the first channel has a second cross-sectional area.

    摘要翻译： 用于控制通过通道的流体流动的装置和方法。 第一衬底限定包括第一通道的特征。 第一通道的至少一部分被界定为具有第一轮廓的可变形材料，其中第一通道具有第一横截面积和第二轮廓，其中第一通道具有第二横截面积。

    In-situ conditioning in mass spectrometer systems
    9.
    发明授权
    In-situ conditioning in mass spectrometer systems 有权
    在质谱仪系统中进行原位调理

    公开(公告)号：US08378293B1

    公开(公告)日：2013-02-19

    申请号：US13229296

    申请日：2011-09-09

    申请人： Bruce D. Quimby ,  Harry F. Prest ,  Michael J. Szelewski ,  Michael K. Freed

    发明人： Bruce D. Quimby ,  Harry F. Prest ,  Michael J. Szelewski ,  Michael K. Freed

    IPC分类号： B01D59/44 ,  H01J49/00

    CPC分类号： H01J49/0027 ,  G01N30/7206 ,  G01N30/7213 ,  G01N30/78 ,  G01N2030/8435 ,  H01J49/0422

    摘要： In a mass spectrometer or gas chromatograph/mass spectrometer system, a conditioning gas such as, for example, hydrogen is added to condition or clean one or more components or regions of the mass spectrometer such as the ion source. The conditioning gas may be added upstream of the mass spectrometer such as, for example, into a sample inlet or a chromatographic column, or may be added directly into the mass spectrometer. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample, or on-line during sample analysis. When added on-line, the conditioning gas may be mixed with a carrier gas such as, for example, helium. In another embodiment, the conditioning gas also serves as the carrier gas through the column; another gas such as, for example, helium may be added to the carrier gas stream.

    摘要翻译： 在质谱仪或气相色谱/质谱仪系统中，加入例如氢气的调节气体以调节或清洁质谱仪的一个或多个组分或区域，例如离子源。 调理气体可以在质谱仪的上游添加，例如进入样品入口或色谱柱，或者可以直接加入到质谱仪中。 当质谱仪不分析样品或在样品分析过程中在线时，调节气体可以离线添加。 当在线添加时，调理气体可以与载气例如氦混合。 在另一个实施方案中，调节气体还用作通过塔的载气; 可以将另外的气体，例如氦气加入载气流中。

    Dynamic adjustment of ion monitoring periods
    10.
    发明授权
    Dynamic adjustment of ion monitoring periods 有权
    离子监测时段的动态调整

    公开(公告)号：US07482580B2

    公开(公告)日：2009-01-27

    申请号：US11375184

    申请日：2006-03-14

    申请人： Harry F. Prest ,  James D. Foote

    发明人： Harry F. Prest ,  James D. Foote

    IPC分类号： B01D59/44

    CPC分类号： H01J49/025

    摘要： Methods, systems and computer readable media for dynamically controlling a time period of ion detection by an ion detector of a mass spectrometer. A current resulting from conversion of an output of the detector is surveyed during the ion detection by the detector. The time period for the ion detection is terminated upon calculation of a statistically valid accumulation statistic, calculation indicating that satisfactory statistics cannot be achieved over the time period, relative to a predetermined statistical threshold, or elapsing of the entire time period having been preset.

    摘要翻译： 用于通过质谱仪的离子检测器动态地控制离子检测的时间段的方法，系统和计算机可读介质。 在检测器的离子检测期间测量由检测器的输出转换产生的电流。 离子检测的时间段在计算统计学有效的累计统计量时终止，计算表明相对于预定的统计阈值在整个时间段内不能实现令人满意的统计，或者已经预设了整个时间段的经过。