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    Modified oligodeoxyribonucleoditides
    3.
    发明授权
    Modified oligodeoxyribonucleoditides 失效
    改良的寡脱氧核糖核苷酸

    公开(公告)号：US5674856A

    公开(公告)日：1997-10-07

    申请号：US393510

    申请日：1995-02-23

    申请人： Hidehiko Furukawa ,  Kenji Momota ,  Hitoshi Hotoda ,  Makoto Koizumi ,  Masakatsu Kaneko

    发明人： Hidehiko Furukawa ,  Kenji Momota ,  Hitoshi Hotoda ,  Makoto Koizumi ,  Masakatsu Kaneko

    IPC分类号： C07H21/02 ,  A61K31/695 ,  A61K31/70 ,  A61K31/711 ,  A61P31/12 ,  C07C317/00 ,  C07C317/50 ,  C07C323/00 ,  C07C323/52 ,  C07H21/00 ,  C07H21/04 ,  C08B37/00 ,  C08F12/00 ,  C08F20/00 ,  C08G65/00 ,  A61K48/00

    CPC分类号： C07H21/00 ,  C07H21/04

    摘要： Compounds for the treatment or prophylaxis of a viral infection in a mammal, which may be human, are provided. The compounds are oligodeoxyribonucleic acid derivatives, and a novel route to such compounds is also provided together with intermediates of more general utility. The active compounds are of the general formula (1): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms, alkyl groups, aryl groups as defined, and anthraquinonyl groups as defined; Z is carbon or silicon; or R.sub.2, R.sub.3 and Z together represent fluorenyl or xanthenyl; R.sub.4 is a hydrogen atom, an alkyl group as defined, an aryl group as defined; Y.sub.1, Y.sub.3 and Y.sub.4 are oxygen, sulfur or >NH; Y.sub.2 is oxygen, sulfur, >NH, alkylene or phenylene; X is alkylene group as defined; m and n are 0 to 10; and B is an oligodeoxyribonucleotide of chain length 3 to 9; or salts thereof.

    摘要翻译： 提供了用于治疗或预防可能是人的哺乳动物的病毒感染的化合物。 这些化合物是寡脱氧核糖核酸衍生物，并且与这些化合物的新途径也与更一般效用的中间体一起提供。 活性化合物具有通式（1）：其中R 1，R 2和R 3是氢原子，烷基，如所定义的芳基和如所定义的蒽醌基; Z是碳或硅; 或R 2，R 3和Z一起表示芴基或呫吨; R4是氢原子，如所定义的烷基，如所定义的芳基; Y1，Y3和Y4是氧，硫或> NH; Y2是氧，硫，> NH，亚烷基或亚苯基; X是如所定义的亚烷基; m和n为0〜10; B为链长3〜9的寡脱氧核糖核苷酸; 或其盐。