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公开(公告)号：US08623294B2
公开(公告)日：2014-01-07
申请号：US12920256
申请日：2009-03-18
IPC分类号： G01N15/06
CPC分类号： B01L3/502738 , B01L3/50273 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , G01N35/1095 , G01N2035/00158 , G01N2035/1034 , Y10T137/8593 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A channel control mechanism for a microchip has a laminated structure formed of members including elastic members, and includes: a sample reservoir for packing a sample therein; a reaction reservoir in which mixture and reaction of the sample are performed; and a channel formed in a middle layer of the laminated structure, for bringing the sample reservoir and the reaction reservoir into communication with each other. The channel control mechanism performs the reaction and analysis in such a manner that the sample is delivered into the reaction reservoir through the channel. A shutter channel (pressurizing channel) is provided in a layer different from a layer in which the channel is formed so that the pressurizing channel partially overlaps the channel. The channel is closed through applying a pressurized medium to the shutter channel (pressurizing channel), and the channel is opened through releasing a pressure of the pressurized medium.
摘要翻译： 用于微芯片的通道控制机构具有由包括弹性构件的构件形成的层压结构，并且包括：用于在其中包装样品的样品容器; 反应容器，其中进行混合物和样品的反应; 以及形成在层叠结构的中间层中的通道，用于使样本储存器和反应容器彼此连通。 通道控制机构以通过通道将样品输送到反应容器中的方式进行反应和分析。 快门通道（加压通道）设置在与形成通道的层不同的层中，使得加压通道与通道部分重叠。 通过将加压介质施加到闸门通道（加压通道）来关闭通道，并且通过释放加压介质的压力来打开通道。
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公开(公告)号：US08591417B2
公开(公告)日：2013-11-26
申请号：US10556880
申请日：2004-05-19
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B5/02007 , A61B5/021 , A61B5/0456 , A61B5/489 , A61B5/7239 , A61B8/0883 , A61B8/0891 , A61B8/14 , A61B8/463 , A61B8/485 , A61B8/488 , A61B8/543 , G01S7/52071 , G01S7/52074 , G01S7/52087
摘要： There are provided a transmission unit (102) and a reception unit (103) for transmitting and receiving an ultrasonic wave with respect to a subject, a tissue tracing unit (115) for analyzing a received signal to trace the movement of a tissue of the subject, and a property detection unit (120) for detecting a property concerning the movement of the tissue of the subject. The property detection unit (120) subjects either one of the received signal, a Doppler shift, and the movement of the tissue of the subject to signal processing, detects a property concerning the movement of the tissue of the subject that is in synchronization with a heartbeat, and generates an initializing pulse based on the detected property. The tissue tracing unit (115) is initialized by the initializing pulse. It is possible to obtain a distribution image of an elastic modulus of the tissue of the subject as well as a tomographic image of the subject with a simple operation of only applying a probe to the subject without the necessity for a special connection between the subject and the device.
摘要翻译： 提供了一种发送单元（102）和用于相对于被摄体发送和接收超声波的接收单元（103），用于分析接收信号的组织跟踪单元（115），以跟踪所述组织的移动 对象和属性检测单元（120），用于检测与被检体的组织移动有关的属性。 属性检测单元（120）使接收到的信号，多普勒频移中的任何一个和对象的组织的移动信号处理，检测与主体的组织的移动相关的属性，该属性与 心跳，并且基于检测到的属性生成初始化脉冲。 组织跟踪单元（115）由初始化脉冲初始化。 可以通过简单的操作来获得被检体的组织的弹性模量的分布图像，而不需要在被检体和被检体之间进行特殊的连接。 装置。
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公开(公告)号：US20130273487A1
公开(公告)日：2013-10-17
申请号：US13996949
申请日：2011-12-19
申请人： Minoru Asogawa , Hisashi Hagiwara
发明人： Minoru Asogawa , Hisashi Hagiwara
IPC分类号： F24H9/20
CPC分类号： F24H9/20 , B01L3/5027 , B01L3/52 , B01L7/52 , B01L2200/0684 , B01L2200/142 , B01L2300/0816 , B01L2300/14 , B01L2300/18 , B01L2300/1805 , B01L2300/1822 , B01L2400/0481 , G01N2035/00356
摘要： In a sample heating method which uses a microchip, using the microchip which includes a vessel portion (70e) in which at least a portion is configured of an elastic member and a flow channel (61b) which leads a liquid sample to the vessel portion (70e), after a liquid sample is put in the vessel portion (70e), the liquid sample is heated while pressure is applied with respect to an inner portion of the vessel portion (70e).
摘要翻译： 在使用微芯片的样品加热方法中，使用包括容器部分（70e）的微芯片，其中至少一部分由弹性构件构成，而流路（61b）将液体样品引导到容器部分（61b） 70e），在液体样品放入容器部分（70e）中之后，相对于容器部分（70e）的内部施加压力，加热液体样品。
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公开(公告)号：US20120230888A1
公开(公告)日：2012-09-13
申请号：US13477303
申请日：2012-05-22
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/50273 , B01L3/505 , B01L7/52 , B01L2200/0689 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/1822 , B01L2300/1827 , B01L2400/0481 , B01L2400/0655 , G01N2035/00158 , G01N2035/00346
摘要： For heating or cooling a sample contained in a vessel portion through a heat transfer member held in contact with the vessel portion, there is used the vessel portion, which has a part formed of an elastic member, expands and contracts for injection and discharge of the sample, is closed other than a connecting port with a channel connected to the vessel, and expands and contracts for injection and discharge of the sample. The vessel portion expands correspondingly to the injection when the sample is injected through an inflow path serving as the channel into the vessel portion contracting in a non-contacting state with the heat transfer member. A predetermined amount of sample is injected into the vessel portion so as to expand the vessel portion, and the vessel portion comes into contact with the heat transfer member. The vessel portion is heated or cooled through the heat transfer member.
摘要翻译： 为了通过与容器部分保持接触的传热构件来加热或冷却包含在容器部分中的样品，使用具有由弹性构件形成的部分的容器部分，其膨胀和收缩用于注射和排出 样品，除了具有连接到容器的通道的连接端口之外，并且扩展并收缩样品的注入和排出。 当样品通过用作通道的流入路径注入到与传热构件非接触状态收缩的容器部分中时，容器部分对应于注射膨胀。 将预定量的样品注入到容器部分中以使容器部分膨胀，并且容器部分与传热构件接触。 容器部分通过传热构件被加热或冷却。
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公开(公告)号：US20100112681A1
公开(公告)日：2010-05-06
申请号：US12530377
申请日：2008-03-04
CPC分类号： G01N35/08
摘要： Compressed gas is supplied from above to a specimen vessel having an open top. Transfer channels to reaction vessels are provided under a microchip and transfer channels extending from the reaction vessels are provided on the microchip. Transfer element is provided outside the microchip so as to supply the compressed gas from a member (cover) holding the microchip.
摘要翻译： 压缩气体从上方供给到具有开口顶部的试样容器。 在微芯片下面设置向反应容器的转移通道，并且将从反应容器延伸的转移通道设置在微芯片上。 转移元件设置在微芯片外部，以从保持微芯片的构件（盖）供应压缩气体。
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公开(公告)号：US20090209861A1
公开(公告)日：2009-08-20
申请号：US11884440
申请日：2006-02-16
IPC分类号： A61B8/06
CPC分类号： G01S15/8981 , A61B8/06 , G01S15/8988
摘要： An ultrasonic Doppler blood flow meter has a clutter component estimation unit 110 for estimating amplitude, initial phase, and phase velocity of the clutter component using an output from the phase detector 104 to reduce a transient phenomenon. Using the estimated data, initial values of the wall filter 105 are generated by the initial filter value generating unit 11 and then provided to the wall filter for the filtering process.
摘要翻译： 超声波多普勒血流计具有杂波分量估计单元110，用于使用来自相位检测器104的输出来估计杂波分量的振幅，初始相位和相位速度，以减少瞬态现象。 使用估计数据，由初始过滤器值生成单元11生成壁过滤器105的初始值，然后将其提供给用于过滤处理的壁过滤器。
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公开(公告)号：US20090163811A1
公开(公告)日：2009-06-25
申请号：US12293520
申请日：2007-03-13
IPC分类号： A61B8/14
CPC分类号： A61B8/0858 , A61B5/02007 , A61B8/485 , G01S7/52036 , G01S7/52042
摘要： The present invention is to provide an ultrasonograph which can accurately measure an IMT value of a blood vessel by using an ultrasonic wave. The ultrasonograph includes an ultrasonic signal emitting unit (1) for emitting an ultrasonic signal, an ultrasonic echo receiving unit (2) for receiving, as a reflected signal, an ultrasonic echo from inside tissue, and converting the ultrasonic echo into an electronic signal, an amplitude information processing unit (5) for processing amplitude information on the ultrasonic echo, a phase information processing unit (6) for processing phase information of the ultrasonic echo, and a boundary detecting unit (7) for determining a distribution of a boundary between a blood flow region and an intima and a boundary between a media and an adventitia on the basis of at least one processing result output from the amplitude information processing unit and at least one processing result output from the phase information processing unit, and an IMT value calculating unit (9) for computing an IMT value of a blood vessel from position information indicative of the position of the boundary between the blood flow region and the intima and position information indicative of the position of the boundary between the media and the adventitia.
摘要翻译： 本发明提供一种能够通过超声波精确地测定血管的IMT值的超声波诊断装置。 所述超声波诊断装置包括用于发射超声信号的超声波信号发射单元（1），用于从内部组织接收来自内部组织的超声回波作为反射信号的超声波回波接收单元（2），并将超声波回波转换为电子信号， 用于处理关于超声回波的振幅信息的振幅信息处理单元（5），用于处理超声波回波的相位信息的相位信息处理单元（6），以及用于确定超声回波的边界分布的边界检测单元 基于从振幅信息处理单元输出的至少一个处理结果和从相位信息处理单元输出的至少一个处理结果，媒体和外膜之间的血流区域和内膜以及边界，以及IMT值 计算单元（9），用于根据表示t之间的边界的位置的位置信息计算血管的IMT值 他的血流区域和指示介质与外膜之间边界位置的内膜和位置信息。
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公开(公告)号：US07455640B2
公开(公告)日：2008-11-25
申请号：US10560375
申请日：2004-06-10
IPC分类号： A61B8/00
CPC分类号： A61B8/485 , A61B5/021 , A61B5/0456 , A61B8/08 , A61B8/14 , A61B8/463 , A61B8/466 , A61B8/5238 , G01S7/52042 , G01S7/52074 , G01S7/52087
摘要： A tomographic image and a tissue characteristic image that are in conformity with each other in terms of time-phase and positional relationships can be displayed superimposedly, thereby providing an excellent ultrasonic diagnostic apparatus that enables an easy and detailed observation of a relationship between a structure and a characteristic of a subject tissue. During an operation of ultrasonic wave transmission/reception (in a live mode), a control part (100) allows a tomographic image to be renewed continuously, displayed on a monitor (107), and stored in a tomographic image memory (110), while allowing an elastic modulus image as a tissue characteristic image to be renewed per heartbeat, displayed on the monitor, and stored in an elastic-modulus-image memory (111) as a tissue characteristic image memory. During a suspension of ultrasonic wave transmission/reception (in a cine mode), the control part (100) allows the elastic modulus image to be read out from the elastic-modulus-image memory and the tomographic image that is in synchronization with the elastic modulus image to be read out from the tomographic image memory, and allows these images to be displayed on the monitor.
摘要翻译： 可以叠加地显示在时间相位和位置关系方面彼此一致的断层图像和组织特征图像，从而提供优异的超声波诊断装置，能够容易且详细地观察结构与 主题组织的特征。 在超声波发送/接收操作（在实时模式中），控制部分（100）允许连续更新断层图像，显示在监视器（107）上，并存储在断层图像存储器（110）中， 同时允许弹性模量图像作为组织特征图像在心跳上更新，显示在监视器上，并作为组织特征图像存储器存储在弹性模量图像存储器（111）中。 在超声波发送/接收（电影模式）的中止期间，控制部（100）允许从弹性模量图像存储器读出弹性模量图像，并且与弹性体同步的断层图像 将从断层图像存储器读出的模数图像，并且允许这些图像显示在监视器上。
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公开(公告)号：US20080021318A1
公开(公告)日：2008-01-24
申请号：US11572726
申请日：2005-07-27
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B5/02007 , A61B5/1075 , A61B8/0858 , A61B8/0891 , A61B8/485 , A61B8/543 , G01S7/52042 , G01S15/8906
摘要： An ultrasonic diagnostic apparatus according to the present invention includes: a transmitting section 14 for driving an ultrasonic probe 13 sending out an ultrasonic transmitted wave toward a tissue of an organism; a receiving section 15 for receiving an ultrasonic reflected wave, produced by getting the ultrasonic transmitted wave reflected by the tissue of the organism, through the ultrasonic probe to generate a received signal; a phase detecting section 17 for detecting the phase of the received signal to generate a phase detected signal; a positional displacement calculating section 31a for calculating the magnitudes of positional displacements at multiple measuring points, set on the tissue of the organism, based on the phase detected signal; a thickness variation calculating section 31b for calculating thicknesses or thickness variations, each measured between two arbitrary points set with respect to the measuring points, based on the magnitudes of positional displacements; and a maximum/minimum value calculating section 31c for finding the maximum and minimum thicknesses or thickness variations during a maximum value finding period and a minimum value finding period, which are defined as respective partial periods of one cardiac cycle of the organism. At least one of the greatest thickness difference, strain and elastic property is calculated based on a difference between the maximum and minimum thicknesses or thickness variations.
摘要翻译： 根据本发明的超声波诊断装置包括：发送部分14，用于驱动向生物体的组织发送超声波发射波的超声波探头13; 接收部15，其通过超声波探头接收由生物体的组织反射的超声波发送波而产生的超声波反射波，生成接收信号; 相位检测部分17，用于检测接收信号的相位以产生相位检测信号; 基于所述相位检测信号计算在所述生物体的组织上设定的多个测量点的位置位移的大小的位置位移计算部31a; 厚度变化计算部分31b，用于基于位移位移的大小来计算在相对于测量点设置的两个任意点之间测量的厚度或厚度变化; 以及最大/最小值计算部分31c，用于在最大值发现周期和最小值发现周期中找到最大和最小厚度或厚度变化，其被定义为生物体的一个心动周期的相应部分周期。 基于最大厚度和最小厚度或厚度变化之间的差异计算最大厚度差，应变和弹性的至少一个。
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公开(公告)号：US20070032725A1
公开(公告)日：2007-02-08
申请号：US10569661
申请日：2004-08-30
IPC分类号： A61B8/00
CPC分类号： A61B5/02007 , A61B8/0858 , A61B8/58 , G01S7/5206 , G01S15/8979 , Y10S128/916
摘要： There is provided an excellent biological signal monitor device that allows a living tissue moving in accordance with a body motion or a vibration to be observed as if it were standing still. A reverse correction processing unit (114) subjects a B-mode image to reverse correction based on a movement amount of the living tissue detected by a movement amount detection unit (113), and outputs the B-mode image corresponding to the living tissue moving in accordance with a body motion as quasi-still image information. An arithmetic processing unit (115) subjects the quasi-still image information from the reverse correction processing unit (114) to arithmetic processing such as averaging and filter processing, so as to remove a random noise component. As a result, it is possible to display, for example, a contour portion of a blood vessel wall as the living tissue clearly.
摘要翻译： 提供了一种优良的生物信号监测装置，其允许活体组织根据身体运动或振动进行移动，就像静止状态一样被观察。 反向校正处理单元（114）根据由移动量检测单元（113）检测到的生物体组织的移动量对B模式图像进行反向校正，并输出与活组织移动对应的B模式图像 根据身体运动作为准静止图像信息。 算术处理单元（115）对来自反向校正处理单元（114）的准静止图像信息进行诸如平均和滤波处理之类的算术处理，以便去除随机噪声分量。 结果，可以清楚地显示例如血管壁的轮廓部分作为活体组织。
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