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    FLOW PASSAGE CONTROL MECHANISM FOR MICROCHIP
    2.
    发明申请
    FLOW PASSAGE CONTROL MECHANISM FOR MICROCHIP 有权
    流量控制机制的MICROCHIP

    公开(公告)号：US20140079605A1

    公开(公告)日：2014-03-20

    申请号：US14082356

    申请日：2013-11-18

    Applicant: Minoru ASOGAWA ,  Hisashi HAGIWARA ,  Tohru HIRAMATSU

    Inventor： Minoru ASOGAWA ,  Hisashi HAGIWARA ,  Tohru HIRAMATSU

    IPC: B01L3/00

    CPC classification number: B01L3/502738 ,  B01L3/50273 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0655 ,  G01N35/1095 ,  G01N2035/00158 ,  G01N2035/1034 ,  Y10T137/8593 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575

    Abstract: A channel control mechanism for a microchip has a laminated structure formed of members including elastic members, and includes: a sample reservoir for packing a sample therein; a reaction reservoir in which mixture and reaction of the sample are performed; and a channel formed in a middle layer of the laminated structure, for bringing the sample reservoir and the reaction reservoir into communication with each other. The channel control mechanism performs the reaction and analysis in such a manner that the sample is delivered into the reaction reservoir through the channel. A shutter channel (pressurizing channel) is provided in a layer different from a layer in which the channel is formed so that the pressurizing channel partially overlaps the channel. The channel is closed through applying a pressurized medium to the shutter channel (pressurizing channel), and the channel is opened through releasing a pressure of the pressurized medium.

    Abstract translation: 用于微芯片的通道控制机构具有由包括弹性构件的构件形成的层压结构，并且包括：用于在其中包装样品的样品容器; 反应容器，其中进行混合物和样品的反应; 以及形成在层叠结构的中间层中的通道，用于使样本储存器和反应容器彼此连通。 通道控制机构以通过通道将样品输送到反应容器中的方式进行反应和分析。 快门通道（加压通道）设置在与形成通道的层不同的层中，使得加压通道与通道部分重叠。 通过将加压介质施加到闸门通道（加压通道）来关闭通道，并且通过释放加压介质的压力来打开通道。

    TEMPERATURE CONTROL METHOD AND SYSTEM
    5.
    发明申请
    TEMPERATURE CONTROL METHOD AND SYSTEM 有权
    温度控制方法与系统

    公开(公告)号：US20100221814A1

    公开(公告)日：2010-09-02

    申请号：US12679358

    申请日：2008-09-16

    Applicant: Minoru Asogawa ,  Hisashi Hagiwara ,  Tohru Hiramatsu

    Inventor： Minoru Asogawa ,  Hisashi Hagiwara ,  Tohru Hiramatsu

    IPC: C12M1/38 ,  F28F13/00 ,  F28F7/00

    CPC classification number: B01L3/502715 ,  B01L3/50273 ,  B01L3/505 ,  B01L7/52 ,  B01L2200/0689 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0481 ,  B01L2400/0655 ,  G01N2035/00158 ,  G01N2035/00346

    Abstract: For heating or cooling a sample contained in a vessel portion through a heat transfer member held in contact with the vessel portion, there is used the vessel portion, which has a part formed of an elastic member, expands and contracts for injection and discharge of the sample, is closed other than a connecting port with a channel connected to the vessel, and expands and contracts for injection and discharge of the sample. The vessel portion expands correspondingly to the injection when the sample is injected through an inflow path serving as the channel into the vessel portion contracting in a non-contacting state with the heat transfer member. A predetermined amount of sample is injected into the vessel portion so as to expand the vessel portion, and the vessel portion comes into contact with the heat transfer member. The vessel portion is heated or cooled through the heat transfer member.

    Abstract translation: 为了通过与容器部分保持接触的传热构件来加热或冷却包含在容器部分中的样品，使用具有由弹性构件形成的部分的容器部分，其膨胀和收缩用于注射和排出 样品，除了具有连接到容器的通道的连接端口之外，并且膨胀和收缩用于样品的注入和排出。 当样品通过用作通道的流入路径注入到与传热构件非接触状态收缩的容器部分中时，容器部分对应于注射膨胀。 将预定量的样品注入到容器部分中以使容器部分膨胀，并且容器部分与传热构件接触。 容器部分通过传热构件被加热或冷却。

    Microchip, solvent displacement method using the microchip, concentrating method, and mass spectrometry system
    6.
    发明申请
    Microchip, solvent displacement method using the microchip, concentrating method, and mass spectrometry system 审中-公开
    Microchip，使用微芯片的溶剂置换法，浓缩法和质谱系统

    公开(公告)号：US20060070951A1

    公开(公告)日：2006-04-06

    申请号：US10536597

    申请日：2003-11-28

    Applicant: Masakazu Baba ,  Toru Sano ,  Kazuhiro Iida ,  Hisao Kawaura ,  Noriyuki Iguchi ,  Wataru Hattori ,  Hiroko Someya ,  Minoru Asogawa

    Inventor： Masakazu Baba ,  Toru Sano ,  Kazuhiro Iida ,  Hisao Kawaura ,  Noriyuki Iguchi ,  Wataru Hattori ,  Hiroko Someya ,  Minoru Asogawa

    IPC: C02F1/44 ,  B01D15/08

    CPC classification number: B01D67/0062 ,  B03C5/00 ,  G01N1/40

    Abstract: A particular component in a sample is recovered in a high concentration and solvent-replaced. A separator 100 is placed on a microchip and includes a channel 112 for flowing the particular component. The channel 112 includes a sample feeding channel 300 as well as a filtrate discharge channel 302 and a sample recovering part 308 which are branched from the sample feeding channel 300. There is formed a filter 304 for preventing passage of the particular component, at the inlet of the filtrate discharge channel 302 from the sample feeding channel 300. Furthermore, there is formed a damming area (hydrophobic area) 306 for preventing entering of a liquid sample while allowing for passage of the liquid sample by applying an external force equal to or larger than a given level, at the inlet of the sample recovering part 308 from the sample feeding channel 300.

    Abstract translation: 样品中的特定组分以高浓度回收并进行溶剂置换。 分离器100放置在微芯片上，并且包括用于流动特定部件的通道112。 通道112包括样品供给通道300以及从样品供给通道300分支的滤液排出通道302和样品回收部分308。 在滤液排出通道302的入口处，从样品供给通道300形成防止特定成分通过的过滤器304。 此外，在样品回收部的入口处形成防止液体样品进入的阻止区域（疏水区域）306，同时允许通过施加等于或大于给定水平的外力使液体样品通过 308。

    Test reagent container
    8.
    发明授权
    Test reagent container 有权
    试剂容器

    公开(公告)号：US09186676B2

    公开(公告)日：2015-11-17

    申请号：US14114016

    申请日：2012-04-20

    Applicant: Masahide Inoue ,  Minoru Asogawa ,  Yoshinori Mishina

    Inventor： Masahide Inoue ,  Minoru Asogawa ,  Yoshinori Mishina

    IPC: B01L3/00 ,  B65D5/72 ,  G01N35/00

    CPC classification number: B01L3/52 ,  B01L3/5027 ,  B01L3/523 ,  B01L2200/04 ,  B01L2200/141 ,  B01L2300/044 ,  B01L2300/0819 ,  B01L2300/0832 ,  B01L2300/0851 ,  B01L2400/0683 ,  B65D5/726 ,  G01N35/00

    Abstract: A test reagent container including a discharge port, formed by depressing a projecting part formed on a container bottom part, through which content can be easily and reliably discharged. The test reagent container includes: a bottom part; a peripheral wall raised approximately perpendicularly from a periphery of the bottom part; and a storage part defined by the bottom part and peripheral wall. A projecting part is formed on the bottom part in a projecting manner toward outside the container. A proximal end of the projecting part is formed in a bendable manner relative to the bottom part, and an easily breakable part is formed on a periphery of the projecting part except for the proximal end of the projecting part. The easily breakable part is broken when the projecting part is depressed from outside the container to be pushed into the inside of the container to form a discharge port.

    Abstract translation: 一种试剂容器，其包括通过按压形成在容器底部上的突出部分形成的排出口，通过该容器底部容易且可靠地排出内容物。 试剂容器包括：底部; 从底部的周边大致垂直地突出的周壁; 以及由底部和周壁限定的存储部。 突出部分以突出的方式形成在底部上，朝向容器外部。 突出部的近端相对于底部以可弯曲的方式形成，并且在突出部的除了突出部的近端之外的突出部的周边上形成容易断裂的部分。 当突出部分从容器外部压下以被推入容器内部以形成排出口时，容易断裂的部分被破坏。

    Immobilizing device and immobilization method using the immobilization device
    9.
    发明授权
    Immobilizing device and immobilization method using the immobilization device 有权
    使用固定装置的固定装置和固定方法

    公开(公告)号：US08628732B2

    公开(公告)日：2014-01-14

    申请号：US13119246

    申请日：2009-10-19

    Applicant: Minoru Asogawa ,  Hayataro Kochi

    Inventor： Minoru Asogawa ,  Hayataro Kochi

    IPC: G01N15/06

    CPC classification number: G01N35/04

    Abstract: Provided is an immobilization device for fitting a connecting member of a chip and a connecting member of a cover together, where a spatial clearance between the chip and cover is small. The immobilization device includes a substrate (102), a cover means (101) including a fitting means to fit with a chip (103) placed on the substrate (102), a rotating arm means (201) rotatably joined to a first joining means (301) of the substrate (102) and to a second joining means (302) of the cover means (101), and a parallel maintaining means (203) for fitting the fitting means and the chip (103) together with the fitting means and the chip (103) maintained in substantially parallel by the first joining means (301) or the second joining means (302) moving along a chip surface or a plane parallel to the chip surface. The fitting means rotates freely against the chip (103).

    Abstract translation: 提供一种用于将芯片的连接构件和盖的连接构件配合在一起的固定装置，其中芯片和盖子之间的空间间隙小。 固定装置包括基板（102），包括装配有放置在基板（102）上的芯片（103）的装配装置的盖装置（101），旋转臂装置（201），其可旋转地连接到第一连接装置 （101）的第二连接装置（302）以及用于将装配装置和芯片（103）与装配装置（103）一起装配的平行保持装置（203） 并且所述芯片（103）通过所述第一接合装置（301）或所述第二接合装置（302）基本平行地保持，所述第一接合装置沿着芯片表面或平行于所述芯片表面的平面移动。 配合装置自由地旋转于芯片（103）。

    Method for immobilizing compound onto column carrier
    10.
    发明授权
    Method for immobilizing compound onto column carrier 有权
    将化合物固定在柱载体上的方法

    公开(公告)号：US08013180B2

    公开(公告)日：2011-09-06

    申请号：US12209956

    申请日：2008-09-12

    Applicant: Minoru Asogawa ,  Toru Matsumoto

    Inventor： Minoru Asogawa ,  Toru Matsumoto

    IPC: C07C303/00

    CPC classification number: C07C303/06 ,  B01J20/3219 ,  B01J20/3251 ,  B01J20/3253 ,  C07B2200/11 ,  C07C303/38 ,  C07C303/40 ,  C07C309/40 ,  C07C311/19

    Abstract: It is intended to provide a method for immobilizing, onto a column carrier, a compound having a sulfo group or a compound to which a sulfo group can be added. The method comprises immobilizing the compound onto the column carrier using a linker comprising: a sulfo group-binding group capable of forming a bond with the sulfo group in the compound; and a carrier-binding group capable of forming a bond with a group present on the surface of the column carrier.

    Abstract translation: 旨在提供一种固定在柱载体上的具有磺基的化合物或可加入磺基的化合物的方法。 该方法包括使用连接体将化合物固定在柱载体上，所述接头包含：能够与化合物中的磺基形成键的磺基结合基团; 以及能够与柱载体的表面上存在的基团形成键的载体结合基团。

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