摘要:
Described are multivalent multimeric antibodies comprising at least two binding sites specific for the human B cell marker CD19 and human Fcγ receptor III (CD16). Also described are polynucleotides encoding said antibodies as well as vectors comprising said polynucleotides, host cells transformed therewith and their use in the production of said antibodies. Finally, compositions are described comprising any of above mentioned antibodies, polynucleotides or vectors. The pharmaceutical compositions are useful for immunotherapy, preferably against B cell malignancies such as non-Hodgkin's lymphoma.
摘要:
The invention discloses a device (10) for clamping particularly an eye glass lens blocked on a block piece for processing and/or coating said eye glass lens, comprising a receiving space (34) having a center line (M) for a clamping section of the block piece, and a plurality of clamping surfaces (36) provided in a boundary region of the receiving space, which may optionally be engaged in the clamping section of the block piece in order to clamp the block piece. In order to avoid excessive deformation of the clamped block piece, the clamping surfaces are positioned opposite of each other in pairs at a radial distance to the center line and can be displaced optionally toward or away from each other by a clamping piece (38) in order to clamp the clamping section of the block piece by way of clamping forces (F), which are substantially oriented in a tangential direction at a radial distance to the center line, or in order to release the block piece.
摘要:
A machine for processing optical work pieces having a work piece spindle for the work piece driving rotationally about a work piece rotation axis. At least one processing unit has a tool that can machine the work piece and an adjusting mechanism causes a relative movement between the work piece spindle and tool to selectively enable loading, unloading and processing of the work piece. The adjusting mechanism has a linear drive unit and a swivel drive unit that are stacked on each other to rotate the swivel drive unit and the work piece spindle about a swivel axis that is perpendicular to the work piece rotation axis, and has the linear drive unit move the work piece spindle along a linear axis that can be perpendicular to one of the swivel axis and the work piece rotation axis and parallel to or aligned with the other axis.
摘要:
A grinding and polishing machine, in particular for lenses, has at least one tool spindle and at least one workpiece. The tool spindle is constructed to hold a respective tool on the same axis at both ends and is mounted in a spindle housing which can be pivoted about a pivot axis arranged at right angles to the tool spindle in order to provide in each case one tool for machining engagement and also at various defined angle positions with respect to the workpiece spindle. A drive arranged on the pivot axis pivotably moves the tool spindle about the pivot axis for the desired machining engagement and rotates the tool about the pivot axis into the various angle positions with respect to the workpiece.
摘要:
The present invention relates to a process for the preparation of iron oxide/iron oxyhydroxide-containing weakly basic anion exchangers prepared according to the phthalimide process and their use for removing oxo anions and their thio analogues, preferably of arsenic, from water and aqueous solutions and to a regeneration process.
摘要:
The present invention relates to the use of amphoteric ion exchangers for adsorbing oxo anions, preferably to the use of iron oxide/iron oxyhydroxide-containing amphoteric ion exchangers for removing oxo anions from water and aqueous solutions, and to the preparation of these amphoteric iron oxide/iron oxyhydroxide-containing ion exchangers.
摘要:
An assembly device for binding bunched cables with a plastic fastener having a serrated tension band and a separate locking clasp including a housing for holding a wound roll of the tension band, an exit opening in one end of said housing through which the tension band can be fed, a first guide channel in the housing having an entrance end and an exit end and positioned for feeding the tension band from its roll to the exit opening and a second guide channel located in the housing above the first guide channel for feeding an endless chain of the locking clasps interconnected together by frangible webs to position the locking clasps one at a time in the exit opening so that the tension band can be passed out through the opening in the clasp. A cutting blade is mounted in the housing between a locking clasp positioned in the exit opening and the exit end of the first guide channel, the channel being pivotally mounted in the housing adjacent its entrance end so that the channel can be pressed down from the feeding position to bring the tension band down into engagement with the blade to serve the band after it has been firmly wrapped around a bunch of cables and engaged with the locking clasp and a spring for returning the first guide channel to the feeding position.
摘要:
A device for the fine machining of optically active surfaces in particular spectacle lenses, has a spindle shaft which has a tool-holder portion and is mounted in a spindle housing such that it can rotate about a tool rotation axis. The device has an electric rotary drive with a rotor and a stator that rotates the spindle shaft operatively connected to the rotor about the tool rotation axis. The tool-holder portion can be displaced axially in the direction of the tool rotation axis. The rotor and the stator parts are axially guided in a guide tube along the tool rotation axis. The spindle shaft is in the form of a hollow shaft, via which the tool-holder portion, which is configured to hold a membrane chuck, can be subjected to a fluid.
摘要:
A device for the fine machining of optically active surfaces in particular spectacle lenses, has a spindle shaft which has a tool-holder portion and is mounted in a spindle housing such that it can rotate about a tool rotation axis. The device has an electric rotary drive with a rotor and a stator that rotates the spindle shaft operatively connected to the rotor about the tool rotation axis. The tool-holder portion can be displaced axially in the direction of the tool rotation axis. The rotor and the stator parts are axially guided in a guide tube along the tool rotation axis. The spindle shaft is in the form of a hollow shaft, via which the tool-holder portion, which is configured to hold a membrane chuck, can be subjected to a fluid.
摘要:
An assembly device for binding bunched cables with a plastic fastener having a serrated tension band and a separate locking clasp including a housing for holding a wound roll of the tension band, an exit opening in one end of said housing through which the tension band can be fed, a first guide channel in the housing having an entrance end and an exit end and positioned for feeding the tension band from its roll to the exit opening and a second guide channel located in the housing above the first guide channel for feeding an endless chain of the locking clasps interconnected together by frangible webs to position the locking clasps one at a time in the exit opening so that the tension band can be passed out through the opening in the clasp. A cutting blade is mounted in the housing between a locking clasp positioned in the exit opening and the exit end of the first guide channel, the channel being pivotally mounted in the housing adjacent its entrance end so that the channel can be pressed down from the feeding position to bring the tension band down into engagement with the blade to serve the band after it has been firmly wrapped around a bunch of cables and engaged with the locking clasp and a spring for returning the first guide channel to the feeding position.