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公开(公告)号：US20150353538A1
公开(公告)日：2015-12-10
申请号：US14589939
申请日：2015-01-05
申请人： J. Adam Willardsen , Jeffrey W. Lockman , Brett R. Murphy , Weston R. Judd , In Chul Kim , Se-Ho Kim , Daniel Feodore Zigar , Kraig M. Yager , Tracey C. Fleischer , Ryan T. Terry-Lorenzo , J. Jay Boniface , Daniel P. Parker , Ian A. McAlexander , Matthew Gregory Bursavich , David D. Dastrup
发明人： J. Adam Willardsen , Jeffrey W. Lockman , Brett R. Murphy , Weston R. Judd , In Chul Kim , Se-Ho Kim , Daniel Feodore Zigar , Kraig M. Yager , Tracey C. Fleischer , Ryan T. Terry-Lorenzo , J. Jay Boniface , Daniel P. Parker , Ian A. McAlexander , Matthew Gregory Bursavich , David D. Dastrup
IPC分类号： C07D471/04 , C07D213/61 , C07D213/65 , C07D401/12 , C07D235/06 , C07D213/71 , C07D409/12 , C07D213/75 , C07D413/12 , C07D213/64 , C07D213/73 , C07D333/22 , C07D417/12 , C07D213/68 , C07D233/64 , C07D307/48 , C07D237/20 , C07D213/53
CPC分类号： C07D213/75 , C07B2200/05 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/34 , C07C275/40 , C07C311/21 , C07C311/47 , C07D209/14 , C07D213/42 , C07D213/53 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/71 , C07D213/73 , C07D215/46 , C07D231/12 , C07D231/40 , C07D233/64 , C07D235/06 , C07D237/20 , C07D261/08 , C07D307/14 , C07D307/48 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/22 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated autoimmune disease, ischemia, and other complications associated with these diseases and disorders.
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公开(公告)号：US20120329786A1
公开(公告)日：2012-12-27
申请号：US13601879
申请日：2012-08-31
申请人： J. Adam Willardsen , Jeffrey W. Lockman , Brett R. Murphy , Weston R. Judd , In Chul Kim , Se-Ho Kim , Daniel Feodore Zigar , Kraig M. Yager , Tracey C. Fleischer , Ryan T. Terry-Lorenzo , J. Jay Boniface , Daniel P. Parker , Ian A. McAlexander , Matthew Gregory Bursavich , David M. Dastrup
发明人： J. Adam Willardsen , Jeffrey W. Lockman , Brett R. Murphy , Weston R. Judd , In Chul Kim , Se-Ho Kim , Daniel Feodore Zigar , Kraig M. Yager , Tracey C. Fleischer , Ryan T. Terry-Lorenzo , J. Jay Boniface , Daniel P. Parker , Ian A. McAlexander , Matthew Gregory Bursavich , David M. Dastrup
IPC分类号： A61K31/549 , C12N5/02 , A61K31/5377 , A61K31/50 , A61K31/519 , A61K31/47 , A61K31/4545 , A61K31/4406 , A61K31/4402 , A61K31/357 , A61K31/17 , C07D417/12 , C07D413/12 , C07D237/20 , C07D471/04 , C07D215/46 , C07D401/12 , C07D211/98 , C07D211/04 , C07D317/46 , C07C275/40 , A61P35/00 , A61P29/00 , A61P19/02 , A61P3/04 , A61P3/10 , A61P9/10 , C12Q1/02
CPC分类号： C07D213/75 , C07B2200/05 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/34 , C07C275/40 , C07C311/21 , C07C311/47 , C07D209/14 , C07D213/42 , C07D213/53 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/71 , C07D213/73 , C07D215/46 , C07D231/12 , C07D231/40 , C07D233/64 , C07D235/06 , C07D237/20 , C07D261/08 , C07D307/14 , C07D307/48 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/22 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated autoimmune disease, ischemia, and other complications associated with these diseases and disorders.
摘要翻译： 本发明涉及可用于治疗癌症，全身或慢性炎症，类风湿性关节炎，糖尿病，肥胖症，T细胞介导的自身免疫疾病，缺血以及与这些疾病和病症相关的其它并发症的化合物，药物组合物和方法。
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公开(公告)号：US20150344426A1
公开(公告)日：2015-12-03
申请号：US14582641
申请日：2014-12-24
IPC分类号： C07D213/58 , C07D401/12 , C07D403/12
CPC分类号： C07D213/58 , C07D213/40 , C07D401/12 , C07D403/12 , C07D405/06
摘要： The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated autoimmune disease, ischemia, and other complications associated with these diseases and disorders.
摘要翻译： 本发明涉及可用于治疗癌症，全身或慢性炎症，类风湿性关节炎，糖尿病，肥胖症，T细胞介导的自身免疫疾病，缺血以及与这些疾病和病症相关的其它并发症的化合物，药物组合物和方法。
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公开(公告)号：US20120122840A1
公开(公告)日：2012-05-17
申请号：US13243876
申请日：2011-09-23
申请人： Dange Vijay Kumar , Ian A. McAlexander , Matthew Gregory Bursavich , Christophe Hoarau , Paul M. Slattum , David A. Gerrish , Jeffrey W. Lockman , Weston R. Judd , Michael Saunders , Daniel P. Parker , Daniel Feodore Zigar , In Chul Kim , J. Adam Willardsen , Kraig M. Yager , Mark D. Shenderovich , Brandi L. Williams , Keith D. Tardif
发明人： Dange Vijay Kumar , Ian A. McAlexander , Matthew Gregory Bursavich , Christophe Hoarau , Paul M. Slattum , David A. Gerrish , Jeffrey W. Lockman , Weston R. Judd , Michael Saunders , Daniel P. Parker , Daniel Feodore Zigar , In Chul Kim , J. Adam Willardsen , Kraig M. Yager , Mark D. Shenderovich , Brandi L. Williams , Keith D. Tardif
IPC分类号： A61K31/541 , C07D473/32 , G01N33/567 , A61K31/5377 , A61P35/00 , C07D473/16 , A61K31/52
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention relates to compounds, pharmaceutical compositions, and uses thereof, including therapeutic uses thereof, such as methods useful for treating cancer.
摘要翻译： 本发明涉及化合物，药物组合物及其用途，包括其治疗用途，例如可用于治疗癌症的方法。
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公开(公告)号：US20110144069A1
公开(公告)日：2011-06-16
申请号：US11873356
申请日：2007-10-16
CPC分类号： C07J53/00 , C07D213/40 , C07D213/56 , C07D213/78 , C07D213/89 , C07D215/26 , C07D215/42 , C07D333/40
摘要： The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.
摘要翻译： 本发明涉及可用于治疗病毒感染的化合物，药物组合物和方法。
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6.发明授权公开(公告)号：US07176310B1
公开(公告)日：2007-02-13
申请号：US10407870
申请日：2003-04-04
申请人： Theodore A. Baughman , Jim P. Boyce , Ihab S. Darwish , J. Jeffry Howbert , Nathan C. Ihle , Randy W. Jackson , Scott C. Jeffrey , Dean Maeda , Kraig M. Yager
发明人： Theodore A. Baughman , Jim P. Boyce , Ihab S. Darwish , J. Jeffry Howbert , Nathan C. Ihle , Randy W. Jackson , Scott C. Jeffrey , Dean Maeda , Kraig M. Yager
IPC分类号： C07D239/00 , C07D239/70
CPC分类号： C07D239/47 , C07D401/04
摘要： This invention is directed to compound of the following formula (I): wherein R1, R2, R3 and R4 are as described herein. These compounds and pharmaceutical compositions containing the compounds are useful in treating inflammatory disorders in mammals.
摘要翻译： 本发明涉及下式（I）的化合物：其中R 1，R 2，R 3和R 4 如本文所述。 这些化合物和含有这些化合物的药物组合物可用于治疗哺乳动物的炎性疾病。
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公开(公告)号：US20100240630A1
公开(公告)日：2010-09-23
申请号：US12794300
申请日：2010-06-04
CPC分类号： C07J63/008
摘要： The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.
摘要翻译： 本发明涉及可用于治疗病毒感染的化合物，药物组合物和方法。
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公开(公告)号：US06737415B2
公开(公告)日：2004-05-18
申请号：US10227327
申请日：2002-08-22
申请人： Stephen R. Cooper , Kraig M. Yager
发明人： Stephen R. Cooper , Kraig M. Yager
IPC分类号： A61K3169
CPC分类号： A61K31/381 , A01N43/26 , A01N43/82 , A01N43/90 , A01N55/00 , A01N57/36 , A61K31/38 , A61K31/425 , A61K31/66 , A61K31/69
摘要： Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1, and T2 are each independently selected from the group consisting of O, NR, and CH2, where R=H or C1-C8 alkyl, or C1-C8 oxoalkyl, and L is selected from the group consisting of ethylene, propylene, and four to six-membered alicyclic and aromatic rings, provided that structure I does not include AI-2-borate. The compounds may be used to treat bacterial infections in human beings and to regulate biofilm formation. Pharmaceutical compositions comprising one or more such compounds are useful for treating bacterial infections in human beings.
摘要翻译： 结构I的化合物可用于治疗细菌生长，其中E选自B，P和S，T1和T2各自独立地选自O，NR和CH 2，其中 R = H或C 1 -C 8烷基或C 1 -C 8氧代烷基，L选自乙烯，丙烯和四至六元脂环和芳环，条件是结构I不包括AI-2- 硼酸盐 该化合物可用于治疗人类的细菌感染并调节生物膜形成。 包含一种或多种这样的化合物的药物组合物可用于治疗人类的细菌感染。
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9.发明申请AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1 审中-公开作为IKK EPSILON和/或TBK1的抑制剂的氨基吡啶化合物公开(公告)号：US20120238540A1
公开(公告)日：2012-09-20
申请号：US13445627
申请日：2012-04-12
申请人： Ryan C. HOLCOMB , Kazuyuki Suzuki , Robert J. Halter , Paul R. Sebahar , Donald A. McLeod , Mark D. Shenderovich , Kraig M. Yager , Matthew Gregory Bursavich , Ashantai J. Yungai , Burt Richards , Paul L. Bartel , Daniel A. Wettstein
发明人： Ryan C. HOLCOMB , Kazuyuki Suzuki , Robert J. Halter , Paul R. Sebahar , Donald A. McLeod , Mark D. Shenderovich , Kraig M. Yager , Matthew Gregory Bursavich , Ashantai J. Yungai , Burt Richards , Paul L. Bartel , Daniel A. Wettstein
IPC分类号： A61K31/506 , A61K31/5377 , C07D405/12 , C07D413/14 , C07D403/12 , A61K31/551 , A61P29/00 , A61P19/04 , A61P17/06 , A61P11/00 , A61P1/00 , A61P3/04 , A61P5/48 , A61P3/00 , A61P35/00 , C12N5/071 , C07D413/12
CPC分类号： A61K31/505 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/635 , C07D239/42 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/08
摘要： The invention relates to certain amino-pyrimidine compounds that inhibit IKK epsilon and/or TBK1, methods of making such compounds, pharmaceutical compositions comprising such compounds, and the use of these compounds in treating a variety of diseases and disorders.
摘要翻译： 本发明涉及抑制IKKε和/或TBK1的某些氨基嘧啶化合物，制备这些化合物的方法，包含这些化合物的药物组合物以及这些化合物在治疗各种疾病和病症中的用途。
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公开(公告)号：US20090105203A1
公开(公告)日：2009-04-23
申请号：US11873342
申请日：2007-10-16
IPC分类号： A61K31/56 , C07J53/00 , A61P35/00 , A61P31/18 , C07D305/08 , C07D213/56
CPC分类号： C07J53/00 , C07D213/40 , C07D213/56 , C07D213/78 , C07D213/89 , C07D215/26 , C07D215/42 , C07D333/40
摘要： The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.
摘要翻译： 本发明涉及可用于治疗病毒感染的化合物，药物组合物和方法。
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