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公开(公告)号：US08143600B2
公开(公告)日：2012-03-27
申请号：US12032959
申请日：2008-02-18
IPC分类号： G01N21/64
CPC分类号： G01N21/4795 , G01N15/1436 , G01N2015/1445 , G01N2021/1787 , G06T11/006
摘要： A method for 3D imaging of cells in an optical tomography system includes moving a biological object relatively to a microscope objective to present varying angles of view. The biological object is illuminated with radiation having a spectral bandwidth limited to wavelengths between 150 nm and 390 nm. Radiation transmitted through the biological object and the microscope objective is sensed with a camera from a plurality of differing view angles. A plurality of pseudoprojections of the biological object from the sensed radiation is formed and the plurality of pseudoprojections is reconstructed to form a 3D image of the cell.
摘要翻译： 用于光学断层摄影系统中的细胞的3D成像的方法包括相对于显微镜物镜移动生物体以呈现不同的视角。 用具有限制在150nm和390nm之间的波长的光谱带宽的辐射照射该生物物体。 利用摄像机从多个不同的视角检测透过生物物体和显微镜物镜的辐射。 形成来自感测辐射的生物物体的多个伪投影，并重建多个伪投影以形成该细胞的3D图像。
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公开(公告)号：US20100321786A1
公开(公告)日：2010-12-23
申请号：US12862553
申请日：2010-08-24
申请人： J. Richard Rahn , John W. Hayenga
发明人： J. Richard Rahn , John W. Hayenga
CPC分类号： G01N21/4795 , A61B5/0073 , G01N15/1468
摘要： An optical tomography system for viewing an object of interest includes a microcapillary tube viewing area for positioning the object of interest in an optical path including a detector. A motor is located to attach to and rotate a microcapillary tube. A device is arranged for transmitting broadband light having wavelengths between 550 nm and 620 nm into the microcapillary tube viewing area. A hyperchromatic lens is located to receive light transmitted through the microcapillary tube viewing area. A tube lens is located to focus light rays transmitted through the hyperchromatic lens, such that light rays from multiple object planes in the microcapillary tube viewing area simultaneously focus on the at least one detector.
摘要翻译： 用于观察感兴趣对象的光学断层摄影系统包括用于将感兴趣对象定位在包括检测器的光路中的微毛细管观察区域。 马达位于附着和转动微毛细管。 设置有将波长在550nm和620nm之间的宽带光发送到微毛细管观察区域中的装置。 定位多色透镜以接收透过微毛细管观察区域的光。 管透镜被定位成聚焦穿过多色透镜的光线，使得来自微毛细管观察区域中的多个物平面的光线同时聚焦在至少一个检测器上。
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公开(公告)号：US07787112B2
公开(公告)日：2010-08-31
申请号：US11876658
申请日：2007-10-22
申请人： J. Richard Rahn , Jon W. Hayenga
发明人： J. Richard Rahn , Jon W. Hayenga
IPC分类号： G01J1/00
CPC分类号： G01N21/4795 , A61B5/0073 , G01N15/1468
摘要： An optical projection tomography system is illuminated with a light source. An object-containing tube, a portion of which is located within the region illuminated by the light source, contains an object of interest that has a feature of interest. A detector is located to receive emerging radiation from the object of interest. A lens, including optical field extension elements, is located in the optical path between the object region and the detector, such that light rays from multiple object planes in the object-containing tube simultaneously focus on the detector. The object-containing tube moves relatively to the detector and the lens operate to provide multiple views of the object region for producing an image of the feature of interest at each view.
摘要翻译： 用光源照射光学投影断层摄影系统。 其中一部分位于由光源照射的区域内的含有物体的管包含具有感兴趣特征的感兴趣对象。 探测器被设置为接收来自感兴趣对象的新兴辐射。 包括光场延伸元件的透镜位于物体区域和检测器之间的光路中，使得来自物体的管中的多个物平面的光线同时聚焦在检测器上。 所述含物体的管相对于所述检测器移动并且所述透镜操作以提供所述物体区域的多个视图，以在每个视图处产生感兴趣特征的图像。
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公开(公告)号：US20090208072A1
公开(公告)日：2009-08-20
申请号：US12032959
申请日：2008-02-18
IPC分类号： G06K9/00
CPC分类号： G01N21/4795 , G01N15/1436 , G01N2015/1445 , G01N2021/1787 , G06T11/006
摘要： A method for 3D imaging of cells in an optical tomography system includes moving a biological object relatively to a microscope objective to present varying angles of view. The biological object is illuminated with radiation having a spectral bandwidth limited to wavelengths between 150 nm and 390 nm. Radiation transmitted through the biological object and the microscope objective is sensed with a camera from a plurality of differing view angles. A plurality of pseudoprojections of the biological object from the sensed radiation is formed and the plurality of pseudoprojections is reconstructed to form a 3D image of the cell.
摘要翻译： 用于光学断层摄影系统中的细胞的3D成像的方法包括相对于显微镜物镜移动生物体以呈现不同的视角。 用具有限制在150nm和390nm之间的波长的光谱带宽的辐射照射该生物物体。 利用摄像机从多个不同的视角检测透过生物物体和显微镜物镜的辐射。 形成来自感测辐射的生物物体的多个伪投影，并重建多个伪投影以形成该细胞的3D图像。
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公开(公告)号：US08947510B2
公开(公告)日：2015-02-03
申请号：US12999515
申请日：2009-06-08
申请人： Michael G. Meyer , J. Richard Rahn , Anna V. Tourovskaia , Julia Oi Yan Yu , Christy A Lancaster , Thomas Neumann , Mark E. Fauver
发明人： Michael G. Meyer , J. Richard Rahn , Anna V. Tourovskaia , Julia Oi Yan Yu , Christy A Lancaster , Thomas Neumann , Mark E. Fauver
CPC分类号： G06T11/006 , G01N15/1434 , G01N15/1475 , G01N21/49 , G01N21/6458 , G01N2015/1445
摘要： A method for 3D imaging of a biologic object (1) in an optical tomography system where a subcellular structure of a biological object (1) is labeled by introducing at least one nanoparticle-biomarker. The labeled biological object (1) is moved relatively to a microscope objective (62) to present varying angles of view and the labeled biological object (1) is illuminated with radiation having wavelengths between 150 nm and 900 nm. Radiation transmitted through the labeled biological object (1) and the microscope objective (62) within at least one wavelength bands is sensed with a color camera, or with a set of at least four monochrome cameras. A plurality of cross-sectional images of the biological object (1) from the sensed radiation is formed and reconstructed to make a 3D image of the labeled biological object (1).
摘要翻译： 一种用于在其中通过引入至少一种纳米颗粒 - 生物标志物标记生物体（1）的亚细胞结构的光学层析成像系统中的生物物体（1）的3D成像的方法。 标记的生物体（1）相对于显微镜物镜（62）移动以呈现不同的视角，并且用波长在150nm和900nm之间的辐射照射标记的生物物体（1）。 用彩色照相机或一组至少四个单色照相机检测在至少一个波长带内通过标记的生物物体（1）和显微镜物镜（62）发射的辐射。 形成并重构来自感测辐射的生物体（1）的多个横截面图像，以便制成标记的生物体（1）的3D图像。
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公开(公告)号：US07933010B2
公开(公告)日：2011-04-26
申请号：US12862553
申请日：2010-08-24
申请人： J. Richard Rahn , John W. Hayenga
发明人： J. Richard Rahn , John W. Hayenga
IPC分类号： G01J1/00
CPC分类号： G01N21/4795 , A61B5/0073 , G01N15/1468
摘要： An optical tomography system for viewing an object of interest includes a microcapillary tube viewing area for positioning the object of interest in an optical path including a detector. A motor is located to attach to and rotate a microcapillary tube. A device is arranged for transmitting broadband light having wavelengths between 550 nm and 620 nm into the microcapillary tube viewing area. A hyperchromatic lens is located to receive light transmitted through the microcapillary tube viewing area. A tube lens is located to focus light rays transmitted through the hyperchromatic lens, such that light rays from multiple object planes in the microcapillary tube viewing area simultaneously focus on the at least one detector.
摘要翻译： 用于观察感兴趣对象的光学断层摄影系统包括用于将感兴趣对象定位在包括检测器的光路中的微毛细管观察区域。 马达位于附着和转动微毛细管。 设置有将波长在550nm和620nm之间的宽带光发送到微毛细管观察区域中的装置。 定位多色透镜以接收透过微毛细管观察区域的光。 管透镜被定位成聚焦穿过多色透镜的光线，使得来自微毛细管观察区域中的多个物平面的光线同时聚焦在至少一个检测器上。
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公开(公告)号：US07907765B2
公开(公告)日：2011-03-15
申请号：US11532648
申请日：2006-09-18
申请人： Mark E. Fauver , Eric J. Seibel , Michael G. Meyer , Alan C. Nelson , J. Richard Rahn , Thomas Neumann , Roger H. Johnson
发明人： Mark E. Fauver , Eric J. Seibel , Michael G. Meyer , Alan C. Nelson , J. Richard Rahn , Thomas Neumann , Roger H. Johnson
IPC分类号： G06K9/00
CPC分类号： G01N21/4795 , G01N15/147 , G01N15/1475
摘要： An optical tomography system for imaging an object of interest including a light source for illuminating the object of interest with a plurality of radiation beams. The object of interest is held within an object containing tube such that it is illuminated by the plurality of radiation beams to produce emerging radiation from the object containing tube, a detector array is located to receive the emerging radiation and produce imaging data used by a mechanism for tracking the object of interest.
摘要翻译： 一种光学断层摄影系统，用于对感兴趣的物体成像，包括用多个辐射束照射感兴趣物体的光源。 感兴趣的物体被保持在物体容纳管内，使得其被多个辐射束照射以产生来自物体容纳管的出射辐射，检测器阵列被定位成接收新出现的辐射并产生由机构使用的成像数据 用于跟踪感兴趣的对象。
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公开(公告)号：US20100322494A1
公开(公告)日：2010-12-23
申请号：US11532648
申请日：2006-09-18
申请人： Mark E. Fauver , Eric J. Seibel , Michael G. Meyer , Alan C. Nelson , J. Richard Rahn , Thomas Neumann , Roger H. Johnson
发明人： Mark E. Fauver , Eric J. Seibel , Michael G. Meyer , Alan C. Nelson , J. Richard Rahn , Thomas Neumann , Roger H. Johnson
IPC分类号： G06K9/00
CPC分类号： G01N21/4795 , G01N15/147 , G01N15/1475
摘要： An optical tomography system for imaging an object of interest including a light source for illuminating the object of interest with a plurality of radiation beams. The object of interest is held within an object containing tube such that it is illuminated by the plurality of radiation beams to produce emerging radiation from the object containing tube, a detector array is located to receive the emerging radiation and produce imaging data used by a mechanism for tracking the object of interest.
摘要翻译： 一种光学断层摄影系统，用于对感兴趣的物体成像，包括用多个辐射束照射感兴趣物体的光源。 感兴趣的物体被保持在物体容纳管内，使得其被多个辐射束照射以产生来自物体容纳管的出射辐射，检测器阵列被定位成接收新出现的辐射并产生由机构使用的成像数据 用于跟踪感兴趣的对象。
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9.发明授权Method for image processing and reconstruction of images for optical tomography 有权用于光学层析成像的图像处理和重建方法公开(公告)号：US07835561B2
公开(公告)日：2010-11-16
申请号：US11750924
申请日：2007-05-18
CPC分类号： G06T11/005
摘要： A method for reconstructing three-dimensional (3D) tomographic images. A set of pseudo-projection images of an object is acquired. Error corrections are applied to the set of pseudo-projection images to produce a set of corrected pseudo-projection images. The set of corrected pseudo-projection images are processed to produce (3D) tomographic images.
摘要翻译： 一种重建三维（3D）断层图像的方法。 获取对象的一组伪投影图像。 误差校正被应用于伪投影图像集合以产生一组校正的伪投影图像。 处理该组校正的伪投影图像以产生（3D）断层图像。
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公开(公告)号：US08368035B2
公开(公告)日：2013-02-05
申请号：US13402149
申请日：2012-02-22
IPC分类号： G01N21/64
CPC分类号： G01N21/4795 , G01N15/1436 , G01N2015/1445 , G01N2021/1787 , G06T11/006
摘要： A method for 3D imaging of cells in an optical tomography system includes moving a biological object relatively to a microscope objective to present varying angles of view. The biological object is illuminated with radiation having a spectral bandwidth limited to wavelengths between 150 nm and 390 nm. Radiation transmitted through the biological object and the microscope objective is sensed with a camera from a plurality of differing view angles. A plurality of pseudoprojections of the biological object from the sensed radiation is formed and the plurality of pseudoprojections is reconstructed to form a 3D image of the cell.
摘要翻译： 用于光学断层摄影系统中的细胞的3D成像的方法包括相对于显微镜物镜移动生物体以呈现不同的视角。 用具有限制在150nm和390nm之间的波长的光谱带宽的辐射照射该生物物体。 利用摄像机从多个不同的视角检测透过生物物体和显微镜物镜的辐射。 形成来自感测辐射的生物物体的多个伪投影，并重建多个伪投影以形成该细胞的3D图像。
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