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公开(公告)号：US08165684B2
公开(公告)日：2012-04-24
申请号：US12184663
申请日：2008-08-01
申请人： David A. Putz , Bharat S. Joshi , Bruce Lanning , James A. Nolan , Gregory J. Nuebel , Dennis D. Spencer , Hitten P. Zaveri
发明人： David A. Putz , Bharat S. Joshi , Bruce Lanning , James A. Nolan , Gregory J. Nuebel , Dennis D. Spencer , Hitten P. Zaveri
CPC分类号： A61B5/0476 , A61B5/0017 , A61B5/4094
摘要： A wireless system for monitoring a patient's brain tissue including (1) a plurality of electrodes abutting brain tissue, (2) main circuitry outside the patient's body to transmit power at radio frequencies and send/receive data using infrared energy, and (3) subcutaneously-implanted remote circuitry connected to the electrodes and configured to (a) receive transmitted RF power, (b) capture and digitize EEG signals from the electrodes, and (c) send/receive data to/from the main circuitry using IR energy, including sending digitized EEG signals from each electrode to capture the full bandwidth of each EEG signal. The system preferably includes circuitry to measure the electrical impedance of each electrode for real-time monitoring of the condition of the electrode/tissue interfaces to enhance interpretation of captured EEG signals.
摘要翻译： 一种用于监测患者脑组织的无线系统，包括：（1）与脑组织邻接的多个电极，（2）患者身体外部的主电路，以射频发射功率，并使用红外能量发送/接收数据，以及（3）皮下 连接到电极并被配置为（a）接收传输的RF功率，（b）从电极捕获和数字化EEG信号的移植远程电路，以及（c）使用IR能量向/从主电路发送/接收数据，包括 从每个电极发送数字化的EEG信号，以捕获每个脑电信号的全部带宽。 该系统优选地包括用于测量每个电极的电阻抗的电路，用于实时监测电极/组织界面的状况，以增强捕获的EEG信号的解释。
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2.发明授权
公开(公告)号：US5404877A
公开(公告)日：1995-04-11
申请号：US72570
申请日：1993-06-04
IPC分类号： A61B5/00 , A61B5/0464 , A61B5/0205
CPC分类号： A61B5/0006 , A61B5/0464 , A61B5/7207
摘要： A leadless implantable cardiac arrhythmia alarm is disclosed which continuously assesses a patient's heart function to discriminate between normal and abnormal heart functioning and, upon detecting an abnormal condition, generates a patient-warning signal. The alarm is capable of sensing impedance measurements of heart, respiratory and patient motion and, from these measurements, generating an alarm signal when the measurements indicate the occurrence of a cardiac arrhythmia. Because it requires no external leads or feedthrough connectors, the hermetically-sealed patient alarm is minimally invasive and results in reduced trauma to a patient.
摘要翻译： 公开了一种无引力植入式心律失常报警器，其连续评估患者的心脏功能以区分正常和异常心脏功能，并且在检测到异常状况时产生患者警告信号。 该报警器能够感测心脏，呼吸和患者运动的阻抗测量，并且在这些测量中，当测量显示心律失常的发生时产生报警信号。 因为它不需要外部引线或馈通连接器，所以密封的患者警报器是微创的，并且导致对患者的创伤减少。
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3.发明授权Minute volume rate-responsive pacemaker employing impedance sensing on a unipolar lead 失效在单极引线上采用阻抗感测的分钟体积响应起搏器
公开(公告)号：US5201808A
公开(公告)日：1993-04-13
申请号：US833435
申请日：1992-02-10
IPC分类号： A61N1/365
CPC分类号： A61N1/36521
摘要： A rate-responsive pacemaker employing a rate control parameter of respiratory minute volume, derived over a unipolar lead. The pacemaker performs the minute volume measurement by periodically applying a measuring current between the lead and a reference point on the pacemaker case. This measuring current has frequency components in a range from approximately 10 kilohertz to 1000 megahertz. Application of this measuring current allows the pacemaker to detect the voltage which arises from the applied current and, from the detected voltage, to measure the patient's spatial impedance. Spatial impedance and minute volume vary as a function of the patient's pleural pressure. The pacemaker derives minute volume and rate-responsive pacing rate from the spatial impedance measurement.
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公开(公告)号：US4907449A
公开(公告)日：1990-03-13
申请号：US926361
申请日：1986-10-31
申请人： David B. Call , James A. Nolan , Steven J. Lassman
发明人： David B. Call , James A. Nolan , Steven J. Lassman
CPC分类号： G01W1/08 , G01L9/0072 , G01L9/125
摘要： A radiosonde has a novel and improved measuring circuitry for measuring atmospheric conditions, such as, temperature, humidity and pressure through the direct conversion of resistance and capacitance values into binary numbers. The binary numbers are transmitted in digital form along with calibration coefficients to a remote ground station. The measuring circuitry can be mounted on the same substrate with the pressure transducer, and the electrical connections between the pressure transducer and measuring circuitry are simplified by utilization of an offset diaphragm, pressure cell arrangement.
摘要翻译： 无线电探空仪具有新颖和改进的测量电路，用于通过将电阻和电容值直接转换成二进制数来测量大气条件，例如温度，湿度和压力。 二进制数字与校准系数一起以数字形式发送到远程地面站。 测量电路可以使用压力传感器安装在同一个基板上，压力传感器和测量电路之间的电气连接可以通过利用偏移膜片，压力单元布置来简化。
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公开(公告)号：US20140296732A1
公开(公告)日：2014-10-02
申请号：US14279882
申请日：2014-05-16
IPC分类号： A61B5/00 , A61B5/0478
CPC分类号： A61B5/6814 , A61B5/0006 , A61B5/0017 , A61B5/0031 , A61B5/0476 , A61B5/0478 , A61B5/4094 , A61B5/6803 , A61B2560/045
摘要： A wireless system for brain monitoring/mapping of neurological-disorder patients includes a plurality of electrodes each configured for surface abutment of brain tissue and main circuitry for placement outside a body of a patient and configured to transmit power at radio frequencies and send and receive data using infrared energy. Remote circuitry is provided for subcutaneous implantation in a head of the patient. The remote circuitry is connected to the plurality of electrodes and includes a multiplexer sampling signals from the plurality of electrodes. The multiplexer outputs electrode signals to an amplifier and A/D converter for transmission to the main circuitry. The remote circuitry is configured to (a) receive transmitted power at radio frequencies from the main circuitry, (b) capture and digitize full-bandwidth EEG signals from each of the electrodes, and (c) send data to and receive data from the main circuitry using infrared energy.
摘要翻译： 用于神经障碍患者的脑监测/映射的无线系统包括多个电极，每个电极被配置用于脑组织的表面邻接和用于放置在患者体外的主电路，并且被配置为以射频发射功率并发送和接收数据 使用红外能量。 提供远程电路用于皮下植入患者的头部。 远程电路连接到多个电极，并且包括来自多个电极的多路复用器采样信号。 多路复用器将电极信号输出到放大器和A / D转换器，以传输到主电路。 远程电路被配置为（a）从主电路以无线电频率接收发射功率，（b）从每个电极捕获并数字化全带宽EEG信号，以及（c）向主机发送数据并从主接收数据 使用红外能量的电路。
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公开(公告)号：US20120238855A1
公开(公告)日：2012-09-20
申请号：US13429109
申请日：2012-03-23
IPC分类号： A61B5/0478
CPC分类号： A61B5/6814 , A61B5/0006 , A61B5/0017 , A61B5/0031 , A61B5/0476 , A61B5/0478 , A61B5/4094 , A61B5/6803 , A61B2560/045
摘要： A wireless system for brain monitoring/mapping of neurological-disorder patients includes a plurality of electrodes each configured for surface abutment of brain tissue and main circuitry for placement outside a body of a patient and configured to transmit power at radio frequencies and send and receive data using infrared energy. Remote circuitry is provided for subcutaneous implantation in a head of the patient. The remote circuitry is connected to the plurality of electrodes and includes a multiplexer sampling signals from the plurality of electrodes. The multiplexer outputs electrode signals to an amplifier and A/D converter for transmission to the main circuitry. The remote circuitry is configured to (a) receive transmitted power at radio frequencies from the main circuitry, (b) capture and digitize full-bandwidth EEG signals from each of the electrodes, and (c) send data to and receive data from the main circuitry using infrared energy.
摘要翻译： 用于神经障碍患者的脑监测/映射的无线系统包括多个电极，每个电极被配置用于脑组织的表面邻接和用于放置在患者体外的主电路，并且被配置为以射频发射功率并发送和接收数据 使用红外能量。 提供远程电路用于皮下植入患者的头部。 远程电路连接到多个电极，并且包括来自多个电极的多路复用器采样信号。 多路复用器将电极信号输出到放大器和A / D转换器，以传输到主电路。 远程电路被配置为（a）从主电路以无线电频率接收发射功率，（b）从每个电极捕获并数字化全带宽EEG信号，以及（c）向主机发送数据并从主接收数据 使用红外能量的电路。
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公开(公告)号：US5197467A
公开(公告)日：1993-03-30
申请号：US902242
申请日：1992-06-22
IPC分类号： A61N1/365
CPC分类号： A61N1/36521
摘要： A metabolic demand rate-responsive cardiac stimulation apparatus and method are disclosed which employ multiple physiological rate control parameters, such as respiratory minute volume, patient motion and cardiac stroke volume. The parameters are derived using a single standard pacing lead or transducer. The apparatus and method perform each physiological measurement by periodically applying a measuring current between two points within the apparatus. This measuring current has frequency components in a range of from approximately 10 kilohertz to 1000 megahertz. Application of this measuring current allows the apparatus to detect the voltage which arises from the applied current and, from the detected voltage, to measure the patient's spatial impedance. For a particular measurement, the apparatus controls which physiological parameter is sensed by regulating the frequency content of the measuring current. The apparatus analyzes the physiological parameters to determine the best pacing rate in terms of characteristics such as response time and stability.
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公开(公告)号：US20090149913A1
公开(公告)日：2009-06-11
申请号：US12184663
申请日：2008-08-01
申请人： David A. Putz , Bharat S. Joshi , Bruce Lanning , James A. Nolan , Gregory J. Nuebel , Dennis D. Spencer , Hitten P. Zaveri
发明人： David A. Putz , Bharat S. Joshi , Bruce Lanning , James A. Nolan , Gregory J. Nuebel , Dennis D. Spencer , Hitten P. Zaveri
IPC分类号： A61N1/36 , A61B5/0476 , A61B5/053
CPC分类号： A61B5/0476 , A61B5/0017 , A61B5/4094
摘要： A wireless system for monitoring a patient's brain tissue including (1) a plurality of electrodes abutting brain tissue, (2) main circuitry outside the patient's body to transmit power at radio frequencies and send/receive data using infrared energy, and (3) subcutaneously-implanted remote circuitry connected to the electrodes and configured to (a) receive transmitted RF power, (b) capture and digitize EEG signals from the electrodes, and (c) send/receive data to/from the main circuitry using IR energy, including sending digitized EEG signals from each electrode to capture the full bandwidth of each EEG signal. The system preferably includes circuitry to measure the electrical impedance of each electrode for real-time monitoring of the condition of the electrode/tissue interfaces to enhance interpretation of captured EEG signals.
摘要翻译： 一种用于监测患者脑组织的无线系统，包括：（1）与脑组织邻接的多个电极，（2）患者身体外部的主电路，以射频发射功率，并使用红外能量发送/接收数据，以及（3）皮下 连接到电极并被配置为（a）接收传输的RF功率，（b）从电极捕获和数字化EEG信号的移植远程电路，以及（c）使用IR能量向/从主电路发送/接收数据，包括 从每个电极发送数字化的EEG信号，以捕获每个脑电信号的全部带宽。 该系统优选地包括用于测量每个电极的电阻抗的电路，用于实时监测电极/组织界面的状况，以增强捕获的EEG信号的解释。
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公开(公告)号：US08738139B2
公开(公告)日：2014-05-27
申请号：US13429109
申请日：2012-03-23
CPC分类号： A61B5/6814 , A61B5/0006 , A61B5/0017 , A61B5/0031 , A61B5/0476 , A61B5/0478 , A61B5/4094 , A61B5/6803 , A61B2560/045
摘要： A wireless system for brain monitoring/mapping of neurological-disorder patients includes a plurality of electrodes each configured for surface abutment of brain tissue and main circuitry for placement outside a body of a patient and configured to transmit power at radio frequencies and send and receive data using infrared energy. Remote circuitry is provided for subcutaneous implantation in a head of the patient. The remote circuitry is connected to the plurality of electrodes and includes a multiplexer sampling signals from the plurality of electrodes. The multiplexer outputs electrode signals to an amplifier and A/D converter for transmission to the main circuitry. The remote circuitry is configured to (a) receive transmitted power at radio frequencies from the main circuitry, (b) capture and digitize full-bandwidth EEG signals from each of the electrodes, and (c) send data to and receive data from the main circuitry using infrared energy.
摘要翻译： 用于神经障碍患者的脑监测/映射的无线系统包括多个电极，每个电极被配置用于脑组织的表面邻接和用于放置在患者体外的主电路，并且被配置为以射频发射功率并发送和接收数据 使用红外能量。 提供远程电路用于皮下植入患者的头部。 远程电路连接到多个电极，并且包括来自多个电极的多路复用器采样信号。 多路复用器将电极信号输出到放大器和A / D转换器，以传输到主电路。 远程电路被配置为（a）从主电路以无线电频率接收发射功率，（b）从每个电极捕获并数字化全带宽EEG信号，以及（c）向主机发送数据并从主接收数据 使用红外能量的电路。
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10.发明授权Time domain reflectometer impedance sensor method of use and implantable cardiac stimulator using same 失效时域反射计阻抗传感器的使用方法和可植入式心脏刺激器的使用方法
公开(公告)号：US5361776A
公开(公告)日：1994-11-08
申请号：US104382
申请日：1993-08-06
CPC分类号： A61B5/0538 , A61B5/0535 , A61N1/372 , A61N1/375 , A61N1/3931 , A61N2001/083
摘要： A time domain reflectometry (TDR) impedance sensor is provided for measuring body impedance along a lead or catheter implanted in a patient's cardiovascular system. The TDR sensor applies an electrical stimulus to the lead and measures reflections echoed from impedance variations along and distal to the lead, which are superimposed on the applied stimulus. The measured signals may be analyzed with respect to time-of-flight and distance along the lead to detect a plurality of physiologically meaningful signals.
摘要翻译： 提供了时域反射（TDR）阻抗传感器，用于沿植入患者心血管系统的导联或导管测量身体阻抗。 TDR传感器对引线施加电刺激，并测量从引线的沿着和远端的阻抗变化回波的反射，其叠加在施加的刺激上。 可以相对于飞行时间和沿着引线的距离来分析测量的信号，以检测多个生理上有意义的信号。
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