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1.发明授权公开(公告)号：US08354261B2
公开(公告)日：2013-01-15
申请号：US13174479
申请日：2011-06-30
申请人： Oscar Alvizo , Mike Benoit , Irene Fusman , Jack Liang , Luan Nguyen , Scott Novick
发明人： Oscar Alvizo , Mike Benoit , Irene Fusman , Jack Liang , Luan Nguyen , Scott Novick
CPC分类号： C12Y402/01001 , C12N9/88
摘要： The present disclosure relates to β-class carbonic anhydrase polypeptides having improved properties including increased thermostability and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides formulations and uses of the polypeptides for accelerating the absorption of carbon dioxide from a gas stream into a solution as well as for the release of the absorbed carbon dioxide for further treatment and/or sequestering. Also provided are polynucleotides encoding the carbonic anhydrase polypeptides and host cells capable of expressing them.
摘要翻译： 本公开涉及具有改进性质的碳酸酐酶多肽类，包括在胺化合物，氨或碳酸根离子存在下增加的热稳定性和/或稳定性。 本公开还提供了多肽的制剂和用途，用于加速二氧化碳从气流吸收到溶液中以及释放吸收的二氧化碳用于进一步处理和/或螯合。 还提供了编码碳酸酐酶多肽和能够表达它们的宿主细胞的多核苷酸。
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2.发明授权Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine 有权用于合成（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的生物催化剂和方法公开(公告)号：US08932836B2
公开(公告)日：2015-01-13
申请号：US13817295
申请日：2011-08-08
申请人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
发明人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
CPC分类号： C12P13/001 , C12N9/1096
摘要： The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
摘要翻译： 本公开提供能够将底物2-（3,4-二甲氧基苯乙氧基）环己酮转化成至少2:1非对映异构体的反式非对映异构体产物（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的转氨酶多肽 比例相对于顺式非对映体（1R，2S）-2-（3,4-二甲氧基苯乙氧基）环己胺。 本公开还提供了多核苷酸，载体，宿主细胞，以及在制备（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺及其类似物的方法中制备和使用转氨酶多肽的方法，产物化合物可以是 进一步用于制备作为离子通道阻断剂的氨基环己基醚化合物（3R）-1 - [（1R，2R）-2- [2-（3,4-二甲氧基苯基）乙氧基]环己基]吡咯烷-3-醇。
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3.发明申请BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXAMINE 有权（1R，2R）-2-（3,4-二甲氧基苯基）环己基胺的合成的生物化学和方法公开(公告)号：US20130164794A1
公开(公告)日：2013-06-27
申请号：US13817295
申请日：2011-08-08
申请人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien L. Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
发明人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien L. Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
IPC分类号： C12N9/10
CPC分类号： C12P13/001 , C12N9/1096
摘要： The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
摘要翻译： 本公开提供能够将底物2-（3,4-二甲氧基苯乙氧基）环己酮转化成至少2:1非对映异构体的反式非对映异构体产物（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的转氨酶多肽 比例相对于顺式非对映体（1R，2S）-2-（3,4-二甲氧基苯乙氧基）环己胺。 本公开还提供了多核苷酸，载体，宿主细胞，以及在制备（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺及其类似物的方法中制备和使用转氨酶多肽的方法，产物化合物可以是 进一步用于制备作为离子通道阻断剂的氨基环己基醚化合物（3R）-1 - [（1R，2R）-2- [2-（3,4-二甲氧基苯基）乙氧基]环己基]吡咯烷-3-醇。
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公开(公告)号：US08748143B2
公开(公告)日：2014-06-10
申请号：US12210195
申请日：2008-09-13
申请人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
发明人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
CPC分类号： C12N9/0006 , C12P7/22 , C12Y101/01 , C12Y101/01184 , Y02E50/17 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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5.发明授权公开(公告)号：US08962285B2
公开(公告)日：2015-02-24
申请号：US13525048
申请日：2012-06-15
申请人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Rama Voladri , James LaLonde , Gjalt W. Huisman
发明人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Rama Voladri , James LaLonde , Gjalt W. Huisman
CPC分类号： C12P17/00 , C12N9/0006 , C12P17/167 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成手性化合物的方法。
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6.发明授权Stereomerically pure fused bicyclic proline compounds useful for preparing hepatitis C protease inhibitors 有权用于制备丙型肝炎蛋白酶抑制剂的立体异构纯合并双环脯氨酸化合物公开(公告)号：US08859784B2
公开(公告)日：2014-10-14
申请号：US13294930
申请日：2011-11-11
申请人： Jack Liang , James Lalonde , Jun Zhu , John M. Gruber , John D. Munger, Jr.
发明人： Jack Liang , James Lalonde , Jun Zhu , John M. Gruber , John D. Munger, Jr.
IPC分类号： C07D209/02 , C07D403/04 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/18
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译： 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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7.发明申请Substantially Stereomerically Pure Fused Bicyclic Proline Compounds and Processes for Preparing Boceprevir 审中-公开基本上独立的纯熔融双环脯氨酸化合物和制备波普瑞韦的方法公开(公告)号：US20120289709A1
公开(公告)日：2012-11-15
申请号：US13465735
申请日：2012-05-07
申请人： James Lalonde , Tao Li , Jack Liang , Benjamin Mijts , Roger Sheldon , George S.K. Wong , Aleksey Zaks
发明人： James Lalonde , Tao Li , Jack Liang , Benjamin Mijts , Roger Sheldon , George S.K. Wong , Aleksey Zaks
IPC分类号： C07D209/52
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译： 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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8.发明授权Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds 有权用于制备基本上立体异构纯的稠合双环脯氨酸化合物的生物催化方法公开(公告)号：US08178333B2
公开(公告)日：2012-05-15
申请号：US12490190
申请日：2009-06-23
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein.
摘要翻译： 本公开内容提供单胺氧化酶及其在生物催化方法中用于制备基本上对映异构体纯的以下结构式的杂双环化合物的方法，其中A，M，M'和R 5如本文所述。
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9.发明申请公开(公告)号：US20090093031A1
公开(公告)日：2009-04-09
申请号：US12197286
申请日：2008-08-24
申请人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Rama Voladri , James Lalonde , Gjalt W. Huisman
发明人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Rama Voladri , James Lalonde , Gjalt W. Huisman
CPC分类号： C12P17/00 , C12N9/0006 , C12P17/167 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成手性化合物的方法。
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10.发明授权Method for forming a film over a spin-on-glass layer by means of plasma-enhanced chemical-vapor deposition 失效通过等离子体增强化学气相沉积在旋涂玻璃层上形成膜的方法
公开(公告)号：US5792702A
公开(公告)日：1998-08-11
申请号：US770170
申请日：1996-12-19
申请人： Jack Liang
发明人： Jack Liang
IPC分类号： H01L21/3105 , H01L21/316
CPC分类号： H01L21/02112 , H01L21/02126 , H01L21/02274 , H01L21/02282 , H01L21/02337 , H01L21/3105 , H01L21/31608
摘要： A method for forming an oxide film over a spin-on-glass (SOG) layer by a plasma-enhanced chemical-vapor deposition (PECVD) is disclosed. The SOG layer is pre-processed in a forming gas of hydrogen and nitrogen in a PECVD chamber. Then the oxide film is formed over the SOG layer by means of the PECVD process in the PECVD chamber.
摘要翻译： 公开了通过等离子体增强化学气相沉积（PECVD）在旋涂玻璃（SOG）层上形成氧化膜的方法。 在PECVD室中，在氢气和氮气的形成气体中预处理SOG层。 然后通过PECVD室中的PECVD工艺在SOG层上形成氧化膜。
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