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公开(公告)号：US08859284B2
公开(公告)日：2014-10-14
申请号：US13679335
申请日：2012-11-16
申请人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman , Kimihiro Susumu , Michael H. Stewart , Ryan Walters
发明人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman , Kimihiro Susumu , Michael H. Stewart , Ryan Walters
IPC分类号： C12N5/00 , A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61K47/20 , C12Q1/02 , B82Y5/00 , A61K47/48 , A61K49/00 , G01N33/50
CPC分类号： A61K47/20 , A61K47/48192 , A61K47/4823 , A61K47/48238 , A61K47/48861 , A61K47/48884 , A61K47/59 , A61K47/61 , A61K47/62 , A61K47/6923 , A61K47/6929 , A61K49/0067 , B82Y5/00 , C12Q1/02 , G01N33/5058
摘要： A peptide attached to a nanoparticles (such as quantum dots) selectively directs the nanoparticles to neurons in a tissue or organism.
摘要翻译： 连接到纳米颗粒（例如量子点）的肽选择性地将纳米颗粒引导到组织或生物体中的神经元。
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公开(公告)号：US09791368B2
公开(公告)日：2017-10-17
申请号：US14207927
申请日：2014-03-13
IPC分类号： G01N33/551 , G01N21/552 , G01N33/543 , G01N21/64 , G01N21/59 , G01N21/27
CPC分类号： G01N21/554 , G01N21/274 , G01N21/59 , G01N21/6458 , G01N21/648 , G01N33/54373 , G01N2021/6491
摘要： A label-free method for the spatio-temporal mapping of protein secretions from individual cells in real time by using a chip for localized surface plasmon resonance (LSPR) imaging. The chip is a glass coverslip compatible for use in a standard microscope having at least one array of functionalized plasmonic nanostructures patterned onto it. After placing a cell on the chip, the secretions from the cell are spatially and temporally mapped using LSPR imaging. Transmitted light imaging and/or fluorescence imaging may be done simultaneously with the LSPR imaging.
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3.发明申请公开(公告)号：US20130158244A1
公开(公告)日：2013-06-20
申请号：US13774493
申请日：2013-02-22
申请人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
发明人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
IPC分类号： C07H21/04
CPC分类号： C07H21/04 , A61K47/6921 , A61K49/0093 , B82Y5/00 , C07H19/00
摘要： Described are nucleic acids encoding a polypeptide for delivery of a nanoparticle to the cytosol, the peptide comprising: (a) a nanoparticle association domain, (b) a spacer domain, (c) an uptake domain, and (d) a vesicle escape domain, wherein the domains (a) through (d) appear in the same order as listed above, and wherein the peptide, upon addition of a non-hydrolyzable lipophilic moiety to the vesicle escape domain and binding to a nanoparticle, is effective to induce uptake of a nanoparticle by a cell and delivery of the nanoparticle to the cytosol of the cell. Also described are methods of delivery of a nanoparticle to the cytosol of a cell, the method comprising providing to a cell a nanoparticle attached to such a peptide. Exemplary nanoparticles include quantum dots.
摘要翻译： 描述了编码用于将纳米颗粒递送到细胞溶质的多肽的核酸，所述肽包含：（a）纳米颗粒缔合结构域，（b）间隔区，（c）摄取结构域，和（d）囊泡逸出结构域 ，其中所述结构域（a）至（d）以与上述相同的顺序出现，并且其中所述肽在向囊泡逸出结构域加入不可水解的亲脂性部分并与纳米颗粒结合时有效诱导摄取 的纳米颗粒，并将纳米颗粒递送到细胞的胞质溶胶。 还描述了将纳米颗粒递送到细胞的细胞溶质的方法，该方法包括向细胞提供与这种肽连接的纳米颗粒。 示例性纳米颗粒包括量子点。
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4.发明授权公开(公告)号：US08409858B2
公开(公告)日：2013-04-02
申请号：US12908601
申请日：2010-10-20
申请人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
发明人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
CPC分类号： C07H21/04 , A61K47/6921 , A61K49/0093 , B82Y5/00 , C07H19/00
摘要： Described are peptides for delivery of a nanoparticle to the cytosol, the peptide comprising: (a) a nanoparticle association domain; (b) a proline-rich spacer domain; (c) an uptake domain; and (d) a vesicle escape domain comprising a non-hydrolyzable lipid moiety, wherein the spacer domain is between the nanoparticle association domain and the uptake and vesicle escape domains, and wherein the peptide, when attached to an extracellular nanoparticle, is effective to induce uptake of the nanoparticle by a cell and delivery of the nanoparticle to the cytosol of the cell. Also described are methods of delivery of a nanoparticle to the cytosol of a cell, the method comprising providing to a cell a nanoparticle attached to such a peptide. Exemplary nanoparticles include quantum dots.
摘要翻译： 描述了用于将纳米颗粒递送到细胞溶质的肽，所述肽包含：（a）纳米颗粒缔合结构域; （b）富含脯氨酸的间隔区; （c）摄取域; 和（d）包含不可水解脂质部分的囊泡逃逸结构域，其中所述间隔区位于纳米颗粒缔合结构域和吸收和囊泡逸出结构域之间，并且其中所述肽在附着于细胞外纳米颗粒时有效诱导 通过细胞摄取纳米颗粒并将纳米颗粒递送到细胞的胞质溶胶。 还描述了将纳米颗粒递送到细胞的细胞溶质的方法，该方法包括向细胞提供与这种肽连接的纳米颗粒。 示例性纳米颗粒包括量子点。
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5.发明授权Binding interaction of proanthocyanidins with bacteria and bacterial components 有权原花青素与细菌和细菌成分的结合相互作用公开(公告)号：US09040250B2
公开(公告)日：2015-05-26
申请号：US11832852
申请日：2007-08-02
IPC分类号： G01N33/554 , C07C53/00 , C07H21/00 , C12M1/00 , C07K14/00 , A61K31/353 , C07D311/62 , G01N33/569
CPC分类号： A61K31/353 , A61K47/55 , A61K47/552 , C07D311/62 , C07H1/00 , C07H21/04 , G01N33/56911 , G01N2333/415 , G01N2400/50
摘要： A composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6. A method of administering to an immunosuppressed patient or a patient diagnosed with sepsis or septic shock a composition having a proanthocyanidin. A method of administering to a patient diagnosed with a gram negative bacterial infection a composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6.
摘要翻译： 具有至少约6的平均聚合度的原花青素化合物的组合物。向免疫抑制患者或诊断为败血症或败血性休克的患者施用具有原花色素的组合物的方法。 向诊断为革兰氏阴性细菌感染的患者施用具有平均聚合度至少约6的原花青素化合物的组合物的方法。
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公开(公告)号：US08835172B2
公开(公告)日：2014-09-16
申请号：US13621880
申请日：2012-09-18
申请人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
发明人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
IPC分类号： C12N5/00 , C12N5/02 , A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61K49/00 , G01N33/58 , C07K17/14 , B82Y5/00
CPC分类号： C12N5/0006 , A61K49/0054 , A61K49/0056 , A61K49/0067 , B82Y5/00 , B82Y15/00 , C07K17/14 , G01N33/588
摘要： A peptide directs nanoparticles (such as quantum dots) to the plasma membrane of mammalian cells. A method of delivery of a nanoparticle to a plasma membrane of a cell includes providing to the cell a nanoparticle attached to a peptide configured to direct the nanoparticle the plasma membrane, and allowing the cell to take up the nanoparticle. The nanoparticle can be a FRET donor to an organic dye.
摘要翻译： 肽将纳米颗粒（例如量子点）引导到哺乳动物细胞的质膜。 将纳米颗粒递送到细胞的质膜的方法包括向细胞提供与配置成将纳米颗粒引导质膜的肽结合的纳米颗粒，并允许细胞吸收纳米颗粒。 纳米颗粒可以是有机染料的FRET供体。
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7.发明授权公开(公告)号：US08796435B2
公开(公告)日：2014-08-05
申请号：US13774493
申请日：2013-02-22
申请人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
发明人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
CPC分类号： C07H21/04 , A61K47/6921 , A61K49/0093 , B82Y5/00 , C07H19/00
摘要： Described are nucleic acids encoding a polypeptide for delivery of a nanoparticle to the cytosol, the peptide comprising: (a) a nanoparticle association domain, (b) a spacer domain, (c) an uptake domain, and (d) a vesicle escape domain, wherein the domains (a) through (d) appear in the same order as listed above, and wherein the peptide, upon addition of a non-hydrolyzable lipophilic moiety to the vesicle escape domain and binding to a nanoparticle, is effective to induce uptake of a nanoparticle by a cell and delivery of the nanoparticle to the cytosol of the cell. Also described are methods of delivery of a nanoparticle to the cytosol of a cell, the method comprising providing to a cell a nanoparticle attached to such a peptide. Exemplary nanoparticles include quantum dots.
摘要翻译： 描述了编码用于将纳米颗粒递送到细胞溶质的多肽的核酸，所述肽包含：（a）纳米颗粒缔合结构域，（b）间隔区，（c）摄取结构域，和（d）囊泡逸出结构域 ，其中所述结构域（a）至（d）以与上述相同的顺序出现，并且其中所述肽在向囊泡逸出结构域加入不可水解的亲脂性部分并与纳米颗粒结合时有效诱导摄取 的纳米颗粒，并将纳米颗粒递送到细胞的胞质溶胶。 还描述了将纳米颗粒递送到细胞的细胞溶质的方法，该方法包括向细胞提供与这种肽连接的纳米颗粒。 示例性纳米颗粒包括量子点。
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8.发明申请METHOD OF USING A COBALT-AMINE BASED METAL COMPLEX AS AN ANTIVIRAL COMPOUND AND A METHOD FOR THE PREPARATION OF FUNCTIONALIZED ANALOGS THEREOF 审中-公开使用基于钴 - 胺的金属络合物作为抗病毒化合物的方法及其制备其官能化的类似物的方法公开(公告)号：US20080182835A1
公开(公告)日：2008-07-31
申请号：US11934424
申请日：2007-11-02
IPC分类号： A61K31/555 , C12N5/06 , C07H21/04 , A61P31/12
CPC分类号： A61K31/555
摘要： The present invention is generally directed to a method of prophylaxis against viral infection of a cell or subject or a method of treating a subject infected with a virus including administering an antiviral composition having the general Structure III, wherein each of R1, R2, R3, R4, R5 and R6 is the same or different and includes an N-based ligand donor atom selected from the group consisting of ammonia, primary amine or secondary amine, or salt thereof. The present invention is also generally directed to a method of preparing an antiviral agent including providing a cobalt pentammine salt having a non-amine coordination site and mono-substituting the non-amine coordination site with a functional group incorporating a strong coordinator atom to cobalt to form a CoHex structure of Structure III, in which R1 incorporates the functional group having the strong coordinator atom coordinated with the cobalt atom, or a salt thereof.
摘要翻译： 本发明一般涉及预防病毒感染细胞或受试者的方法或治疗感染病毒的受试者的方法，包括给予具有通用结构III的抗病毒组合物，其中R 1， R 3，R 3，R 3，R 4，R 5和R 6， / SUB>相同或不同，并且包括选自氨，伯胺或仲胺或其盐的基于N的配体供体原子。 本发明还通常涉及一种制备抗病毒剂的方法，其包括提供具有非胺配位位点的钴五胺盐，并将非胺配位位点单一取代与钴结合的强配位体原子的官能团与钴 形成结构III的CoHex结构，其中R 1含有与钴原子配位的强配位体原子的官能团或其盐。
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9.发明申请NANOSPLASMONIC IMAGING TECHNIQUE FOR THE SPATIO-TEMPORAL MAPPING OF SINGLE CELL SECRETIONS IN REAL TIME 有权用于实时单细胞分析的空间时间映射的纳米平面成像技术公开(公告)号：US20140273002A1
公开(公告)日：2014-09-18
申请号：US14207927
申请日：2014-03-13
IPC分类号： G01N33/569
CPC分类号： G01N21/554 , G01N21/274 , G01N21/59 , G01N21/6458 , G01N21/648 , G01N33/54373 , G01N2021/6491
摘要： A label-free method for the spatio-temporal mapping of protein secretions from individual cells in real time by using a chip for localized surface plasmon resonance (LSPR) imaging. The chip is a glass coverslip compatible for use in a standard microscope having at least one array of functionalized plasmonic nanostructures patterned onto it. After placing a cell on the chip, the secretions from the cell are spatially and temporally mapped using LSPR imaging. Transmitted light imaging and/or fluorescence imaging may be done simultaneously with the LSPR imaging.
摘要翻译： 通过使用用于局部表面等离子体共振（LSPR）成像的芯片实时地对来自各个细胞的蛋白质分泌物进行时空映射的无标记方法。 该芯片是一种玻璃盖玻片，适用于标准显微镜，具有至少一个图案化的功能化等离子体纳米结构阵列。 将细胞置于芯片上后，使用LSPR成像在空间和时间上映射来自细胞的分泌。 透射光成像和/或荧光成像可以与LSPR成像同时进行。
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10.发明授权Applications of the binding interaction of proanthocyanidins with bacteria and bacterial components 失效原花青素与细菌和细菌成分的结合相互作用的应用公开(公告)号：US08715949B2
公开(公告)日：2014-05-06
申请号：US11832834
申请日：2007-08-02
IPC分类号： G01N33/554 , C07C53/00 , C07H21/00 , C12M1/00 , C07K14/00
CPC分类号： A61K31/353 , A61K47/55 , A61K47/552 , C07D311/62 , C07H1/00 , C07H21/04 , G01N33/56911 , G01N2333/415 , G01N2400/50
摘要： A composition having: a proanthocyanidin; and a macromolecule, an assembly of macromolecules, a semi-solid, or a solid surface to which the proanthocyanidin is immobilized.
摘要翻译： 具有：原花色素的组合物 和大分子，固定有原花青素的大分子，半固体或固体表面的组合。
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