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公开(公告)号:US20100222873A1
公开(公告)日:2010-09-02
申请号:US12715577
申请日:2010-03-02
申请人: Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Amey , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
发明人: Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Amey , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
CPC分类号: A61L31/148 , A61L27/34 , A61L27/446 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2400/12 , A61L2420/04 , C08L67/04
摘要: A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.
摘要翻译: 医疗植入物包括生物腐蚀性部分,其包括生物可蚀解聚合物和生物腐蚀性金属。 生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。 生物腐蚀金属在生理条件下降解形成碱性降解产物。 酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。 在一个方面,生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。 在另一方面,医疗植入物可以包括主体,身体上的生物可蚀解聚合物的多个离散沉积物,以及身体上的生物可腐蚀金属的多个离散沉积物。
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公开(公告)号:US08267992B2
公开(公告)日:2012-09-18
申请号:US12715577
申请日:2010-03-02
申请人: Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Arney , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
发明人: Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Arney , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
IPC分类号: A61F2/06
CPC分类号: A61L31/148 , A61L27/34 , A61L27/446 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2400/12 , A61L2420/04 , C08L67/04
摘要: A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.
摘要翻译: 医疗植入物包括生物腐蚀性部分,其包括生物可蚀解聚合物和生物腐蚀性金属。 生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。 生物腐蚀金属在生理条件下降解形成碱性降解产物。 酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。 在一个方面,生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。 在另一方面,医疗植入物可以包括主体,身体上的生物可蚀解聚合物的多个离散沉积物,以及身体上的生物可腐蚀金属的多个离散沉积物。
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公开(公告)号:US20090118815A1
公开(公告)日:2009-05-07
申请号:US11934463
申请日:2007-11-02
IPC分类号: A61F2/06
CPC分类号: B05D1/12 , A61L31/08 , A61L31/146 , C23C24/04
摘要: Endoprosthesis includes coatings of selected porosity formed of particulates of ceramics, metals, drugs and/or polymers.
摘要翻译: 内置假体包括由陶瓷,金属,药物和/或聚合物颗粒形成的选定孔隙的涂层。
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公开(公告)号:US20100004733A1
公开(公告)日:2010-01-07
申请号:US12166507
申请日:2008-07-02
申请人: Liliana Atanasoska , Tom Holman , James Q. Feng , Robert W. Warner , Afsar Ali
发明人: Liliana Atanasoska , Tom Holman , James Q. Feng , Robert W. Warner , Afsar Ali
IPC分类号: A61F2/82
CPC分类号: A61F2/86 , A61F2/0077
摘要: An endoprosthesis includes a member having a surface that includes a fractal structure.
摘要翻译: 内假体包括具有包括分形结构的表面的构件。
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公开(公告)号:US08354120B2
公开(公告)日:2013-01-15
申请号:US12608534
申请日:2009-10-29
申请人: Jan Weber , Tom Holman , Tracee Eidenschink , John Jianhua Chen
发明人: Jan Weber , Tom Holman , Tracee Eidenschink , John Jianhua Chen
IPC分类号: A61F2/02
CPC分类号: A61K31/01 , A61F2/0077 , A61F2/02 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2250/0067 , A61K9/00 , A61K45/06 , A61L27/303 , A61L31/084
摘要: Methods, systems, and uses of bucky paper are provided in the present invention. These embodiments include covering medical implants with single or multiple layers of bucky paper, treating bucky paper with various therapeutics to be released through the bucky paper to a target site, shaping bucky paper into non-conventional configurations for improved therapeutic deliver, and using bucky paper alone or in conjunction with other materials to treat a target site.
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公开(公告)号:US08550985B2
公开(公告)日:2013-10-08
申请号:US11011454
申请日:2004-12-14
申请人: Jan Weber , Tom Holman
发明人: Jan Weber , Tom Holman
CPC分类号: A61M25/0009 , A61M25/1027 , A61M2025/006 , A61M2025/0062 , A61M2025/09108 , A61M2025/09133 , A61M2025/1031
摘要: Medical devices have material that that has a laser induced periodic surface structure (LIPSS) pattern on at least a portion thereof. The LIPSS pattern is provided by exposing a material surface to a pulsed polarized laser energy fluence below the ablation threshold. The LIPSS pattern is useful for purposes such as reducing contact areas on sliding surfaces, increasing total surface area for adhesions, providing anisotropic reinforcement of a material layer or layers, and to provide multiple channels for directing cell growth.
摘要翻译: 医疗器械具有在其至少一部分上具有激光诱发的周期性表面结构(LIPSS)图案的材料。 通过将材料表面暴露于低于消融阈值的脉冲偏振激光能量通量来提供LIPSS图案。 LIPSS图案可用于减少滑动表面上的接触面积,增加用于粘连的总表面积,提供材料层或层的各向异性加强,以及提供用于引导细胞生长的多个通道。
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公开(公告)号:US20100047317A1
公开(公告)日:2010-02-25
申请号:US12608534
申请日:2009-10-29
申请人: Jan Weber , Tom Holman , Tracee Eidenschink , John Jianhua Chen
发明人: Jan Weber , Tom Holman , Tracee Eidenschink , John Jianhua Chen
IPC分类号: A61F2/00
CPC分类号: A61K31/01 , A61F2/0077 , A61F2/02 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2250/0067 , A61K9/00 , A61K45/06 , A61L27/303 , A61L31/084
摘要: Methods, systems, and uses of bucky paper are provided in the present invention. These embodiments include covering medical implants with single or multiple layers of bucky paper, treating bucky paper with various therapeutics to be released through the bucky paper to a target site, shaping bucky paper into non-conventional configurations for improved therapeutic deliver, and using bucky paper alone or in conjunction with other materials to treat a target site.
摘要翻译: 本发明提供了巴克纸的方法,系统和用途。 这些实施方案包括用单层或多层巴克纸覆盖医疗植入物,用各种治疗剂处理巴克纸以通过巴克纸释放到目标部位,将巴克纸成形为非常规构型以改善治疗递送,并使用巴克纸 单独或与其他材料结合来治疗目标部位。
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公开(公告)号:US08454681B2
公开(公告)日:2013-06-04
申请号:US11520920
申请日:2006-09-13
申请人: Tom Holman , Jan Weber
发明人: Tom Holman , Jan Weber
IPC分类号: A61F2/06
CPC分类号: A61F2/954 , A61F2/856 , A61F2/958 , A61F2002/9583 , A61F2210/0033 , A61F2250/0074 , A61F2250/0097
摘要: A catheter assembly including a side branch locator that is moveable between a retracted position within a main vessel of a vessel bifurcation, and an extended position wherein a distal end of the side branch locator extends into a branch vessel of the vessel bifurcation. The side branch locator includes a first end fixed relative to a portion of the catheter assembly that remains in the main vessel. A second end of the side branch locator is moveable between the retracted and extended positions. The catheter assembly can include a moveable sheath that holds the side branch locator in the retracted position. The catheter assembly can further include a stent having a lateral branch opening through which the side branch locator extends.
摘要翻译: 一种导管组件,其包括可在容器分叉的主容器内的缩回位置之间移动的侧分支定位器和其中所述侧分支定位器的远端延伸到所述血管分叉的分支容器中的延伸位置。 侧分支定位器包括相对于保留在主容器中的导管组件的一部分固定的第一端。 侧分支定位器的第二端可在缩回位置和伸出位置之间移动。 导管组件可以包括将侧分支定位器保持在缩回位置的可移动护套。 导管组件还可以包括具有横向分支开口的支架,侧分支定位器通过所述横向分支开口延伸。
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公开(公告)号:US08114153B2
公开(公告)日:2012-02-14
申请号:US12205004
申请日:2008-09-05
申请人: Tom Holman , Jan Weber , Afsar Ali
发明人: Tom Holman , Jan Weber , Afsar Ali
IPC分类号: A61F2/06
CPC分类号: B32B38/06 , A61F2/0077 , A61F2/82 , A61F2240/001 , A61F2250/0067 , A61L31/088 , A61L31/10 , B29C35/02 , B29C35/08 , B29C59/165 , B29C65/56 , B29C65/64 , B29C66/02 , B29C66/034 , B29C66/3032 , B29C66/71 , B29C66/712 , B29C66/742 , B29C2035/0827 , B29C2035/0838 , B29C2791/009 , B29K2001/00 , B29K2001/12 , B29K2003/00 , B29K2005/00 , B29K2007/00 , B29K2009/06 , B29K2021/00 , B29K2023/00 , B29K2023/06 , B29K2023/065 , B29K2023/083 , B29K2023/12 , B29K2025/00 , B29K2027/18 , B29K2029/00 , B29K2067/043 , B29K2067/046 , B29K2069/00 , B29K2071/00 , B29K2075/00 , B29K2081/06 , B29K2083/00 , B29K2305/00 , B29L2023/007 , B29L2031/7542 , B32B1/08 , B32B3/266 , B32B3/30 , B32B7/04 , B32B9/02 , B32B9/04 , B32B9/041 , B32B15/06 , B32B15/08 , B32B15/18 , B32B23/04 , B32B23/042 , B32B23/14 , B32B23/20 , B32B25/042 , B32B25/12 , B32B25/14 , B32B27/08 , B32B27/18 , B32B27/28 , B32B27/283 , B32B27/30 , B32B27/302 , B32B27/306 , B32B27/308 , B32B27/32 , B32B27/322 , B32B27/34 , B32B27/36 , B32B27/40 , B32B2307/51 , B32B2307/714 , B32B2307/7163 , B32B2535/00 , B29K2089/00 , B29K2077/00 , B29K2071/02 , B29K2067/003 , B29K2067/00 , B29K2039/06 , B29K2033/26 , B29K2029/04 , B29K2027/00 , B29K2025/08 , B29K2025/06 , B29K2023/0675 , B29K2023/0616 , B29K2009/00 , B29K2001/18 , B29K2001/08
摘要: Endoprosthesis assemblies and methods of making endoprosthesis assemblies are disclosed. For example, endoprosthesis assemblies are described that include an endoprosthesis body and a polymeric coating about the endoprosthesis body. The polymeric coatings are engaged tightly to the endoprosthesis wall through engageable features created on the surface of the polymeric coatings and the surface of the endoprosthesis wall prior to engaging the surfaces.
摘要翻译: 公开内置假体组件和制造内假体组件的方法。 例如,描述了内置假体组件,其包括内置假体和围绕内假体的聚合物涂层。 通过在接合表面之前在聚合物涂层的表面和内置假体壁的表面上产生的可接合特征将聚合物涂层紧密地接合到内置假体壁。
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公开(公告)号:US20100063584A1
公开(公告)日:2010-03-11
申请号:US12205004
申请日:2008-09-05
申请人: Tom Holman , Jan Weber , Afsar Ali
发明人: Tom Holman , Jan Weber , Afsar Ali
CPC分类号: B32B38/06 , A61F2/0077 , A61F2/82 , A61F2240/001 , A61F2250/0067 , A61L31/088 , A61L31/10 , B29C35/02 , B29C35/08 , B29C59/165 , B29C65/56 , B29C65/64 , B29C66/02 , B29C66/034 , B29C66/3032 , B29C66/71 , B29C66/712 , B29C66/742 , B29C2035/0827 , B29C2035/0838 , B29C2791/009 , B29K2001/00 , B29K2001/12 , B29K2003/00 , B29K2005/00 , B29K2007/00 , B29K2009/06 , B29K2021/00 , B29K2023/00 , B29K2023/06 , B29K2023/065 , B29K2023/083 , B29K2023/12 , B29K2025/00 , B29K2027/18 , B29K2029/00 , B29K2067/043 , B29K2067/046 , B29K2069/00 , B29K2071/00 , B29K2075/00 , B29K2081/06 , B29K2083/00 , B29K2305/00 , B29L2023/007 , B29L2031/7542 , B32B1/08 , B32B3/266 , B32B3/30 , B32B7/04 , B32B9/02 , B32B9/04 , B32B9/041 , B32B15/06 , B32B15/08 , B32B15/18 , B32B23/04 , B32B23/042 , B32B23/14 , B32B23/20 , B32B25/042 , B32B25/12 , B32B25/14 , B32B27/08 , B32B27/18 , B32B27/28 , B32B27/283 , B32B27/30 , B32B27/302 , B32B27/306 , B32B27/308 , B32B27/32 , B32B27/322 , B32B27/34 , B32B27/36 , B32B27/40 , B32B2307/51 , B32B2307/714 , B32B2307/7163 , B32B2535/00 , B29K2089/00 , B29K2077/00 , B29K2071/02 , B29K2067/003 , B29K2067/00 , B29K2039/06 , B29K2033/26 , B29K2029/04 , B29K2027/00 , B29K2025/08 , B29K2025/06 , B29K2023/0675 , B29K2023/0616 , B29K2009/00 , B29K2001/18 , B29K2001/08
摘要: Endoprosthesis assemblies and methods of making endoprosthesis assemblies are disclosed. For example, endoprosthesis assemblies are described that include an endoprosthesis body and a polymeric coating about the endoprosthesis body. The polymeric coatings are engaged tightly to the endoprosthesis wall through engageable features created on the surface of the polymeric coatings and the surface of the endoprosthesis wall prior to engaging the surfaces.
摘要翻译: 公开内置假体组件和制造内假体组件的方法。 例如,描述了内置假体组件,其包括内置假体和围绕内假体的聚合物涂层。 通过在接合表面之前在聚合物涂层的表面和内置假体壁的表面上产生的可接合特征将聚合物涂层紧密地接合到内置假体壁。
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